T -2 L Y T ,-July I y S cc t I on c,,n c ;OrvE@,z L a tory a 1 c t I o n 6 Declassifi-.4 87475@ '4ate E T9 7-7' Ab 2 a) C4 4L* in zr 2 en VW 2 cr A ou CL a 2 Oti Dr -1 ie Cb 40 2 & 0 Z) 2 Is a C% t-) 2 r* C 2 IV.% CL O- -,t- el's 4c 2 tL in C 0 11 0 C# @i 2 It Ci. 0) -2 el) 2 0% -+- - - C el- e2 4M cn 2 zr i2L4 w rri C's t4 43$ 2 t7 0 Cl, 2 tx eb 2 :01 .0t e4 2 C *vA _lr 2 t3 91) i'4 t4 -1 2 n @14 2 9,Fi IVA zp 2 t- I's 8 V'l addictiort* lnsofar"as- can deter-.ilntd bV t I,,: V e d rt s c s t., n a@',,Aiction arc la the no r n,.a r a n This that* t!-e rz@!3- -n for excretion duria-S addici,to,-; is d@,@., block at fh;a level. The Neuro,3hysiolopical Section has been concern.@*d with 2 experi.,,ncntu en t@,e of a tgst for :)re I In, Jra. hysical denendeice II-Ability In In do.:@so Gnd with the lnterrziatl'ors hips of -iorp2Sinc and @,;'a I I Inc. The in cf%ndill0n-d inf"tbit'. rafs @4-f Four t u,-i t t v--i-re pub i Is'41izd III I t2!a -quarter ar;d tw-@ 'ictfur-cs were-.presentcd bcf -.c-t 3 c ter, t I f@tc r d S?4 -i J I @:z s -z @-i n-z 3 2 Ar r a Y. yrii 0 r h d C h I o r T'ii s C s i@; s i 3 t- s r c i-# c -i i@, n,: i3 -@!5- 4'9 e@ n t tI C u 1-@-:s Declassified by @fate 4 FEB 1977' 2..S to M. 9* we-rlc to 17 Pontoterant 4d,@-.IcfB. Definite eyidence of i.-@orph;nc-ilke gul'-Ihorio began to a Q.:@c a r is't @he 30-.-.iG. level. Eu,@horl;2i &,-.d pronounc cd at- th-z 60 I eve I. Eui-4horia vart ai3;-) 60 fo 75 mc* v.,cre ad;atnlstered orally. i'@o untoward feixic reactions were observed. Sixty to 75 -r-S. of tho lcvo isoner every f-,ur ho2urs c4used marked sup,@r'cssi-,,t of Sul--stlfuted for ,rorphine In 2 stron2l,/ a-4.,4, Icte-i evidep-@e of rr-orphinz-tll-.C ev:,I@oria was sc%-n -alth t@l-te 2 of abstlnznce ;i:as obsar;i.ld A I t h 0 u c a Is s,-7.al to draw I fs which will cxcee-zl, t 4 t of c -o c I n -.4 .0, 2L2 @hy I-L I ne (,Y@K-37 4 a p a w 0 u 3 c nshown t h 5 ft b T 5 Ij C 1@. @4 cuphor la s-,i to r;-:@ c r r-,o i-,-)h I- -.i z as a,-. -d ye rc fc t I vi @-I ilir,a -s f 2i I e ri c ar,:@ n -@i -3 h i -.Ir i@o-s tow bve,-i s t tid ;e-.j n -rza fler .ie ta i I .I a I k." 1, u ci@,l ri a rr; v r o r r ca s ri Z,; e c ic -i s v,, a"Y @i 6r v e M. I 1 as at t r s e.:n I ii I s t r a t i o r. ci tc du - a n d v a6 s c, cI t ,Declassifis,-d by -18741-5. ;date B 1977 C 0 0 cr 0 2 f-D n 2 W i*- C4 el 2 zt ti 2 dq -4, 2 ,it 96 2 CL a r4 Is 6v ti 2 9 -C a 2 0.4 cr 2 cr 40 4,9 lut. 2 cr < 2 @!i r4 40 C4 :P c@@ 2 Ti 14 n C -4 Ln f-) C-IL 2 OA rn CL 2 Ott 2 zr 44 't') Ir 2 t4 2 4A co at 2 t) @7. - 2 0 it) Ir 2 44 VA 'Lli C, 2 0 -4f- ,J 2 -4-, Lk, r4 2 zr n 2 el 22 f4 :J ft 2 -1 MAP 2 IC 2 ri C). 