.TH. E-L)I.JC "'FIC) r-.!, AN!D WE ZE PUELIC 'riEALTH S!@RVICE Lexington, Kentucky P-IPLYI.'@--. ADDRE--S THZ 2 21 July 1954 N I h,H Ac!ciictlon Resear@h Center Could you suoply rne wi.fh an add!',-ional ar-ount of Corynanthine2 ',We have not been able to show any siani l'IC6 nf -,-blocking effect when 15 rng. 2 of this coripoung' were 3,0 minutes prior to 40 microam of LSD-25. %@'le are -iow c-ivinc 15 m-. every f'wc hours for three dose.,,. This, of cour@,,, means our consumo,ion is raf@-tr high at this We hav2e now comp feted the T'irst trials on the e.'f'fecl,-s of "-A-101 on 't-h--"@",cardiovascular resp@ons,-, to sfa.-teinr,. t 'A 11 I "-@ p@l-iiei)'I-s sho..@sed in fD,2-,Ise rate, a d rr- c, in both systolic aid 0'1,-istolic blood oressure@;, with marKeu narrowing of the oul'qe pressvreo Llrhis c-,Cfecf was evidet-,.' @,,)urs 3f!(@r 2 oT' 'ri,e deue iia:d bzen ,ivzn a-p@@ared @o be maximat 3;f,@r fr,,,7 druc, h-3u' ,a n v,! r., , a n d we r c s p r-e s o ri @iou r s a-T'@ e r f h z d r u,7. z r i:) L; r s 2 a I t ho uch re s po n s - s v;erc in Lhe normal rance, h ey we re s higher th-an"Pre-t-'rug con@rcis. V e r y s i -i c e r yot-irs *k@Ll V ,u 3 r3'r 1 s s I-,z i It Director o.-' rn