-Si-Gl@ET (When Filled Zn) SUBMITTED ay 2 DATE - VOUCHER NO. 2-12 ACCOUNTING BY INDIVIDUAL PER! OD OF ACCOUNT l,'4G FOR ADVANCE. TO NOTZ, Follow ZnvtfuctiOns On Reverse 1. CASH ON HAND BEGINNING Of PERIOD S 23 S. EXPENSES THIS PE IOD: 2. OUTSTANDING ADVANCES BEGINNING OF PERIOD DA-re DESCRIPTION AMOUNT 3. K-CEOPTS L@HIS PERIOOI2 Moon" See 4Ltt*jebed RECEIPT DESCRIPTION 14U%P.SER ATE ooous 2 I TOTAL EXPENSES O. PFFU 0 0 HEVIIEWIT04 I ICAXOO I leo )Not* 2 7. PUTI.TAMOING ADVANCES END OF PERIOD (Attach listang) CASH ON HAND No OF PER 00 ON 9 LANC D@t ADVANCE9 4. 2 TOTAL TO ACCOUNT FOR -RPTA ACCOUNTED FO I CERTIFY FUNDS ARE AVAILABLE T 2 AP ROVED I car that t a expen &a listed hereon and OVALIG.*EF. @0. ICHARGE FAN ACCOUNT NO OA7E Si@NAT7 A7ROVONG O@F@@l@ 2 t h war ur ad for of icial' put. t t re 'hot payment or 2 ;c @,.d and th..@ rr c !^7 SL -kl%!XO2 WIT= urp F t@u 1, DATE S GMIITIftE 01 AUT.ORIZING OFFO CER CERTIFIED FOR PAYMENT OR CRED T SIGN URE iO@ PA 2 E DATE SIGNATURE OF CEPTIFYIN OFFI FR! SPACE BELOW FOR EXCLUSIVE USE OF OFFICE OF FINANCE OESCRIPTlOt4-ALL OTHER ACCOUNTS 13-33 34 39 2 &O. &2. 40 50 51-54 55-46 s@-70 49 7.00 20-33 ST2ATION 4'@ OOL:@ CA S FAN OBJECT c c REF, NO. PAY Of! GE ACCOUNT CLASS coo L NCCIIA.L YMBOL ..... ; 9 ...... 0 ... PER c DESCRIPTIO14 - c p0 AD VJ.. et 'CT. NO 2 IE S 13-27 0 : '@t c ....... CODE T ....... DUE ADVANCE ACCOUNT2 LIO. OS I'Ac DEGI EOTT 0 EMP, NO@ F. 00. DATE i, T CR .I'. POO . YR. . . . . . . . . . . . . . . .............. ..... ............. 2 . . . . . .. . . . . . . . DATE PREPARED BY DATE REVIEWED By TOTALS F 2 GROXM 1 oRm 282 SETRE-T SCHEDULE FOR G FUND-DISBURSEMENT@@ No. 109 $@5, Z@7 v.@o o:::: I July 1960 "00- 00@- I October 1960 5. Z70. 00 I January 9 5oz7oloo-- I April 1961: Alm #1 Oslo Wu slntc,,o- A* umagoad oni viou 2 70- Ot Avog"lq d_l"op IOTO UT 02 *CZ6 tg6t 9 Om 0961 tat -601 "J. Egli %)Li6,(%L I (When Filled Zn) SUBMITTED BY DA4rE YOUCHFR No. 2-12 ACCOUN'TING BY INDIVIIDUAL 109 PER I 00 OF ACCOUNT I NG FOR ADVANCE FROM TO 2 -2% 6 6 NOTE: Follow Instructions on JTOVVFNO 5. EXPENSES THIS PERIODI 1. CASH ON HAND BEGINNONG OF PERIOD Y.2" %"EFRII DATE DESCRIPTION AMOUNT 2. OUTSTANDING ADVANCES SIGI NING OF PERIOD U% RE-CEIPTS THIS PERIOD$ see Wt-t-^-Zii2e-d REr EIF DATE DESCRIPTION SUMSED LIA3%ae A TOTAL EXPENSES 2 MEREWIT 6. REFUNDED CK C.Sen 2 0 OF PERIOD (AtFoch lioltino 7. 00TS AND G ADVANCES EN S. CASHION AND N OF PER OD @ft ALANC2E YE OVA CE A. TOTAL TO ACCOUNT FOR TOTAL I A FOR APPROVED ate her ICERTIFY FU S ARE AVAILABLE 2 C ftify t VAN ACCO T 44 IITF@ tA GOFF 0 t !er a utire OSLIC.REF. 0. ICHARGE 2N )., a id A p fg enti, I tur A t 2 P:Yop ntthe edit thf has o ed, n 2 S 17 17 @77'@ @,111 i@ &Is r :,I, I i 947 11 Li 'T DATE SI NATURE OF AUTHORIZING OFFICE CERTIF@EO FOR PAYMENT OR CREDIT SI R DATE SIGNOKTLOR Of CERTIFYI" OFFIZ 5FACE utL(;W FOR EXCLUSIVE USE OF OFFICE OF FtNANCei re2ESCRIPTION-AI.L OTHER ACO.OUt4TS 13-33 34-39 AD. 42-47 AS- 50 51-54 S5 6 co ' 6 67-70 71,802 AS 09JECT Al OBLIG. CA ST FA: AMOUNT 211, 53 2 SYATION SYM CLASS CODE E FIEF. Mo. PAY OR FOAI ACCOUNI OL, C C-"" 2 ............. AC .......... @PER. LE ". 61-66 :69-70 @P0 A 0ACC-11 DESCRIPTION spop,o 0C. L la. S N2o., v CREDIT .. : Due DESIT DVANCE ACCOUNTS 13-27 ........ @N CODE T Y: ": - t E REV. .00. DATE 0 :Cmp. No. YR. ........... 2 o riv 09 DA DATE REVIEWED DV P, 2 TOTAL$ Palo.". --"7w r@@oi VP F TOIMATM r 4 4 Ovst sm 287. September 20,' A96 Dr Dear DC. d -of enclos ance.Vit- In accord ih t'kt t rms our. grant to Dr .1 in 6du iicate t"m ex aditurt report.-- r 1963, to Au" t 31, 1965. This covers t'@e Period -1@@Ptezb@e- Verl. cc. or. @.116s- T16 Project Titl#-.i Investi ?h. D d of tha Departmanto Dot#; August itell AUT2pristi 2,114.25 2-114.225 i'Wow Associated, Assistant#: -052- -0 -3 .44 -052. SUpplits 004 YAtGrt&l#- 3# 0 Equtpzont 1-1. 