1 0'4 like- cu-, 3n C.. I C va I ircroh I ne- ria ;was cvtd--,-@t at the F u r t st#jdiC3 arC I:t "Jr:@C"C$so b@ Addiction Llab2illt-iozs of 1,Alxturez. Txo of the who werc addlcted to t'i,a mixture of r-orrhir@e-14alline have bczn reoddicted to n-or-htne -nen ,And to @@Ia I Ilne In o.,rparate izx,-3tri, tisinc, the so,,.it dosae,-s of both druG5' fti4t werc orti@--nt In thr, mixture. Following wiflit4,raical of rorphine, Abstlnc@,icc was t,,,%.r mo.-e Intense th,3n 2 ol' tle mixture. folio-ainc, withdravial of t,4a'tllnc, no clear.cvtk evidence of abstinenct w4s, o@,-servzt,4. C* (,Iepzr d I ne (C@,-z.,rcrot This st2t;o'-.,r i3 ,-3 a c-c,..Icratlyc r.@rclect wlth tha C! !.-I I C,a IZ;#,--ff 0.f T I c 3 'T v f.-'! w -a t zc' L,-. ---ou-.e r @: 3 1 d'e t d 4i r s c n e I the Association the Surcton Ccn%-r a I and cx-@rcs sc,4 aL@-@ut t,.@c I rc. Inc !A- C n C 2 to ip. :-.rlvate Folit,--einc, reczi,-.)t of 2 I 4, t cirr.1 cef part of the a survey a.r i-ic rc-@or's c-f all -s t o r pe r I I t I 0 -athercua fro,-.I the rzc.:)rAs will Declassified by --18,87475--- 'date 4 FEB1977 occupi-At I@@nt locationt stated r,,!aso,-. for u r-z etc. In addition tp, survzylng fliz record@; ottier di J--L f,'@c P-o-vcl..,Iatric staff of the @,osoltal will un2dartakc titensive case studle3 of a nu.,Pbrr of addicts. The Addic'#-ion Rezcarc,@ 'k.-.crtt:r@s i,)art of f,@c I s i t a b I 1it f,he :3resencl-0 of ;).hvsical de,icndcnce in2 "-,ri;@nary' addicts and to stuiy idrlicti@c@-i In dcs;se The methcd for ;.)rovln@D tliet abli-inence occ-.,-rs in '$primary" meperldi.-it addtcts utlii--es the standard technic of Pal#-tents with h2i.-Otories o,r' addlction tc,- fi-.@Dcridine but of-addlctl,--n to r"i c@th,-r drug .*,re selectc(4 for study. These patients are sfsbtit'---d -n r.,zl-.ocridtne f-.zr li of 4'r t-i lfj' doy3, f@-,,?n tlic It, for ticis altle ,@z - cc ;t hat-"' f tr r i J r, doa;@s of acc 1.@,) be. a;td t@)e retl2zf OTP a r I w i7 e r 1,71 i tic o r@, I --I s s a r yfor 't n c I -W, -0 c. n ::'r 5 a id w i I I .3 i @-I I n Ir v i e1 n 0 r Ti 6 c 1 4 C:7 1 P e n t s v c L- c c r,- s t c- t,., iA I I s hd vt r,,? dz f I n i ta bs i ii c 'I C,@- of Declassifidd by -187475- date 4 FEB 1977 4 q poandoic@ s4Dzi -.