TVIA CODF; NO LEX KY 477 DEPAR-TMENT OF P, E A LT H, E 7, (D t'f. 4D \;'v E L Fe-, R.;-.' E- C, I --+ a LT-Y2---A- G eb 9-i - PusLic HEALTH SERVICE LEXINGTON. KENTUCKY Ar'OQES'l THE 8 March 1954 PVBLTC HEAI-TT( SERI.'ICE HOSPITAL NliV.4 Add I c t !on Res ea rch Cen te e I am enclosing a table which gives data obtained In ex2p;rt- --n.ents'concerned.,with the development of tolerance to LSD-2.')* Eleven subjects completed these exp&.rimentse The firsf 5 subjects wer,@f- negroes- the last 6 were tihite. Two negro silb- jects RE ane, GO did not com@'lete f-he exp2eriment because they p got Into trouble with the author,.ifies:(not connected.with f,@e LSD expiri.nents). The re,@ults.-oblained with these 2 subjec,@3 for complef e"ss sake.1 are.shown below the totals and the averages. In the co.-2itro I exper 1-nenf all the subject., were given wifer at a..-n. and at 9 p.m. On the fourth day, they were given 75 mcg. of LSD-25 at-9 a.m. and questi,.oniaircs were filled out houriy .r- - - @ - .@ .1 t $%j6 @.ftj:si ii;itirs2. "-;init;ci' noics,on be,@avior were kc,-Nt. in th-, other ,.xperi,.mznt., patients re--eived increasing doses of LSD-25, (10 2,:) a.-ii 30 mc--.) at 9 a*.,il* Ord 9 p.m.'for three days 0 ii the fourih day,.fhey were aea,in tested 2with 75 mcg. of LSD-23. Ha I f o f t h e p a t I e n t s w e n t t h r o vh t h e w ac r r o u t I n c f I r s ta I f we.-i t1'h.-oug,@ the LSD first. Decia3s,;-f'ied by data 4 l@'@ 8 j,9317 Res u Its o a t h-c qttert Ion n a ire s 'were es t lma fed 4 linp,ly I)y counting the number of positive a-4swerT (those score d positivz., after being scored negative prior to Ingesting the drug). The degree of the symptom.so recorded was ignored. 'Clinical grades" were assigned by mysel'f on the basis of lntervi2elit during the test day and. flie. day fol loving. Crtteria for the grades were as follows: 0 Absence of nervousness and apprehension Nervt)usness and apprehension without distortion In shape or size of self, other persons, or tn.a.ni.-nate objeci-s, 2 Nervo2usness and appr-,ehension, plus distorflons in o,.jn body image, o Ither pzrsons, or inanimate objects, bu@ without halluc.inations and with retention of insight, 3 Ner%,ousness aoprehension, distortions and elementary'! hallucinafions. Tru-t-"h.311ucinations may be present, 2 but insight apparently retained, 4 Same as Grade 3. but true hallucinations present and Insight lost. Grade 4 is apparently quite rare In riy experience. Tabulated data-.-how that these patlznts gave a,,i avera-c of 98 positive respooses after three days on water and only 22 a'T-tcr fhre-P, days on LSD6-25. In ternis of, clinical grade, the averages were-,1.95 after three days' of -iatzr, and 0.6 after three days of LSD-25. Declassifieci by date @187,,47.cz I I n -*le rptfa t data as Indicating avery s I.gn Ifican t cre'@flee of tolerance after f.@ree days on these s,-na 11 amounts of LSD-25. Tolerance h6wever, was not complete In 5of the patients. Two of the patients, FO and GR, had very lift le response to the 75-,ncg. dose.- even after three d,3ys of water., so the presence or absence could not be determined. I hope to confirm these resulfs using pupillary, blood pressure s and reflex responses in another experiment which will begin as soon as fhe dose-effect.experimenf which is currently underway is completed. I2 am currently carry.ing out another tolerance experinent In rti%tch patients will r'zceive one dose of LSD-25 daily during art 8-day period In amoun,fs increasing fr.om 20 to 75 mcg. I believe this parfi-.Ui@r schedule--*III result In complete., rather than Pi.rtial tolerance, If.fhis- is true, we will theh'be in pos It ion to attempt to determine how much the dose must be elevated to break through this degree of tolerance, I am sendini @ con" of :e@ afid 1'ef ier io Vtr. Korrets ky,.. .whom Ian expecting to arriye in Lexington about'March isth. 2 I @a-,re just received your letter of @Aarch 5th concerning aOL-148 -r I ved in -he ma I 1. This wil-I nof and three vi Is have a. permit more than a very preliminary evaluation., buf I will give you the results as soon as possible. Yours very.0 s trcerely., Harris lsbel II, ',A. D irecfor of Research Hi r n "nclosure Dt@-classi-I ied S DC- -o L '),D - 2 5 After 3-days After 3 days LSD-25@( FO 26, H 0 at 0900 a.nd 2 2100 30 mcg. at 0900 and 2100) 2.. PATi@tNT No. Positive Clinical No. Positive Clinical Answers Grade Ans vie rs Grade FO ..18 1/2 7 1/2 2 251 3 89 1 GR 5 0 I 0 DO 32 15 0 AU 101 2 2 l'O 0 F 1 120 3 54 2 VA. . 41 2' 30 WP@R 215 3@ t 6 167 1 5 2 DE 97 3 8 0 5 34 0 0 Tota I I 081 21-t/2 245 .6-1/2 Avzrage 98 2 1.95 22 0.6 PE 0 0 co 43 2 E)eclassified by date 874475-,