Randy Pausch, the charismatic young college professor who chronicled his battle with pancreatic cancer in a remarkable speech widely-known as the "Last Lecture," has died at the age of 47. Pausch's lecture and subsequent interview was one of the most powerful accounts of hope, grace and optimistism ABC News has ever featured, and drew a worldwide response. "I'd like to thank the millions of people who have offered their love, prayers and support," [his wife] Jai Pausch said in a statement. "Randy was so happy and proud that the lecture and book inspired parents to revisit their priorities, particularly their relationships with their children. The outpouring of cards and emails really sustained him." It all began with one, age-old question: What would you say if you knew you were going to die and had a chance to sum up everything that was most important to you? That question had been posed to the annual speaker of a lecture series at Carnegie Mellon University, where Pausch was a computer sciences professor. For Pausch, though, the question wasn't hypothetical. Pausch, a father of three small children with his wife Jai, had been diagnosed with pancreatic cancer -- and given six months to live. Friends and colleagues flew in from all around the country to attend his last lecture. And -- almost as an afterthought -- the lecture was videotaped and put on the Internet for the few people who couldn't get there that day. The lecture was so uplifting, so funny, so inspirational that it went viral. So far, 10 million people have downloaded it. And thousands have written in to say that his lecture changed their lives.