@z 1 e4uzlu 2ti4 P-,II ;".I 9 4 -1 .1 jrtu Put' 2 Os 4 Uzi "ft" Di '>I 40gnAr, Zlu I fn -o p z@ 't 4 sA I ,%,I i@ Z A A J Z114 Jo zi3t,,l P, .To AI t:o Z 4 J 2tJ D 1 4 ;D 4 A UI S I? St ti4i -tuoig- P zr-lwplA,,4viC Z44 ti4tA U014f:@IM04ut 2q4 -ut ZJV U014:@IPPV OUIPI-izf-zw UO ZalPn4S 2s344 Jo ALIP ut 3ultivi-4 q4ifA -Aq 4OU PtnO:@ !)Du--3L'14sqV pz4lqllxz 2 4.1 2t A 0 :,;;j C-@lizczw 10 05W CC@t- Sul Alaaaj svta 'C@4;A 9 4uzt4t$d --*U.nl 's r4 7 ,4i:p luzivd--Op Zi.%A A I azi2ki SIX -atte,,it@; n,z C-0 @a c for-cr ad,41-ts votv;itc-r,@4 --5crvdtions a-re for the c@t. -,vr t@l-.cn In July, ccatrol olf.W obtis lln;zcl* Thcst@,, i nc I uded @,hV s i ca i , p-s @; c ilo I a e@. 1 c.-3 I 9, ps y r I c cu .a..ii na t Ions . 2el In lc@,.t I olserva t tons three ti.-@izs daily, .4itccfrc@. clectreencapholo-rains, blood chc;-,4iistry, an(J llvcr funcfion tests. Folio-.vIng fhe control p@!rtodp an 2 etie!-Pt was made fo dc4-@@--r-mina t@.e thr-eshtid- 4-*sc (dose vibich aould jusi ln4.,,uce mlld Subjcctivi:., cfl'zci4sl for eacn patlcnt. in fhl*.z 2 prell.-ttinary a-.p-,r,.Imznt, f.@c dru.,i va;s glyea daily. Iniflat@y, do,qes c.,f to 40 micrc-raris were admini.sterecl and 4thc %4,osi 2 was lncrcas,,.-@d co.?:@S dnl. Very fc,4y cff.-c.'s until th-- d-@3r- h@md beca At @ic i .1 i 2 f d s b c i d I c '.I a r wcrv- ncit vc ti c, i,. s v -b s u;@, n ,I A i:;,. I -t I s t r a I o n,2 o f I 0 t o l@O@O -.)aticnt:s. n!:ik beon recalvin- tll,.-. d.-u5 J,3ii-y I n,2 ;j .-Ic we rf -j I Z U."j TCt IV 2 a 3 I en S- n @i ve ff p @a C'm I ti I a f ,i a s c r,@.7 f o r c d 3 ,5 c t I n u- Z W; t N C; 2 o r v*;-y wzrt obierve,-'. c c,,@s s a v t D r s:) -i c t@ a 6c a s r c e. Declassif,,ed' by -ia7 date 4 V'C as I's tz.-t t et n o dru c T'f ea ar,,J dvrat of ti@e ro.@att fic@rl @s -,*,e r a r - t t li a d c T he t o f c.rug AC-CCZZ * f'f t,-i e I 1 c 1 @, t @lt a f Y@'zc t the rance extendin- frc.-i ,e@ I widely In -cliffer-nt patients., 90 to 3'vv' .ntcro(7rams. The obl-l@1--cilve effects of Inciirli et-.vaf ion O :,y3fol ic cnd 'VicoJ: pr-@.@5sure... of pupils (reasured In controll@,d kisht), lncrcasccj itsdon ctflexcs, and decreased, skin refteiess Cootefieshi; f Inc intenti-oli trz:r;@r of tinz f 4nkle cl@-nis fre:@--or of larg,- ccns ol2zcrved. iiie nent@pl P,@ffccts --%f' L"-@D-2-3 w-,,re vcry strlkin- dnd varicd fr,on .:;erson to -);zrson. @@o obvious c@-,rrelation w'ft@t 2 L- r, c n t I c f r cc t a c,,) n s i t. n n c u d z n x 'i ;3 I'z,: i i -i of' unrea I I ty Y.,a r lo!j @@ ba.