544-.7t777-AIS-544-.,@79 -0- -470.96 47V.95- Sub-TotAl i8 Personnel Bud&t@- To Cover Rat. - .00 -148000- .0--- -00@@L In&. 15% of Total Budgeti To Cover 2 9-.56- 6 Total 5 WU* 243620 4609k-The o FM 15,, 1964, Director,.- Def W otbb*'r8 e ei4neo-,- to-- th ri 2 etttr of- se -a-copy 0 find"eiicio' - f o- u- -r ret of kuoistl .-and cAoVilei --o r @@6rLei tor latink@ to repditw requirements 2 It th@ t@asiti,-f:oi@Lthle rePArt is no t corret ---if de- you sire additional',Information,.pl@oo4k., -let we kii6 2 W. -:As@ -!:,;e lstint --!Oent tV Dr. 2 ICr A/C) 7- Bi5 ROFFICE-COMA4UNI(---@Ti ON-- k-- t Fmm: To: --446 Zn accorveml>er 19Q 109 Authorization 421,080-00 3U5@@3W2 15 r 1962- FOR TEM-FEC SubP suBjwT MMTRAs roject 109 of-tbie-subproject is to Ovi4e@ funds for--- 2 tion of a study of-pottbti&l@@opharm4@apt@@@@ the coat agent-6 n particul-a--r------studies All 'tm-diiii@cted-@Wtbe-elucidation---- of interrelationships betv-e-en-mole-cu2lar-consti-tutift-and biolo cal respmee.-- Studies vilr-be- conducted into the, biochemical cbamc- teris:ti&gdof tyt>es -of CbemiUl moieties-vbich are of in- terest -to TSD/tWLiALOrrY@@ Out its program orA tb2"t@@@ Of means to-control or. 2-Th"ttached_Budot-i-ndtd&twthe extent of the inve8ti- gations-that vill-be carried OUt-u-nder the direction of z @in facilities available i The funds-fo2r this-- ject vill-b4- transfo6'@-VA.ing the I as a cutour..:- 3@z7ThOCOtOlO beiiig-t&"Ie"t under this originall"lWMed-to cover a period or-6pp@@imately five years 6 -;@-HW"eri-the change in ecu@@@@ based upp-the attached-ftb!4$al of the@prerent TsD@@@ requires that these- lalns be altered-- considerab,y@@@@@bas therefore agrti@@prg-- d est'ole during the-- duce " MnY actual@tnd--Ltem c-Oml>Oun, 2 next year-and als@@to-consider thit@Wthe final year@-of_tbe projec+..-For@@this it"wthe attached budget down from the original-estimate of W,578-00 -- to-$21,080.00. The mostly lowe @cl perso@nel costs occasioned b -tbe-simpl"eve2lbpd*btal-activities-nov l@d. a period,, of-one -year not exceed t- b4-@ tkie- e; t -$21,92a@@@ fee to-th ing the total amoun Charge3-LshWiaito:04e azainst Allotment No.- 3125-139(-39020 a 5@- The- quires th t submit to them asummary accounting:on-an-annua of all@t@ie -)dio, unexperided funds vill be retumed-2by-@@@ as soon as possibit@T@the cldw- of 6@@A-re irement fdt--"ix months'-info-rmaV7&cc=ting on the p&7rt offue-principal investigator Is waived-------- 7@@lt ted-that-any-permanent e6quiTp@@@will- pa be needed-for-tbis--prog@@ in connection vith traver=under-this prpjectp it_is agreed tbat@- the Agency vill- sdeept- the -travel do4;umente6tiOn-8nd accounting vbich confom vith the Vr"tices of thei g. it is agr""at tec2hnicar-t*ports-ref.le4,,ting the' progres -Of tba research-PrOgrgm sbell b4 submit:ted at mutu&IIY------- acceptab- -intervals. vith the-planning and moa- lo. - All- 2 SECFMT AgencTiq@k@V:@ itoring OtAhi*_program possess TOP approval.- ttrat leaves the -Thi"roject will be unclarsifii@(i af BIOLOGICAL BFMCH plttacbment,. proposal-& BiAget Di a tributi On Original only PROPOSED--RESEARCH-PROJECT-. PORTED- BY TR AT project@Title: Thie.Synthesis and Bibthemical Evaluation of Potential Psychot>harmaco- logical-A&@@@s. 2 Principal Investigittoi@: Ph.D., Professor aid-Head-of -:tWD,@oartdie7nt- o - a ceu cal and Medicinal Chemistry,, Colle-ze-of Phar--- macy. For the past several years, the applicant has b@@-7@"ed-in-research-involving@ 2 (1) the synthesis of:6t&nit@t"iti"-having potential effects-upon thd-ttht"l n6r. vous system, and (11) the evaluatibd--df-c-on-ne-ccid"-between-theftb@@mical and pharma-- codynamic properties -o"h4oA:j@"oundtT@@polieant is- primartly@i2ti@r"ted -in the fundamental studyi@ittitA@@@@en molecular constitution and bid@ihemi.