-@kA LD50 320,0 GREAT ME030 56*0 -189U-l8OoO- RATIO L050/t/...ED50 UNK STATE C-@CLID INTRAVENOUS TOXICIT2Y TO MICE 0 DOSE Dvt-Lly RFA-T- REACTION SIGN MIN, D F-'G f G F R A C T o 2 APPR R E Lz R E C,;"- V F- P 2 C,, 12,U 2/2 y 15 .iEC LC-Crv','@CTOR ACTIVI; 124 -2151TIVITY TO l-'(:.U@qD 2.10 60 2.'s nc@t S20.0 3210 2/,- ALTERED 13Z 0 .1 . .; @, ? r'EC ;3,EA@,,",%,C- F-c""UENCY 632 0 12 t) o 0 3 e- 32OoO 2 f@ 2/2 PTOBI"-@-tiCNPARALYTIC 1.49 30 G 212 Pu:,ILLtRY LIG.HT REFLEX 2kt35 152 8 6- '=2ncO 2 4y-RvAals I i.; !d L - 154 8 60 32'030 32.C- 2.12 !iNC PESPIRATCRY DEPTH 2 161 8 23 .0 2/2 ;RREGULAR RESPIRATORY RATE. 362 o 3 (i 1/2 MCT !@EF PORIZONTAL STRIP 47 1 8 4 ;2"*O 32,0 101"2 POT' I 8 FE, 37 Z E VERTICAL ROD @2r),O i 11 2 Z T ROTA-RC)L) 2 7TI a ,20.0 12&G 1/2 NC I- 1,N Et) 5TRIP 671 8 a i2O*O 32,0- 2;2 LOW POSTURE @241 15 12r4' 212 2 DEC LOCOMOTOR ACTIVITY 124 15 2@ 0 v lo,.,,o $-,,,e2 ---uCIAL INTERACTION ALT@R.RED 132 G 2 3(;", I&OCCIO 0 DEC 14EAkING FREQUI-.NCY 632 8 G 100.0 1010 2/2 EYELID PT3SIS-NONPARALYTIC'@149 60 240 32.0 3.2 2/62 NO EFFECT' 73 DTL. 0.5% M.C. SUSP QS C-H 20 LDI,'-O 220*0 -180,0-280,0. ME050 1*8 -0956-5*6- RATIO L05o/MED50 120oo STATE SOLID INTRAVENOUS TOXTC-ITY TO Mi%rlaz. DOSE 2 DILLIT RF-ACTO REACTT.CN S-&C-iN 1 E. MG/KG Ml-./KG PRACT* v F 3---OaO 212 DEATH 10010 1010 2/2 DEC LOCOMOTOR ACTIVITY 124 c 2 100*0 1000 1/2 ABNORMAL REACTION TC PAIN 4-79 10010 JMIO 2/2 INC SENSITIVITY TO TOUCH 131 30 100*0 10*0 2/2 SCCIAL INTR-RACTT.CN ALTLRED 132 icoso lo,o 112 EYELID Pf'OSIS-NONPARALYTIr 149 3,tl ioo,o 10.0 @/2 MYDRIA!ilS 154 a "ioooo leo 1/.7- IRREGULAR RE-CPIRATORY DEPT'-,2e! 1;! 10010 ioo 2/2 INC RESPIRATORY RATE 2 1,@2 O' 32*0 3,2 2/2 DEC LCCOYCTCR ACTIVITY '&24 0 32oO 3.2 2/2 SCCIAL INTERACTION ALTERFD f'32 0 10*0 1010 2 I)cC LOCOTIOTCR ACTIVITY 2 .124r C, .40,0 io,o 2/2 50'-IAL TNTERACTION ALTERED 1-12 a - 0 INC PREENING 140 15 4,000 I 0 a 212 ft looo 10.o 51/2 MYORIASIS 0 3o2 3.2 .7/2 DEC LOCOMOTOR ACTIVITY 124 0 PAGE c t, XlrjTY TC i E INTRAVENOUS '-90 P,IN* vose DIL!'T REAt-To KEACTIC-N SIGii M K G ML/KC- FqACTo AR-:PR RrE 100 jo.(" 2/2 No EFFECT 73 74 0 25CeO 2510 212 DEAfrH 20010 20,0 012 DEATH 74 0 74 0 0..12 6, C) r-I E a T H .&OSO D!L* 2 H2C CS C H20 LD50 280,oO -220*0-360*ow MED5'L' 0*56 -0018-108- RdT,fO LD50/MED50 500*0 .CTA'TE 50, 10 2 INTR.4VENOUS TOXICITY TO MICE D@3CE Di@.t'T REACT* R,VACTION SIGN MIN9 0---G- M"%Ne .KG M'V-@KG ;:PACT* 114c-. 2 APP E R 3;0.0 37-.O 2/2 DEATH 74 a I'@colo io,o 2/7 DEC LOCOMCTOR ACTIVITY 1,24 0 0 0 0 10000 2 INC SEtl$ITIVITY TO TOUR@H 0 2 , r 110010 1010 2 & /2 SCCIAL LNTERACTION ALTERED I'@22 0 2 0 0 0 0 10 0 RECURNCY 2/2 DE@,.@REARJN(i F @632 0 10000 1000 2/2 DEC REARING HEIGHT 73@ 0 ioo,o 210.0 2/2 DEC PREENING - 240 0 10000 10,0 112 EYELID PTOSIBANONPARALYTIC 149 60 ISO 10000 1000 @/2 MYORIASIS 154 - 0 2 10010 10.0 212 PUPILLARY LIGHT REFLEX ASS 152 0 3C)o 10000 10.0 2/2 INC RESPIRATORY RATE 162 0 G 330 locoo lo.o 712 MOT DEF HORIZCNTAL 2 WIRE 171 0 10010 lo,o 2/7 MOT DEF VERTICAL 5CREEN 271 0 10000 1000 212 MOT DEF HOR!ZCNTAL STRIP 471 0 1010 9 0 J6 2 371 0 2/2 MOT CEF VERTIRAL ROD !-F-0 looso MOT DEF ROTA-RCD ?71 0 L 1010 2/2 loot2o lo.o 212 MCT D@-F INCLINED STRIP 671 0 32oO 3o2 2/2 DEC LOCOMOTCR ACTIVITY 124 0 32*0 3,2 1/2 INC SENSITIVITY TO TOUCH 131 0 60 V \-C U 5 E T P --"AC' C- M;2/K,.'l MLIKG F2PACT* 0 .2 214 ;4@'C I A!- ?.@*"".=RAC-Tir,'N ALT'L::RED 1 E RE'R47,@iZ C- F- E,%' 1 N C, 2 k4;; 3 0 2 !NC P E R A k 4 T 3710 E F 32-'" 2 IICT WEF V E,-@. ',-.AL 2 27?. -2 4-! 9?'D 0 2 F q 0 T A R 2 IVIC 212 1 N 0 C C 0 T C R A I V I T Y e".24 L-)o 0 1010 2/? i) E '.OCL)i'407'%'W'R PAC71VITY 124 10.0 :I/? INC 2 -.@E.%IPIRATCRY RAT;@ 0 3o2 3,2 2/2 1 ACTTVITY 7 4 0 hio. t 1: 3 2 12/2 -@-Mcel.Ty.t@ITY TO TCU%'@',@ I 'A '2 3 2 1 iiZ A N G 44 Z) 0 0 1/2 INC L 0':,Z; 0 0 P A2'--- T IT& V 1 Y -724 0 s 0 'to I/:- 1 N TO 1'-2 1 3 -11) 4 !;4 P- R ao ^,i2 INC t@-RA7CW!NG @40 I z 2 212 t-IC EFF'-CT 9 3'.i 5 p C C H 2 0 LD50 100*0 -79*0-12000- ikiED50 0032 wooillo-loo- RA-.10 1-0504MED30 344.090 2 E 5 OL ID TRAV'"--i'4CUcw 'TCX-I<@.!T'f T() MICE -Gap C C 2 REACTION "-IGN MINO Di E= L L, T ',:@'ACTo APPR R K G FqACTo 2 74 0 oli 0 2,0 2 DEATH ?..C DEC.LOCOMOTOR AC71VITY 124 .0 2 i/2 I CCO.Y.0,010.R AC"i T.VITY 224 240 G Boo 2.0 1/2 INC .0 UND 230 0 2.0 1/7 DEC SENSITIV!-:Y TO cO 231 t --NSITIVI'iY T,%"O,.TOUCH 2 I @o 0,0 2.0 112 D-C cc G 0 io IN%-. z-EN51TIVI"iy To TOUCH 131 Lao 2.0 1/2 2 3 D @c. C REARING FRECU'U:.NCY 632 0 .0 2,0 1/2 2 C' 20C. INI@- RLARIN- FREQUENCY 432 240 0 2,0 1/2 '3 11 ;; 2 7 I ItAp TAIL 3'@2 3 0 46 - 2.0 I/- .3 C' .10 2 35 -15 100.0 2,0 1/2 AT."-'XIA EC PREE-NIING 240 0 so 2,0 Ailp 0 2 140 240 G 300 0 2.(7, 1/2 Iti-l- PR@@ENING % % 2 442 .0 w -ING REFIEX ABS 28 112 PLAE%. 'Colo 1: 642 2 0 ICO.0 2.r. !/.2 C-RO'ABPIN- 16 4-!2 MOT DEF R07A-ROD 771 0 0.32 l6cO 2!2 MOT DEF INCLT.N-CD STRIP 671 0 0032 16*0 2.2/2 -LOW CAKRIA%@3E L75 8 Oo3Z i6,0 2/2 OP@STHOTONOS 8 30 Oslo 500 2/2 DEC.LUCOMOTOR ACTIVITY 124 8 2 TION ALTERED 132 0 0.10 5*0 2!2 -SOCIAL INTI@-RAC. O'DIO -CIO 2/2 DEC R;-@ARING FREQUENCY 632 0 G 0,10 5so 1/2 STRAUB TAIL 233 60 olio 5,0 2.1"2 ATAXIA 35 0 ooio 500 112 RUBBIN(3 NOSC- 340 0 0010 500 2.12 TREMORb-MOV@-:MENT ONLY 2 244 0 0010 5,io 0 ,21,2- El%j,,ELIU E?-i'VSIS-tNG4'iPARAg-@Y-T,4C@ 149-----60-@ G C, 0 -X ARS 152 0 0 5 5oO PUPILLARY LIGHT Rc@FLr_ 0,10 5,0 1/2 MYDRIABIS 154 0 Oci-O 540 21,f2 SPASTIC GAIT. 375 8 H20 EIC'irRACT ZZ, STAT,C@ I-IGUID INTRAVTNOUS @o'^'!CITY "IPU MICE C)n C 'Z Ri@AC@kloN.BIGN MINE 0 F- ,-Z D'LLUT REACTO 2 M K G MLIKG FRACT*' APPclR R 74 3080 40,0 .2/2 DEAin 74 0 .:)032 16,0 2/2 DEATH LOCOt-TOTCR'---XCi-rVrTy--2@-'-1'24 -2 DEC ooio 5 j SOCIAL INTERACTION ALTERED 1-2 0 Ogi.0 5.10 2/2 .1) CY 632 0 G ,0,10 5.0 2/2 DEC REARING FRE2GUCN. I 'ic.ilo 5*0 2/2 DEC PRTENING 240 0 G oo,alo 5*0 2/2 INC RLBPIRATORY DC-P'IH 1618 240 .0910 @.1) 2!2 IRREGULAR RESPI'@'!',r@'RY DE PT H3610 -- 0,10 5.0 2/2 DEC RL!DPIRATORY RA-;,-E 262 8 G 240 0.10 5.0 2/2 IRREGULAR RESPIRATORY RAT%C. -1620 DILE H20 UNFILTERED SUPERNATE OF THE EX7RACT -N I MP% C. C.. %i %.O 5-:ATE LT.-OUla-- INTRAVHNOUS TOXICI',Y ',rO MICE DOSE DI@@UT REACTO REACTION SIGN MINE DEG- M@--Nb 2 -;a f4G,'KG ML#'KG FRACT* APPR REE RECOvc-,u% 0180 40,0 2/2 DEATi-i 74 0 Oo32 16,0 2/2 DEATH 74 0 0010 Sao 2/2 DEC LUCOMO'2IROR ACT61VITY 124 15 60 001-0 500 2/2 DEC REARING FREQUENCY 632 15 60 0110 5,0 2/2 DEC Ril@-SPIRATORY DEPTH 261 0 0 0 5,0 2/2 IRREGULAR RESPIRATORY 4 0 oelilo 5*0 2/2 INC RESPIRA70RY RATE 162 0 30 oolo !500 2/2 IRREGULAR RESPIRATORY KATE 362 3 1.5 DIL* H20 FI:LTERED EXTRACT EXTRAC'R 3UOOO(; STATR-- LIQUID IN't"RAVtNOUS TCXICITY TU Ml'%-.E i)CZ DILUT REAC-10 REACTION 5IGN 2 MINE DEG- MTNO 7' APPR REE R.@-0'-'PR MGIKG ML/KG FRACYNO OeBo 212- DEC-LOCOMOTOR ACTIVITY 124 8 G 0080 40,0 2212 EYELID PT0515-NONPARALYTIC 149 15 G 0080 4OoO 2/2 DEC RESPIRATORY DEP'FH 261 0 01.@80 40'0 2'1 Z- INC-RE5Pi@RA:-'@ORY-RATE--- --@- @-1'62 0-, 0080 4OoO 1/2 HEMORRHAGE-INJZ-CTION SITE 169 0 O.;32 1600 2/2 DEC,LUCOMOTOR ACTIVITY 124 15 G Oc32 l6oO 212 EYELID PTOSIS-NONPARALYTIC 149 30 G iso 09322 16,,O 30 1/2 INC REbPIRA7i'@l-RY DEPIH 161 8 0,,,32 16.0 1/2 DEC RESPIRATORY RARE 262 8 30 003;1 162oO 112 IRREGULAR RESPIRATORY RAI-E 362 0 30 Oo:,"2 IbQo 1/2 HEMORRHAGE-INJECTION SITE 169 0 8 *,to 0 5oO 2/2 DEC LOCOMOTOR ACT'AVITY 124 30 0010 5,0 2/2 EYELID PTOSIS-NONPARALYTIC 149 60 011-0 H20 "NOW STA Tr- L 1,.U 1-D- IN-iRAVtNOUS TOXICITY TO MICF- CGB=- D 4' @L-Lor REACTO REACTION 5IGN' MIN* D 'I@'-G M 'L7 N c 7 ,'iC-,!KG ML."KG FRACTO APPR REE 0.80 40.0 ?.1'2 DEATH 74 0 0 . 31&1 1.6.0 2/2 DEC &-OCGMOTOR ACTIVIT-Y 124- -a- 0.31, 1-6.0 2/2 CIRCLING MOVEMENTS 025 0 0.32 16.0 2/2 INC OEARING 2 FREQUENCY 4320 0.32 'k6.O 2/2 DEC REARING FREQUENCY 632a G BCO -8 0.32 16.0 2/2 MIXED CONVUL51ONS 336 0 0.32 &6.0 2/2 DEC PRLEN'ING 240 0 G 410 2 0 0.3141. 6.0 -2/2 RUBBING NOSE 340 0.3&' 'L6.0 2/2 BL'ANK!Nlb-EXCE55IVE 247 0 O.-12 16.0 2/2 EYELID PTOSI5-NONPARALYTIC 149 0 G 3C!- 0 . 3'-) 162.0 2/2 LACRIMATION 50 0 0.3'Al 1&6.0 2/2 PUPILLARY LIGHT REFLEX ABS 152 0 0.32 16.0 2/2 MYDRIAbl5 154 0 0.32 16.0 2/2 DYSPNEA 60 0 N%"- R@-SPIRA"'ORY DEPTH 16120 0.3&' 16.0 2/2 1 It 0 . -zo 2 '.6.0 2/2 IRREGULAR RESPIRATORY P T H B 6 10 0. 32 11.6.0 2/2 DEC RE5PIRATORY RAIE .262 0 0.32 i.6.0 2/2 IRREGULAR RE5PIRATORY 4RATE 3620 0 . 3 16 !.6.0 1/2 VASODILATION 265 3o 0,32 16.0 212 MOT DEF HORIZONTAL STRIP 471 0 G O 0.3" 16.0 2/2 MOT DEF VERTI'%-.A'@ ROU 371 8 G PAGE A- 9 INTRAVENOUS TOXICITY TO MICE DOSE DILUT REACT* REA-'-TION SIGN MINO DEG- M:f,,' MG/KG ML/KG FRACT* APPR REE RP-C 0.32 16.0 '!2 MOT DEF ROTA-ROD 771 8 9 0 . 3 2 16.0 @12 MOT DEF INCLINED 5TRIP 671 8 G DILE H20 S@IATP NTRAVHNOUS TO"'ICITY TO MICE I MINO DEG- M7.No 73 r, 0 S;-: DI'-L;,-j REACTO R@;ACT-ION SIGN 2 APPR REE RECOV-tcl MG."KG MLIKG FRACT& 50000 lo,o 2/4 DEATH 74 0 loc 500210 lo,o 1/4 DEC LOCOMOTOR ACTIVITY 124 120 .50000 1000 1/4 INC SENSITIVITY TO SOUND 130 120 "oleo IVI'rY,,TO TOU(-H 131 6D 500.0 1/4 INC SENSII 2 .0 - 50000 1000 1/4 HEAD TW.ITCH 531 1807 500,0 io,o 2Y4 INC REARING FREQUENCY 432 120 G '-ZOO .1% 2 io,o 1/4 SUB-CONVULSIVE MOVEMENTS 436 180 2z',Ij 500,0 214 INC PRTENING 140 8 -Z( 500,0 1000 244 12o G 3oo 50000 1000 1/4 TREMOR5-MOVEMENT ONLY soolo ;0,0 114 INC RESPIRATORY DEPTH 161 120 G 500.0 iO.0 1/4 DEC RE5PIRA'tORY RAIE 262 120 G 50"*C ioeo 1/4 TOSSING HEAD UP AND BACK 79 18;^j 3^1.0.0 3210 1/2 !NC LOCOMOTOR ACT.'*'ITY .22,4 0 3299 112 RUBBING N05E 141) 0 '.z2O.U 320.0 32-0 1.12 NO EFFECT 2 -1 ioeo It /2 NO EF@ECT ILOOCO 2 DILE H20 OS C .420 LOCot4OTOR ACTIVITY OF MICE GROUPS OF THREE Mil-E NTS AT INDICATCD INTERVA,L cou 2 50MINI 55MIN 6OM'N CMpt4o LEvf:,.- 5MIN i6M'TN 15MIN 20MIN 29MIN 30MIN 35MIN 40MIN 45MIN 96* 1170 0 515 1. 291- 502* 3379 400o 342* 228*@ 229o 264* 2089 0000 - 40 620- 51s. 365. 3609' 323a 229o 178a 181. 118, 157. 311. 230* 315, 2602o 205.- 174o 127. 288* 174* MEAN 5680' 47i. 328. 330* 21. 6* 2CS9 10.000 200. -96. 207, 1219. 181o 100o ioi,, 90.. 281q, 39. 299. "714. 133. 235* 165, 134, 82, 100.: 272o 193, 119* 34, MEAN 250.. 155- 170, 178* 173* 117* 92o 95 177a 116* 70* 20* 89 2 28 90 48a 1.000 684, 39i. 465. 332a 2309 7, 175* 100.@ 579 71. 49'4* 394* 336* 334* 4689 2769 332o 309a 350. 146a 880 AN 700. 444, 430* 334* 282* 3789 226o 216, 1839 2il. 78, 68* 21o 89 1100 241" 14A- Bi, 131,o 121* 7@4a ale 121. 1419 21- 21* 2 -4 454, 358. 277. 357, 327. 351, 202, 561: .97. 302. 422.' 357o 401. 2 " 199. 249* 174, 186o 112* MFAN 704 192, 277* 239, 264* 220a 2263 0.00o 696. 73q* 432. 4780 375* 374. 412, 324. 364, 211. 2036 185, 723. 677, 522 549o 5039 4229 440, 2650 372. 407 354, 385, MEAN 710. 6ii3. 477* 514o 439* 3980 426* 2950 368. 309: 279. 285. 100.000 243' 3 84o 106. 171 2263 1! 76'. 107. 103* 145a 50, 28. 650 1100 2 414. 34,Q. 263. 237* 869 46. 829 286, 219 0. 78. 118* 329'0 276* 183. 1170* 1169 38. 55* 176, 53* 53. 125, 114, MEAN 7-263 106000 690's 641. 461. 45!f* .,820* 417. 403* 398& 356* 476* 436* 6.3-.-4 P44. liso. lltl5. 152tlo 1-!.839 1391* 1.4kR#. 4376o 1329,, 1361. 1289- 1100. IN 767. a @,h 948. 9-VO. gt32. 91-4 2926., A,03. 843; 919. fi 1, LOCOMCTOR ACTIVITY OF Ml(:E GROUP3 OF THRTE Mlr-E COUNTS AT INDICATKD INTERVAL IN 3tMIN 40MIN 45MIN r-OMIti 55MI(4 60MIN @-"VEL 5fl-IN 16M.IN 15MIN 20MIN 25.MIN 30M 2263 1#000 331. 171* 61* 161* 151* Ilie i5l* 151' 15le 108. 141* 47* 2 891' 6' 4-68 353c 473* 377c 93, 1689 119, 14o .177* 445. 301* 2 MEAN 611: 265: 257, 312* 244o @64* 2936 226* 201. 1525, 83, ?263 0100 354 22i* io3. 192, i72* 2ii lit* 97, 101* 830 211. 918' 6496 714* 6499 760, 37, 62,4@ 4409 518* 249, 3139 2 6660 AN. 636a 30, 468o 376* 4769 396* 4 155,p 418,i 276* 308& 175* 198* 854 2509 553* 2519 16 71 OOOOO 443i'b 341. 