Tom Patterson lay in a coma. Three months earlier ... Patterson had suddenly fallen ill, so severely that he had to be medevaced to [University of California-San Diegos medical center]. The core of the problem was an infection with a superbug, a bacterium named Acinetobacter baumannii that was resistant to every antibiotic his medical team tried to treat it with. He was dying. We are running out of options to save Tom, [Tom's wife Steffanie Strathdee wrote to the hospitals head of infectious diseases, Dr. Robert Schooley]. What do you think about phage therapy? Phages are viruses [that] kill only specific strains of bacteria. They can quell infections without inducing a terrible diarrheal disease ... that occurs when the balance of bacteria in the gut is disrupted by antibiotics wiping out good bugs along with the bad. But for phage therapy to be deployed routinely in the United States, phages would have to be approved as drugs by the FDA. To treat an American patient with them now requires emergency compassionate-use authorization - effectively an acknowledgment that nothing with an FDA license can save the patients life. The FDA agreed to let the pair attempt phages. The whole treatment process was a scramble. Patterson, however, made it. He left the hospital ... having beaten the superbug using phages. He was the first person in the United States to have been successfully treated intravenously. Strathdee ... says she hopes to see phages become a routine option for serious infections, available to substitute for antibiotics.
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