-,---- cal response, and is particularlk::j@@@with_the effi@@t-of-gt@i@@nges in the chemical structure-of@:@@ti"ntiti4i up6n isolated m 2 -,,@U=e - ,@fgrred to ;(A) report"ubmitted-@" and (B) ubliqhed accounts 8-IT-@@UPR@@al infdii@at-ion.--- The applicant plans to-co@ntinue his-ihV@@@gation in accor.dance-with-the principl2es set forth ia the cited@::munumic&tiQm,3@@o@cifically, h@i--i.ntetid"o: 1. Synthesize patterned afti6t7(a) -otoni4@ Amines known to affect@@the-central -nervous syAUm,-_and (b) i@@iettes acknowledaod as sub-2 strates in enzyrR"y#tems:ifilplitAte-47t"he 1>ha@@@codynamics -off@@@@osses-w----- sing psychopharmacoldti@@41-0@@ The membor_comRq"d§7of-(@acW-§eries will be designed wittv--gradual--changes in-their-constitution, or-physical properties, or both; forthermorei@3hey-will t@"la -in-such a tanner-that Dotential dtffd. reaces in thb;int4raction between the member_cotiipounds of a given svntheti&-Series--- and a given enzyme-may.@teroTgt@@d-in-terms of@@epts reasonably well estab-2 lished in contemporary-theorettcal t@temist-ry--.-- 2. Study the effec"f enzyme- preparations believed to be associated-i@ii brain function, And (b) other 14ausiblii-bi6chemi"l-systems. 3. Explore relationships between-the biochotatedi activity-of each series of-de-rivat es and the- successive@@hanp-es-in the-chemil-,al-and physical chiracteristics of the------ member compou,.ids.-- At present, our synthetic work-is centered around series-Qf arylalkylaminoalkylaceta-- mides, and pyridine- and a, 2 -pipertdi6ttttbbk niA._q ,isOAlii6d As moieties-- derived from the psychotomimetic-mblecul@ LSD (td@67Figures l@7II 111-and IV-@@her series have been planned). Concurrently, the completed compounds-are beina evalu-ated-in isolated cholinesterase systems in which LSD ha! 6Shown-remarkable specificity. -Our manometric-procedures Effective July 1, 1960 (on-ldave of absence July Is 196D tnrough Juhe-309 1961). Pace TV* 0 NN C2H5 c e 2 C-N" -N HN I G2H5 c IN 05 LSD. o-- 11-IC2HS \t--c --N HN H 5 R C2 @c-C-N' HZA2 N CH3 LSD@ FIGURE 1. S U 8 S T I T U T E 0 A R Y L A L K Y L A M I N 0 P R 0 P I 0 N A M I D E A N A L 0 0 U E S 0 11 IC2'15 C-N %C22H5 LSD 0 11 ,C2H5 c "5 11 ,C2@5 c- C- c C- 2 2 5 c c 3 71 CH, H 2 0 R /C2 11 5 27.5 C-C- D 2 c GA-@ I SI IC, 2T.5 3 14.810 0 3 ( C D 2 3 R R co i "3CO'-C/ 3 r.A-34 0 GA- 143 2 C@ H3CO c H GA-44 GA- 1 34 3 2 N co co m cc@37--N\5.. H3C @37-7\\,.. :3 GA- 1 53 2 co " co 3 H3Co \\ %1%0 83 2 13 - h3 H C, co "-165 r- GURE TI. Page Four. it LU LL tit Paso Five 0 H- 11 I - 11: ,,,CH-3--- C- N-CH@@ C:N N CR CH 2 5 1 C- C.N -N-C iH c2H N N CH CH 3 Page Six isolated pseudo- and a etylcholin6t ield very precise measurements of activity in c y terase systems, and 6nable-us to evalu-a--t-e--the-significance of even minor variations in activity due to small eodstitqtional-@thanges in a series of@&b2le-eules@@@ We are aware of the fact that-the e-ffdctiVt@@@f a-pt@ythopharmacologitAl-ag@dt in vitro cannot be interpreted as-evidence f4t@the involvement of-th"pgcific enzyme@ Tn the mechanism of psychotomimetic responses@@Ydt even -with-out,conclusive causal- connection, this approach-m4y--fur-nis"aluable inf orma t i6-n-o-n-' the nature of pharmacological agents. It is felt that this investigation may yield (a) information assi6,@ing-the eludida- tioti of interrelationships between mol@@l@@@d"ti-t-ition and bi-logical response, 0 2(b) better insight into-L-the bioch6Acat@@@@istidz--and therapg@Mic potentiali@@- ties of certain typei3:E@offd6iL@@@(c) several sei!647@6f new organi6-compounds-and information about their@.ohysical thdratteristka -and (d) data="ppl:@@ing-0our knowledge of the neurochemical processes assocUttd-l@4ith the'actioh-6f psychoo'b@irm;i cological agents. The references cited inith"t@g@-aragraph of-th@-@li"--arL---listed on the p ing page. January 22, 1960 cc: Page Se@ven Reference a :-to--til 31 june 19'55, Second 2. A 3. 