2 SI' 2440; 148. 396. 275. 250, 356. 25A, 92, 184a 170, 76. 138* ,@20' 3SAO 350* 364* 3539 1949 EAN 2 532b 350a 3186 307a 4534 304, 212* 168, 166o 283, 176* 32OoOoo 14o 63, 110 5* lb6a 7* 0. .00 0. 28, 36, 227t 255 16* 419 91, @,57* 31, 180 1. 80 00 74* MEAN 20,i. 44a 590 14o 23* 99o -32* 16o 9* 1* 180 18's 2271 1009000 539A @4'q, 2 l8s6 218a 256* 4149 445o 372* 321* 247. 188* 179* 770. 5o-q* 312* 3599 414o 3089 @16o 245* 2269 139* 140* 233* 6554 379* 249o 289t 3359 361* 381* 3092* 274* 193* 164, 2069 MEAN 2271 100*00a 546. 3-?'30 2646 1790 184* 192o 253, 326. 338* 136. 323, 211# 658, ige 395* t370* 349o 339o @32,o 284. 332o 313, 255o 274* 5 MEAN 602* 446@ 330.& 275a 267a 266o 2939 3050 335* 225- 2899 243o 2271 loOOO 843. 74to 5410 503o 17@to -413a. 3949 320, 214o 2 1646 100, 4-Ye 631, 4,i'7o 312o 293a @00* 2790 286* 187, 155c 166* 199o 201a MEAN 737, 57-4* 4270 399* 339o 346o 340o 254* 2859 165* 15LIo 124. LOrOMOyop ACTIVITY OF MICE GROUPS OF TVIREP- MICE COliNTS AT INDIr-ATtt) IN"I'ERVAL 2 MIN 30MIN 95MIN 601-IIN Ct4P,ND LEVEL SMIN 16M'TN 20f@,;(,j 30MIN 3@MIN 401-ili"4 43 go 213, 327. 61* 540 390 104, 2438 00000 907. 79A, 745, 621io 4386 67 591. 37'7. 381* 308* ':),58* 4040 ?39. 392. 287o 3230 157o Ilge 541a 226o 46002 174a 189* 98, 1120 MTEAN 749. 587* 5636 466o 98* 167, 246, 231 241, 138. 205, 192, 2438 100.000 492 145. 166. 1549. 214* 453: 2 SiSo 180* 147o 140o 1329 124o 92:: 85, 72. 58. .73* 173i 162,. 163o 105* 132o 133* MEAN 473. s3n. 1512o 177* 150o 185o 8 10,000 419. 267- 39T. 438* 346., 241',p 13go 86. goo 5ge 4go la. 564, 267* 323, 2439 238o 268* 325* 415, 336o 227* 341a 3339 4924 262o 1606 3419 2929 255o 232* 2molo 213* 143. 195. 1769 N 2 15 OSOOO 720, 5IRe 600. 5909 1031o 322* 456o 250. 446o 284* 249* 275o 2814' 5914 4.820 629c- S95. 517* 465o 371, 405o 3914 31;2. I'@77* 41, 610a 713o 420o 461* 311, 426* 338& 3019 40io MFAN 167. 5566 5 22600 102*615 61n. S79o 279. 3910 3300 276o 211o 120* 00 170 14, 110 7326 51q. 413, 29(o 267* 223o 305, 214. 141 119. 104a 34, RAEAN 671. 45o* 346- 2 141o 29S* 250o 258o 167.. 71: 68- 59o 236 2615 10.000 621. 55no 473, 479a 741* 3296 46le 285, 177* 196. 92i 282* I - 93. i27. 2 396 319 64o 31* !so 2n, 46* 27 18* Te t4FAN '6 255,, 403. tSO, 24ri, 157,, 112,, 112: 55. 145o '439 256i (:..Ooo 76P. 514, 3,!,@.. 4 1.',' A 28i.. 2 p 3 6 1 51. all 4 2 LOCOIIOTOR ACTIVITY OP MICF GROUPS OF TI-IREE MICE COUMTS AT INDICATED IN'TERVAL -6mTN 15MIN 2OPlIN -SMIN 30MIN A5MIN 40MIN 45MIN 50MIN 55MIN 60MIN cmpno LEVEL 5MIN I 329000 544. 249. 215a 264* 339a 257* 2050 195o 224. 1060 20* 2776 4 t) 466' 254, 209, 1609 2330 254o 3399 272@ 218c 20'f, 1900 140* 187* 249o 297c 298, 2 239. 207o 14 505& 3f)2* 229, 216, 8, Soo 2776 10000 187" 424& 319* 299o 243* 391*, 229*. .570 226* 91 Ot 00 316, 285* 268* 3669 292* 309. 3179 271. 7s 2449 MEAN 7856 438o 3286 2929 2569 37ge 261* 183. 172o 1402* 49 122* 08 OOOOO ql9. 687. 535. 340o 1383 280, 581, 278 1489 277. 259, 107, 866'.' S'no'. 424, 512o 404: 395, 391, 352* 2 4679 318, 2450 207* AN 893. 634, 480a 4261 894o 338o 486# 315.; 308a 2q8* 252* 157a 21108 32,ooo 3260 376. 371* 4446 10454 194, 824o 17. 44a 12. 7o ol 325, 4930 liq,Oe 470, 602* 381, 2@120 181. 17, 4* MEAN 41A. 354, 347, 469* 11189 336* 2 443o 199, 158# 970 120 20 2808 10*000 830& 545o 399, 373* 4710 455o 361* 305. 286* 364. 302a 227* 777a 4AS4 445a 2 4089 463o 376*. 350o 397. 2'74o 253. 158* 1779 MEAN 804. 565'a 422a 391* 467* 416o 3569 351i, 2809 309. 230, 202* 2809 3#200 1343. 5'6i* 435* 358o 400* 435* 444* 620, 361o 412. 757* 796* 16500 419* 346* 4409 512* 519, 425* 425, 294o 324, 918* 795,o MEAN 2 1497. 560* 391t i3q9o 4569 477a 435* 523* 328* 368* 838* 796o 2808 0000 65 50t 72;; 47,@o 4@,5, 4-"q, -499. r69,.) 4-02. 385. 5260 5, 452, F-t i) 49'lo 4 -:i'@ t. F! 7 4?.f! 0 4 55, e'_365 236, 450s 3 3 &@, a 0 S.',2-, -k56a 4?,6c 4,5"'-,@ 4774 42Ao 3ISo 416t 4@"4^ t,i E t4 1649. s so 6;. o LOCOMOTOR ACTIVITY OF MICE GROUPS OF THR@,,E MICE COUNTS AT INDICATED IMTER@/AL "MIN 4OM41N 45MI2N 50MI CMPND LEV-RL 5MIN ibM'TN 15MIN 20MIN 25MIN 30MIN 34 N 55MIN 60MIN 597, 595o 580* 663, 510* 465. 401* 456. 234* 562, .844 041000 949, 8 2 245, 4goo 4806 323o 3770 405o 301o 276- 342 117, 257* 649* M 8716 4599 479*2 5340 406a 371i 372* 3870 246*' 304o EAN 5590 7 156. 466 27e. 90 so 10 5' 20 1844 100*000 19 6, 5ib 16,o Isi's 1820 96. 101* 74o 16* ,12,o 0 3* 3, 150 .2o AN :174. iS'i, 71* 64* 42c 100 7@ 36 3a 50 10* 9,0 2ME 4" 10.000 6840 49@, 376, 336a 413* 302o 3539 2490 271o 2576 213* 1560 627. 42@., 3919 198o 305o 2794 230* 142* 165* 129* Igo 21ge 656, 2 45'?e 385, 267, 359* 291* 2920 1966 218o 193, 1160 1880 ,g 0 0,000 86q' 6ii. 608. 545o 705* 634* 488* 563'0 6139 610* 556. 326* 464 621. 5ig. 3546 i 360* 313* 382o 412. 349* 407o 250* 179* EAN 7466 !igr L 505,b 533* 474* 435o 488, 481* 509o 403, 253* o 481,b 2850 500@000 5124, 40!o 1616 el* 245* 261o 57, 254, 281, 370. 362* 22@, 2216' 723,b 156, 207o 4170 333# 3166 296, 2709 238. 311* e-68* MFAN 361& 315* 159, 1244o 331* 297* 187. 275. 276* 3044 337o 246* 7.850 104000 387 32s. 2gq4 2736 121* 337o 256* 333, 288o 1364 371* 277* 465, 486#i 561o 549o 515* 554, 5240* 485& 415t 376, 9926 577i MEAN 690, 45i* 3824 13806 441# 443o 366c 444, 414o 411. 393o 32'to @1,851 06000 563- 500, 4 o 4A!o 32990 3 9 2f-,3. 355u 346. 3'@,5e ii I t, 0 85,, 3i* 4 o V, 14 4 310. @'4 258. 5 s 5 7, 4 -r, 302 LOCOMCIOR ACTIVIT* OF MICE GROUPS OF T@fRE9 MICE COUPITS AT INDICATED INTIERVA@L '6MY14 15MIN 2OMt&N 25MIN 30MIN 35,MIN 40MI14 45NIIN 50MIN 55!41N 60MIN CMPND LEVEL 5MtN I 2851 100.000 154. 7i, 159 439 41* 20o 90 0,! 130o 244, 786 !44, 2 14: 250 44* 18le il2* 24 7 5 ol 58* 128* 34o 43# 1019 MEAN 80. i9,6 870 2 ;!11, 126; 78* 122* 680 136* 2851 lOoOOC) 425.' 54'9,t .-'..28. 403. 439. 643,, iO6. 3'49: 303o 30'3. 36to 230o 866' 408, 559* 2460o 754# 118* 117 13, a i 49* li. 8 -UAN 646. iRS', .418. 48le 450. 699. Z12, 233*'@. 176* 157. 185,o 2 12.2* I 1,000 570" 76i. 2010 276o 296. 24le 287. 2590 253o -258d'b 170a 173* 6.540 5149 498, 318* 353* 2689 331* 2344 213. 153* 56* 67o 2 N 6126 3RAo 350, 297o 325* 2554 309* 247.' 233. 206. 1130 120. 2881 OOOOO 960. 661. 4124 347* 3e5* 398* 399* 296, 258* 263, 418o 194* 76'f, 4-i2A* 405, 270o 401# 3709 496* 4470 441. 384& 343a 3'A,9* IAEAN 864o sblo 409* 309* 394* 3849 448* 3'12o 350* 324, 381* 25T* 2881 1004000 .571. 1,4it 3586 426a 2 1999 401, 344. 2.f,2. 312a 225. 200, 161, 265 iggo 205o 195* 305, 2669- 266* 298. 2450 153, 97, 870 MEAN 418.0 32'1* 282* 3119 352* 334* 305* 280* 279o 2 189* 149o 124a 2881 lOoOOO 4896 groo 39to 328* 243o 271a 33to 295, 28f)s 347* 228* 14@o 681. 415-ho 355 i447* 334-6 3819 253* 338, 4327a 304, 1526 1860 MLTAN 5850 41A* 373: 388* 28go 326o 292* 311, 3599 3-e66 190a 166* 14* 2 0 e) 5 32-@7, 2 P@90 16Ai 104) 121. .64 & @'2 -S* 128. 133* 156* 25*0 7 350' 1,1 N all 42 1"9.) 15. LOCOMOTOR ACTIYITY OF MICE MICE GROUPS OF T,HREE 2 T INDICATED INTERVAL COUNTS A IN 20MIN 25MIN 30MIN 35MIN 40MIN 45MIN 50MIN 55MIN 60"IN D LEVEL 5MIN i6M'iN 15M CMP2N 2897 lOOsOOO a 1'4 50 17o .33it 3 00 2 00 21, 2, 0, 00 2 2: 00 00 00 00 09 00 ol Oo 73, 3e MEAN 50 7a 3o 9* 170 20' Oe 1'. 00 47* 3* 00 .2897 329000 127. 2 319. 290, 2149- 1760 890@i lee, 1, 00 7, 0, 00 455' 364. 360* 2489 129,s 2610@ 260,. 343. 254* 147. 31, 11 MEAN 3910 342* 325, 231* 2539 1750 1399 172. 1279 77* 16. le 383 236* 288, 289* 99o 26. 23* 7 10*000 768. 176o '2836 368, 3049 0 361o 305* 246 150 844. nsi. 245o 155.- 1970 247, '61, N 8o6. 6214o 320* 365o 305* 3150; 2419 2226 243* 173. 44* 190 a 0,000 629.' '4A4. 556* 453* 4239 221' 1480 30. 00 0. 187, 101* 617' 52--l-4o 569,t 5500 4810 406 520* 481, 359* 560* 248* S26o MEAN 6236 5646 563, 502* 452* 3i4o 334* 256, 1809 280, 218* 214o 2 05o' 121* 110. Ble 37* 101* II* 2981 100-000 21* 10 1010 219 1 3c). 7314: 73. 156* 40o 243*.'-4589 199. 224. 320. 127, 959 7, 129* 31o 174 2906 155* 1539 179. 114* 83. MEAN 30, 530 3 gle 120* 2 91 44, 970 81. ill 4* .2981 100000 105. 125, 1486 121* 7on' 455. 514* 353,i 2520 3400 3le 337, 322,o 797. 27'5, 186* 2 407. @qO, 331-a '237i 172* 230,s 205: 1916 2100 189. i43. 956 MEAN 197, 173. 264, 260, 79,11 L.000 67A6 f, Ir, e. 31;31 2 8 271, 5130 1 It 6.t 122. 2",- 72410 197. 4:@0, '303o 3t)7v, 199. 4B5* 4 '--18, 175a 7-19o N 7010 49,?e 07, P I'@'w S04, @Oat@ 2,1.2 1 C, L 2 %,.6 Ot f'46& 2 2 C) -0@ICTok CTIVITY OP MICE GROUPT OF TIIREE Mll,'E COUNTs AT INDICATED INTERVAL 2 TMPMD LEVRL 5M!N 16M'TN ISMIN 20MIN 25MIN 30MIN 35MIN 40MIN 45MIN 50MIN 55MIN 60MIN 2994 OOOOO 516' 414. 408, 382 31.2o 355, 377, 364d@ 216o 314'a 254, 205, 7821.' 6q4. 536. 662: 496. 406, 540o 5206 444a 4SI, 3646 130o MEAN 6496 @5'4'o 472* 532fa 404o 381o 459a '442A 3!Oo 373. 309* 168* 2 i @994 1000000 145. 83, 30# 62o 640 46o 44i is 0. 61, 48, 400. 254, '260,, 93o 17a 5200 201o 1410@ 84, 12. .19o ol .273. 1816 MEAN 172o 62o 40o @57& 124, 73.' 43* 6* 24, 94 1046000 692&' 4542* 4510 446a 364o 237a 275. 349 286. 292a 272* 2986' 3ild 204. 2200 2806 2156 189* 151. 133: 260. 217. 168* N 495. 36i, 329. 3364, 363o 2909 213* 2134i 2419 2'r3. 255o 2209 2994 loOOO 673.' 47-;, 447* 405o 399o 1450 348o 330'e 215, 256's 220, 221o 72 2 00 04 9. 637. 378, 3tas 324# 259i 2164 202a 113o 1. @iEAti 701. 555o 4156 361@ 362o .302o 202* 2660 164c 129. 110t 1110 0 2994 #010 392. 40'i, 411. 340o 411* 460o 30go 310. 2079 260, 252, 176* 65 2 4090 386o 386o 433o. 223* 292', 298o lo2Ob 222, 2?7o la 5i9a MEAN 5234 4634 410o 3639 4024 4479 266o 301, 253o 340* 237* 227* 2 5o34 OOOOO 639. 196, 608 550* 548* 482o 511t 331, 377o 383. 492* 4526 476& 47A. 456: 2690 350. 163, 439. 351. 249. 213. 240. 171, MEAN 2 558i 434o 532* i4lOi 449* 323* 475* 341, 313o 298a 366a 312a 5034 10*000 '304 221, 21^w. 2 2P7* 322* e'_ '@-, 4 2t) 1 o '3"4, 34io 1. r@- 2 2 r-- C, o 223. 3? 5 o 273,, 3402, 3 661t 495 50%1 6 40io 3?@e, 2ikon i 3". 364 @64* @i 483. 161& 4cf)l 392Ae "07c 292 331a 215. 313a 282. 280* 247... LOCOMOTOR ACTIVITY OF MICF GROUPS OF THREE MICE COUNTS AT INDICATED INTERVAL MIN 40MI@ 45MIN 50MIN 55MIN 60MIN CMPNO LTVEL SMTN IOMTN ISMIN 20MIN 25MIN 30MIN 35 5034 1*000. 5710 300, 2350 248* 2080 239a 322. 239o 220. 247, 264* 469. 4010 2 338* 324 418* 42r)41 416o 351. 3656 286o 850, 1100* MEAN 711- 70r,, S85* 319q 293o 266* 329o .374@ 328o 286, 306* 275o *100 2 534' 386i 3130 377* 345 44!o 275, 265o 207. 1167. 237* 5034 297, 0 I 469o' 4569 486, 3699 450. 311* 457, '325, 2 335* 823 448* 4650 MEAN 679. 423o 3914 4179 @416o 405* 363' 288 332t 246* 286* 3736 6 0*000 842. 651o 5396 5839 6239 549* 5472a 537@ 558* 466o .513o 476* IO-c76 6q7o 557, 465o 517 502a 323o 411' 279* 219* 297a 265* N 935. 674e, 548* 5249 570: 526a 4350 4740 419* 2343, 405* 371* 5o36 10,oOOO 373" 187o 259, 266* 297, 266* 325o 3064 339* 346, 336o 6800 4514 4836 4559. 341* 5322o 429* 506, 527o 483* 334, 379o MFAN 5270 .1800 395, 397,o 344, 434c, 308o 383* 397* 390. 300* 352* 5036 16000 553. i64, 5144 4824 433o 459* 528* 515 2.464* 283, 403* 374* 728 55A. 509. 391* 5820 403, 4496 338: 343a 321. 191, 266, MFAN 641's 531o 51-20 4376 5080 431* 489* 42'14 404* 302, 297* 320* r 2 4059 381. 417 308.' 220a 315* .@,036 4100 821' 566. 534. 4014 423* 562o 734. 511* 466* 4169 377# 435* 654a 488. 665* 453. 489* 589, 2 MFAN 778. 5394 50010 i4G9o 400o 499o 530. @435. 54is 381. 355* 452* 5049 0.000 ili'4 @73. 474. 521(b 314,, @59,; 24i5.i 'C'700 148a 232. 2 ltl?* 'L3tlo 61,3. si5. 2',o 4340 34 1.@ 3790 30@. 416* 411@t 496* 3719 3 716 o MFAN 6 7o34 52q4 @74* 549. 264a 271, 302* LOCOMOTOR ACTIVITY OF MICE GROUPS OF THREE MICE COUNTS AT INDICATED INTERVAL CMPND LEVEL SMIN i6M'TN 15MIN 20MIN 25MIN2 30MIN 35@IIN 40MIN-45MIN 50MIN .55MIN 60MIN 5049 1006000 i@2., se'St 84o. '289 16* 7o 10* 4.! 