@)lt s %-,ts,3 i ir@.ts f CZ I I MCS Of giCCfri- ahdCL- on the t f O I :;a t- I -1, 0 ftnoli.-,- -s %. sktnl z@ 3 z r. a t I o -, s c;-, c.'.. I n 9 2 T s t c --, pi s,,,nc I I a;;@pe 4 r cd f c u r a r' c ri o s c s vi:z r r c r t d t c bT h I- I i rt -,a t- 1 1, in the body I t c r n s r a f r!- 2-u qn y r r, i; ZJ to perce3k[on t@ere re-)orfcd. T,icze lnclu@6ed ilurr!nn Ur t,@ r c c n C 6 of @;a n t oil t'- a Oa I I -7@.ei Declassified b 187475- date - sh-od,ows -I n,-- i,n r@o t s of I leihts, ar.-J of rolo- Frequgntly, inanii@--ate obj--cts wzr- dtatr@rted 4rd ctS,3n-@-zd In 2 312C. @-,ccas Iona I IV patterits rc.@orted se;long vistots coeislat. of 1 n G f t a i I ; s c c.-i c s oi@ i c b r es e-ti d z-: t t Di s'n cy 114';o v I c s ?ati--rits had d*IfT'icutil i,-t descri.@iing thesc sgns4t len's !W-h'tle uiidcr pf LcWD-2-5 werc n;uch i-nore likely to give r,-.ood descri.ptlo.,ts the day f@-l@t-owinG the experl.-.iznT'. Thev complairke4 df difficulty lr. conccn'r ra t ton an-,I' c'f" a Irus,@ of 'r4;t ]en ts wert ut ua a--athzt IC and so--izwhit withdrawrt durtric. -c-hi of f-lie ,-@,sy. chosis. I ns I @@h t@x wa2s a lw,3ys 14--i I nad . ';@O mtnufas to one Lour after T ii cr cf fects usua I li bz-an r, i 3 t i, q c d r, and --c4k c e c i s u 2s u a y r c,3 c-,i o.,-,c and r,-ne-half fq t@.ree a,<--d and- r@-@re co.-@i-)Ictefy slitce., ,@ours. 2 T'c@r o 'T s r o r. t I 0 h e 1.z c -o c e Z) by r t I p!i t 1 VI -3 i. 11 .1 c z d t I c 5 t n I 7 r c d t o n li n e t r c c!a o r- .3 f c@- c I i:,,- r s ;t, r n c fcl Declassified by ---7187475- date 4-EE2 477 CL f4 2 et C cr 2 tq 2 to in 4@k 44 L4 zo iw tu I & C.,@ 2 -*-. 03 C'@ -#- #;qt :3 x 2 n :j ,U C% 2 f,# -.- 2 IC. L4 2 n V, 2 4P =#I r4 2 -"6 CIO 2 4-1 0 2 =r :3 ro el n n C 2 t Si. (I 0 @2Iv vo io L! 2 4A (b tx 2 co C 2 -1@ A 0 ILI% 0 2 cr 2 0 41# CL 04 IOU 2 :3 co FA 2 co f@ 0 LL 2 4-4 fo I-It 2 L,7 LID 0 4'4 0 2 cr tA v2o 04 49 2 C4 ol -t- Co zr 10 *Ili zi f.) n e4 6 -9., 7; f ..t"2cys but a! $,.-t 4r.r.luded Pot o;ilvt a d dec res r, tr@ I a tte c f f ect s on L- I o.-)d pr,@! o re ;Du ts rv s t-z oad de--a ten.4.on rcfle,,%,CSO !-.,i on vzlthc,'r.3xa I of LSD-23 after 14-e. A, y's of t*laer. 6nce fo 2 -.ccurs ;rore rd-)Idly and, ao-3cars to @.,e mor-, CO*.I:.)Iute than with apy dru- we havt ever studied. The ra-)Idity Siochl-.