2 ecember 9§56.10 -Third Report to tile Fou 1-- rt to t 4, I-Say l@5 5. U2 Lt-@O@ 6 2 the 7. p -- ---- 8@ Chem., 1: 799, .1956@@@---- 9. VE 21: 805, ;1956. g. Chem. 21- 9528 1956. 10. Chem.s 22: 837, 11957.- 12. II-El Intern. -pharma od J. Org. Chem., 23:11'577*- 1958.-- 13. j,,,Org.--Che2mi-@3-. 2005@71958 WWII @harm. Assoc.) Sci. Ed.$ 16- mi-WIN Ab§tracts, Am. -Soc-.-Pharmacol.---- i-@184: 1922, 1959.. 17 9 Chem.@ 2: in ordss, 18 try, J. me.d. pharm, 197F. 19. med. pharfa. Chem. 2: in press,-1960. PROROSEDi&UaGE.@@SEARCH PROJECT BY THE AT (De 4-We;r, mr, f9F67-rh-r Project Title: The-S@@6ttves-is and Bi-0--c-hemical-E--i atiom-of P tential va u 0 P2sycliopharmlaco-l-@@§i-4@-al- Agents.- Principal Investigator: (@h.D., P-rofesso"nd Chai-r-m-an----- -of the-D-6p--a-r-tment of Pharm@ceutic6i and Medi- I I of-p[- ci ege2 tarmacy,, C---- a- -u- l@ 0(6.oo- Personnel (Associates, Assist nt@@ ons ------ Supplies and Materials- Travel 600-@-iDO-' SUBTOTAL 1 7% of Personne I Budget retireme2nt, etc.------ $ SUBTOTAL 11 IS% of Subtota I II 18,330-44 to cover participation in-indirect-costs -2- ---086.--O-O--- .TOTAL Cliecks -S--h@ld b@i-'Oayable to the May 31, 51962 Branch-- Catego fptbeoi WA MSIUS+AIA of pot44tLiki It@WClassification--V"UA"fi*t@@ Project Title- Project Crypto c t -2Pr@ol@ct Branch Project No.---- Contractor-- Contract No-@' Type of Contract---"* Date! l@itiated--:@@1-2 Date-L completion Cost Purpw., Igluoulatioa ot iavw" ot '4141"t ta Status, besto 'bi PZWTM= lot*,Mal,ly astarated Lot "i)bY 44td fOr OPOI@@ bt91 -l',otl*AtLon-- -- --- --- b"io-laorm%LO ola tb@sr@@@. Ma 3i. i962 y Dr. Dear a-inly::Ojoyo'ta I cert morni-ng For you -ni ence, I am-enclosiii6-@6-- opy--of the 2 r cnve c proposed budget f@d"he next-g-r--o-n-t--p-e--r-i-gd (December____ 196"Ki@-@h-. November 301---190'3)-,--- With the very--Eest regards-, Enclosur By Air Mail ------a n slurp P.S.-.@ My home address is. 1862 AA-IF-RICA'S LA ND-GRANT UNIVI,'RSITIES CEI,,EBRATE A CENTURY OF Sk'RVICE-----1962 Ile clolisAALXANTI.@;,H@l P TO THE I (Dec@emt)er is 19@7, through Nove'M'Re'r -P@@f4is-o-r and Chairman of hi 5 Medicinal -the-De@p-aiitihent of - - ---- I ,go- of -Pharmacy,., Chemistry, Coll# 3 000-00 May 31, i962 P-'ZOPOSAL FOR FSTA-BLISFVuqNT OF@@FACILITIES FOil PSYQHOrTO141@U4TIC-D.RW-Tr-,STIM----7- First Year: SurveZL2t@isi4 compourds Literature revie-- so2urces--seminars tuagestio-ns @Practicoll F.ffects to be screened,.- convulsant&-@@n-ti66iftl 3 speoifii*-arterial dilator;@@@stri6tbfd-@tissrotonin eff6dt@-@-- cho2linesterase-inhib ors--- Neurolq,,-,ist .6=pr4nelpal-ii&6,sttgat@D@@@@ Clinical 143000- Research assistatts-- 10 000 Statistician aerviooa-(part 2 1.2 Resident assij-,n,,rentsA8@-P--O-.---$300/mo.-)---- 21)400 Equipn@ent anJ sup6l-a- e.g. calld-u tor - carera- F,,Eoljo-servicaj-computor serviceF-@@--. 4POOO 'rravel -tal- To $35..200 To the budget figures must-be added 7% of personnel budget for retire- ment and 15,1. of overall-costs-for-7bO@6@h5"d.