00 80 00 1* 247'a' 67o 50.6 60* 93, 36,6 401 29 2, 7, I* MEAN 190. 610 670 :309 38* 500 23* 4i to 5. 4* lo ,60-49 106000. .4500" @'3'0', '2136' 335* :357,2o 283o 1250 2601 287* .'382. '277* 220o 625. 'Soge .426. 312* .356o 471* @39o -415.. 332* 295* .343o 399i, MEAN 53Ao .4206 320. 324* 357* 377* 2282* 3380; 310* 339. 310* .310o 49 1*000 '744" 5'-qi. 469. 13989 453* 476o .45go 208,.@" '2859 207 !209* 280o 707& 50qo 335o 379o 305* 2 '226-o @16* 2354'9@ 188* 131.' 251* 288* AN 726' '5@ 388t 222@ 237* 169, 230a 2849 .402,o 389* 379o 351* 04 2 0*000 8030" 462, 473,e 336* 362* 2086 189i 224* 2420 170* 216o 4690' 4.76* 490. 328* 340# 353o 3336 268,; 237* 18716 245* MEAN 636a 514@ 476* 401* 338i 358* 271* 229a 231* 2154 202* 231* 5104 lOOoOOO @1'26.",. 7-4. 50, 42o 250 22,0 33* 30o 7* @as 30 300 2 3o 00 284 6no 400 27* 18* 4* 2o 2. 0 q, MEAN 305,%'';' 67* 45* 35* .16o 2 .2o, @189 17* 5* 5* 2* 150 5104 10.000 384. 3104 238* 3q2* 3020 271* 289. 251* 175, 25, 68* 384, 26i6 2654 328o 1946 260o 200* 2 103. 580 58, 39* 13o 3844 3n7o 288* 283* '293# MEAN 281 i39# 196. 155o 117& 329 41@o 5104 0*0@00 5436 417,b 2 3C)6.o 266*' 239* 356* @261* 189. 296# 1914b 169, 13o* lOtIA 7??4 5884 401@ 425a 427* 1984 406, 383* 258.i 328* 321* MEAN 7786 471,@6# 4476 3340 3326 3920 330o 2984 340* 225o 249# 226& LO%@Ot%'.GTOR.ACTIVITY OF MICE GROUPS OF-THRE@R Ml%'-'E COUNTS AT L@@NDICATED IMTER@IAL CMPND LEVEL 5 M T N I C) 14'T'N 115MI!4 20fl@&N 25@IIN 30MIN 35MI,"i 40MIN 45MIN SOMIN 55MTN 60MIN 5104 63*'&Cl 55. 340 359 90 110 22o 10 12o 90 00 00 00 104, 48* 40o 2 43* 54a 28* 99 2, 151& 16, 50 150 ME-AN 80. 4is 38. 269 33* 25o 50 '74 12o 80 3, a* 5104 10*000 621. 371* 336. 1849 3839 2080 3039 22:-). 262, 86, 223, 141* 86'7. Sig* 470, 490o 5309 4560 4799 363, 276o 408. 2420 1279 MFAN 744- 4495, 403* 337* 4579 332* 391* 294. 269* 247. 2330 134, 13 0,0020 487. 366. 341. 2619 370, 310, 257.e 292* 112* 104. i69o 139, 630. 4iO. 333, 358, 319* 492, 400, 320. 364s 2634 335, 285. AN 559. 40'A. 337. 310a 345* 401@o 329o 306* 238a 184, 252# 212* 13 100.,000 210' 15i, 235, 178* 204* 153* 579 73, 1020 26* 14. 13* 271. 352. L48. 215o 224* 263* 184o 6@@o 65* 2 45,o 74. 32o MFAN 241. 255. 192. 197, 214. 208, 121cs 714 84* 360 44, 23. 5113 lOoDOO Ban. 672* 607, 6419 535* 541, 417* 38-Y. 416* 345. 219, 132-0 2 79q" si=,e 388. 439* 3760 465, 389, 247. 248* 234. 262, 207, MFAN 800- 579, 4.98. 540* 456* @030 403s 318, 532o 290. 241* 170* 5113 1,000 646" r)54, 510, 2 531. 528* 51-@o 442, 434, 329* 385. 465. 415* 453o 507 516, 478, 496' 466. 386. 440, 245. 606. 470. NIFAN 626. Si2. 513. 1492a 52lao 516* 46(o 465. 398# 386, 453 330, 5113 0.00(3 7220 478, 362o 1419 @399 324. 269. 21C)a 1570 174* @>006 8061* 6050 384. 3219 393 429a 454. 337, 311'c 275- 11?00 14,160 MEAN 764. 533, 431* 3429 367: 134. 389, 3C.13, 264o 216, 172, 208, ;-OCr,,MOTOR TivtTv of' MICF GR"U"UPS OF -VHF@FE. I-IICE COUNTS AT INDICATED INTERIIAL 2 -5MIN 30MINI 35MIN @-GMI(4 45!"IN 5014IN 55MIN 60MIN CMPND LEVEI. 5MIN IOMTN 15MIN 20MIN 5113 100.000 374@e 274. 393. 3109 239- 148, 286o 9el. 12,a 3. 149, 1'&6* 68. 241. 231, 2400. 259, 259. 132o 55, 23 3* 6620 416o 2 276* 235* 194* 273o 176. 72* 29* 86: 60. FA14 5ins 4@"20, 40 2689 303 2320 245. 5113 10.000 798. 504. 350. 301. 317*2 90 263 & 106* 86c)" 562* 330 380a 354* 2844 1949 293: 175. 214. 211, 2, 176* 2 352@ 302o 278. 222o 259. 22 MEAN 8340 534* 340* 341o 336& 24 0,000 767. . 727- 491, 4939 390o 437, 412* 416 - 303* 320. 316* 345* 679'a 557* S97. 475. 534* 500, 524. 417. 385,p 299. '214Q 427 723. 6 t-, 0 -AN 444. 484, 462o 2469o A'ofi, 417, 344a 310. 315,s 386: n f.150 30# i2ig 72* 491, 346 36 00 76 25q@24 lOCaOOO 261. IQA. i,49. 150. i2l@10 itot k4&,, 23-'Oo 184, '-?14. 94, 960 56, 191. ir 2 0 0, 135o lr,-3, III* 10!'JS 49, 41;o '203, MEANI ?2f* I 5 150* 2 95 7 5124 1",000 354. 3466 365. 34:-7o 3OSo 'eD94,. 31's@', 241, 166* 191, 93* 860 417, 5 , -42c,. 27r' 2 125. 430. C36, 460, 215. 277. 189c '-A56a 3@s&a .265,t 218: 203. 185- 1389 NitL:AN 2 5!Oo 3t.6# 396* 441c 3829 @3 28, 247* St.24 19000 665* 527a 392. 1.57* 301* 135* 380a 3722. 254a 210. 3 0'2. '.20it i294o 280* 161* 270a 198, 3009 540* 52ri, 320a 9 13 409. 242. 2849 MEAN 784. 924* 401. 326c 291* 348* 325a 285. 277c 37.@oo 4 73, 1 r)og ,4 9 '?32* t; 5,u, o @6 6 5 9. 3BB4 504. 392a 415. 292. 1809 5t29 0.000 11 35, 398c lq6, 405o 259, 1439 1789 6@5, 511. 573o 4'7 t 4 9094a -1606 C-C,4-o 5939 't@63,) 368o 4-=Oo 3S9c 33'@- 3169 179a MEAN LOCOMOTOR ACT"IVITY OF MICF GRCUPS OF THREE MICE -TATED INTERVAL COUNTS A'sr INDI 2 CMPND LEVEL SMIN lo@l'I'N i5PlN 20mlf,' 2SMtN 3'JMIN 351%14aN 40MI14 45M!N 50MIN 55MIN 60MIN. 'A. r .)129 "2 000 22 224, 117* 219c 66 199, 194. 320o 283. 18 265, 147. i:@'pe 414, 426$ 4'3@3,, 363@o 262o 24i. 283o 239. 178. 254a MEAN 193. 165. 319* 2 273* 326ii 21r-, 220. 302* 261 180, 260o -io 301, 286o. 3780 420@ 351 32'). 250o 256.2 244* 192, 5129 lOoOOO 538. 314 697. 460* 337o 308* 296* 3814 257: 254. 327. 172. 121. 65. MFAN 618, 396* 119* 297* 337* 4019 3049 288, 2899 2214* 183* 1290 45 0*000 672. S"' Oc 307o 806a 34'1, 317a 792* 363* 261* n4, 459* 314# 3'7 6'700 S&se 459, 5822* 518* 532'0 '165o 434. 642c 494, 4209 315* 41@.i9, 446c 444@o 42Q 686. 391. 4809 643. 392. 288, AN 671 514 r. 10,000 234. 2 7c;b 71, 85C 549 r,5 167a, 72. 34#A 37* CID 153* 4, a 6 8 I go 3 8 o 3 7 161c 103e M E A."4 2i6. 9!') 5 5-- 6Sv 160o 71. 31* 206o 9te 128$ 5149- 1 c, 25@., 306c 46Ci. a I ?3t,, 2582, 2 9 C(i 5 40;, 3 4(jQ - 136. 341t 283t 262i 294t 2@91. 314c 216f; 4 iF '485* 4%4e 2 -*'t 295o S6! 330a 201 5* 161* MEAN 285n 23-* 26 5145 .100 470" 36c-io 269, 342* 328* 21go 218a 2 253. 195e B25. i83t 14!C. 697: 476- 458, 266* 2e5* 28go 244t 259. 172o 155. 98* 13Ts P,EAt4 584. 423. 374, 1304c 307* 2540 223le 256. 1849 240. 141, 140, 5,>It 0.000 711. 4,F.@, 375, 320* 305# 28do 3&lo 218, 274o 190. 212o 19'Y6 !56t). iii. 253* 190* 3]1go 2illo 182* 202* 1300 134a 151a 406* MEAN 636. 417. 353. 287. 248o 299 311o 00, "38t 160, 173a 175o T ITY IF LO@--C @TOR AC p 0 F Ti P,;-: rl 1,@ 2 C,,I--j".ITS AT 1,N@Dir;ATED l.k@!-;-:RVAL M N 2 C.,@ i 2 rl- t,,, t t,, 5CIt-",@-N 60MIN C.MPND E V A @i 5211 TO'U,CCIO 2i!'& i.4-,, 1'9,b- 3006 "OLO 3@@60 37-7. 98c-. 134. 13'l2a P36 I I r) r,., a 0 6 1 $'?* -,, '? (- 0, -'960 L9. 300, 5 4'-" 0 5 2,,j * 3'-IOS M;;A.',j 131, 2 99, 52c 22-,)s 341, 346o 2!a. 199c 337. 326t 2@U'2& 5211 'L.0-000 -tOl. 255o 256* 191v 316* 212* 2890 2 114. 81, 4ir I 2 2fie 674' 2150., 3619 3919 Z974 36o, 225. 24-8w 2,,)3, 219. M'RAN 5 F@- 5 . 4(1' 2 7 . 3 "'U" 6 o 3224t 244@ C 219. 269* 159& 150* 35. q it 547a 529* 48S@ 486, 450. 5zo9o 527. 364, 2 3454 1,000 826. 747, 5r-8. 645 P23, 4029 423, 3R?o 411. 264o 454, 303, e'-6T, 876. 2 I - A%, "2, 535a 456c 45e,, 422, 41-.I, 401-a 491. 334, 3C)t* 852. 6@-3, 6v 0,C!OC, 4c4' 42r- 24-4 @ C. 4 0 344v a73.2 436o 31E. 215v StQc 'Z; G. A 6,:-. o, 5 3 . 5 1 C. c 45j',. 37,@ 432,., F A 5 5 2(i,@ 46S, 518t 475, ti 3,@. 477n 385. 29@, 38cie 251 2 C 865E 27,@. 2' -) 8 5'B . e, 7 C, 2 5660 if 416, ZE@. . 3 ci 214. 26'-, 30-,. @IEAN 0 3 2 5 Q 4 '@) 6 fo 3 5 3 t- 3,t, S c 2 -s 229'iL 2 1*000 573. 4nn, 246,, 25-fle ?41t 2810 363c 2E'O, '@2329 37'jo. 402. T:tz, 782. 439* 421, 396, 2 3769 4360 41-L6o 214, 2130 31,0. 195, 29,14io MEAN 6?a- 41A, 3340 i327o 310* 359o 395* 251, 3IBo 342, 299* 2SL2$ 04000 943, 591& 530., S71a !50rj, 367* 384& 409, 9 R 265. 2 4;@'y 4 305.. 6 ' ;3& 444* & 2919 40ao9 333u. 2 z;o@ I o 200* o 229* 204o 2119 MEAN 783. 51;a 4 6. 3"lo 4549 350o 118. 345. 322o 217 LC-C(,'OTOR CTIVITY OF P-ICE -RGuPs oF -TIREE Mli-Ir' 2 I.,)UNTS AT INDICATED INTER'@A-- CMPN- L E @l t-I l5t4tN 20MIN ';S@iIN 3t)!"Ik- 45V'IN 50kiOL14 55t"lltv 60!llt4 2 3-:,000 1916 iEs. O, O, 00 0, 0. 0, 0. 0. rie t'). 291. 81 co 40a 1, 281, 37, eso2 0. O, Os MEAN 4* 04. 2Ctp IQ 1.;r 1,? 43a O, 0 0 00 U.000 60-? -03, 125,e. 124o t7C)a 2 5?c, 83, 43, el 20, 90, 73 731. 6:.!r,. 545. 401o 4TK,, 2216 307. 2yg. 245, 206. 2390 243t 667. 2 45, 'zT4, 26.i;@ 300* 196c, 182o 194, 144a 107, 1':'Oo 167* loOOO 1223. qie,, 925g 8874 726o 7240 -,@14, rl-42, 485o 2 481, 362a 434r, 6'? p - '2 2 7 C. .4 '@ p. a 36.4', 314a 3 4 6- v 2 219, 2 -"k!@ . -1 , - 12@@o. 1 551. 617, 5946. 6010 @130 41-re 3'?Oo 296o 303, 3=-'Z'o 2.r-,B, 01.0o 6pfi. 48t@,, 3C?, 2 3t?o 38@-o 18"-, 14i, 131. 156c 404. 28t, 136, 4 3 @@ T,,' 3 3':-:,z 2CPc @Ot. 16F;o 7 6 6'-2- I2t's 3 r 2 5 7 fi 7:,., log 8 42C;, 261,., 2 3 9.-4, 2C-2 550. i&7 391, 360. 4-71. ',R 4 I 2L-so 24Z'. 'i 4 5 2 4 2'@ o 43)a 40'4'e @@b6c 2be'. 3019 331. 271 o 2 '@- -5 o P, F A-!@' 4@334 4,i;; o 43cl, 32.00n 4)s '41i. 25-. 187, 265,o 2 106 260 219. 48. 22. 91 1*934 6 3 a 2 c 7.q6. 407, 246 2854 374o 9980 355* 286. 1489 106. 2 10, 6, 60?. i6-qo 250 '236o 320* 3029 308o 1439 77, 16o 90 )> MFAN 2a3- 2 rn 1093463 1 O.') V, 0 793. !gS. 251@. 1 3329 907, 321, 3.915 . 222c 84. 182* 2--112o 4ii0o 41le 473- ?57f, 3(6* 503* 300* 130, 200a 204, 180a 169a 63-7. 404* '-A62. 337o !Igo 305, 311* 2431. 2119 144. 181, 19t, @)F Mi'--E Gk'OU-PS CJF@ TI-IR[E t-', I 2 CO@;NTS AT IrICilCATED INTERVAL C14pt@:4 LEvEl- AMIN 15t'TN i-OtlIN 093463 1.000 3,Rn. i4@;). 2k-C@. -el F,'&I@ 4 2 z "I 8 132. 8 54, lc,:5. 7rl, 440, 30---,o 301, 403, 386, 405. 296, 290. 2Q-7o @iFAti ,53a 2 571s S43, 279i-. 2434 304a 204G 1'726 1193462i 0.000 57o@ 182. 31S, 30a@, 4-.23, ;57*' 203, 24-2a2 238. 194, 202, 63,L-. 51@. 46'-e 48"t 404, 353, 254 t a 22i5. 189, 'AO-Pg.. I 9, . l4FAf4 6,07, 4kmo 447, 401v 394* it2C, 2 331c, 2?fl. 3,-, c. 2 3 621 32,000 564" 3.-i.:i 27'&'. ZLTII I 132. 1 -.@ 9 162o 181. 2 Is I 3 C 2 4,7;h. 3FI5. 68a 136 2'@t. 67. 37. 17, EAN 6 -v 'IO 1 e'_'9 2 6 c. 2ICo 2 5;1 I OC: 2 7Ci & 4; 2 o 124. 4=0 15, 621 1;3 v OOCJ 43h' 44 4 .0 2 20'--,,. 25'0 ')26. 314,, 14", '3',. 2 -S F! Cf, 501, 0 .5 e 497,. ME"N' 55;. 4-.4'%.j 1-15c 4 7k c, 423t: 9 2e, 9"14621 !,,ODA 6cli@. 45,@o 2 37L, 4 2".) 4-i@t, 410c B 5,4.c, 'jg, 9 4,, 2 fj,.--Oz 22!v. 2 6 2 239. 194. I2bC, 9 -t i MEAN 6 I I 471,. '457, 338, 3 "A l@3' 2 2 241-, 5@@, 4934629 0 o 6'@,l C- 68'u'. 31A, 6 4': c 325#, 'i4 @@ 9 364o 40!;e 3 7 Bib@, ;;.48, 2 2 551o 4241& 420a 31ri, 3709 4090 2249 3OZo 3a3o 429@ 420o MEAN 616. 1909 391, 316o 357o 397c 314* 359. 309a 316. 323. 3429 34629 32.000 462. ?44o I'll* t-41* 182* 181, 205* 110. 1039 63o 138 70., 8 -v 9 , t 2 9 S@l, 43"4 384, Sktu 400. 4-c9ot 3880 223c 26.@,, 166, 156u l,iEAN 267]o 589. 303* 3tle 2629 29@.. -'.48o 249 163* 165. 153, 114a 5 C) LOCOMCTOR:,ACTIVITY oF MICE CROUPS,OF THRFE MICE COUNTS A7 INDle,ATED INTERVAL CMPND LEVEL r)i-'TN IN-M'IN !SMIN 20t"-IN 25MI*N 3@'O2MIN 245Mlt4 40MIN 45MIN so@@ilti 5514iN 60MIN 0934629 10.000 762. 441. 294* 318* 2289 ;301, 3732 289. 198a 128. 108. 24, 5434 Z;L91. 287. 300o 254* 258, 192. 267. 218o 108. 72, 19, MEAN 653a 462o 291* 109a 241o ?80* 283o 278, 208o 118. 90* 22* 4934629 1.000 631. 44-4, 370, 299, 277, i930 294* 361. 1979 257. 158* 116,v 2 554. 265* 165. 130. 130. 121c 144. 3, 4o .413, 304, 259o @IFAN 593- 388. 337. 2-199 271* 2299 2129 246, 159o 201. 1110 600 4631 0.000 310. 367, 362. 293, 324o t4O6 299o 329. 239* 283a .13flu 55c 780, 463. 348, 226o 262* 2319 237o 236, 69a 35. Be 69 IAFAN 545. 395. 355. 2525o 303o Z869 268c 2330 154* 159, 73o 3t* 364 68. 32, 90 4631 loooooo 349. 141, 309* 276o 108, 323, 248. 212* .676" 4266, 563, 449,. 3T2. 358. 455. 396, 302* 140, 146, 1679 TAEAN 520, 4nn, 352.6 379* 3249 133o 389. 322, 257a 104o 89* 884 0934631 10.000 6260 .453, 454. 501* -502, 4.04i 497,2 450. 3?2@e 416o 3900 330, 535. 4A5, 361, 396, 3820 J33. 422. 320. 306, 272. 208, 156, @IFAN 581. 469* 408* 449* 4429 169* 4609 385, 340* 344o 299* 243* 4@934631 1-000 2732.' 520. 369* 347o 372* @@71* 284* 135. 218a 197@. 