Ir.43 ADD=TIOH LL%BniTx-zs oy sy4":=ic SUMTITUTES FOR COrZ-tr- garri3 UbCll r,V-lq Addiction Rtsearch Can' or. LIM. Lai2l-n6-ton, EY. Be Pe ltraser. A. Vikler. V. 2. Martin and D. E. aloseri?.erg 101-149 To develop s-ynthatic substitutes for codai,-w which are les3 addictive than codeine. T%,s,tin2i; for addiativene33 -das complelvad or Is in S)roVes3 on t]@.e followin5 nlra conpmnds 6irin; the reporting @-ar: (1) 1.21-B@Fdro-7-vl.5.9-t.-I=tb7l-6.7- benzowrphan (2) l..*-F.2;dro.V-5.9-di=tbyl-2(2-phenethyl)-6,T-benz=crph= l-R7droxyethoxyeth-71.4-ph--n7l-4-prwio.-,;I-piperidlne (I-D-22); (4) (lev=tp.-cmazirA. VI-C-5); (5) 2 phorqlir.dar.e (6) L7) mixture of 1-H-1 (:es above) and =-*-I (!i-allylaorphenizoeine); (8) 22-Hydroxy-5,9-dinetbyl-2(3.3-di---att,-Vlallyl)- 6,'7-benza=rpha,n (11-C-2); (9)2 2-C.-Iclopropylmtrql-21@.h7d--ov-5,9-di7,--th:71-6.7- Of ttlese, I-E-1 tcraII7) and the mi--ture of 1-2-1 and ZI-C-1 Proved to h-ave addi*tivenes3 Zreater than codeine and have bee?i dropped f2rm rurt'nor, consideration. J-D-22 (an =tltus-,Ive) =id 11-C-2 had lots addi,.tiveness t),.= codel.*e. n-C-2 deserves further inveatlgel= as an analgesic. 1-71-2 and VT-C-5 had no add:Lctiveness. 1-9-1 and I-N-2 are probabl7 too to3:io lo-.r u3e. VI-C-5, a chlorPro==".ne c*n,--ner, deserves extersive lnvosti,t-.ation In chr=io pain. 11-C-2 has co-.,4.sid--rable t!ae*r--tical Interest, s2ince It Is --orphint-like behaviorally and creallas rild Pb73iCal addiction bulw will not suppress abstir-brce frm mo*hine. n-C-3 13 still boing studied. rwLTe. Itior!c will be continued butiilll be finished aftev, I O@3tober (a) lans 1962 by the NStIOnal jrst4tutes of gealth "tther th= by Office of talml Researdh. (b) I=ed4-ate, Dru:s-s to2 be tested d"--ing the cc:31.19 year- include 11-C-3 abcte), 14-h7d.-ox7-9-all7l.dllVdro=rphim, and su--h otbar acr-pounds as are recor@mnded by the Co=:Lttes an Drug Addiati= and Harocti*s, A%atioral Razea2rch council., R:-:701= A= PMZCAfM,13 Pmstr, E. V., Essig, C, ?,, and Volbach. A. B. "Z7tluztiOU Of derisoprodol and phon7ramidol for addiatitgmso.t' Full. Urco-.ics,'13. 32-T. (b) Volbik.., A. D. =d rraser, 'g. P.. (1962). 'Addiction liaDilit7 of Btlv;l- h,-dro4hloride." Bt,.lletin D,.,6,g Addictio,.n ar,,d Narootic:s, Natioml Re'vearch Council, D.C.