-- FACILITIES-FOR PSYCFO-iOIIDIETIC-D-R.UG Second Year: Trials-cf -mw c2a@unds@ Screening potentikil"yaluable-offoo Chronic to3doi in-anira U,u,2nan trials - double b!W and/or concurrent trials-s@-- psychoVo-gi6al@_if f Go -e autotiomie@ anticonvulsa-nt@-: anti3pasriodid@@@@ 2 antiebolinestera@"limit -ed@-@@thdnia gr.avl"ati-ents) antiserotonin-("olustdt" headaches) BUDGET --SFCOND-YKA-.Tt SRAFF- Neurologist - .Nrinoinal-ihires2ti ator@@- $-3)000@ Clinical pharmaeo lst 14-.9000- Experimental paycl,.ol@o--g-itt 10(.000 Research assistants------ l2o..5ou Statistician service3 Clerk-statistioi,a 3.0000 Resident- 3s6oO@@ Equipment and supplies 4000 2'rravel 40i@@@ Total $50$7 (+ 7% personnel-f6e-k4tirement) (+15% overall-for@@@d) It may be adv-'@.s.A9ble--also-t6@e6nsider th"deition-of a basic - obarina- colo,,list to the sWf-iii@@ (or third) year. March-9 -1962 Atten io Dire Dear Sir.- - Enclosed-i"he-cqm 6hoal eip6nditure report 11 1 4 tdi on yoti"rantAo-Dr @ This f6r-the-,oer-i-od July 1, 1960,-to-tlovemi@-- Yours:@veryLtrOy, cc: P@i. D. 1862 AMFRICAS LAND-GRANT UNIVERSITIFS -CELEBRATE A-CGVTURY OF SERVICE 1962 Budcet Report-on-Pesea,.rch-Projdct by. at (JUIVI, 1960 throuoh l,oveacei--30,-1961) Project Title: The Syiith4sis and Bi66henical--Evalij@&tibh@df Potential Psychophar@nacoloc-i-,al7@7-@----- Agents r rrincip,Bl Irive5,-.igator: I 11 Ph.D., Frofessor and Fead 'of-Ahi@-I partrient-of .harmaceutical and-!@idin-ai@@c@istry@@Colleg-e 6f-Pharmacy - Date: t4oven'oer 30, 1961 Outstanding- UnencVthb6red Ll'-O 'Li AporoLLiati@@@@Ercumbrance'S aalane PC-rsonnel: Frincipal Investigator' $-3 000 oo-- -$ 3,-Ooo-oo- $ -0-7------------$---(----- Associa-Lles, Assistants Consultants- Supplies anti i%'aterials 7,-061.557;;;@7-061- 55@ -O- -0---- 6,'-;24 Travel 2 -0- -0- Sub@total: 7/c/3 of Personnel Budget; tD cove -0- 0- Piet.-Soc.See.-Ins. 15,'O/ of Entire 3udoet; to @uover 2,749.56 -2,749.56@ -0- -0- 4 Indirect Costs Total: $2!. LO.OG--$ 0--- ana sabmitted I bave '40 ivision 29-Mtit!iLI962 MEMORANDUM FOR-,.--Th-e-Rec-ord SUBJE-CT@@--7@---MKULTRA, Subproject 109-Cost of E4uit@@Ek&@@ed Budget-E-stimat6- 1--Thi6@ot Pot@@ for Siit@@iect 109- dated- 22 Ja'nuary 1960, had @i-p@sed fioki@-of 5. OOO.-OG-for supplit@I@ mat@&tials.- -- Tiie-re was no anracipation -o -any eqWp,-tLent, 2.-- Ar"eed@IhUng report has been-received-fotahe period-l-J419@@@rough-30 NdVi@@er 1961. : T is report I -SSforsupp4esand-mater.ia,ls@#-,-.-------,--- refte,4ted@6@@#_@ 061. and $6, 2324.-93 for equipment. hese amowit@t-exceeded the- figur-e-a in the original 7o)@@d budget. 3. TEis@e-Tiipment was- expendable- and tti@@- tures have th6:-a@-oproval oUTSD/RB as beinL_lessential-fofL@@------ tb.@e succes-aful@@9d-O@letidii7 of the research work that was--- conducted.----- TSD-/Research Branch-' Match-9, 1ID62 C/ Att4riti@n Dear Enclos# Brancli tlttough TSD/Budi*C i@)ff'tcer by ZO Novoaiber 1961. 3* - This- it 1.0 &Atlcli*ated -4a wtU b4@otltgated for iMs proj"c-. tho ittes that ad-.Iition&Lfu* 1 involve -the fbiloving two checks Receipt is hereby-acknov!6dga--for--,---- Casbier'@ clieck No .1 ,"" Move .00, payabl Treasurer-@"ti@7@N6 ted Novext2o-r.-, 2n6l n ipat-e -PAQ-%al e t MM-mm te UEMO.IMIDU',q FORT Chiefs IX-.-Ision VIA SVBJECT Allotmont NoL445-139,0-39024! paymoat oho@d4 4* M,%Jo as fon6ws; 2 tcv@@@24, 090 00@ d tti@@t a $963 2a@7@@- *it a o4yabl4 to Z. - Pielso to@@@ the checks -W Cbi et# TSD/Aoso&rch 2 BroAch th@-r*4"T$D/BAWlet OMco@W28-Ni6VOmbor 196L@@@- -4"11 b4@id4t44-for this projoet- tho ftlas tbat additi"al fd-7i $hmld Aot b6 CIOS" 2 Ch f Invoice Ik Cortifigaagras --TSD/Z%A.SS-- Ck;RT!r,-,,C-AT!aC)NS rr d t In t.A k!4i 2 r4r, 13-Novamber 1961---- i-. is lnvrtc* 4Lppli,.,ii to Siibpr(i tr@t 109 ;tt%ci@,L-,l -c,@A fhx,@ memqrtnd@@rn t@,f 13 April 19@03 -ffcr@i imam DR A- 2-November 1961 EMORANDUM FOR-.