152o 1339 P200 4'7@o 408* 392* 3069 540* 3869 371. 1979 170. 123a 410 MFAN 776. 49A* 3890 370o 339a ?06, 2 335* .-53. 208* 1840 138, 87 0914637 0*000 4596 4@39 489o 3789 3469 422o 413c 262* 407o 425- 290a 270o 534& .4 1 5369 4,31o 352* 380* 352* 297- 304* 258* .gA* 430. 359o MFAN 497- 411# 4609 369* 441@ @,,27* 3839 321* 380o 361- 297* 264a Mel" GROI)PS OF THF;%EE MICR COUNTS AT INDICATED INTERVAL C@IPND LEvll- 5MIN !OMIN 145MIN 20MIN 2siAlK. BomiN 3541,F@i 40141? 2 4$;MIN 5Ot4lN 55MIll to@ilt! #93,4631 32.000 520. 3'%Oo 411, 3260 338* @41, 3714 369, 311. 230, 141* 704. 5nqa 456. 506, 406* 1336o 612, 3480 354, 295. 2 217. 204* 3894 492o 330 362o 303. 224, 173. 612a 413, 434& 416o 412a 000 686'& 5'46. 443. 585a 463, 428. 458,6 2@356. 31440 191. 315. 2680 J#934637 106 4219. 360. 220. 3829 228. 233, 1254 8430 A71,m 760, 3860 399* 0 409. 288 MFAN 761.. 766. 602. 48@,s 2431o .@29 348,, 210. 304* 197o 411o 393* @go, 314a 39). 272* 295. 199* 132* 637 1.000 7270 66' 34.4* lain 47le 5029 654* 373. 2849 5522. 262. 170* 492'- 401 67oo 27R, 424. 231, 151* 703, 546* 4 EAN 373: 3974 43 !o96o 484,2. 382. 4569 335* 379. 277* 14'5- 77m 7* 663 0-000 692" stic), 510. 446, 184, t460 454, 3a9, 268a 312. 212* 157* 6316' 6221's 491. 461. 344 Sol, 4549- 264: 401, 395. 359. 273* 22915 1450 829 MEA14 662. 5650 327a 213. R53. 1650 225i 709 89 92. 1199 2 *934663 100000 5010 430a 392. 0-is' 454. 393, 365a 2489 153. 288. 145. 141* tl7: 0. 7 60* 2 602o 442o- 393. 346* 23to @03, 227* 185. 106o 103- 46* MEAN A 469, 244t* @369, III* 76, 69a 14, 35, 00 .934663 10000 784, 4i', 307 2 05t,, 206* 169. IOl. 36* 1* 0. 807. 556* 385, 4039 3189 @13a 159a 123. 88o 25o 18o 00 796. 487. 346.1 4369 2 28le MEAN fl9S4663 0100 4o3. 197, 445. 200o 28-41 J36.. 269o C.13, 3'@z?o 146, 19o, 14!o 3639 102: @71, 2* ol 00 6,, 0. 00 535. 435. 520* '155t 4'r, 166* 76. 950 710 4694 441i, $ -Z) JAEA2N 483. 2812* 1954 136% ArTl%,,'I'fy C,F t-i-CE Loc(t.ioT r%l GROOp,@@ OF TH,@FE f-ItCr-- 2 TED lN7Ei4VAL AT INDICA 35141ti 4-1"lT,'@l 45MIN 5@-)I@iIN 6OM"IN" 2 CMPNO LEVEL ;"u 46 gil'- 3r-to 31'7 3",7 190, 1 34, 16, $9 3-; 6 ii 00000 66!). S-- j lo I t@- 0 2 0 72, 240o 4, 267o 222 a 669. 5RAo 481. 4380 430v 310. 337, 103. 336a ?62. lig" =66. 450. 395, 371o 3142, 2649 '@3a. 2889 133, 1519 667- 3'13, 37v@, @81;1 zgi-l 217. 110. 33.@ 0. 13. 14,o &9346AS 10.000 ',72 (i 4'?9. 225a 249'y, 344* -A28. ?,969 190. 31@2* 208. 20* 8, 594. 26qt 170 lie 2 307,, 68- 313f, 151), 173a l@04& I-'. E A N, 1,000 61@4. 4A@le 444., 31Ao 2 146t 316o 3109 309. 163o 990 'r665 a7-7. 1 1020 65* cr@22. 465. 392r 1.6ov 4349 '2-2$ag. .64o 21'?o 350, 318, 164a 2090 101. 50t 465. 3r.--3. 157* 373* 718. 5140 tAF N 468'f Ol'OCJO 51@50' ti4Ra, 426, 347c 3TSt 5039 346* 31,'), 323* 332. 201. 218o 416, 273* 317, 382* 306, 380* 3o2. 1920 126.) 515. 447* 430, IAFA!@J 520, i52;. 428. 382* S74. 410a 364, 308. 352o .31-'- 197. 173. 2 -AS 1. 1, 0, 0 5.7r. 714,, 2671 226. 129,p 27. 1$9 346 P 7 10.313 440, 3 4-07,2 3 3 2 170* 276. 1150 16' 550, )I- lrg 908. 5700 2,o -, v 205. 1.03o 139* 580 92a MFAN 7422. 44r,). 3@;7. 357o 295* 393, 1450 45. 1. 0. 0934687 1,000 557. 4AIS 408. 426a 3-fl;t 282, 326. 2 287. go, 23, 439 804. 537* 40,5, 422* 528,,. 435o 437, 336. 231* tAFA@j 681, SlOo 407d 374, 450* 359o 382* 312. 188* 68. 2 12* 224 ,13 0,000 761 StOo 498o $940C 407* 1-ifi@i 2 1 5.@, 3,4,6 I - 3089 eq. ?20o 64* -t3-1 3'?Iv 329* 1,54, l@-6* 350 760 489. 844.. 3600 439* 4 io i3B. 30B. 232* 62, M F @-4 go5. 5al. 524. 4 ',-' 3 6 433.. 293,, 06 q 04, + 2 lOE + ooz 4 ooi lo.000 MG PER KG .I-ATi't.": C"Lt@'4'@ PE14 3 -'@41'E FCR 2!)63 AT 1 kil C, rvl C) 0 2 9000. 6000, aoooo 0 to 15* 200 256 300 3050 40. 450 !500 5 I.Ooo PER KG T 1.11 E CUtIULATI@o@- COUTITS PER 14!('-E FOR 2263 AT 9000* liq 1000,b 30(")* 1.0000@ 5i)ooo 6000rh 7000, 60009 100000 4 MIN" a* .100 200 256 30, 35* 40, 45, -To 50* rri. 55 CUM(JLATIVE COUNTS PER 1 Ml%e-l tOR A 2?4-3 AT *!00 MG PER KG 9000, 3000o .5000* 7300, -Z- 0 0, , 4000a 9 a Ir 200 250 30o 35* 40a 450 500 Tl"iE CU@IULATIVE COUNT4 PER 3 MIC6c- FOR 2271 AT 0,000.MG PER KG 1000, 3000* 5000.0 7000, 90000 n. 20001, 40009 6000, 0000$ 10000 T I + + 10. 15, 200 25 0 30. 350 40D 0 45, TI MF CUMULATIVE CCQNTS PER-3 MICE FOR 2271 AT 320*000 MG PER KG I.N 1000, 30000 5000, 7000, 9000, 2000* 4000* 60000 80000 loop',* 00 5, 1 Joe ISO 200 300 350 40. 45, 50. 550 T I NiE CUMULATIVE COUNTS PER 3 MICE FOR k 2271 AT too. 000 MG PER KG IN 1000, 3000. 50000 7000o 90004, 2 10000 ml?\" no 2000, 4000* 6000, 80000 50 106 ISO + 206 25,s .0 30* 40, 4 + 450 de CUMULATIVE COUNTS PER 3 MICE FOR 2271 AT looso0o MG PER KG TIME 10000 3000o 5000, 7000* 9000* tA I N. n. 2000o 40009 6000, 8000* 100000 0, 51 100 20* 2 5 30o 350 40. 45o so* 550 60. TIPE CUMULATIVE COUNTS PER 3 MICE FOR 0 2271 AT ioooo MG PER KG i IN 1000. 3000, 5000* 7000* 90004 MIN* 2000a 4000* 6000, 80004 100000 6 C,b 50 100 156 206 25, 30. 35* 40, 450 55.1 ,ooo MG PER KG CUMULATIVE COUNTS PER 3 filCE FoR 2436 AT 0 Tlik!E 3000 50000 7000,o g2ooo. 1000, n. 20009 40000 6000o 8000* 10000* T Is I 0 15* 2070 250 300 35. 40, 45* Tj'!-iE CUMULATIVE COUNTS PER 3 MICE FOR 2438 AT 100*000 MG PER KG 1.1i.: 10(o. 3000, 5000* 7000. 2000, 4000. 6000. 8000$ 9000, 100000 on I 8 lo. 150 20. 25, 30* 350 40, 4 !C Sb to Tv&.-NAE '%.'UMULATIVE COUNTS PER 3 MICE FOR 243a AT looo0o MG PER KG 1000, 30000 .5000, 7000* 90000 2000* 4000* 6000, 2 8000* 1.00000 dO m la 15 20. 25, 30a 358 40, 4"4o Fi 15 a AT 102*615 MG PER KG TIME CUMULATIVE COUNTS PER 3 MICE FOR 2600 IN 1000, 3000* 5000, 7000, 9000, MIN. 20000 4000o 6000, 80000 100000 7 00 Joe 150 20* 250 30* 35o 406 m 45* w 50. m 550. TIME CUMULATIVE COUNTS PER 3 MICE FOR 2615 AT o,ooo MG PER KG IN 10006" 3000. 5000* 7000* 90000 MINS 2000* 4000* 6000* 80000 looo( I I 00 0 50 too + 1 5 .200 250 30* 35 408 45, 500 TIME CUMULATIVE COUNTS PER 3 MICE FOR 2615 AT lo,ooo MG PER KG IN 10000 3000* 5000, 7000, 90000 MIN* 20000 40006 6000* 80000 iooool 0 100 0 ISO 200 250 @300 356 40, 45a 500 550 TI %'E CUMULATIVE COUNTS PER 3 MICE FOR 2776 AT 6.000 MG PER KG IN 1000. 30009 5000. 7000* 90000 MIN.. 20CO, 4000* 6000, 80009 100000 8 10 20a 250 30* 35* 40* so& TIME CUMULATIVE'COUNTS PER 3 MICE FOR @2776 AT 32*000 MG PER KG IN 1000, 30009 50000 7000, 90000 MIN* 2000, 4000* 6000, 80000 iood 50 VP 100 8200 25a Om 30,i 350 40, 45, 504 55, CUMULATIVE COUNTS PER 3 MICE FOR 2776 AT 1*00o MG PER KG TIME 3000o 50000 goooo IN 1000, 7000a 80000 100000 MIN* 2000, 400019 6000, 00 50 104 150 20* 250 300 350 40* 45o Soo. 55 a TIME CUMULATIVE COUNTS PER 3 MICE FOR 2808 AT OOOOO MG PER KG IN 1000, 30009 50000 7000o 9000. MIN* 2000, 4000o 60000 80000 100000( 00 0 5*- Joe 154 20* 25* 300 35* 40, 45o 50, 5r. TIME CUMULATIVE COUNTS PER 3 MICE FOR 2808 AT 32,000 MG PER KG IN 1000, 30009 50000 7000,b 90000 MINO 2000, 4000a 6000, 80000 100000 I ol 6 5, 100 150 20. 25, 30. 35a 400 41 45* 50. 55, 2808 AT ioooo MG PER KG CUMULATIVE COUNTS PER 3 MICE FOR 0 90000 TIME 50000 7000o 10000. IN 10000 3000a 0000 6000* 7 80009 I 4 MIN& 2000* 1 06 + 54 108 20& 25* 30a dw 3r), 40* 45,s 5,0 a !55. TIME CUMULATIVE COUNTS PER 3 MICE FOR 2808 AT 3,200 MG PER KG IN 10000 3000* 5000, 70009 90000 MIN. 2000, 40009 6000, 800010 loooo( I I 00 + 3 5* 10. 20- 25* 30. 3501 400 45a so* 55* CUMULATIVE COUNTS PER 3 MICE FOR 2808 AT 19000 MG PER KG TIME IN 1000* 3000* 5000* 7000* 90000 2000, 4000o 6000, 80000 iooooo MIN* 04 51 10. 204 25* 30. 35 40* 450 so* 550 ooooo MG PER KG TIME CUMULATIVE COUN 5 PER 3 MICE FOR 0 2644 AT IN 1000, 30009 50000 7000, 80000 90000 10004- MIN, 2000, 40009 60000 06 5 50 100 15* 20* 25o 35a 400 450 0. 55* TIM-E CUMULATIVE COUNTS PER 3 MICE FOR 2844 AT 100*000 MG PER KG IN 1000. 3000* .5000* 7000, 9000, MIN'. n. 2000, 40000 2 6000, 8000* lood.-, T I I I I 04 5 Joe 20. 250 30, 35, 40, .45, 4 500 55. TIME CUMULATIVE COUHTS PER 3 MICE FOR 2844 AT 100000 MG PER KG IN 1000. 3000, MIN* 60' 2000, 50000 7000. 9000. 4000* 6000. 80000 6 100000 T 06 54 + 10. 150 20. 25, 30, 35* 40,o 45* 50, 550 TIME CUMULATIVE COUNTS PERI@3 MICE FOR 2850 AT 0*000 MG PER KG 5000, IN 10006 3000* 7000* 9000* 8000* 1020000 MIN* 2000, .4000';o 6000.6 I I I I t I I I 00 lo* w 156 m 200 2 5.6 300 350 40* 45* Soo 1 55, 600 TIME CUMULATIVE COUHTS PER 3 MICE FOR 2850 AT 50*000 MG PER KG IN 1000. 30000 5000. 7000, 90000 MIN6 n 2000* 40009 6000, 80000 lood T 00 8 5, 10. 150 200 250 300 35* 40* 45o 50* 60. 000 MG PER KG TiPtE CUMULATIVE COUNTS PER 3 MICE FOR'# 2850' AT IO& IN 10006 3000* 50000 7000* 90000 2000, 40002* 6000, 80000 100000 00 50 GP Joe ow 15* m 20* 25 300 35* 40, 450 500 6 550 TIME CUMULATIVE COUNTS PER 3 MICE FOR 2851 AT oeo0o MG PER KG IN 1000, 3000* 50000 7000* 80000 90000 10000.1 MIN, n. 2000o 4000* 6000, 06 100 150 3 20. 250 300 315 a 40. 45a 50-6 556 CUMULATIVE COUNTS PER I MICE FOR 2851 AT to.000 MG PER KG TIP,E 5000* 7000o 90000 IN 1000, 3000* 4000* 6000* 80000 10009 2000o t 51 I 0 1 2 0 25. 30* 356 40* 45a 500 55 a .TIME CUMULATIVE COUNTS PER 3 MICE FOR 2851 AT 100-000 MG PER KG IN 1000, 30006 5000, 70000 90000 Ml,%,* n, 2000* 40009 6000, 80000 100000 t 3 100 20. 35*, 40,6 45a 5 oll 550 CUMULATIVE COUNTS PER 3 MICE FOR 285'1 AT 10000 MG PER K TIIIE 3000* 5000. 70000 gooo* 1000. 100000 2000o 6 40000 6000* 80000 0 5 10, 150 20, 250 300 350 40* 45o so* 55,. TIP-E CUMULATIVE COUNTS PER 3 MICE FOR 2881 AT 0.000 MG PER KG IN 1000, 3000o 5000, 7000* 90000 MIN. 20006 4000o 6000, 2 80000 100000 oe + I 0 15,s 206 25, 30* op 35a 40,o 45* Soo 1 55,6 CUP-ULATIVE COUNTS PER 3 @IICE FOR 2881 AT IOCOOOO MG PER KG Illy 1000,b 3000, 5000. 7000, 9000* 2 2000, 40009 6000, 8000* -JO T 50 + 100 9 150 20* 304 35* 40* 454 so, 55, 'CUT!ULATIVE coUNIS PER 3 M'LCE FOR 2881. At 1(%9000 MG PER KG I (-'E 10006 3000* 5000, 10000 90000 n. 2000* 4000* 6000, 80000 100ujo Oa + 56 1590 20m 25* 30* 35a 40* 45* so* IvE COUN TI!,PE CUMULAT TS PER 3 MICE FOR 2897 AT o,ooo MG PER KG 1000, 30000 50000 7000* 90000 MIN!O n. 2 2000, 4000* 6000, 8000* 100000( 00 51 10* 20* 4, 2 5,o 30* 35. 40,i 3 45i, SO& 55 TII"E cut",ULATIvE COUNTS PER 3 MICE FOR 2891 AT 100,000 MG PER KG IN. 1000, 3000* rl-oool 7000, gooofi 2000. 4000, 6000, 8000@ 10(looo I I I I I 0 50 106 150 20* 25* 30i, 3 35,6 40,i 45* 500 me 550 T I E CUMULATIVE COUNTS PER 3 MICE FOR 0 2891 AT 32,000 MG PER KG IN 10006 3000* 5000, 7000* 90000 MIN. 20006 4000* 60006 8000* tor I* 0 106 7 15* 206 25,b 300 35* 406 45,6 5 0.6 TIME CUt4ULATIVE COUNTS PER 3 FOR 2897 AT 10*000 MG PER KG 10000 3000# 50006 7000a 90 OC. n. 2000, 4000* 6000.o 8000V 10 1 Oo 56 I 0,6 200 25* 300 35* 40a 45* 506 TI@'E CUt4ULAIIVE C(,'UtJTS PEP 3 MICE FOR 2981 AT 0.000 MG PER KG .0000 90000 1000, 3 5000, 7oon, 9 M-fri. n. 2000, 4000, 6000, 80000 ioooo.( 10. 20, 25 3016 35* 40,o 45* 50o CUMULATIVE COUNTS PER 3 MICE FOR A 2981 AT loo.000 MG PER KG T I!AE 10004 3000i 50000 7000* 90001, 141N, n,, 20000 4000,. 6000, 80000 100000 2 20. 2 5 30* 35* 40,o 45,i 506 6(). CUMULATIVE COUNTS PER 3 MICE FOR 2981 AT 10.000 MG PER KG IN 1000, 3000, 5000, 7000* 90000 20009 4000* 6000, 80000 I 0000 t . t I I - I I I I I I I 0* + 1016 206 25* 30, 35 tb 406 45to 50,6 55.' T&IV-E CUMULATIVE COUNTS PER 3 MICE FOR 2981 AT ISOOO MG Pe'R KG IN 1000, 3000 $-"0006 7000, 9000* 2000, 4000, 6000. 80000 10 T I t I 3 (110 0 0 10, + 20. + 250 30* 350 40* 45, 500 o,ooo MG PER KG Ti,'@E CU@.IU'ATIVE COUNTS PER 3 MICE FOR 2994 AT IN 10000 3000-P 5000, 70(0* 80006 2 90000 toooolo 6000a 2000* 4000,o t-i I N ti I I I I T t 5 I I I I I I fa 20@6 25* 30,o 35* 40d 40 45i, 500 CUM(ILATIVE COUNTS PER 1 MICL FOR 2994 Al looooOO MG PER KG T I NF 3000* 50000 7000* 90000 IN 10000 2 4000c. MIN 2000, 6000o 80000 100006 I 0* 100 15& 20,6 30* 4w 35a 40* Soo 550 Tit@E CUMULATIVE COUNTS PL 9 3 MICE FOR 2994 AT lo.000 MG PER KG IN 1000, 3000-e 5000* 7000* 90000 P.INI. 2000* 4000o 6000, 80000 iooo( 10, 8 Is* 200 256 30, 35o 40* 45a Tl,kAE CUMULATIVE COUNTS PER 3 MICE r-OR 2994 AT 1,000 MG PER KG 1.11.! 