IEALTH, EDUCATIO,14, ANDV, -FAR" F -.y PU13LIC HEALTH SERVICE Lexin,-ifon, Kentucky IN RgvLyltifz. ADOFTE= TM 8 Dec@mber 1954 N[tvH Addiction Resear2ch Center' Subject: 1) Report to CNR 2) Project Description and Budget for Fiscal.Year 1956 3) Recent Progress @-6) (3) Enclosed her?wlth is copy of the annual progress report for the Office- of Naval -Rese'arch., which Is being sent to Capt. F. H. Quimby, ONR,2 as was done in the pasf two years. Also enclosed Is a project description and budget for f-he fiscal year IP56. In for-/arding this I aim assvrr-Vi-g- fl-ha-i- ar-ra-rrgeny,@-nts .t ior continu,5@i-on of the projf!ct wt;il.bi., raed@,- and t2hat the same procedure villf be foll,)wed-as %,ias carried out last year. I am a I so enc los I ng two copi -Z s0 f a n 'a bs t r:a c t wh I,-- h I s sj bm I t t e e for clearance prior to submission to the S.@cretery, Soclcfy for Pharniaco!.:)gy and Expertm-enfai Ther@arcuflcs. 2 tf the abstract is cleared and the information reclassified, I I.-ifend to present fht4- pa p e r a t f h e fq e c f I n g o f t h e S o c I c t y f o r P ii a rrna co I o gy a n d E x p e r I m e n tI Therapeutics In San Francisco., Apri-I 10-16, l@P55. Since my return frori Europe I have completed 2 some viorlt-. which -,iay be of interest to you. The experifnenfs wi@,@ Bufoten Inc were pushed until the subjects were receiving orally total doses of 2 mg. of No discernable effe-cfs vicre obfain.ed ince Y.-ork this compoun,,. with @his conip2ound di(I no,#, seem at all work with it, at least tempore..rily. I t@hi-n-k. vi-,t, obtain another sample of the material.i@-, order to be sure wz are doing work with the carref-.f corr..,oov-,d. Vic hivz jusi cor,-,pleted anof;ier serf,@,.s with patients who recei-/ed 75 r,-.g., Chlorpronazi.-ie T'oll-owerJ by 6C, mcg,-@i. LSD-25. This makes a total of 18 patients who have bccn studied with this par@i,.-@ul3r combination. Definite blockirg of LSD-effec'tls did 9;4 oc-cur, but not as great as In the pilot experlr,-,ents. We have now furned to testiig the ability of chlorprc,ma@Ine to reverse LSD-cffects once they are well developed. As yeT sufficient data are not available to make any statement. I mus t be 1 n New York the n Igh f of F ebrua ry 3rd I n orde r to 2 9'lve a tecfure at the New York Academy of Wedicine,, It Will be convenient to stop In Washington 'on either February Ist or 2nd,.provided you wish me to do so. Wi th k I ndes t pe rs on,.- I riga rds Very sincerely your$ Harr Is Is be IM.D. 4 Direci'or of Researcii Hl:rn Enclosures !2'