-- THE RECORD m SUBJECT --MKIULTRA, Subpoiect 109 1. Th@6-purp-ose. of-thig--tubproject is to priavido--fu-nds for the continuation-of -"tli f -i>otential psychoph4rmacological--- agents. In artitular7"tudi=6"11 b"irected to the eltitidatioi@----- of interrelati6ii-thip:$Ibetween molecuIA-@@tit-ution- and biological 2 respo.nse@-@Stvdi@F"ll be conducted into the biochemical-charac----- teristic s -of -t@tain typies -6f-Imoieties which are of -intet@6@ to d Budget indicates the extent of the investi- t@ 'll-V6@@@@dut-undet the directlon--of -Dr. 2 -WC gations tha WI facilities available t the -NMI funds f r tt%is project will l@@ti@ift.-ife---r-re-d-using the owl-- as a cutout niin4istrative purposes in this project, the salary of the principal investigator, WI -be c Dr. li arried as a separate budget item-and will paid directiyioihini(b-y-the cutout. /07- A-4. The cost of tht@--@@C@for a period of -one year -will -not- exceed $2 ,O8O.-OO7t67*hich must be added-tWfo-Air-per::cent fee-@MAhe I 2 making the total amount-$ZS-i-Ot37.@@U.-C arges should-be rnade-against Allotment The requires that the ubmit t o them a summary accounting on an annual basis of all monies-receivedfrom the o, unexp"4ed fWi2di-wilV@@@ be returaea-li"h@L as soon as possibl9-upon the close of the grant year. V' A r@@@@t-for-a six months' informal accounting on the part of the priAcipalinveSt'---Lt--' aived.--------- 2 _gaOr2SW t It is not@Anticipated that any permanent equipment will-- be neecled-for--this-program. In conn.-,ction with trave-@l -u--n-d6r this-p-oject it is agreed that the Agency will@@@he travel documentation and accounting- which co nf6fft@Vith-th Itis-agreedthattechnical-icp@qrts-reflecti@@th@7Wogress .@ I '$. - of the research program-shall b@& submitted at mutually ac-ce.ptabl@@-- inteirvals. 3- connected with the planning and monitoring of this program pq"@@ss TOP -SECRE-T--- urity approval. T S-P"iett-wilLVt@@lassified after it leaves the TSD/Reiearcly@@@@- 0 APPROVKD FOR OB LIICATION OF FUND rector Date: Attaciirnent: PioposalLktBAdg6t Distribution@ Original only 2- PROPOSED- BUDGET-FO,'R RESEARCH -PROJECT Bif THE AT 2 (De7cembe-r---t, IYOI tnrougri n I- tion-ol@@P- @Pr-oject Title:---Th"yn- $---- ca ve ua otent a Psychopharmacologic@al--Ag-ent-s-.-------- Principal lnvestigato., h.De. Profeisor--&n-d-We Of of Pharmaceutica-t--a6d Medi--Cl----- ma I -C em St", Co 1--I*de@ @Pharmae Personnel (Associates, Assistants-and Consultants)- $-12-000 00---- Supp I i es and Mater i a I s 41890:@" Travel 600.00--- 2SUBTOTAL 1 $ 171490.44 7% of Personnel Budget-($ 12@000.00); to cover retirement, etc.. 840-00 SUBTOTAL 11 $ 18,330.44 15% of Subtotal 11 ($ 18,116."); to cover participation in i nd i i@4,ot- Co -St a --- @2,742.56 TOTAL 210080.00 Cheekt should be payabLe-Ao the October 2, 1961 cc TO THE W emt@-er SU, M27 (De i-,i@rough No@ h. D. P -r- -o fs-s- o-r -a n-d H o- a d o f -t h-e- Departm 0 Ph-a-rmaceuticil and Pi1edicinal Chemistry, Oct,ober 2, 1961! :2@ SUBJECT Al inubco- &-I t ODilA@@ -tnd tl,,@ fvoin the @i- log 3 043* 20 D-rot'oz TSD/FASS T$D/P.B 4"961 ATTEN'T I Dear Er,closed, herewith--is the@@firt',- nual- report for ygq"rant to Li el-@t--Yours- 2 Sincer C, "?ncWl'osur9 H- PROJEOT@ BUDGET IKEPORT ON RES&KRO u By 1961) Project Title: The Synthesis e-nd-Bidohomittl2-Eialuation--of Potentikl@-F@V@"cological@ Agentse Principal Investigator Head ofAht@-@@ of Phar- Pr Itedielml Chemistry@ Coll@go-of PtA@r-maoy* 2 Datet December 51# 1960,,@ ITEM AP MERED M-7- Personnel Principal Investigator: $7@@@,000,00--$-lt5OO*OO $ -0.@@@@@91500000-- ki;sootates, Assistants an4- Consultants: 9,000.00 1,000.00 -0@@8,000-00 - 94 Supplies and l@&terials,. 4$890.44 13.5G@@@ -0---- 4,8760 Travels -600.00 SUBTOTAL: $ 17,490.44 of Personnel Budget,- -to cover insurances - ratiro@k:@@ Monts ote.t 840*00@@@5000@- -0-- --------665.00 15f* of Entire Bu2dget; =777 cover partioipeltion In indirect costs,. -97 TOTAL. $ _LI 2_O_P,_ @4232._Il -17, co Dr r A I Asst@@tQ-t e-Vir-a-President---- .