1000. 3000-o 5000, 7000, 90000 MIN* 2000a 4000o 6000. 80000 10000 1 I 0 50 ioe 204 25* 30* 350 40. 459 Soo TS PER 3 MICE FOR 0 2994 Al 010 MG PER KG CUMULATIVE COUt4 70000 90000 Ti 3000- 50009 80000 icoooj 1!@, 1000#t 2000* 8 4000* 6000a Pt I N',t na 06 5 1 150 200 25* 306 356 4 O.& + 45& 55* 9000 MG PER KG CUMULATIVE COUNTS PER 3 MICE FOR 5034 AT 0 90000 27000a Ito 30009 50000 4 10006 4000* 6000* 8000* ioriot 14! N 20000 0 0 low 15* 20* 25d. 30io 35.o 406 50. 559 TIVE CUMULATIVE COUNTS PER 3 MICE FOR 5034 AT lo.ooo MG PER KG IN 1000. 3000* 5000. 7000* 9000, n. 20009 4000, 60004 80000 iooooi oe 50 too is* 20* 250 30- 35* 40,s 45,6 500 550 LOCOMOTOP ACTIVITY OF MICP GROL)ps OF T[ikEE MICF-: CC)UN'IS AT INUICATED INTERVA,L 2 45M!N SOMIN 55MIN ()MtN 15MIN 3014IN 35@IIN 40@ilk 6e%1"11N cmpt4(l, LEVEL 514IN iom'TP4 15MIN 2 2 2T. 00 J9405t3 -2,000 427. @44* 148. 2ee 9* 2,-n. 2f,@,i, 186. 197* 320 500 133o 24A-.' 113* 3. 139. ME2AN 323a 264* 167o '&13* 2le 65* 674 153. 62o 2. 83* 920 ... 248, 208o t67* 1190 101o, 131.' 141, a7, 121, 196* 11940,513 10,COO 511, Pln& 77.9. 64796 477. 2819 367* 34()a 276o 62.4 1309 94. 2, 500 123* 6450 4?t%& 3623, 2@45. 2674 230, 189* 970. 136o 91. 62* IAFAN 188* ?79. 22@l. ?4o 90 70 74a 369. 41S* 1779 - 2 0511 i,000 711'10 448- 4'.?Io 395o 3479 3199 544.' 3.':04o 296. l9s4 182a 6t)la 5170 404o 3620 2544, 283a 286, 2 189o 153, 102* 128o MFAN 731, 4934 420& 0940535 0*000 15450' 541, 49st 308 3754 249. 316* 291' 274* 182. 103a 57, 939. @ni. 47@. 4'?O: 2 161* 292* 338* 113.6 150,0 1.800 92. 125* 389* 368o 2719 327* 3026 212* 181- 9se 916 t,iEAN 1242. 571. 463. IA9405S5 10,000 599. 2 24A* 192. 186o 161. 139* 51, 79, 14, 13. 00 11 li)2(. 4?io 428. 295* 353. 353* 1910 97. 174* 144. 78, 1 6, jolo. 13 2 a 39* 94* MEAN 5106 241* 257o 246* 12to P,8 94* 79. 0940535 1*000 9-?2. 64i6 554* 57R. 564* 415* 399o 257o 228* 2496 102o 132o 2 9526 1174a 1446o 1551* 1622* 164@7. 15869 1479. 1232o 1271- 1232., 1299,o 1065* 1093* 103le 993o 868, 730o 760, 667* 716& MEAN 2 962. tong- 10000' 473* 5000 256, 299* tal, 18&o 128* 13s 4* .940535 0100 719* 569, r,'45, 12K 10549 1052. 1130, "107T2e ISMA* 14980 14669 1596o 12634-1121 -94 1666. . .. 970o 948t, 761Oo '?10: 723, 4620o 590i 572o 541* IAFAN 1190., 10647* 1022* LOCOMOTOR ACTIVITY OF MTCE GROJPS OF Tt4RFE PIICE COUNTS AT iNDI@,@--ATED INTERVAL CMPND LEVEL IN 15ti!N 2 .YMIN I.nM oM7N 25M'I'N 30NIIN 35MIN 40MIN 45MIN 50MIN 55M!N 60MIN $940539 0.000 6290 67'n'* 399* 3599 3790 1850 00 289, 263a 61. 12. 30 688. 450* 333o 232o 267c 208, 213, 182, 38* 38, 7, 00 MEAN 659. 560* 366t 296o 3239 197* 107*- 236o 151o 504 100 2o 2 0* $940539 10,(00 151" i2 61 @Re loo 69 1010 5t, 42o 1. 11 Ai3. 5576 500. 4359 1760 305, 192* 161. 369 90 ill 2 @IEAN 4820 253. 222o 193a 156'0 147o 106. 39* 54 6* 4o 0539 16000 813.0 646. 3@-2. 279a 233c 290* 320, 142. 174c 32. 2, 7-"* 'P".56 - . 4949 427o 26590 31379, 149* 160, 28c 2. 00 5ol a 611 MFAN 7900 A31o 418a 333o 249* 339* 235* 11519.. 1010 17, le 661* N T ER. AL cmptld L-rVEi- Stil I N i6M'T'N 15MIN 20,kifN 2 5?!@ 114 2 30MIN --,5MIN 40MIN 4514IN 5014IN 5514IN 60MIti 11940547 0.000 6690 45.6, 463. 652a 388* 434o 3199 301. 125o 226, 287* 1889 758. 2 489, 346. 2@td@o 229c, Ig-"Ito 88,0 git. S150 52. 170 80 MEAN 714. 4730 406, 4634 309o 312o 204o 201, 320o 139, 152* 2 980 lOOoOOO 199-. 6.6* 32C 43,i 100 80 53* 6-a 219 80 2* 139 3410' 1490 510 890 190 27, 78o 35, 2 So 21. 40* 00 MEAN 270. 107* 42, 66o is* 1.80 66o 21, 139 15. 21* 7* 0940547 109000 '291. 199, 185* 180a il4c 151 2 5,, 63, 17c, 41, 46, ig 9 8134 604o S85, 43to 4049 16S, 9it 161, 187a 7402 109C 3're TA,EAN 6026 46i* 285* S06o "L59c 160c 94t 115, 102o 56, 78c 190 40547 1*000 1245. Pnq, 54,.4, 568c 2 43so 1,00o 396o '@134* 315c 388, 411, 26r.1c 73qz 74S, '294* 224o 4019 2450 2v7, 150. 164c 124. 17* 14o MEAN 2 992- 829* 4199 396* 420* 123* 337o 2420 250o 29-6. 214o 13TV 00000 70. 646a 41-@4. 522* 579* 40'oo 34le I-bT* 459o 3642. 284b 445o 832& 591* 464, 571o 502* 408a 454o 516* 4,66o 340& 33So 472o 14 A. N 4516 619, 459, 547e 541c 40ge '. e.% . 1; 4A,2# 463c 352. 309, 459c IBEM 3,.2C)o 550,4' 355t 216. 234o ^71t 3FIc 224"-@o 81. 3!9c 236. 101. 14,;& 874. 7no@, 63@. 376o &59Cf, 50'ta @8$o 4,35, 462a 241. 127't MEAN 712, 531* 49'@it it.1:17-k 431# 446,@c 366c 245* 39i* 234, 114& 180.@'t 1*000 526, 404* 454, 450c 2320 381%,,, 39,;Ig 305. 253c 16@. 1700 244,9 2 419, 62'4* 334* 3086 376o 385* 376* 2966 2gle 229. 130c 162* MEAN 47S* 51'4c, 394r. 379c 1104-t. 3036 !-.677o 301* 272t 198, 150t 201t Gpout)$ OF RH.REE Ml(.E %--OUNTS AT it4D.1i,@@-@ATED T-NTr'PVAL '6M'I'N 15MIN 20MIN 25MIN 301,llt CMPND LEVEL 5MIN 1 2 435MIN 4O.M!ti 45MIN 501@,IIN 55t4tN 60MIN *032 629'a 4'ql-o 282* 248o 307* 248ri 7-64o 241i.it 150o 202.1 86-m 209 302g, 295-o 1139 147i 2819 152. 62o 62* 944. 577o 392. 208,s MF-AN 787. S.- 228o 305s@ 272:o 189, 1911@ 216* 177, 749 41, 34. 337* C C, N f 5 R 1 ri '7 r, 0 0 2 5 30-o 35 40, 45* 50 us w N) Ni + C7, 9 Lt) A3 'it !-'ULA-'IVE 3 FA!,C.E F,@@R 42089 AT lo.ooio MG ;'ER KG cu COUNIS PER '70000 Ski 3000, 2 9cooo itlooo 1.0000( -cool 4000# 10, 20. + 250 '30 35* 40* 45,76 50* 55, Tit-iE CUMULAT!VT COUNTS PER 3 IAICE FOR 2089 AT 10000 MG PER KG IN 1000, 3000& 5000,o 7000, 90000 mit@ll 2000, 2 40009 6000, 80000 10000*( t 00 40 IO& 20.6 250 300 354 6 40* 45* sob 550 mG PER KG 89 A@ i@ck 3 el I C R 2 20 #0 C, 0 7000* LI LI 0 c 0 25* 30* 8 35ti 400 45* 50, 44) tl I 2 C3 C3 c- 9 Ln tri 7it"E CUMULATIVE COUNTS PER I MICE FOR 50'$4 AT 19000 MG PER KG 1000, 3000-P 50009 7000a 9000, 2000a 40009 6000 80000 410000* 00 50 10. 150 20, 250 30* 35* 40a 45* 50* 550 loo MG PER KG TIME CUMULATIVE COUNTS PER 3 miCE FOR 5034 AT 90009 IN 10006 3000* 5000, 6000, 7000a 80006 100000 n. 2000* 4000* 7 5 too .lsdk 20i. 254 30,6 35,i 40,% 45* 500 55* TIME CUMULATIVE COUNTS PER 3 MICE FOR 5036 AT 0*000 MG PER KG IN 1000. 3000* 5000, 7000* 9000* MIN. 2000o 40009 6000* 8000* 100000 I t I 6 04 5 10 a 150 200 2516 30a .35, 400 45* 50,i TIME CUMULATIVE COUNTS PER 3 MICL FOR 5049 AT 10 ooo MG PER KG IN 1000, 3000@ 5000. 7000* 90000 MIN, 2000, 4000o 6000* 80000 10001 51, 2 10, 150 20* 300 35.* 40,o 45& 500 4VIVE COUNTS PER 3 MICE FOR T'll@E CUMULA 5049 AT too0o MG PER KG 10,001. 30009 50000 7000o 90000 MIN, 2000o 4000, 60000 110000 iooo( T 0 51 loi, 156 20, 25o 30* 40. 45* 506 55, TIVE ('-UtiULATIVE COUNTS PER 3 MICE r'OR g@IG4 AT o,o0o MG Pr@-R KG IN 1000,1 3000* 50000 7000* 900016 2000,, 4000* 6000* 80006 looq T 00 51 + 10. 20, 25, 30, 35o - 40* m 45o 50* 550 9 Cs TIME CUMULATIVE COUNTS PER S MICE FOR 5104 AT 100,000 MG PER KG IN 1000* 3000o 50000 7000* 9000* MIN* 20000 4000(t 6000. 8000* 100000 O* 500 10* 15a 20, 25, 30.6 35a 40a 45* TIP-E FUMULI,TIVE COUNT5 PER 3 MICE FOR 5104 AT loon0o MG PER KG IINI 1000, 3t)00* 5000, '70000 90008 t,ilrv. 2000, 40500, 6000, 80000 100000 oll 58 10 20o 259 - 30* - 35., 40a m 45i, m TS PER 3 MICE FOR 0 5tO4 AT o.ooo MG PER KG T!ME CUMULATIVE COUN ilk" 1000* 3000* 50000 7000* 9000, 80009 I&OOOOO 6 2000* 400.00 6000* 0,& 10* 15* 200 25* 304- 350 40* 45, kin Soo 55* r% TIME CUMULATIVE COUNTS PER 3 MICE FOR 5104 AT 63*100 MG PER KG '10000 IN 100(l 30000 50000 90000 141ti., 2000* 4000* 6000, 80000 0 100001 t 1 0 20,6 25i, 300 350 40* 45* 50* TlfvtF (j,"@,U-iTIVE COUNTS PER 3 MICE FOk 0 5iU4 AT 10*000 MG PER KG it-.' 1600. 3000, 50006 7000* 9000, ti 200c, 7 400c, 60001, Boact, 01, 30. 40, 45, so, tips CUMULATIVE COUNTS PER 3 MICF FOR 5113 AT 0*000 MG PER KG 1000, .@30000 1-@1000, 7000o 9000, MIN, n. 20000 4000* 6000, Booo,, loooooi 0 + 56 106 15o 20, .25, 306 3 5 40o 45a @50* 55,s TIME CUMULATIVE CO UNTS PER 3 MICE FOR 5113 AT 100,000 MG PER KG 1000* 3000* 5000, 7000a 9000, 2000, 4000. 6000. 80000 100050 0 51 106 150 200 .25a 300 35 400 45* 6 0 TI@IE CUM.ULATIVE COUNTS PER 3 MICE FOR 5113 AT lo,ooo MG PER KG IN ioooe 3000# 5000, 7000* 9000* 2000 40000 6000, 810000 100004 MIN,6 0 too 15 a 200 30* 35a 40* 45,6 506 550 CU@IULATIVE COUNTS PER 3 @ilCE FOR 5113 AT 1.000 MG PER KG ,TIME 90000 1000, 3000* 50009 7000* soooe 10000 3 t@IN" 20000 4000* 6000. I I I I 0 + I 0 + 2(a 30* .35a 40& 45* 500. 55 40 T I II-E C,.J!,IL;ILATIVE @%'CUt4TS PER 3 @IICL- FOR 5113 AT o,ooo MG PER KG IN 1000. 3000* 7000, 90000 20000 4000c 6000, 80008 100000@ 7 51 200 25,, 300 35& 40, de 45* 50& me 55 "'IVE COUNTS PER 3 MfCk FOR Tlt'E CUMULAI 1 5111 AT 100*000 MG PER KG l@4 1000, 3000, -;Oooe 7000o 9000, 2 2000, 4000* 6000, 80009 iooooot .T 00 100 15* 20* 25* 30a 35o 40* 40 0 50,6 55,o Tll%!E CUMULAT.*&VE COUNTS PER 3 MICE FL)R 5113 AT loso0o MG PER KG 1.\, 1000, 3000,6 5000, 70009 90000 MINE 2000, 4000a, 6000, 80000 10000 7 00 10* 15* 20. 30* 35& 40* 45,o 500 TIVE CUMULATIVE COUNTS PER 3 MICE FRJR 5124 AT ooo0o MG PER KG 100(il 3000* 50000 7000a 9000. 2000. 4000. 6000, 80001, iooq I 0 0 56 20, 2 -*, a,m 30i 3!6 406 45* Tlf,'E CUMU)-ATIVE COUNI"I"S PER 3 MICE FOR 5124 AT loo.000 MG'PER KG IN 1(004 30000 50000 7000* 90000 2000 40300, 6000, 00000 100006( 00 50 10. 20. 30* 35* 40* m 45* w so* uliiULki'IVE :OUNTS PER 3 141CE FOR k 5124 AT 1(,.@,(Oo IAIG PER KIG lujo* 3000* 50000 7000o 90000 80004 10OUL" 0 0 0,; 0.3 j@i 40, m 45.o w 5'D + TIME CUMULATIVE COUNTS PER 3 MICE FOR 5124 AT 1*000 f-IG PER KG IN 1000. 3000o 5000* 70000 90000 20009 40000 6000, 8000V 100006( 50 104 1 15 20* 25* 30a 350 40o 450 551, o,ooo MG PER KG CUMULATIVE COUNTS PER 3 MICE FOR 5129 AT IN 1000, 3000* 50009 7000* 90000 no 20000 4000a 6000* 80000 10000* 9 0,6 50 100 15a 206 250 do 30* 35* 406 45* to 556 CUMULATIVE COUNTS PER 3 MICE FOR 7 itAE 5129 AT 32oCO6 MG PER KG 1000, 3000a, 5000, 7000* 90000 2 20000 40009 6000. 80009 1000orp 00 50 too 15,6 20. 3 250 30i, 15i, 40a 45* 50ib CUMULATIVE COUNTS PER 3 MICE FOR 5129 AT lo*ooo MG PER KG TIME IN .1000. 3000. 4000* 50000 6000,s 7000o 80000 9000* ioooo.( MIN* 20006 20* 250 306 1 35* 40* 45a Sao 55* @U@IULATIVE COUt4"',?S PER 3 t4lCE FOR 5145 AT OSOOO MG PER KG IN 1000, 3000* 5000, 70000 9000* 20000 4000* 60008 2 80000 100000 0* 1 0 0 150 200 25* + 300 + 35& 40, 45* 50,o 0 55* 60* TIME CUMULATIVE COUNTS PER I MicE POR 514q. AT looo0o MG PER KG it.1 10000 30009 50000 7000. 9000.1 MIN. 20000 40000 6000, 80000 100000( T. I 0 + loo + 15,b 20,. 25, 30* 35o 40* 45. 500 (U@iU'AT!vE COLJNTS PER 3 MICE FC)R 5145 AT 1*000 MG PER KG 1000. 3000o 5000, 7000, 9000, PIN,. a, 2000, 4000., 60000 80004 10000.( 0 so 106 15* 20. 25* 30* 3r)o 40, 450 50* 554 T'4,vE CUMULATIVE COUNTS PER 3 MI'E *100 Mt'-a PER KG FOR 5145 AT IN 110004 3000* 7000, 900C)a 2 JA I Ij , 2000, 4000* 6000, 60000 Oo 5. io. 20* 25 30, 350 ..40a 45, 550., 550 Kamm TIME CUMULATIVE COUNTS PER 3 141CE FOR 5211 AT toooooo MG PER KG IN iooog 30000 50000 7000* 90000 MIN, 2000* 4000,o 6000, 60000 100000 5016 0 156 206 25, 30a 35, 40* 45* 500 55o PEP, F FC) A 3 0 6 0 Z) L) ri 3 46003 3 3 cl 0 100 2 0 25. 30, 40. 45a so 0 55 a TIP-E CUMULATIVR-. COUNTS PER 3 MICE FOR 5211 AT 19000 MG PER KO% IN iooo* 50000 7000* 9000, MIN, 2000. 4000,; 6000. 80004, 10000, 00 100 3 20. 25* 30. 35, 40, 45, 500 600 CUMUL 3 MICE FOR 8658 AT 0,000 MG PER kG ,TIME ATIVE COUNTS PER 1000, 3000* 50000 7000, 9000, I f-li 2000* 4000, 7 6000* 80000 ioooo( MIN, n. 00 Joe 20& '25* 30* 35-m ''40* 450 .500 550 TIME CUMULATIVE COUNTS PER 3 MICE FOR 8658 AT, 10*000 MG PER KG IN 1000, 3000a 5000, 7000, 90000 2000, 60000 8000* 10000*( .T. I I I I I 2 I 0 lb + 56 100 20. 250 300 350 40, 45* so, %-.OUNTS PP-R 3 Mi@'-E FOR 8658 AT 1,000 MG PER KG Ti.-E CUMULATIVE 30009 50004 7000* 9000's I.. 1000, 2 80000 toooogi MI%.