Marie began taking fluoxetine, the generic form of Prozac, when she was 15. The drug an S.S.R.I., a selective serotonin reuptake inhibitor " was part of her treatment in an outpatient program for an eating disorder. It took its toll on her sexuality. Marie told me she has PSSD, post-S.S.R.I. sexual dysfunction, a loss of sexuality that persists after the drug is no longer being taken. Clinicians have published more than 500 case reports in academic literature about the experience of PSSD. A 2020 editorial in The British Medical Journal argued, "Post-S.S.R.I. sexual dysfunction is underrecognized and can be debilitating both psychologically and physically." The effects of S.S.R.I.s on young sexuality are all the more relevant because prescriptions for the drugs have soared. Around two million 12-to-17-year-olds in the United States are on S.S.R.I.s. One large 2024 study ... tallied, month by month, the percentage of that age group who filled an antidepressant prescription between 2016 and 2022. During that time, the rate climbed by 69 percent. There are no dedicated studies of sexual side effects among the young. All that is available is extrapolation from research among adults. Depending on the symptom, drug and duration of use, between 30 and 80 percent of adults taking S.S.R.I.s live to varying degrees with diminished desire, sensation and function, according to a 2019 study.