-ILL rterly gr@@nt-in--aid check foV are T-he f rese.a h hould be forwarded-- Each quarterly payment is rt ly 1, igbo- octo-b-e-r 11--1960; Ja7nu!rY It 3 Quarterly-p;kyn@ents are die on Ju 1961; ancl ii-i. 19610 No,. Co@t-Account Object Class dated 3 Obligations Oblii,,atio" R6ih@nd Refet@@M@ Incurred Ld Date FES 19r>o MCUORANDUM F<)R: -C@OMPTROLLER DiviitW t-MKULTWA@- Uftdtf the &Qtb"itt-t"" I"k*-U#Mora§Awn dat4d, 13 April -DCII"ko DDIA* &ad ik4--Weasiott tithis authority @a subseqotnt momor&*A&,' Subproj*ct 10 9 h" b**t----7 &"Twv*d 4a4-$alo9al. 10-6f tk@-@@luprojec-t UKULTR-lk foads bay* be*& obllS&tt4 to--"Yor the s*Uproj4ctld expqcb$4$-an4- should bt c%*f&44 to-AUOWMVOSZS,*1009-49039-i 2 Chief "PROVEDIFOR-OBLIOATION@@ of, YUNDSI.-- let - ;9 a;tlify IlikT fC,@Jr;S 7 CK,&TGE FO Date: Oil& Ik Z7:..-@Addrossee i,:@,TSS/OC _,4@- TSS/FASB Z-W-Tsstm-- TSS/CD -.9dddwmL-. 19 Feb 60) I August 1960 )AEMOR,ANDUU roRi:::"Igr-rLNANCE-I)IVLIION- VIA avolco #I- SUBJECT .1009 ---4902 2tavelt's #I-t&4tics the above subptojict I"ttgcktdl Payment abotdd.b*-M&4,i@-at follows: t of $21 060 00 drawtk C499biletILLkeek Irk 0 &moon cashisels check ln-tke amount of $843-0 101 draw* *a Each ch C"Obvo t-o the plogg*1(6t***4:th"backe to Chief* TSD/Rasoalth-Bta@-fich lb-r,o,ath TSD/Btd -Office# by 15-Aut"t 1960* 3. lbtii-is a (1"1-invotco H*w4ver sloe* It I's antitt#*W not be closed. Attachment,. Invoice & Cortutitations Distribution: orig. &t 2 - Addrosece- i 731 5 c, -@ITSD/FASS- TSDIR15 A li 1i RECEIPT Receip"s he-r-e-by@@*Onowledged-foi the fo)lowing twO checks: ',h"k No. T-"asurers C the--a@mount of Zi 0 o-IF, pa-yabl@-to 4 drawn on Official Ch-e-ck No ated AUAUIIIli,1960 in the am -t oij 3. Na JAEMORANDU)A jror CHI-Er0VINANCE IDIYISION -.rsDiBtidg4t Officer VIA SubiicT -)AKU"RA, Subpt*J4ct-#lO9-#- 14 AJI*Wtrit OSZ5-*Ioog--4102 2 tjbptoject to attacked*- I P,Symofkt should be made as to wole c.atki a amount of $Zlt- 060. 00, drawn C,& tko-amocat of $9430 ZOM- drgwm Om 2 th Ea 0 checks- to Chief TSDIRON*Srck Bf"th 2. Plea" forward th by I"ugAst-1960. 3. This I -a final ttk*otco. Howavor-,---tinCe it.lattaticio*t4d----- "III this project,& the file$ shoald that additl*oall4"-- aot'k@e clo$044L, ZWOT Attachment,. lavoice coru(icattons- Distribution., 5 Orig. & Z --AddttWo- I - TSD/FASS-- z - TSD/PB /U@- 2,k INTOICE For S*rAce# $210 gas. zo CERTIFICATIONS (1) It is hereby cortifiedAhat-thWis-16*4ttC"pplyink to Suboojttt-_ 109 of MKULTRA,--th--- --- -- i - --- -- I-- --- lif@i-doi@ that- so"lces at i ormance o mat being accompliiihod-1.4@@itici wltViiiuto*!:*ti@@ents, that4 2 detailed &&*ad& of ts--on tile lti@@TSD/RB. that this bill Is just an4-corrttC*64Ati*@@ther4eof b!Lsnot-y*t been tnade. Ch-Ut-fo-TSY/i;;.arch Bi*ac Date: 2 (2) It to horeby-eartlfiod-tkat thWitivo@@@lies to Su act No*- to of MKULTRA which *as duIY7*pp@@,--- and-thi"li@oject is beldt7---- carriedoutia'accoTd&nc* ith-th*-zy@i7.xnd4ii@@p@W1953-from tht DCI to the DU/A, and the extension of this authority ln-subsequent inemoranda. Research Dtt*ttot Vat*: MEMORANDUM YO",O)dPIROLLSR-------, ATTENTION- F-te"@* Divlitt#fk SUDINCT- t3 April 1953-friOm the DC4 to-tWDDIA,, "d tke itxtoaatoa-bf tbi24 Vogt *"TOV04 and $31- 13. 10 of the over-all Pitooct UKULTit-A fi&Odji@: h&vo be Sim oblisat4d A* toy" the shodd bt cbarg*d to-All4ti6"t-oszs 1009 4902 TSS/Ck*Wcal DLvi -Sion "PROVED MR OBLI-OAT OTFUNDS*.-- Res*arc% Dtir4gtor I .- TSS/Oc_____ I - TSS/FASB TSSIC:9D/4'4'@@ 60) NW (19 Feb D R A F T 19 February-1960 BIEMORANI)UM FOR@-7THE-ItECORD--- SUBJECT MKULTR-@Subproject 199 1. T.