-nic6i 5tu4ies @.01 to Ica I of' Addiction. T p5zs 9 tlk-* i z p4rt lcii'lar prol@-.ct I.-t the 1.:.@st quartcrl-/ rcoort was completzd ,jurlnr, t@;?Is qt;arfer. 2 n @, r Of intusions oi Interr-citio I uiits of ',-TM durl lntil qa a d d !t a t 1 3 n s I ia 3 in t;u@;ns cf n-ii 1.1 r,,rloi- f.@ lct Tcin, H,-@wivcr thk lnarco3e In ter@-.@s of tha usual t-iiaily ex--,rction was nreater dur'.PT- raintdined adlictlior-a I n a d I t n JL i 7 - k c t @D s c r i i c r i ie r ii f us i -1 n c r i, a t f t h p f A--@'TH 2 r r. c C C:) c r;,, of c r o n t r A W- I t I r;!;-,.--:e c. r s z in (-7f uric 3cli 2 'T r. f u s -o n f P'V'-TH a a r c -d +,,i a s f4r c t d u r 1 n.Z -ia i ii t 4 1 s 4d c t, a r o r ad <@ i t- i T c I n c I n t@,;T s 1 r 2 E)eclassified by date ceunt dur I ng t I e d A-,--Tll I n f us: o n!, i,,ii t@ a t- s I o wc r d u r !,-i a maintain-ed addiction, bu t a I -@@.-ays fI t to- zcro (or ng-a rtt &o Y In ci'Sht hours. Increase 1,-i excrctton of t7-ketosta'roldt after the inle--tiot of 1000 international units of chorionic @onadotropin for five consecutive days wa3 at great In terms of milllgr,3r@-s and In terms of -ercentage chant-a fron '&tie usual excretion during addiction as during the control perto2d. The data definitely show that the testes and the adrenal glands are capable of rcsponding to the sp@.'Ciflc pituitary hormones- during addiction to morihine. lqevertheless, excretion of 17-ketostert-.)ids Is r,,arkedly reduced'durinc addtctlon and en2hanccd during wlthdraiial. Dr. DorTr-ann.. of fti-c ',.@orecster foun%-ilafion f,.-r Expcrir;ieD6@al Bloic'ry, kindly analyzed a fzw so.-,7:)Ies of urinc I'or us o n a t IC-,n t swho v:cre 2addiciled to and during a-ct-""te withdrawal of i-norphlae. The excrction of c,zrtlcollr-4s is r,-.ucN lower durin- i-,.-iintained ac!dictio.,t. The nos t r,easonabic hv-i,--,thesis ex,.jlainlnq the fact: know,-t 2to 4,afe It Future work wi.it includz 'ICA. cor@Icloi-d exc-reticii'-(prov',%Aed a suitc-ble r;@eihod can. Lc a frccfion4tton uririar--, c-orttco'%-,-',s by r.r. Dorf-mann# a.n d charionic -onedotrooln dcter;-iin-affoi-.z (to bp d,,-)ne by f-Sr. ZI) f,@atic.qil %'-'ancer lnstitutc, ,3rovi.:;'ed certain te@-.ili5nical Declassified by date at Leulngton cei t v e-r0 a a 4 .0 thyrol-d status clu r I r,#S r.-c. i i f,3 1,--f Ion,, u,3 I r ,I z cc t:rof-.Ia boun4 la-jine and @.5 b. Serum TheSC 3tU2-@41CS have be@-.n extcn-Jed and m3rc h-3v*- bten collected on f-ortazr aldo'tcis- an-3 o-i n::inaddicfs. I deterr.