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Study 329: The Big Fraud Is Finally Under Review
Key Excerpts from Article on Website of Brownstone Institute
Posted: November 28th, 2025
https://brownstone.org/articles/study-329-the-big-fraud-is-f...
In 2001, the Journal of the American Academy of Child & Adolescent Psychiatry (JAACAP) published a paper declaring that the antidepressant paroxetine (Paxil) was “generally well tolerated and effective” for adolescent depression. That conclusion was false. The manufacturer, GlaxoSmithKline (GSK), knew from its own data that the drug failed to outperform placebo and carried a serious risk of suicidal behaviour. Instead of telling the truth, GSK hired a public-relations firm to ghostwrite the paper, enlisted academic co-authors who never saw the raw data, and used the publication to promote Paxil to doctors treating children. It became known as Study 329 — one of the most infamous cases of scientific fraud in modern psychiatry. The paper remained in circulation — cited hundreds of times, shaping prescribing habits, and legitimising a lie that cost young lives. The paper listed 22 authors — two were GSK employees, and most had never reviewed the raw data or disclosed their financial ties to the company. Once the article appeared in print, GSK’s sales force distributed it to thousands of doctors as “proof” that Paxil worked in teens. Within three years, the company made more than a billion dollars from what it called the “adolescent market.” In 2003, the FDA concluded: “There is currently no evidence that Paxil is effective in children and adolescents with major depressive disorder.” In 2012, GSK pleaded guilty and paid a $3 billion settlement to resolve criminal and civil charges.
Note: For more along these lines, read our concise summaries of news articles on Big Pharma profiteering and mental health.
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