@ie purpose-of thit@@@ubproject is to a2 study of4ptintiai@@opharmacological agents. In particvl-ar, studies willit@@dLr-t-cted to the el(ididation of interrelationships--- between molecul&t:@t"stittition and biological reoppnse@.--Studies will be conducted into the biochemical-tharacteriati-csioUtt@aain 2 types of ii6o to-T Z@@T-K4-@hed -indicates the-extent-of gations that-will b@@@arri-e-d-@-dut-diider the directiori:-of-D-r in facilittes--a-vailati@@hd'. I'he f2unds for this project will be-tri@isfdY"d@"ing as a cut o ut. PM prog-r--a--m--for a per od of -one -ye 3 -The-@cost of thii@ 2 ar-will nrit- 4 - !-'@ 50,,) f) exceed $?.Y, 080. 00@WWhich muat be add@@@h@-f ciur-per -cent fee to the 1-ng-the-tota-1--am-o,unt-,$Z-I-i?;t3,-e2O9 Ch,@-a---r-g--e--s--3hould be made against-Alloti-nent No. 4. The eqa ires that the submit to them a surrmary accountihg on all nionies-received from'the Fd-". Also, une.-xpended funds wilt be retuined-h"he as soon as possible-kipon the close of the grant-year - - - 5, -A reqtiirement fo-r---a---six--- -months' inforrnal accounting . on the art of-th p2l(@pal investigator is waived- p L6. It i snot-antici ated that any pern-tanent-equip!,n"t be needed for this-program 7@=rd!@@@tion-witti travel under this-project, -it-is agreed that th6 A ency will accept the travel doc4mentation- and-ac2counting-- which conforiii@with the practiets OfA" $*--It is agreed that technical reports reftecti4glt§Al]p@@ess of the tesearch program shall-be subiiiitted at mutually4@@@@ planning arid-i@i@itoring.. -146ficy securi y of this program po"ess-TOP SECRET 't aDi)ro_val.__ 10;@@-Tliit:project will-be unclasaifi-ed ift@efr it-leave-a the APPROVED-FOR OBLIGATION OF einical Division Rese rc Date: Distr r Attachment: Proposal R no,= J:ROPOM BUDGE7-FOR RESEM BY Project Title: The SYnthesis and BiOOh emical E-valua@66 of Potential- P,sychqpha---- colo ical Agents.-- Principal 2Investig4tof Professor an& rut-i-caian'd Medicinal Cheniis-try, College of Personnel -li&6AU tor w Principal Associates., Assi@t&-nt8-and Consultants V9.4000. -00 Supplies and Material- $ @@75,000. Travel --600. SUBTOTAL w-- 7% of,Porsonnel Budget-($-12,000.00)2; to cover Insurance, retirement, social d.ecurity eto. $ 840.00--,- 1,% of Entire Budget ($ 17,600.00); to cover participation in Indirect costs TOTAL $@21:;080.00- Checks should. be payable to Janix@-4ry 22. 196C) Effective July 1, 196o "R ILWXOCR PR04n=------ SOPOM BM17- -SU -Potential- Project Title.* The SYrAbofl#--NA DiOW0210a) lv&lu&tiw Priwipai@ Investigator A Rea& Of the 'Dopik)@@ .D. 0professor ar "I and XediolMl Ch*ghotx7o C011*96 Of Persolml Principal ilriv-eatloxw7@7- 3 000-00 9, kesoolat*$-Assistants arA C@i4"twits ooooov@@ Supplies wA Materia @0000. 2 6oo.oo SUVMAL 17 -6W - 00 7$ of Personnel Bud4t-($ 12,,000.00)j to-oovor lraumnes, - -- 840.00 rotirom*At,4 social security, *to. 1 1% of X@-atire Budget to coyer partioipstion in UAlrect TOTAL 21,1080000 Cho,o,ga should be payabl ,Iartuai-Y 22t 1960 co rffso-tito ;uly 1, 1960---- -BUDGEr-FOR-RES&kRCH-PROJECT PRO OSED SUPPOR (JU is-and Bidthinii@al-Evaluation-of potential.Lpsychopharma--- Project Title: The Synthes cological-Agent2s.-- Principal Investigator: Professor and Head-of7th@7 epar ment '7-%Macedtical and Medicinal Chemistry$- Collqe of Personnel Principal Investigator $L@3,000-00- Associates,; Assistants and CbhtOltants____ $--91090.00 2Supplies and M-aterials $-52-000-.00 Travel $ 600-00 SUBTOTAL $ 17@600-.00 73'i@-of Personnel Budget ($ 12AOO-.00)-@--to-cover insurance retirement, Social sec6rityi-@etc. 15% of Entire Budget 17-600--00)"o cover particwtion--, $ in indirect costs TOrrAL $ 21,080-.00 Checks should be payabl@6@ January 22, 1960 cc Effective July 1, 1§60 (on leave of abtohtt Ju4ly 1 -1960 through June 30, 1961)-- ADD:@@@PIES OF-THE PROPOSED