-.Inatlons arc baing done 1, ,arbltat bu;fcr, rit!i@7,e than ohoz;3b4ic buffer 2 as heretofore. The diff---rcnc-- in It-,e rdl,'Z-lo of beta btc-bul In to gic-bul 1,,i p.-tylously t?reoicr th4n i In aAj,-41c"s- less l@&z Lzen conf ir:n--d a-,id is-r-stat Is t ica I ty t2i rlc"tn t t-.V' a- lez3 0.01. T'liti-re t@ b c z-4c ati -,ive- ,,.4 T -ha' s I1 f I 4 I -4 zd t @-Op Declas'sified by 87475@ date f ,at the various d-osz V!e Is that a larc-I 1 lr...- 43@6tacc-nizes the depricssont z-,f,,-cts 2 f rorp!,-. lie l@ hat-* does a sri& I I 4-os c. Conversclyv a 14rce dos;c of r@larphine ant-ac,--anizes t'ic ct'fccts of a fi,-.C'd 2 of Nlialilne r.-ore than does a dose. b* Addiction of '@,@-hronic Soin-al Dogs to Nallint f,@lixtures. Two chrr.@itic goln-al c.'oss were (;Iven 0 f 0 rp h I -I a -a n d I 2 O f i'@ -'a I I I n c@ I V!a x u r c O-, a - After ftirez Yeekv to this there 2 w4s no evidence of tdlzraicm to tht d@-4-,ressant effects of ll!tz inixturc o a t h I c x o r r -f I e,-, Tt%13 Is a- striking sinc--, 2 havc 11-01-6-cii In .ti I and aficr e@)ch of the ..nixture. ii-se toy-zl of section* i-3s Is 2 sallvtti?)I, etco s or, r ha r. 4 lc! t-iV@;z r rt- f I g x 1 a @,r r;,-nn I n-,7 movetiz@nt s t ii tq @71 -in They chr,7,2nle-- use -.)f rirrl;@'-,.Ii-@@.!- u ,I tp O- t @i I c 5 c c i 'D 0. 11 of ml I bi-, t I t, Q r,- cr o T' x r 3 1,4 Declassified by,-187475- dAte Dcfern. tnift- Addi%-. lit, lability In Q-3 !.nV ar of tne.- @e sfue.,-Ino f',Iz short t'csf fo2r' 1.@,-@,ysic,2t -de@.-.e)-id-encel tiability In doe;s us I n t4, t,;a I I I ne ""-c ha ve car r I c.:f ou t .,, r.- I 1,-n! niry ex -,.a r I. men s usin- tw-.,) -izthods2. The first mqt@'iod 14ivolvcs tl)a liiiecli-ioij 0 of larce a;r@ounts of the dl,-vg undcr study once daily for tirec io five deys c@T'ter whl%-Ph 1:@') @ng2./ko. o r N,'alline are aditnister--,d. After lnjcctlon ol' Mc!*/kS. of m@orph;nz for three to five day3o N'alline couscd defol.-ilite c'1,3nZes In the be',-avi2or of d--Z;s. Af"ter a ,,In In Is ire t ic-n a f r-@ic II In e tli;z do p@s rlst Ivt.3, v--mitcp'. dcveloped and at +h.-. fcundA,4?on of@'t!lc 2 Ila tr,. I T@.csz c.1-onSzs w-.r@-* nDt dbaerved aftcr either ri-zr:Dhln@* cr .re scc@,i 2 of Si.