* ol 20003 4000t, 60009 0* 50 lo* 15* 206 30* .35* 40* -45o 500 55* TIME CUMULATIVE COUNTS PER 3 MICE FOR T 6.00o MG PER KG 3000* 5000* 000, 90000 IN 10000 2000,, 40000 6000* 80000 ioooq MINI. 00 7 100 15* 20. 254 30. 35* -MP 40o 45* so* 550 '@CE FOR AilOW AT T!t-*E Cumu:-ATIVE COUNTIL PER 3 Vi. ',@2.OOCJ MG PER KG IN 1000* 30000 50000 7000* 90000 MIN. 20006c, 40004 6000* 80000 iooriol 00 56 100 ISO 20. 258 @30, 356 w 40* 45, 500 TIME CUMULATIVE COUNTS PER 3 MI'E FOR RAMM AT 10-000 MG PER KG %@ I IN 10000 3000* 5000, 7000* 80000 9000, 100000 2000, 2 4000. 6000, 00 S. loo 15 0 00. 2 25o 30a 35o 4%1 a 45.6 50Q 550, 6 IL TIIO!E CUMULATIVE COUNTS PER 3 MICE FOR AT lmooo MG PER Kt'3 1000, 3000* 500oq 7000a 9000, 20000 4000a2 6000, 80000 100000 MI tlo n. 04 + 10. 20a 25* 30* 35a 40, 45o 5 so 55o 9-) 100 MG PER KG AT CUMULATIVE COUNTS PER 3 MICE FOR T IIAE 3000. 5000, 70000 90000 000 IN 10000 2 80000 10 4000o 6000. 0 14INe 2000* - 04 0 of 200 25* 30* 35* 40, 0 45, 50* TIME CUMULATIVE COUNTS oeo0o MG PER KG PER 3 MICE FOR 4993463 AT IN 1000, 3000* 50009 7000, 9000, MIN, n, 2000, 4000. 6000. 80000 100000 T 00 5, ion 20. 25a m + 30o ft 3S,t 40, 45* 506 55* + 60. T I PE CUMULAYIVE COUNTS PER 3 MICE FOR 4093463 AT 32,000 MG PER KG IN I&OOO, 3000, 50004 7000c, 90000 MIN, 2000, 4000o 6000. 80000 100009 00 5 00 10. ISO 20* 25, 30* 359 40, 45* 50, T.RME CUMULATIVE COUNTS PER 3 @ll-,@-E FOR 4W9A463 AT looo0o MG PER KG 90000 IN 1000.1 30000 50009 7000* MIN,, In, 2000, 40002c 60000 8000.0 100000 T 00 10* is 20* 25o 300 35* .40* 450 Soo TIME CUMULATIVE COUNTS PER 3 MICE FOR 9093461 AT 1*000 MG PER KG IN 1000, 30000 50000 7000o 9000, 00 2000, 4000* 6000.' 80000 100000 100 20.6 25a 30. 35* 400 45, Soo 55* TIME CUMULATIVE COUN't'S PER 3 MICE FOR 0934621 AT ooo0i MG PER KG IN 1000, 3000q. 5000, 7000* 90000 MIN,, 2000o 4000a 6000, 80000 ionooo oil 0 56 100 200 .25* 306 350 40. 45* 500 TIME CUMULATIVE COUNTS PER 3 MICE FC,R*934621 AT 32*000 MG PER KG 10004 30009 @zoooo 7000* 90000 MIN* n. 2000, 40000 6000, 80000 1.00000 06 54 6 0 15o 20a so 25c m 30. m 35* 40, 45, 500 55* 60,) G PER KG I,-E FOR 0934621 AT 109000 M T I POE c 2 90009 UMU'ATivE COUNTs PER 3 M, 3000c. 53009 7000* 10000* 2 IN 10000 40009 6000* 80000 2000a 04 50 104 is 20* 0 25* 30o 35& 40* 45* 50, 550 Mi-@E FO MG PER KG CUt.'ULA7lvE "--OUNTS PER 3 R 0934621 AT toOO TIM-E 90000 10000 3tiDOe 2 50000 7000, 20000 4000a 6000a 80000 10000,o m I 00 lo* 20, 25o 30* 35, 40o 1 45a 500 60* TIME CUMULATIVE COUNTS PER 1 MICE FOR *934629 AT 0*000 MG PER,KG IN 10001, 3000o 53001 70009 9000, MINS 0. 2000, 40009 60oo, 5Booog 10000, I I I 0 100 15a 20, 25a. 30. 35o 40, .45 a 50* 55* 60. TIME CUMULATIVE COUNTS PER 3 MICE FOR 0934629 AT 32od0o MG PER KG MIN, 1000* 3000*, 5000. n 2000, . 70004, 9000, 40009 2 60000 80009 100000 00 10, 15, 20* -26. 306 35, 40, .45. so* .55 602, lo.ooo MG PER KG TIME CUMULATIVE COUNTS PER 3 MICE FOR4$934629 AT 3000, 5000* 70009 90000 IN 10000 2000,i 40000 6000, 8oo0q, 0 100000 I t + 51 100 I 5 20a 2'5 30, 35o 45* 550 M- TIME CUMULATIVE COUNTS PER 3 MICE FOR 0934629 AT 10,000 MG PER KG IN 1000, 3000* 5000 000,@ .9000 1 M 2000, 4000, 6000, 8000 10000@, 00 2 100 200 25, 30a 35, 40* 45* 500 -t .55o 609 T IIME CUMULATIVE COUN@IS PER S MICE FOR *934631 AT ood0o MG PER KG IN 10004 3000. -.,oooq, 70000 90000 MIN'. 0. 2 2000, 4000, 6000* 80000 100000 00 10* 200 25o 304 35a 40a 45* so, 7 60a TIME CUMULATIVE COUNTS PER 3 MICE FOR 093463i AT toocOOO MG PER KG IN 1000, 3000o 50000 1 70009 9000, MIN* 2000, 4000a 6000, 40000 100000 0. 5, loo 15a 20* 25* 30. 35q, 40, 45* 55, TIME CUMULATIVE COUNTS PER 3 MICE FOR 093463j AT loooOQ MG PER KG IN 10000 30009 5000e 7000o goooo MIN, 2000c 4000a 6000* 80000 100000 9 I 00 51 + 10 ISO 20. 25* 30* 356 40* 459 504 550 TIME CUMULATIVE COUNTS PER 3 MICE FOR 0934631 AT toOOO MG PER KG IN 10000 3000* 5000,0 70009 9000, 40009 60009 eooot 100000 MIN, 2000a 00 0 Joe 00 20, 25o 30* 350 40, 45, 500 55, TIME CUMULATIVE COUNTS PER 3 MICE FOR 6934637 AT OOOOO MG PFR KG IN 10000 30009 5000, 7000, 90000 MIN. 00 2000. 4000, 6000. 80000@ 10000* 0 10 200 .250 300 35* 40* 450 .56 TIME CUMU'ATIVE 'OUNTS PER 3 MICE FC)R 0934637 AT 32oOOO MG.PER KG IN 10000 3000* 50009 7000,o 90000 MIN, 2000, 4000 6000. 80009 100000 I 060 10, 150 20o 25m go 30* 35, 40a Ws 45,o 50, 711-iE CUMULATIVE COUNTS PER 3 MICE FOR 0934637 AT toobOO t4G PER K(i IN 1000, 3000* 1.1;.Oool 7000, 9000,0 20000 40004 6000. oooov 1000080 00 too 150 20* 25o 300 35a 409 4 5,a .50, COUNTS PER 3 MICE FOR $934637 AT 10000 MG PER KG CUMULA'I"IVE goooo TI@IE 7000c, 50009, IN 10000 2000; 03000* 40000 6000a aooog 100009 MIN* 106 200 25* 30.6 35.a 40* 45. 50. 550 CUMULATRVE COUNTS TIME PER 3 MICE FOR 0934663 AT OOOOO MG PER KG IN 1000. 30000 50000 70009 gooo, MINI. 2000. 4000o 40004 800010 100000 9 04 51 10* 150 20* 25* + 30a 356 m 40* 450 50o 550 -M FOR 41934663 AT io.ooo MG PER KCi TIME CUMULATIVE COUNTS PER 3 t 53000 7000* 9000@ 100000 I %I 1000* 30000 4000o 6000,, 60000 I MIN* 2000a 3 00 Jos 200 2S* 300 35o .40,o 45* so* 550 TIN.'E CUMULATIVE COUNTS PER 3 MICE FOR18934663 AT 19000 MG PER KG IN 10000 3000,a 5000,, 7000, 60000 goooo iooccio MIN* 2000c 4000a 6000. I I 4 I t or. + 59 100 ISO w + 20. - 25* 30, 35* 40* 450 500 TIME CUMULATRVE COUNTS PER 3 MICE FOR I'1934663 AT 9100 MG PER KG IN loco. 3000-a 5000. 7ooo. 90000 MIN, 20009 4000* 6000* sooo-o 100000 00 5, 140. 20 25a 30* 35a 40, 45, 500 55, E FCR #934685 AT 00000 MG P-R KG Mc CUMULATI,.V,E -OUNTS PER 3 MIC TI 5000o 7000o 9000, ;N 1000, 300'3* B'WOO2* 10000,0 MIN, 200%"J'o 4000, 6000, I I I I 00 + 5 Joe 150 200 25a m 300 w 35, 40* 7 45* 50, 55a t lo#ooo MG PER KG ,ilCE FOR $934685 AT MU@-A'f'IVE COUNT5 Pr-.R 3 k cu i 9000, I2N 10000 3000* 4000a 50000 6000, 7000t 80000 1003(,'* 2000,o mitia no 00 5, up 10,6 20a 25,, 30. 35a 40* 45o T r t,'E CUMULAT-LVE COUNTS Plc-R 3 MICE Ft,'R*9---468r- AT 1.000 P.G PER KG IN 1000, 3OOiDo ;000,; 70004, 90000 MINO n, 4000o 6000. 80000 6 LOOOOO 0 so 5 100 + 20 250 .30a so 35* 40, .45* 500 55* TIME CUMULATIVE COUNTS PER 3 MICE FOR 0934687 AT 0-*000 MG PER KG IN 1000, 3000, 50000 7000. MIN, 2000o .4000, 60000 80000 goooo 100000 00 10. 1 20* 25o 306 35, 40o, 45o 504 TIME CUMULATIVE COUNTS PER 3 MICE FOR 0934687 AT 10.000 MG PER KG IN 1000, 3000* 50004 7000* 9000, MINE 2000,0 40009 6000, 80000 100000 O& 50 1 + lo* 2014 25a 30a 35* 40* 45a 500 MG PER KG 1,000 ylVE COUN75 PER 3 MICE FOR 1$934687 AT 90000 CUMULA -rilAE 30000 50000 2 70009 60009 jooooo 10006 6000., 1 IN, 4000o I 2000, ml 10* ISO 200 250 1 30o 35a 40. 45o 5 0,0 550 09 ooooo t4G PER KG -,U.IIUL'-TIVE COUNTS PER 3P!CL FOR 0513 AT TIME 5000, 70000 90000 1000, 3000o I2N 40009 80000 100009 .0 50 too 15C 20a 25o 30. 3 5.i 40., 45a 50o 4550 604 TIT@IE CUMULATIVE COUNTS PER 3 MICE FOR 0940!il3 At lo'.ooo MG PER KG IN ioooq 3000t 5000,0 7000* 90000 MIN* 2000* 4000t 6000, 80009 100000 010 too 150 20. 25* 30, 40. 45a 500 TIVE COUNTS PER 3 MICE FORi*940513 AT 329000 MG PER KG TIME CUMULA' 1.14 1000, 3000.o 50000 70000 9000'a Mikil 2000, 4000a 60004 eoooa 3 10000. I O,, 5. lo* 15o 20. 25a 30* go 35, 400 45, 50* 55* LIM MG F:C-R KG C- FOR #9;,.l5i3 AT PECZ 3 MI t'- 90000 E 2 70000 locoof IN 60000 '4000, 001 50 200 6 25, 30o 350 40a 45, 50 55. CUMULATIVE --OUNTS PER 3 MICE FOR 094OSSS AT O&OOO @iG PFR KG T I t-IE 3000* 5000, 70004 goooo IN 10004 I @ll a 2 2000a 4000, 63000 100000 04 + 51 106; ISO 20, 25o + 30, 3550 40o 4S* 500 MG PER KG 35 AT 10.000 90000 CUMui-ATtvE COUNTS PER 3 MICE FOR &9405 TIME boooo 70000 IN 2 10000 30009 80009 10'0009 2000, 40006 60004 ,co lo, 154 20a 25a 30a 35o 40o 1 50* 55.6 T I I-'E CUtiULATIVE C(JIJN';S PER io t.41%".E FrjR 094053s AT 000 MG PER K C- 11\1 10006 3000* 7000o 90000 2 4000a 6000,0 MINS 2000Q 00 20.0 25* 30* 3 409 45* so, 6 550 60?. TilvE CUMULATIVE COUNTS PER 3 Ml,:E FOR 0940535 AT 0100 MG P-Zk KG IN 30009, 5t3OOo 70000 Mltlo 20000 4000a 60i)oq 80.300 00 7 50 10. 150 20a .256 30a 35o 40* 45* + Soo 55, 60& kil. 'LJMULAT!VE COUNTS PER 3 MFCE FOR *940539 AT TITAE 0.000 @IG PER KG 10000 30000 5000,0 7000* 2 90001, MIN, 20000 4CO09 6000, 8000c, I I I 04 51 io.- 15o 20a w 3 25* m 30, 35o 40* 45,e 50, 55 a TIME -UMULATIVE ct)k)NYS PER 3 14lcL-' FOR4f 940539 AT 10,000 MG PER KC IN 10000 7000a 91%JOOO MI-N, 20000 4000,8o 6000, a 0 0 0 10. 150 20a 25, 30* 35a 40, 45m 55, .OUNT-4 PER 3 MICF FOR TIME CUMULAT'-@,)c 094,'.'-,539 AT 1-600 1,15 PER KG I t%l 3@io3q 50000 70000 900oz. 2 0011% MI-%, 2000.1 4000o 6000, 5 T 0 Joe 204 256 30a 358 40* 4@. 500 3 60. -L FoR 0940547 AT o.000 MO PER KG CUMULATIVE COUNTS PER M'A%. T 1.1,'E goooj I N 10000 3()00-s LI -.1 70004 80000 10001%",a 2000* 4000c, 6000* 0, 50 lo* ISO 200, 252 30a 350 40, 45, 6 500 CtiNiULAT I'VE @RO(JNTS PER 3 Mt?,--E FOt-Ai*9 401,:47 AT tOOo 00 @i4 PER KG T 10000 70009 gocoo M-IN, 20000 3 4000a 6Qi3O* 80009 0 50 10. 20o 30a 35o 40, 45a 50o .600 T IME C!JMULATIVC CCUNT'P PEt; i4'CE FOR 09-;1)547 AT 104000 MG PEI@ KC, lio0i)o 1.000,# 3000* @oo0q, 2 7000o M I f-I 2000c. 40000 60004 aoooq 'LOO00c, I 00 M+ 10 200 + SO& + 3151b + 40, 45* 508 550 60, Mali;, E FOr,. #940547 AT 1#000 MG PER KG CU%IULA-?V@ COUNTS PER 3 Mt' T!NIE IN 30000 5000,0 70000 30000 0 MIN, 2000* 4000v 6000, 80000 Oa Joe 20c 25o 30* 35* 40,o 450 500 550 60, IE CUMUL AT 0,, O@00 144 P@--R KG Tlq ATI%IE COUN@15 PER 3 Mi"E FOR ASIM IN 10000 3000o 5,00n, 70000 90000 MIN* 2000* 040000 6000. Oooot 10000,3 00 100 20. 300 35* 406 45. 50, -R K%3 E CUMU'@-A.?IVE COUNTS PER I MICE FOR AY $020o MG PC_ TTI 90009 7000* ioool2i 3000* 23300 40009 6000o 100000 MIN* 00 10* 150 20* 25a 30. 35a 40* 450 2 55 60* CUMULATIVE 1-@OUNTS PER 3 MICE FOR #4gmAT 1,300 Mt"; PER KG I ri 10000 300%)* 50000 7000* 9000* 4000o 6000. 80009 100000 5 2000* 100 20z 300 35* 40, 50*, 55. 60, 40 G P-R KG IT!TS PER 3 tl!-@E FOR 04@@ AT m ',E CUt-U!-ATIvE COi@ IN 1000, 7000,@ ei3ooq 2 @000 4000,a 6000, 1000 M I Ns 0 5 10. 150 20. 2 5 306 35 40, 45* 500 6 + 550 60* PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS CAT NO, DOSE WTO TIME OBSERVATIONS AND bEX MG/KG KG* @IOURS 64 F 1007, 3072 0,0 fiEART RATL 144 BLATS/MINVTL HLSPIRATIONS'PER MINUTE 60 2 BODY TEMPERATURE C 38o6 CALM DEHAVIOR9 GENERAL APPEARANCE9 AND CONDITION NORMAL NEUROLOGICAL IESTS NUKMAL N05E cool AND MOIS2T PKL-DOSL (SAME UA.) 0*2 HEART RATE 132 BEAT$/MINUTE RESPIRATIONS PER MINUTE 60 UOUY TEMOLRATURE C 38*9 TONIC CONVUL!)ION FOR 2 SECONDS RESISTANCE TO NLC2K VENTROFLEXION WEAK PERIODIC BRIEF HEAD-5kiAKING NOSE WARM AND DRY ' 1. tUROLOGICALt & BLHAVIORAL SIGNS OTHERWISE NORMAL PHYSICAL9 N 0*7 HEART RATE:140 BLAIS/M2INUTE RESPIRATIONS PER MINUTE 72 IJUDY TEMPERATURE,C 38*8 BEHAVIOR GENERAL APPLARANCEL-AND CONDITION NORMAL 9 15 NORMAL N4LUROLOGICAL TES SOLUTION - PISTILL@D V4AIEN PHYSICAL ANU NLUMOLOGICAL EXA141tiATION OF CATS CAT NO* DOSE WTo TIME OBSERVATIONS AND SEX MG/KG KGf HOURS 64 F 1042 105 HEART RATE 108 BEAT5/Ml#4UTE HESPIRAlION5 PER MINUTE 60 2 BODY TEMPERARURE C 38ob PHYSICAL9 NLUROLOGICALT 4 BT:HAVIORAL SIGNS NORMAL 2416 HEART RATE 132 BEATSIM114U7E RESPIRATIONS PER MINUTE 54 2 BOUY TEMPERATURE C 38*5 PHYSICAL* NLUROLOGICALs 6 BEHAVIORAL SIGNS NORMAL SOLUTION DISTILLED WATER rT 0 cr ok PHYSICAL AND NEUROLOGICAL EXAMINAVION OF CATS IM2271 (I-V) CAT NOG DO!)E WTo TIMT U65ERVATIONS AND SEX tIG/KG KGo HOURS 44 F 29 2*66 ogo @!EART RAT@- 120 EIEATS/MINUIE NESPIRAT2IONS PER 14INUTu- 42 HODY TEMPERAFURE C 38oT NOSE CCOL AMU MOIST CALM BEHAVIOR9 GLNERAL APPLARANCE9 AND CONDITION NORMAL NEUROLOGICAL T@-.515 NORMAL PRE-DO5'1-- (5AM:C'.' UAY) 002 HEART RATE 156 BLATS/MINUTE E5'PIAAIIONS PER MINUTE 96 OUUY TEMPERATURE C 39*2 N05E WARM AND MOIST 2 PHY51CAL* NLUROLOGICAL9 BEHAVIORAL