DE>1p.PARTM>2pENT OF HEALT>2pl>1pi>1p, EDUCATION, AND WELFARE PUB>2pUC H>2pFA>1pLTH SERVICE I December 19>2p,>2p@>2p'>2p-8 >2pM>2pat>2pi>1pes>2pe>2pl >2pi>2pns>2pt>2pit>2put>2pe Mental H>2pe>2pa>2plt>2ph A>2pddk>2p-t>2pi>2p" Res>2pca>2pm>2pb >2pCe>2pnt>2pe>2pr U>1p.3>1p. >1pP>2pub>2pUC H>1pe>2pa>2pl>2pt>2ph S>2per>2pvie>1pw Hospital >2pL>2pe>2p=g>22pt>2po>2pn>2p. >2pX>2p=>2pt>2pu>2pk>2py Thanks for your letter-of 26 November 1958>1p. I do not yet >2p1>2p,>2p,>2prow the January schedule, but I am anticipating t>2phat the Co>2pm>2pmittee on Drug Addiction and Narcotics will hold its ann>2pi>2pial meetin>2p,>2p3 in >2pWashington so>2pmetime during that month. Dr. >2p7>2p-ddy is co>2pr>2p->2p.>2pIng down next week and I>1p.may learn at that time when the meeting is to2 be. I will let you I have >1p'receiv of Psilocy>2pb n>2po>2p,>2p) If you wou>2pl>2pd like some of the material t>2p->2p->2pm>2pe_>2p->2pI>2p(>2pnow>1p. I have now given doses of 2 to 3 mg>1p/70 kg to nd am observing definite effects with >2pdven these dosess >2pi>2pihich are lower than those reco>2pT>2p4>2pmended by the co>2pmpany>1p. The pattern see>2pms to be very LSD-like. Concer2ning the benzimidazoles>1p, I an. enclosing a ther>2pr>2piofax cc>2pvy of part of a letter from Dr. Eddy. The three compounds mentioned are not these of Janssen.. but are produced by the C>2piba Company. Two of them, you will >1pn>1po>1pt>1pi>1pc>1pe>2p2 are tremendously potent in monkeys (see figures o>2pr>2p@ physical dependence). I could probably obtain small supplies of the two most potent drugs, and will ask Dr. >2p'>2p,>22p:>2p.ddy to obtain some for me when he is here next week. I also have a supply of >2pEa>2p-19390>1p, and some information about its use in clinical trials. It is not as potent as morphine in >2pm>2pan and, therefore., is of little interest at the moment. As soon as I talk to Dr. Eddy I will let you >2pk>2pnow about the January dates. With kindest personal regards, 2Yours very sincerely, H is Isbell., M.D. Director HI: tl>1plh >2pEnclosure