DeW-"'.F HEALTH., EDUCATION, AND 'LFA*- Pt. Healt.@ Se-,rvice NATIONAL INSTIT.UTES OF HEALTH 2 October 1957 IN ItSPLY1140 ASORCSS 'rMg HAT2IONA#. tXSTITUT2 OF MISTAL MCALTIF ADOICTtOn RISIARCH CIRTTR U.S. PU#UC Ml[ALT14 SERVICIS HOSPITAL P. 0. Box zago -i---a,-r,.-,-e---nclosing three copies of a reoort "Studies 2 on the Dizf.@,,,Ia.,nlde Os' Lysercic Acid. Ill.- Effects of Pheroxybenzamine on LSD-Rea-@ficn in ',itan.11 v,:u w-i I I n of e f ha f the pre f r ea i'Menf with phznoxy, benzar-.1nz did n of a I@.'er s icn ific@'n@-@ly f he men '.-a I ef f cc fs of I' Vf LS-D. we though,- you viould be interested in this Information and ycu -,lay, of course, pass if on to any other pers@.;ns who are workina in the p s y c I'l os orn i.-ne f i c T' i c I d Recently I h a v e b e e n a2 f f crlp t I n c t o d o t h e opp os 1 t e Rather f han a f ilen, pt i ng to a t tenva -le f he LS6-reac f i on., I have attempt ed f o accen f va f e i t by adr@i i n is f er i ng ep inephr ine . So far vie have tried a co.Tbinafion of I mcgrr./kg. of L2SD plus C.4 mg./70 q kg. of epinephrine subcutaneously. There has been no evidence of any accep,fuafion or blocking of the LSD-reacfion as yet. The work is continuing and the dose of epineohrine %vill graclua-ity be raised. We' are also2 inift.ating prel irrinary studies on d-lyseraic acid morpholide., d-tysergic acid pyrrolidid, d-dimefhylami2c of lysersic acid., and 4-dihydro-tyserGylarnido-d-oxazoildone. All of these materials have been.furnished fo u's by the Sandoz Cornpany. Thz object of the exoerimenfs viiii be to obtain inforrlaflon on the relation of c.@er.-.Ical changzs in the LSD molecule to changes in psychosorr,imefic activity. The first exoerlmenls will be c4esicned to cef a rouch a,->,oroximaficn --f fh,- cffcc@live k-ilse rance If, ii)ar, at'f@r vihich critical experimen',s comparin.9 these tvio dose l@-,ve,s .of each dru- wi fh two dose levels of LSf:) in the sa;-,.e sub.lec2f-s -;iil'L be carried lfh k'!.ndesf per%sonal r e g a r,.-,' s Yovrs very s incere I V, H a r r i s s b c I I D .--@-Hi f k h Director@ Enclosur e S