-ic-le of for thr,--e to five days* In The other matho,.4$ @4.,*-vns were clivcn O"Zvcrat tl;rfies dall-@. e I was t--ur 2 ti@:n-s daily, and oti,-.Zr fe-* -ion. r z,--. as f t .,3121 lrz the d 0 t h r ct.,.: i,. -,e i r f-.2 c y 7 f t I @-'uch hivi n n t t 'to Z.- ci 18 @i c v c-, y r c Z n v c s i r y s Declassifibd by -187475@ date 4 Ad-'Ict ion to 1.@.bronic -r,:)Inal In 2 n!ontotcrant spinal ali-i,@Ic do-.-es *f 10 of prc.,@uced 2 on fi@a reflexes "Fhl.'--h v@gre to tho:,e iiroduccd by 0.73 of ATter of z-lx the deoressant 4fT'ccts was cvl,.,Iznt. Al this fl.,ne o,@ N-all t',Ae ronning C I the contrarys the fit-.or rzftex was %-Alzare33ad (!n:d the dog t-o--be 2 sedated after N4tllne. V;;ben the nupmb,-r oy, doses of oki.piri,ilne were observed In +-he In. c@uci'ed r;.arkzd @t yo c c c t I v r t2 y o f a t I f r a crt,,ssc,J extensor -r flcxcs, t@,.ichl5 r rz@ f s P.- I I C i d by -a z7, @-a I ony bony-p.roof -Irotubzra:@@c4 2 h c level o@t" cord sec&lion, Aftcr si.xteen --4ays of aL-6-ui-,@ tiiglhclrjw4t was carr's-i,?d out '24 @,otirs. Ti@,z 2 Z r n 5 v r z t-11 It@ er C'!) a r, C i e -n -I C 0 -z., r i n e r c r s c n t x c -:7 s @a"%st I -,:t s 2 C f of L @l C t-n e s m n o f L v i r y 1 n v@rz@-i Declassified by 67475 6 date r, the E'EC, ziectro.:@nccihiti->. gra.-.@ bv phot ic s t I-,,nu let olon a,.5pea rs to be enhinced a f r L Z 5 but t h;t stat.latic4i significance 2 of the chances observed re.-na Ins to be evaluated. H,.@%-zvzr, photte sti;nulation cnha,-.ced oarcelition of optical pscudo-)%.-illucloatloiis. 20 2 a. Effects of on Conditit; I n h I b i I n to Rs-is (Ipdiil anxiety'). The of fhls to atten-it to dtttlop an an4t@;csic fc-@stin!a meth,.-,,J lft ratz, b.,W2sgd on 'The se:ne prinl--Iplz as fliot ;F"aa 4file of arxicty rel&-hcd usvd was as fol I Ws ra.@s Y,-zrc fe i (I C r C i:: n a d!n-) U 0 f C- d Z, W C r c t a e 41 k i n -t c -io a c i press a b,;r@,whlch rateaszd pellcis 0 f b 0,3 . i i v a - 2 t'itr. unjiir th-.zse conilslia'.4 fi,;@30 of ccurse 1-1 nd r 45 A4rtcr ,I ',le rats fi4d been trained and 4u-ft4'ined a -.onsta5t raft o-t 2 u i-t U' f,. f3 a i-. u I i;; t; 'r r i,i z -z e r -a n C r 1 c 3 @:5 M4 T' t e r c o r, d i @c,, ti r z o f t-,3 c r c- s I r, c z T' r i c@ s!-@, -I) r r, - r apd c.'Dta Iik fc-ocl I)e I I 5 t I a I ra t eclassified bwy 18-7 "iS@ D 2 .4 date 4 19,7,7 &I top i C., 2 > to ti 'I; do W r_ U *,J, u2 ir to S* 2 40, ti 2 Its 40 Lt 2 qv C) a W IZ 2 .4- .4.1 Ki ti C., 2 iz 0 2-t; OC) CL 6,t 2 C; u I" t,2 -4- F-i 2 *@l 44 a L4 to 2 47@ W4 .4- 2 P-,) rA C-) -RC rz I- 2 'A tri in r@ 2 0 C4 4 2 cn @CZ Ci (.0 It@ Fla 2 > ty 2 06. 