-1 L
                                       4ATIONAL   INSTITU                           OF   HEALTH,
            to lkgpLX9*6. AODX]TS* INS                     28   June    1955
          ADDI=OM RESEARCH CENTER
                     MINTAL KTALTR
        RATIO-$AL 114 VITU?93 Of
    2    IL PU SUC 99ALYN SIltViCt MOS14TAL
              The sample of      LSD rect ived from--.                                       a be I ed
              LSD-25-6111 has now been tested..                 e s e pa r a       'r-i'tn-e 'n s h a v a
              been     done.
              In experiment      I   four  white subjects       received  In   rando.2-itzed orcter
                                  .9
              Oacebo  25 mcgm of LSD-25-61; 60 mcgm LSD-25-61;                 and'60 mcgm
              LSD from our old;,stocks.          As noted  In  the table       average       effect
              In    these    subjects     appeared to be jt:st as great,,Plth the new matertat
              at   th.-.   620-mcgn   level.as   it was at the old.
              In the second      e)-,periment     5     experienced negro          subjects.received
              60 mcgm of LSD-25-610@  ln.table 2, the results obtained are cot-npared
              with those obtalked In a previous run with 60 mcgm of our standard
              material..  It  Is again 2obvious  that the new material is as active
              as  the old.
              In  experiment 3      four-  of   the    su-bjects    received In  rarydo.'nized order
              60  mcgm   LSD-25-61   and   60   mcgm   old   LSD.   In   this    experiment    only
                                                                                  -it  is; obvious
              question.nalre      And-cilnical,gra2des       -acre used.    Again
              that the new-LSD       is   at least   as    active as the   old.
              In  each exp@-.riment    there    was of  lea-z-f cne@ lrtd-tvi-dual w-,ho  s  temecr
              to obtain more effect        from   the   new   LSD than from    the  otd,   sugge:rftng
            .:,that the new material       Is perhaps somewhat more potent2 than              the    old.
              The  nu.-.iber  of  subjectt  1-.i  a.-ty  of  ',%c  three  exper,inents is  f a r +-Oo
              sr..a.! !- f c.- '@t I s po I n i i o bt s c t t i ed v a n .1 t o t es t I t ad equa t c I v. wou I d
              require preparing fresh- 3olut ions of old- and n'2cw LSD of a: range of
              dose  leve-is,  using  a   group   of   af   least   12   subjects.   @l do'nof b'
                                                                                                  e I 1'ev-e
              th I s wou I'd be wortliwh I I e fin let s. t here .1-s 3@on'e reason -to br. I  levt
              LS.D.25 '61  d I f f ers chem, Ica I I-v,2 f rc,'-.n t he -,ia ft.r la I we h.ave been -us tng
              I hope   It  wlil'not-be,    t-oo  long before    we'can have     -a conference
              about the    direction of the progran here.  I should             be   able   to    under.
              take a new ser.i.es oT' experimc.nts in At,,aust or Sepfembei-.  .1  will@
      2        b,,,-. awt-,,l fro;n Lexington from J!uly 7th thc.luty  13th and will  be,
              6%.ay f'rom  Lexington  on  Septeniber  9s-h--a.-teJ-  I-Oth  and  again  on  t\16yerithcr
              [8th and-   19th.    I expe.c.t to  be  In  Chica-,,,)  In  bot-1,  Scpflcriber  dn(I
              f@,,b v c,-,i b c rand could contact our friends  fhere on el@her or bollh
              d.-i t c,,-
                                                      Sincerci-i /ovrs.
              hl:rn

                             COWA    I SCN OF NEW At-,D OLD LSD
                                    Expertment@ t4o.  I
                                         25 Mc gm      60 mcgm    60 mcgm
         MEASURE@             PLACEBO    New LSD       New LSD    Old LSD
         Kn4e Jerk              0.08      0.16           1.68       1,87
         Pupils.                0. 36     0 45
                                                         2.48       2.77
         Blood Pressure         0.03      1.24           1*94       1.86
         Questions              1.0       2.o              76        48
         Clinical Grade           0         0            10-12      1.25
                                      ects
         Averages of 4   white  subi

                           COMPARISCN  OF Nr-_W AtD OLD  LSD
                                  Exper tme f- tqo.2
           MEASURE
                                  60 mcgm
                                                          60 mcgm
                                  Old LSD                 New LSD
           Knee Jerk              3.68                    2.83
           Pupils'               4.630@                    S..76
           St*-od Pressuee.
                                 2.72                     2.43
          Questions                93                       83
          Clinical Grade         192
                                                          1.7
           Averages of 5  negro  subjects.

                             CCMPARTSCN OF NEW AtO OL
                                                     D LSD
                                   Experimcn@ No. 3
             &EASURE
                                  60 Mcgm                 60 mcgm
                                  New LSD                 Old LSD
              Questions
                                    152
                                                7           lit
              Clinical Grade-'    1.75
                                                           1.5
                         40,