SIGNS OTHERWISE NORMAL Oo7 HEART RATE 132 BEATS/MINUTE RESPIRATIONS PER MINUTE 48 MODY'IEMPERATURE C 3898 NOSE WARM AMU DRY 5 REDUCED ANAL TENSION PHYSICALs NLUROLOGICALT BEHAVIORAL SIGNS OTHFRWISE NORMAL SUSPENSION MLIHYLCELLULOSF- Oo556 PHYSICAL ANU NEUROLOGICAL EXAMINATION OF CAYS 227t (I-V) CAT Noa DOSE WT* TIM9@: OBSERVATIONS AND SEX MG/KG KGo HOURS 44 F '-19 102 Hfv-ART RATE L44 BEAFS/MlliUTE RE"@@PIRATIONS PER MINUTE 84 UODY TEMPERAIURE C 39r.0 PUPI!.LARY REFLEX INCOMPLETE PHOTOPHOBIA + NOSE WARI-I ANO DWY P@IYSICALV NLUROLOGICALT & BE@-IAVIORA2L SIGNS OTli@cRWISE tIOR14AL 2o3 HEART RATE 150 BEAtS/MINUTE RESPIF@AIJONS PER MINUTE 102 DODY TEMPERATURE C 38*7 PUPILLARY REFLEX INCOMPLETE 3PHOTOPHOBIA NIC71TATING MEMBRANE RELAXED N05E WARM ANU URY PHYSICALT NEUROL061CALV 6 BEHAVIORAL SIGNS OTHERW15E NORMAL ,SUSPENSI METIIYLCELLULOSE 0*5% ON ptiYSICAL AND NEUROLOGICAL EXAMINATIOfi OF CATS @@2271 (I-V) @CAT NO- D05E WT* TIME UBSERVATION5 @ND SEX MG/KG KG* HOURS 44 F 29 500 HEART RAIE 1-46 SLA-IS/P.INUTE RESPIRATIONS PER MINUTE 108 OOUY 7EMPERAIURE C 39ol N@-OMPI-ETE PUPILLARY REFLEX I PHOTOPHOBIA + 2 NIC71TATING ME@ii3RAiiE RELAXED t+ NOSE WARM AND MOIST Pki@"@ilCAL9 NLUROLOGICAL9 6 BL-@@IAVIORAL SIC-NS OTHERWISE f4ORMAL 21(,l HEARTRATE 150 BLATS/MINUTE 2 KE5PIRATIONS PER MINUTE 72 tiODY TEMPLRAIURE-C 38qO NOSE COOL ANO MOIST ULHAVIO@'%v GLNERAL APPEARANCE9 AND COND17ION NORMAL NLUROLOGICA2L TESTS NOHMA4 5USPENSION-- METHYLCF.Lt-UL05E 095% rn tiATION OF CAIS PHYSICAL AND NEUROLOGICAL LxAml @@24388 (I-V) CAT NOG U05E -,,vT* TIME UDSERVATIONS AND SEX MG/KG KG* HOUPIS 2 BEATS/MINUTE AbKwm 64 F 3o292 0,0 HEART RATE 13 RESPIRATIONS iF-f@ MI-NUTC- 36 6ODY TEMPERAIURE C 38o3 CALM FRIENDLY !IEHAVIOR# GLNLRAL APPEARANCEV AND CONDITION NORMAL 2 NkUR(%,L.(,)GICAL TEST') 9'40RMAL PRE-DOst: (SAIAL t)AY) 0,0 FIRST D05ING oai MOTOR ACTIVity DECREASED + 09? HEART RATE itio BEATS/MINVTE 2 KLSPIRAFION5 PER MINUTE 64 LIODY TEMPERAJURE C 38*8 BLHAVIORs GENERAL APPEARANCEV AND@CONDITION NORMAL L IESTS NORMAL NLUROLOGICA 2 rn Ov7 HEART RATE i5O BEAT5/MINUTE > mE5PIRATIONS PER MINUTE 66 -4 UODY TEMPLRAIURE C 3890 7 EUROLOGICAL9 OtliAVIORAL 5@6NS NORMAL PH*$ICAL9 N. PHYSICAL A14D NEUROLOGICAL EXAMINATION OF CATS 4@2438b (I"V) CAT MOo W70 TIM';, OBSERVATIONS Ai'4D SEX KG* I-ioutis 64 F -+L4 0 9 SECOND DOSIN(I 50ML OF O-OSE ItIJE@..T;@:0 S',)bCIJTANLOU59 IN!iiF-AD OF Ili k'EIN ico @IEART RAIE 144 BEAI'S/f4l.NUTE RE5PIRAIIQNS PE2R MINUTT 90 UUDY TEt-'.I';E.RAtUR-a C 39a3 PHY51CALI NEURtILOl"31CAI@v t- 13L-IIAVIO14AI- 51%eiN,% OTti@:Rol!@E NORMAL UBCUTAt42;-:'OU$ 00@--E SVILL PRE5ENT UNL-)TK :31,ltl 104 HEART RATE 120 BEATS,@I'Milik)TE NEBPIRATIONS PER Mlf4UTE 102 BUUY TEMPLRAIURE C 392o5 PHYSICAL$ N'@UROLOGICAL* 6 bEliAVIORAL. SIGNS OTHENW15E NORMAL SUBCUTANEOU@ DOSL STILL PKEBLNT Utli)LR !IKIN 204 liEART RATE 144 BEATS/MINUTE ,I?ESPIRATIONS PER MINUTE 96 BODY TEMPERA(URE C 39o3 > N05E WARM AND Mcl'jT m PHYSICAL* NLUROLO(il-ALv & BEHAVIOIZAL SIGNS OTHERW2ISE NORMAL > SUBCUTANEOUS DOS@- S'IILL PRESENT UNDER BKIN V4 SOLUTION DISTIL[.Ll) V#AIIER @'HY51CAL APID NEUROLOGICA'@ 9-:XAMINATION DF CAT5 4388 41-Y) CAT NO* 005E @iT* TLmE OBSERVATION$ AND SEX MG/KG KG- Hour-Is 64 F 497 HEART PA-IE 108 BEATS/MI2NUTE RESPIRATIONS PER t-liNt,TE 90 OUDY TEMPkRAiURE C 39o3 NUSE %@.UOL ANU MOIST PHY51CAL9 NEUROLOGI@-AL* 6 BEHAVIORAL SIGNS Cl@IERW15E NORMAL 2 27,4 iitl:-ART RATL 138 BEATS/Mif4L)TE NLBPIRATIUNS PEk MINO-IE 42 I"OUY TEMPEHA(Uf4E C 3892 PHY5iCALs NEUROLOGICALT 6 BEHAVIORAL SIGNS NORMAL SULUTION UISTILLED WA[ER PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS CAT NO, DOSE WT* TIME Ub5ERVA'FIONS AND SEX MG/KG K-3q HOURS 55 F 28 2al 000 HEART RATE 150 BEATS/MINUTE RESPIRATION$ PER MINUTE 30 BODY TEMPERATURE C 38o4 C.ALt4 BEHAVIOR* GENERAL APPEARANCE9 AND CONDITION NORMAL f4;UROLOGICAL TE5T5 NORMAL PRE-005E (SAME DAY) 0121 HEART RA7E 126 BEAT5/MINUTE RESPIRATIONS PER MINUTE 5q UODY TEMPERAIURE C 38o5 PHYSICALs NEUROLOGICALI & BEHAVIORAL SIGNS NORMAL 095 HEART RATE 108 BEA'[S/MINUTE 2 H@5PIRATIONS PER MINUTE 66 BODY TEMPERAIURE C 38*6 PHY51CALs NLUROLOGICALT 6 BEHAVIORAL ;IGNS NORMA@ 1.0 HEART RATE-126 BEA'I'S/MINUTE RESPIRATIONS PER 2MINUTE 60 rr, BODY TEMPERAIURE C 38*5 PHY,51CALi NLUWOL.001'@ALv 0@HAVIORAL $IGN4 MORMA@. bUFjPENSION ME Tirlyl.C.U-I.t.1 -IL05C 0952 priySil.-AL ANU NEURE)LOGICAL 'EXAMINATION OF CAT5 41IW615 (I-V) (38SERVATIONS CAT NOo 005E WT* TIM- AND 5EX MG/KG KG* NOURS A" kitART RATE IZ6 EtEATs/MI14UTE 55 F 28 2-0 KESPIRATION5 PER tilNtiTE 54 dody -EMPLRAFURP C 3990 PHYSICAL-I M@LIR6LOGICAL9 4BE-IIAVIORAI, SIGNS NORMAL 2 HEART RATE 138 BEAT5/MINUTE KESPIRAII(NS PER MINUTL 78 UUY TEMPTKAIURE C 3bo7 "YS@ICAL* NtUROL061CAL-o 4 BFkiAVIORAL 5lGt45 NORMAL 22e9 HCAGT RATE 156 BE2ATS/MlI4UTE HLbPIRATION5 PER MINUTE 60 HODY TEMPERAIURE C'38o6 OGICAL9 BEHAVIORAL Slr;NS NORMAL PHYSICAL9 NLUROL 6 SUSPENSION METHYLCLLLULOSE 095% rn -41 p@iYSICAL. A(iL) r4EUROLOGICAL EXAMIOATION OF CAT5 111IM2776 UH5ERVATION5 CAT NOo D05E WT* AND 5L,@ MG Kr3 KG, HOURS IIEART RATE 162 B!:ATS/Mi@IUTE 9.2 2,84 0,0 PER MINUTT 60 8ODY C @38-'3 t4o5E COOL AND M(IST CAL.M ) EARANCE9 AND COTID;IION bLHAVIOR9 6-1;tILRAL A@P Nr@.UROLOC,ICAL lEbiS NE18MAL PR%c.,DO5E iSAM'r- DAY) 00,02 &@NURE2SIS LXrES5 5ALIVATIUM MEW I IJG RE5PIRA11OM5 PER MINUT@- 90 0905 EXCLSS 5ALIVATIUM 0 DE@ECAIION MEWING 0*1 CALM zo % BOLUTION PHYSICAL AND NEUROL061CAL EXAMINATION OF CAT5 4@2776 I -V) CAT No* DOSE WT* TIME OBSERVATIGNS AND SEX MG/KG KGo HOURS 53 F 9 2 00 2 PERIPHERAL SENSATII',1!4 140 RESPO(4SE TO NEEDLE PRICKS 2 DEEP SENSATICN GUESTIONABLE. EXTENSOR THRUST REFLEXLS AB'ENT9 HIND LIMBS HOPPING REACTION ABSC&.NT ;N INJECTED FOOT GROWLING WHEN HANDLED LYING ON SIDET BUT CAN STAND OTHER NEUROLOGICAL TESTS NORMAL 2 0,,3 HEART RATE 138 BEATSIMINUTE RC-SPIRATIONS PER MINIJTF 138 BODY TEMPERATURE C 38*5 NOSE COOL AND MOIST REDU%--ED ANAL TENSION LYING ON SIDEs BUT CAN STAND PANTING 7 ;,GROWLING WHEN HANDLED NEUROLOGICAL EXAMINATION NOT DONE SOLUTION 20 "TWEEN-20" > rn co PHYSICAL AND NEUROW ol GICAL EXAMINATION OF CATS OW@776 (I-V) CAT NOo DOSE WT* TIME 085ERVATION5 @ND SEX MG/KG KG- HOURS 53 902 Leo HEART RATE 156 BLiA2TS/MINUTE RESPIRATIONS PER MINUI'E 78 OODY TEMPERATURE C 36*9 -SCLERA - VA50DILATION EARS RED N05E COOL AND DRY LYIN-U ON SivEg WITH H@-AD Ui) 2 1','EURvL',)GliZAL IE!;Fv-l NOli@IAL 2*0 HEART RATE 150 BLAI$i'@IINUTE NESPIRATIONS PER MINUTE 54 UODY TEMPERAIURE C 37o5 NUSE COOL ANU DRY 2 5LOATED CALM BEHAVIOR AND APPEARANCE.,- OTHERWISE N8RMAL NEUROLOGICAL TESTS NORMAL SOLUTION 20 Y6'"TWEEN-2010 5 rn OLOGICAL EXAMINATION OF CATS PHYSICA' ANI) NEUR 8 o ts UB$ERVATIONS CAT NO*. DOSE wT* TIME AND,BEX MG/KG KG- HOURS 55 F 202 000 HEART RATL 138 2BEATS@MiliUTE NESPIRAIIIJNS PER MINUTT 42 OODY TEMPRAIURE C 38s5 NDSP- COOL ANO M(EST CALM - NORMAI 2 PVARANCE9 ANO CONDITION BEHAVIOR* GENERAL AP NEUROLOGICAL 'iES'l 5 NC)R@IAL PRE-DC5E (SAME DAY? 0#3 HI-:ART RATE 144 BEA15/14INUTE t4E5PIRATIO2NS PER MINUTL 42 NOSE WARM AND DRY OL-FECATION HITH CLEAR ht)CU5 PHYSICALs NLUROL061CALt 6 BE@IAVIORAL SIGN$ OTHEOWISE NORMAL 0#7 HLART RATE 138 BEATS/MINUTE HESPIRATIONS PER MINUTE 40 BODY TEMPERATURE C 38*5 NOSE WARM ANU DRY > PHYSICALs N@UROLOGICALI 6 OEHAVIORAL 5IGNS OTHERW15E NORMAL @rn 5OLUTIOM-- HYPROCHLCRI(- ACII Ost Mg 05 WITH PIST I t-i@-EP WATER 00 CATS OGICAL EXAMINATION PHYSICAL AND MEUROL zoos 4w ubSERVATION5 '.AT NO* D05E WTO Tlme MG/KG 2 KCo HOURS @,ND 5EX HEART RATE 144 BEAIS!MINUIE 55 F -1295 1*4 NESPIRAIIUNS PER MINUTE 36 b(;Dy TEMPV,7AfUf@F- '-- 30-3 NOSE COOL AND @4015T - BEHAVI2ORAL SiGtIS OTHERWISE i,loftMAL iiEUROLOGI,'-.O.Lv pkiySICAL9 E 120 BLA!5tritiNUTE HEART RAY M!NUTL 22 2 Kt5PI.RATIUMS PER eouy TEMPERATUKE C 38-1 % BL@@AvIOI-I.AL OTI-If-'I'Vil5E t4ORMAL VHySICALoiNbUROLUGIC2AL9 HEART RATE 150 BLAIS/MINUTE 4,0 tiEsPi@RAI-IONS PER MINUTE 30 PERATURE C 31*9 mouy TEM HAL SIGNS NOR@iAl- LOGICAL9 BEHAVIO pHySICALt NEURO tATi5/MINUTE 26.6 HEART RATE 114 B E 54 oLbPIRATIONS PER 14'plljy booy TEMPERATURE C 3799 BEHAVI2ORAL SIGNS NORMAL ALe NEUROLOGICAL4 pliyslc C@p WATER T14@DISTILL 2 pl@. HYDROCHL(RIC Acto Ns 05 WI 501.k)T IO PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS 2844 (I-V CAT No# DOSE WTo TIME OUSERVATIUN5 AND 5EX @IG/KG KG* HOURS 53 F 906 2aO6 000 HEART RATE 156 BEA75/fitNUTE RESP2IRATION5 FER MINUTE 42 IJODY TEMI)LRAIURE C BOod CAL.M --IiAVIOR* G'-14LRAL AP@'@ARANCE4 AN!) CONDITIorl .14 l@3 " 0!@MAL 2 NEUROLOGICAL l@z-5Tr-, @lC@tt,-iAL (40SE COOL ANO MOL.@T PRE-D3bk (!@AME DAYI 0,1 IILARI RATL 144 BEATZ')/MINUTE RE5PIRAIIOUS PER MlliuTt- 78 BUOY TEMIPERATliNE C 3898 t4J5E WARM AND MUIS'F PHY51CAL9 NLURULO(411-.ALt 6 BEHAVIORAL SIC-NS OTIJE14Wl5E NORMAL O-o6 HEART RAIL 132 BEAT2S/MINUTE RESPIRATIONS PER MINUTE 66 UOUY TEMPERATURE C 38o2 NOSE WARM AND M015T PHYSICALs NEUROLOGICALI 6 BEtiAVIORAL SIGN5 OTHERWISE NORMAL 1 m bU5PENSION METIIYLCELLUI-OSE 0 5% 00 PHYSICAL AND NEUROLOGICAI. EXAMINATION ()F CATS 410?844 (f-V) CAT NCQ DOSE ViT TIME OBSERVATIONS AND SEX MG/KG KG* HOURS 55 F 8,8 ill HIART RATE 150 bLAIS/MINUTE 2 H--3PIRA'llOt4S PER t4iNU-iL t. BODY TEMPLIlAti.O'RE C 39*5 N 0 I--- E W A f,M AND MOT-ST P@IYSICAI-9 NLURC-t-CI(31CAL,* BE14AVIORAL 51(i2NS Ofl.IERWISE NORtiAL. ART RAYE 144 BF-A]S/iMlNk)TE 2 4 HE WLSPIRATIONS PER t4lt4UT@- 12 BODY TEMPERATURE C 3902 N05E WARM AND 2DRY PHYSICAL9 NEUROLUGICALT 6 6EHAVIORAL SIGNS OTHLRt.-l.ic@. NO.'-Zi-IA.L 4o3 HEART RATE 1!)O bLATS/MINUTE RESPIRAIJUNS PER MINUTT: 90 2 tsUDY TEMPERAIURE C 39*Z NOSE COOL AND MOIST PHYSICALT NLUROLOGICALI 6 OLkiAVIURAL SiGtIS.OfHER'eil$E NORMAL 2593 HEART RATE 126 BLATS/MINUTE rT 7 RESPIRATIONS PER MINUTE 33 BODY TEMPERATURE C 3891 PHYSICAL* NEUROLOGICAL.9 6 DEtiAVIURAL 4IGN$ NORMAL !itJ@-PE,'qSlotl M Ef I Y I- E L L LI L5 F- Oc,5% 41 TIUN OF CATS URULOGICAL PXAMINA AL AND NE PHY I c 2050 uf3bEgVAIIUNS2 CAT Moz Do!)E TIME MGFKG KGO HOU-M-5 AND 5EX HEART RAFE 132 eL!,TS/MINUT@ 6*3 3o4 04.0 39 F HLbPIRATIUNs P@.q MIPIUTL 4)2 BODY TEMP2ERA'9'URE C 3893 LALM (40SE COOL ANI) ;4UIST N' k)KOLU(ilCAL TESTS NONMAL MD C(NDI t .'ON M(.-.141,iAL 2 RAN(Es A dEI-IAVIOPt G@14F-.RAL .'.',PPEA (bA.M4 DA'f! 0,2 @IEART RATE 116 HL5piRATIUN5 PE2R MINUT@- 36 @IODY TP-tiPERAIURE C 38eti N05@- WARM ANU DRY PHY51CAL9 NtUKOLOGICALt & BE@IAVIORAL SIGN5 OTtIERW15E NORMAL 5 2 HEART RATE 114 BLAIS/MillUTE 0 0 5 PER MINUTE 36 t NOSE COOL ANU OKY rn PHY51CAL9 NhUROLOGICAt-i fr I)@HAVIORAL SIGNS OTHERWI!IE NORMAL. 7 co !)OLUTION HYUIZOCHLORIC ACID 001 Ng 05 "IITH DI$TL@LED WATLIA NEUROLOGICAL EXAMINATION OF CATS P.41'5ICAL A14t) oB5ERVATIONS Oo DU.5E VIT o I (I CAT N AND SEX MG, K Go HOUR5 6 F 16 HEART 2 KATE 120 BLAIS/MINUIE -'LONS P HL5PIRAV ER f,@tIMUlt 60 NOSE COOL APIU 14 ".'j IT P14YSICAL-9 14LUtiCLOCili@.AL., 5LilAIJIURAL SIGNC. OTHERvj!SE NORMAL IIT RATL 150 BtATc/14114UTE ?45 @il:A Hi-BPIRt-IJUNS PER MIN 42 660Y TEMPLRAlUkE C 3'906 2 PHYSICAL* NEUROLOGICAL9 BE@IAVIORAL 5lGt45 t4ORf4AL 3 FILART RATE 13Z BLAISEMINUTE HLBPIRATIONS PER MINUTE. 60 PHYSICAL9 NLUROLUGICAL9 6 BEHAVIORAL SIGNS NORMAL 505 HEART RATE 132 B@-AIS/MI14UTE HLBPIRAIIONS PER MINUTL 54 PHYSICALI NLUROLOGICALV 6 BEHAVIORAL SIGNS NORMAL 27 HEART RATE 162 BEATS/MINUTE HL-'5PIRAIJONS PER MINUTE 40 tiOL)Y TEMPERATURE C 3oo6 CO co PHY$ICAL9 NEUROLOGICAL9 6 BEHAVIORAL SIGNS NORMAL Cl'%§ I I r 7 nhi ... tAvi-ii.