73 3. il .I-- 11) 0 tz C3 ell :@o f.) 2 tr) t-I fz L. 2 CZ .4A. ex O 40 *I,) 7 to m Al > dk 49- 0 45 t,;stst excc-:@t fol- an tncri,-3,-.-,,,. In -,Ih.-@ tot,3t nu,:-.Ler' of rct,,-,onzes aid an 'Inere4se In It%.dicators-.0f onxief'." 2 II) the fcafst elevation of oll clinical scale$ was obsew-veds the @;rti@test tncreascs bzlr,,n Is-% and t'.-.-;aranala" sca'sc4-,, C. 8101-Hlysii--A'L STLOI,'.:s tn -ap..:@,arctus for photic :stimulation 'n the .7. 1 C At first, photlc ztltulation induced artifacis but 2 thi-- tva s clev4tl,,ig tl-.c It' ar@-. silit irio on tht orob)e,.7, of 1:@', for 44he c@t-eafer C'Isiancz 2 The @r--r ri e-, c 1 t z C C C n n a I tvcd frt:.n-- *@c ettir c r haul waz s@ill fourd to be po.@rly, After corres,.,@ondcncc with the @@-anufa%-.turcr t h e c n i r lis t n t i n c o v a r C r C u i s t r a C a n v z I v a C C A IC co-..)y scrs,:@ ri s C n 'T r T u,.n c r c r i d c eJ Dectlm-ssified by -1 8 i'475 8 1977 T 1 D. D IS S::' I tN':'T I Htlig, H. E nd B c.h@onic o.,t k@.otivat;on 4nd js cu I ii r -,-.ord I ni i Ion Arc,.i. t\eurol. 1 v44 '@v,ikiory A. F,rd3,er H. F.2 and lsbellr H,.- r,'-A I I y I f T'c c t s a I n c I -z 2 c s 4 -n d r c @i I of Acut@-. 'Abstinzncc '.-,cthadonc or In Iz r A. a,-i d %--,a r t c r f ',--ts of Sin@le 2 Dosiz-@ f i,4- II / I -.i o r,-r,@-, r n t on @-'Ilndl'4mb tct'lexcs of @eacs "u'riz@ti -yctz-z, a4.' I -i e A c tl!n n 2 e@, Ex-@,cr. ii@t ft Ise I k I r A Analcc.sta. u r o I -n a r r L "u 5 r,@- e d I c a I r 2c c r H@i@ I;i--, rr-.* r@-,h n c 6 nd e r Ar. t -a - n I s s rco t f I I 1 I o f c! c -Ie C;! :@o 2 ce. rzr.-@or reis e r @-i ro I O@ T I 1 'K C I' 5 I 1. z -.i r-1--n c 3 L Y., z I- t)eclassifi'ed by 187475---. date A t t d d t t A 3 n a f t a n a o 4 7j t C2, t y f d ra c o o x Therap@ut lc3-p, t-@@zw i-,dvc"tl Conn.$ 5ep".. -C@ -'t@ t I n i I L- r S n -n,@F 8,6 "C) inical ifesfati@,,ns of Druj Ar-'dict ion'! t!-itv@ors lty ka I IcC-,c of ic Lincoin c b Dept . of i@har;,iacy Harvar--.16 2 School s t c n State i-@)SPI ta I yan,4ton S. Do H.-i so I t a I Conn i s!s To n c r c f N';3 r co t I c s 2 e @7) 1 t a I of c i-:):; I t a I I of r@ r,-.,:3 c I c cv d -d 1 E@ot tr, A "ass 2 C* T r e i t ,3 f t li d I I i t f C,, -z- Cy--lo of 181475- 5 [)Gclassif!,ed by Of date EL lty Association, 'K. ife.-.ber, 19-D-30 eclassli"ed by -@@187475-1