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PSA tests can cause more harm than good
Key Excerpts from Article on Website of San Francisco Chronicle (San Francisco's leading newspaper)


San Francisco Chronicle (San Francisco's leading newspaper), October 1, 2010
Posted: October 4th, 2010
http://www.sfgate.com/cgi-bin/article.cgi?f=/c/a/2010/09/30/...

UC Davis just announced a seminar for the public on "men's health." That title notwithstanding, the program appears to be entirely about prostate cancer and in particular about the prostate specific antigen screening test. Many possible screening programs turn out not to do any good - and in fact some tests like PSA cause harm. That's why virtually all expert public health panels do not recommend the PSA test. A blood test that isn't accurate can fail to find disease that's present, leading to false reassurance. It can also report disease when it's not really there, leading to unnecessary use of other tests (like biopsy) that are not so benign. Perhaps most concerning, the PSA test frequently identifies something that qualifies as cancer under a microscope but acts nothing like cancer in real life. That is to say, the large majority of PSA-discovered "cancers" would never cause any problem whatsoever if they went undetected. Finding something through screening invariably leads to treating it. Most of the men so treated would have been just fine if they never knew about the cancer. But when they're treated ... the majority suffer really life-affecting effects, such as impotence and/or incontinence. That's why both of the two very large trials of PSA screening published in 2009 found no (or at most a tiny) benefit, but a great deal of harm.

Note: This article was written by Michael Wilkes, a professor of medicine at UC Davis, and Jerome Hoffman, a professor of emergency medicine at the University of Southern California. Both are researchers/consultants for the U.S. Centers for Disease Control and Prevention.


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