There is clearly a psychedelic renaissance underway. These agents are now debated at medical conferences smirk-free, and my investment-obsessed friends predict a financial "'shroom-boom". During the 2020 US election ... Measure 109 asked voters in Oregon whether magic mushrooms should be allowed for medical purposes, and Initiative 81 asked Washingtonians about decriminalizing psychedelic plants and fungi. Research is also underway in institutions from Johns Hopkins to Imperial College London. Recently, Health Canada quietly ... allowed four terminally ill patients to take psilocybin under medical supervision. I have also been asked by several patients, at end-of-life, to prescribe a gram of mushrooms or a tablet of lysergic acid diethylamine (which my pharmacy cannot furnish), rather than a "bucket of fentanyl" (which the pharmacy readily can). The Default Mode Network (DMN) ... refers to interconnected brain regions that help us believe we are a distinct self, separate from others and the natural world. This drives self-reliance, but can make us feel isolated. Moreover, as it "matures," we respond in more habitual, predictable, rigid ways. The theory is that DMN overactivity leads to excessive introspection, hypercriticism, obsession, depression, and anxiety. Psychedelics might decrease the tyranny of the DMN, thereby allowing unfamiliar parts of the brain to go on a play-date. We should not throw out the scientific method, but psychedelics could increase the colors in our crayon set.