LEX KY- 477 FED:ERAL SECURITY AGENCY PUBLIC HEALTH SERVICE LEXINGTON. KENTUCKY tM ftgPtYtHO. ACONCSS Tmg 3 Ausus t 1953 POSUC IFULTH SERVICE OSPtTAk NIW,Add it2t ion Research Center - - ----------- 1: feel sure you will be interested to learn that we were -te to begin-' pertments. witir LSD-25 during the month ab our ex of July. We obtained 5 subje'cts who agreed to take the drug chronically, -All of these were negro male patients and all of them Phystcally were In very excellent shape. The time so far has be-'en spent exclusively in obtaining control data which includes physica'l andl;otychiatri-c examinations Rorschach and Goldsteln-Schere.r' tests, Minnesota hiultiphasic Personality -Inve2ntories, ele-efroincephatogram3,,, steadiness test., blood chemistries and ham@a,@'ology. Wii s.hotild be In position to begin exploratory st@odies designed'tid deter.-nine the minimal effective dose for each ma@n -e-a'rly in August. Arrangementi have been made wi,th th2e-Sandoz Company to obtain a supply of the drug. The behavior of the Patient$ In our ward has been disappoint- ingly qu,iet'. All five of the men haye been extremely @uict, agreeable and@polite with each other the osychiatric aides. and the doctors. They. definifeli,- are more-rese2-ved than wc expecied and we have a distinct iceling that th;y are somewhat afraid., most especially of t.')-e physicians@ Involved-. We have made a strenuous effort to break through this barrier but hav@,,- -succ-@!eded ..on ly -part i'a Ity-o' - The relstions@l' 2 with 4.,hc p Ps-ichiatric aides., who 4ctuail',-y will be the key observers., Is bi'coming somewhat more free and easy; but the-degree of'- rapport :ffained sofar Is not nearlyso great as we expect with white subjects. Reserve and la2ck of rapport with the physicians are-as great as iiltially. In all probability, this type of behavior is to. be expected with patients of this type. Perhaps the drug will break down some of the barriers. @-,y -1@074-15 c!a'La - FEB 7977 page,2 -o I haic, a Is heard that the 'Alcomet r, has been repaired and Is being shipped.. If no particular difficulties are experien,ced In the, LSD experiment, this-will enable us to. begin preliminary work with alcohol some time during the 2 fill. Experiments with I-N-allytnor Dromoran and the 3-meth I y ether of N-allylnor Dromoran are not encouraging. Both compounds produce deftnite-subjecf.ive effects when given orally.. The margin however appears to@be quite small. Total doses of 7.5 mg,, orally sel2dom cause any perceptible ef fe cts. Doses of 10 mg..orally al.most invariably do, but concomitantly,, disturbing. toxic effects, c,hiefty of vasovagal tYPC3 (marked,,perspiration dizziness on standing,-weakness and drop In blood pressure) are observed and these toxic effects definitely Interfere with the elicitation of "dep2ressed' material from the patients. Very sincerely yours, M*Do Ha:rr is IsbeiI D'irector of Research H r n i,i p ri b,, 187,175@ 7 4 C;rp lq77