-inir-i-ii np i rA (-T i) nin s t4 t TI-I n V rT I I i Pn i.ih 1,@ R d@W* PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS IM2881 (1-\/) TIME OBSERVATIONS CAT NO* DOSE V47, AND SEX MG/KG KG. HOURS 0,0 2HEART RATE 144 BEATS/MINUTE 44 F 28 2,82 IZEI--PIRATION5 PER MI@IUTE 48 13ODY TEMPERATURE C 38vO CAL@I OR, GENERAL APPEARANCEs AND RONDITION t4O!',IMA@ 2 LAEHAVI NFT)ROLOGICAL TESTS NORMAL PRE-DOSE (SAME DAY) 0110 AT END OF DOSING PT)PILS DILATED + LMESIS EXTENSION OF HINO LIMBS 2 ONT LIMBI EXTENSION OF FR 0003 TEST5 NORMAL KNEE JERK NOT TESIED 001 HEART RATE 144 BEATS/MINUTE RESPIRATIONS PER MINUTE 48 'U 2 BOD'T TEMPERATURE C 38*7 RFnt)CED ANAL TENSION rn PHYSICAL SIGNS OTHERWISE NORMAL > N NOT DONE 0NEUROLOGICAL EXAMINATIO SUSPENSION METHYLCELLULOS@ 0*5% PHYSICAL A140 NEUK'OLOGICA'I- @G.XAMINATION Of CATS !-V) CA) NO* DOSE WT TIME OBSERVATIONS AND SEX 14(3/KG KG,, tiolifis 4/i F 28 0 5 HEART RATL 120 Bte2Nistmi(iUTE RLSPIRAFIONS PER 14it4UTE 84 BODY TEMPERAIUKE C 3601 NO!)E COOL AND 1401 bl REDUCED ANAL TENSION 2 P@IYSICALI; Nti)R(JI-OGICALs BE,'-IAVIQF,'AL 3TL;Ervfsr@ HEART RA-OL 114 BLA1511-11liUlE KESPIRA(ION5 PER MINLITE 108 2MODY 'TEMi'LRA'[UkE C 3994 140.@iE WARM AND MUI!)I' REDUCED ANAL TENSION PHYSICALs NtUkOLOGICALt OEHAVIORAL SIGNS OTHERW15E NORMAL 2 2 HEART RATE 120 BLAT51M2INUTE NEBPIRAIIONS PER MINUTL 120 UUUY TEMPERAFURE C 39t2 NOSE WAR14 AND MOIST REDUCED ANAL TENSION PHY51CAL,o T%'EUROLO7GICALI BtiHAVIORAL SIGNS OTHERW15E NORMAL @BUSPENSION METHYLCELLU@OSE 095% 04 11 "3,.Iblmoim OF CATS -NEUROLOGICAL exAMINATION PHYSICAL AND 4*2881 (I-V) 2 U85ERVATIONS CAT NOo DO!)E WTO TIME ND 5 HOURS A EX MG/KG KG,, 44 P 2 EJ 3*3 ti,'-.ART RATE L26 SLAI$/MINUTE H@t-.SPIRA'IIONS FLR MIMU'%E 824 t!'.)L)'( TEM@)Ei4A'FUR.@; C 31),?o e).40roPHOBIA Ni.)5E WARM AND MOIST REDUCED A14AL I'E rl'-; IO 14 - 2 @HYbl-'AL* t4tU.ROLCCil.CA' 6 I @P.V I (ii.-AL -i KNEE JLRK NO[ TLSILD 4 o -4 HEARI'RATE'144 BEA15/MINUTE 2 IqEbPIRA'tICN5 PER IMINUTE 78 BODY TLMPLRATURE C 38o4 NTOUCED ANAL JENSION N05E COOL AND MU151 ULHAVIOR AND APPLARAN(-E OliiE2RWIbE NPKMAL NEUROLOGICAL TESTS NORMAL KNEL JERK Nu] TT$TED 25 HEART RATF..130 BtAiS/Mit4VTE ro PIRARIONS PER MINUT 81@ 2 OODY TEMPLPATURE 'C BEHAV IORT GENERAL@AIJPEARANCK, ANDCUND NEURoLoGirAL', TEbl!i@ .@KNEE JERK,.Nt)l TIE5TE4 0 AL AND NEUROLOGICAL LXAMI' PHYSIC i4ATION OF CAIS a 9 -.2 (I-V) CA'I' NOo I)OBE WTo TIME UbbERVAfTONS A14D SEX M (J i'K Ci KG* HO IJ P 2 0 32 M 18 ,7 HEART RATT 162 @,'C5PIRATlUr4S PE'rl tlil'4klTt 48 UOUY TEM;zEk@A'iUi@E C 3Ho5 --@lf;4V'A'OR9 GENERA'&. APP@-.&.'@ANC2Vi Ar4O CONDITION 140i,",IAL Mc t);. Nr 1, PER Mli4UTE 78 @"ODY TEMPERATQRF C 38a3 PHYSICALI t4LUIlOLO(.Icpt-q 6 2 Oc5 tIE:'"'HT RATE 1411 BLAISO'MINUTE RESPIRA'IIONS PER MINUTE 48 tiODY TEMPERAFURE C 38*5 PHY51CALs NEUROLOGICAL9 BEHAVIORAL SIGNS NORMAL 2 1,00 HEART RATE 162 BtAls/mINOTE > HL5VlRATIONS PER MINUTE 66 rn tiODY TEMPFRATURE C 3808 PHYSICAL9 NLLJROLO(il8(-Ai-9 13EHAVIORAL SIGNS NORMAL 5USPENSION METtlYI.CELLIJL05E 095% PHYSICAL AND NEUROLOGICAL EXAMINATION Of CATS 40@2-8979 02 (I-V? E CAT r4oo D05E WTo T 114 A14D SEX M'QIKG KGf. HOURS 32 M 2 9 0 HEART 2RATE 138 BEATS.,414INUTE l@'L-@-:)PIRATION5 PF.-% i'@'%IN@JTE 54 BOD'E TEMPLRAIURF- C 3805 E %I'- P'2ll Y 5 I I-- A L 9NEUROLri(i@F-@'.,,IL9 OEHAVIORAL SIG,'IS OTHER@115E T-IORMAL 3,8 H@-ART RATE L6Z 6LATS."(AINk)TE BOVY @EMPERAIURC: C 38o2O 14ASAL CONGEblION Ni,-'VIKOLOGICA@.v BL@i.kVIORAL R-ICNS OTHrR,,@?bE tlOR(-IAL 5,5 HF-ART RATL.150 BLAT2S/PIINUTE 46 KE5PlRA(IONS PER MINUTL HODY TEMPERAIURE C 37*9 ULHAVIORV GLNERAL APPkARANCEv AND C(NDITION 2 NOKMAL NEUROLOGICAL T-CBTS NORMAL 2894 H@-A.RT RATL 156 BLAIS/MINUT@ i@ESPIRAlION5 PER MINUI'L tOg BODY TEMP6ERATURE C 3894 PHv,SICAL9 NtUt@,r)'.C)GIICALl O@HAVIORAL 5IGNS NORMAI. U '@-@PENSION Mt-.7HYLCLLLUI-05E 0*5% CATS AL ANL) NEUROLOGICAL EXAMINATJON OF PHYSIC iw-034 (I-V) obbL-RVA-11OM5 2 TIME CAT NO, D05E WT* AND 5EX MG/KG KGo HOURS 'I 5,@ f-I I li u T E 0,0 tiLAPT RAIL 150 i-3@A 39 F I 0 3 I RATI2ON5 PER MINUTE 42 RESPI ;:MI-JLRAIUkf-- 38o2 MODY T- LOBICAL NORMAL N2F@)RO CALI,'I MAL L%L-HP.VlJR-p GENERAL APIU CONDITION NOR i)FZL-1)0.5t (,5Ai,4E t,,AY) tiLAP,'f RATF- 130 EILA15/14iiiUTi@' ER MI@itiTE 42 HESPIRATIONS P C 2 kio!)Y TE@IPLHAIUR' 3tlo4 PHYSICAL9 NLUKOI.OGICALI BEIIAVIORAL 51(jNS tiORMAL 0 93 HLART RATE 144 BE-ATS/MINUTE REBPIRATIONS PER MINUTE 42 k3ODY TEMPERATURE C 38*q PHY51CAI-9 NHUROLOGICALT 4BEHAVIORAL SIGNS NORMAL @IEAIZT RATE 138 BLAT5/@1114LITE ON5 PER MINUTT 36 HF-5PIRAII tiol)Y TEMPERATURE C 38*3 PHYSICALT NEUROLO(ilCALI 6OEHAY;ORA@ SIGN$ MORMA@ 7 BOLUTION D15TIl-LED WA'F@R lip PHV%SICAL AND NEUROLOGICAL EXAMLNAIJON OF ('ATS CAT Noe DobE WTo TIME 085ERVAIJONS AND SEX MG/KG KGo HOUR5 t 2 39 F HLART RAT@: 144 BLAIS@tilNUTE RE,5PIR@%Tl(t4S P-:-:R MINL)IL 42 BODY TEMPI@ilAiUR" C a$ci i'HY5!C,'ALf, NLUF.6LQ-..@,@&CAL,, & BEtIAVI',)fIAL SIGNS NIJF,'@iAL 4,,O F@ATE 150 r@4LAISit4iiiU'grE I i'A'f 'I 0 @l 5 P ER (Oili'l TL .36 2 ')Y fEe@iPLRAIUPE C 36o3 bU. 'I"AL N',, PHYSICAL9 N;TUROLOGICALT, 6 t3L- I-JAV IO r4ot- Mkt 2 I 1) El; HEART RAIL 150 BLATS/MliiUTF- l@E.-OPIRAfIO(45 PER M[flUTE 40 LIODY TEMPLRAIURE C 38aO PHYSICALP fiEUKOLUGLCALs BEHAVIURAL SIGNS NORMAL 2 BOLUTION t.@@JTILLED WA'I-CR PHY51CAL AND NEUROLOGICAL txAMINAT40N OF CATS I-VI BBERVATION$ CAT PIC* DOSE T TIME u AN.;) SIL-X MG/KG KGo HOLJRS 32 M 16 3*6 000 HLAR'f' RATL lb2 BLAiS.,'l",ill,4UT@- 4@-5P!RAVION5 Ptft @1,414UTh 84 YEI-IPLF"A;'URE C#i@;Z 1@!A'k lrio P.LLAXLI) $:i2.'.OL A.NO 14(jl.5T ACT !'\!Z FRIENDLY f3E@IAV l')R 9 C-ENERAL t.N: -)!\Ii; i NEIJROLOGICAL. lEb-15 NORMAL PRE-005E JSAME UAY) 000 AT ENV) Of; DUbIN(3 CLOt4lC CONVULSION FOR 10+SECONDS PRUSTRAIL - CUULD NUT STAND NICIIIATING MEMBRANE RELAXED PUPIL DIAMEILK NORMAL 2 0*01 PROSTRATE - COULD NOT STAND > EYES FOLLOW -SIGHTED OBJECT rn C(JNVUL51ON5 HAVE ENDED 0903 NUSIE WARM ANO'DitY TREMORS9 HIND LtG5 cr OIHER TE5T$ NOT DONE AT TH14 TIME. HYSICAL AND NEUROLOGICAL EXAMINATION OF CATS p *05036 I CAT NO. DOBE OBSERVATIONS WT-D TIME AND SEX MG/KIZ KGO HOURS (i 2 0 BLAIS/1411@UTL 3 2 f-I HEART RATE 15 l@EbFIRATIONS PER MINUTE 54 UUDY TE@IPLRATU[IE C 36o3 NICTITATING MEMERANE RELAXED NU!,E WARM AMU VRY CAI-M VA 1 E U i@LUROLOGis@-Al- 1\,ORt,iAL F 2 BLHAVICR ANU APPLAtiANCL - Olili-K,@49 0 5 HEA14T RATE 144 BEA15/@IINLJTE kEbPIRA[IONS PER MINUTE 3B BOT)Y TEtiPERAtURE C 3092 2 NICTITATING 14'C-MtigANF. RELAXED NOSE WARM AMU DRY PHYSICALs NhUROLOGICALt & DEHAVIORAL SIGNS OTHERWISE NORMAL 1,2 HEART RATE 14q BEAIS/MINUTE 2 REBPIRAIJONS P@-R MINUTE 24 BODY TEMPERATURE C 3f34oQ NICTITATING MEMBRANE R@LAXED +++ NOSE WARM AND M015T PHYSICAL9 NEUROLOGICAL, & BEHAVIORAL SIGNS OTHERWISE NORMAL PHYSICAL ANP NEURD@L-OGICAI. LXAMINATION OF CATS 5036 CAT N09 D05E WTO TIME ()B5ERVAfION5 AND 5EX MG,KG KGo HOURS 3 2 M -16a HEART RATE 144 (iLAT"-iMI14UTE 2 E 5 P I t;', A I I 'LINS PEft MINUit- 72 C) ,) Y Y 7c-. M @'t N A I U k i--' @. 3 1 f, b NICTITATING HLIIL4KANE RE@-AX@ID l@4UbE tvAK(,ti AN!) t4UI'-.@F PHYSICAL9 NEUkOLLLi]CAL9 i& [iL'l.4VIOF%-AL S!U; HEART RATE 144 BLAISOMliiufL RESPIRAtION5 PER MINOTT 60 UUDY TEMPERAIURE C 38oU NICTITATING MkMbR.AN@- HLLAXF-0 NOSE WARM ANO ML)Ibf t)HY 5 1 CAL tNLukoLLGIC-Att 6 8@@IAVIORAL 51(iNS OTIIERWISE NOIlPiAL 2608 HEART RATE 156 BhAI5/MINUTE KLSPIRATIOPIS PER flilNUT@- 70 BODY TEMPERATURE C 38o4 2 Ix NICTITATING MEM8RAN@ MURMAL NOSE COOL ANU MUIST rn PHY51CALt NLUROLOOLCAL* 6 8EHAVIO0RAL SIGNS NORMAL oc 5OLUTIQN D14TILLED WATER UROLOGICAL EXAMINAT40N OF CATS PHYSICAL AND NE op!iO49 I CAT t@109 DOSE WT* TIME OBSERVATIONS At,D SEX MG/KG KG* HOURS 64 F 14 3,85 o;,o HEAF'T RAIL IOZ BtAT51-';,Illl(JTE KE5PIRATIONS PLR MINJT@. 48 BOL)'T TEMPLR.AFUKE C 70tial (.ALI-I 8EHA'kIIOFo CT:NEIIAL 2Ail[-It-.i-'HAIICE;,. ANL) C(iliDlItON MOR@IAL tif--' ')i4i3LOG I C.AL TE@iT.5 N(JRVIAL FRF--Do5L (SAME U Y o 3 fiEARI IZAT2L 14't f3t.AIS/P'-114UTE kE5PlRATIONS PER MINUT@ 60 t3ODY 'TEMPERATURE C 39ol BREATHING DELP ANU LABURED 2 IIIAL PHYSICALT NEUROL(1(3liCAL* L- BL@liAVIOtAL OTil-r-t@@115E NOR Igo HEART RAIL 156 BtATS/Mli@iUTE vL5PIRAJIUNS PER MINUTE 72 3 HUUY TEMPERATURE C 4UoZ BREATHING DEEP ANU LABORED PHYSICALT NEUROLOGICAtv & BEHAVIORAL $IGNS OTHERWISE NORMAL bUbPENSION METHYLC@T-LULOSE OASS PHY51CAL AND NEUROLOGICAL EXAMINATION OF CATS 005049 (I-V) CAT NOo D05E WTo TIME ObbERVATIONS AND SEX MG/KG KG* HOURS 4 F 14 li@ART RATE 120 SEATSII)IINUTE 2 2 KE5PIRATIONS PER MINUTE 60 MOVY TEMPERATURE C 39o5 kiREATHIN(i DEE13 AND LABORED HEAR-@8EAF WEAK PHYSICALs NLUROLO(ilf-ALl2 6 BE!iAVIOt-%AL SIGNS OTIIEReilSE NORt-IA'- @IIEAP.T RAT4 120 Bf.ATSi@iloliUTE I,'ESPIRATIONSIPER MINUTE 66 BODY TEMi)LRATUtZE C 39oO 2 BREAlHl?4G DELP ANU LABORED b'-@HAVIOR ANU APPEARANCE - Ol'!:4r.-RWILL NLUKOLOGICAL TESTS NORMAL 418 HEART RATE 156 BtATS/MINUTE RE5PIRATION$ PER MINUTE 66 2 UODY TEMPERAIURE C 38o7 BREATHING DEEP AND LAHORED+ PHYSICALT NEUROLUGICALT & BLVIAVIORAL SIGNS OTIJERWISE NORMAL ri 2 25 HEART RATE 150 BEA75/MINUTE RESPIRATIONS PER MItlUTL 40 BODY TEMPERATURE C 3098 BEHAVIORT GENERAL APPEAF?ANCE9 ANU.CUNDITION -:NOt'.MAL 4 NEUROLOGICAL TESTS NORMAL !iU"41)F-IISIOF-4 @iETIIYLk'.r-_L.LLILO""E 0,,, 5 94 PHYSICAL AND NEUROLOGICAL EXAMlt4ATION OF CATS 1049 02 CAT NOu DOSE WT* TIME OBSERVAT.IONS At4D !)EX MG/KG KGo HOURS 39 F 18 3006 000 HLAKT RAIL' 156 ULA-i5lt4l@IU'k'@- 'K'E:@PIRAIIO@15 PEP MINU'i@f- C 3Lc.'i CALI-I 2 A@'P@.#"RAN'ki t@@fid C014DIlION NO@'%M;kL, f 4t,,'k L. 0;-j 1 '4'- AI --j @i A L 2 HEA,- L A'FTJRE C@ 341LPQ"@@2@lli .... TEMP P, -.@:i NOSE COOL;.AND,.MC RA lhf MP' FI'LOI n-S 0 THYLE, PHYSICAL ANO NEUROLOGICAL EXAMINATION OF CATS 1051049 #Z (1-Y) CAT NOD D05E WT* TIME 065ERVATION5 AND 5EX MG/KG KGo HOURS 66 F -1692 lo'17 090 HEART RATE 156 B@.AIS/MltiUTE H2@BPIRATIONS PER MlNtJIL Si tiovy TEMPhliATUR9. C 39o2 ACTIVE + ilLH#'%VIOR9 GENERAL A@ii) fil-U@,ILUGICALI 2 PF.'E-,L)05E (SAM@- IJAY) 062 I'EAR'F RATE 1414 BLAI'5/inti@4L)Tti HL5t)IRATIONS PER MltlUlh 90 BODY TEMP@-FIAI'WPE C 39eU 2 NOSE COOL ANO MU151 BLOATED CALM PkiYbICALt NLIJROLOGICALT & H@liAVIORAL SlGt4S OT@IERWISE NORMAL 0*6 HEART NAlk 156 BEAFS/MlliUTE 2 PE5PIRA'IION5 PER MINUTE 72 UODY TEMPERATURE C 3992 NOSE COOL ANU DRY 5EL)ATEU CALM PHY51CAL* NEUROI-OGICALT liEliAVIORAL6 SIGNS OTH@RW15E NORMAL Ill rirt: n. c; ot ICAL EXAMINATION OF CATS PHYSICAL AND NEUROLOG 51049 #2 UBSERVATIONS CAT NO* DOSE WT- TIME AND 5EX MG/KG KGo HOURS HEART RA T L1526 BEAIS/MINIJTE 66 F HEbPIRAi!UNS PER Mir4tiTE '12 OODY .-IEMPERATURE C 39o8 NOSE COOL AND DRY CALM -LRMAL 2 ALs t4t:tJROI 0(ilCALt 6 BEHAVIURAI- SIGN:S OT14ERWISE rI PHYSIC 2,,O HLAR! RATE IK@6 BLATSIMINUTE HL5plf4AFION5 PER MINUTE 5 4 HODY T@.i%iPERAlUt'E C 39o4 NOSE COOL AND MOI$T SEVATEU CALM PHYSICAL* NLUROLUGICALT 6 BEHAVIORAL SIGNS OTHEKW15L NORMAL 3*8 HEARI RATE 156 BLATS/MINUTE RES2PIRATIONS PER MINUTE 66 BODY TEMPERATURE C 3 PHOTOPHOBIA ACTIVE PHYSICALT NEOROLO(ilCAI-9 6 13EHAVIORAL SIGNS OTHERWISE NORMAL $VSPEN51ON MLYHYLCE@LULOSE 0*5% PHY51CAL AND NEUROLOGICAL EXAMINATION OF CAT5 0051049 CAT NOo DC!)E WT* TIME UbbERVATIONS AND SEX MG/KG KG@ HOUR5 66 F -1692 543 @fLARi RATE 156 BEAT5/MINUTE i4tiSPIRATION5 PER MINUTE 66 UUUY T=.tiPLRA!Ut?E C 38o9 PHOTOPHOUIA ACTIVE PiiYSICAL9 NEUkOLOGICALo 6 bt@kfAVIL)RAL 51GI43 OTtiEKWISE NORMAI- 2 22v7 HEAR5 RATE 150 BEA]5/MINUTE @,@E5plRATIONS P@R MINUTE 66 8UVv TEMPLRAlUkE C 39pit ACilVE NO PliOtOPHOBIA 9 PHYSICAL9 NEUROLOGICAL9 4 Bfr-HAVIORAL 5IGNS OTHERW;SE NORMAL BUSPENSION METHYLCELLULO$E 095% NEU14OLOGICAL EXAMINATION Of CATS PHY$ICAL AND 51139 U65F-RVATIONS CAT N09 DOSE VJTO' TIME AND SEX MG/KG KG* HOURS 55 F 34 2*00 040 HEART RA-TE 162 BLA'i'.i/Ml(4UTE RESPIRATIONS PER MINUTE 24 tiOUY TEMIJERAVURE '-'- 38oO P4obE COOL ANU MC)141-;T CALM BEHAVIORT GENERAL A@IIIF-ARANctg AND CONDITION NONP..AL NEURCLOGICAL,YL-bTb NC"WMAL OZ.E CSAIIL I)A'fl PRTF-D 04,2 HEART RATL 12(i Lii--ATS/Mli4k)TE 2 HLBPIRATIOMS PER MINUT@ 6 IJODY TEMPERAIQRE C 38*5 NOSE WARM AND DRY PERIPHERAL b4NSikTION NUT TESTE@D PHYSICAL9 N@UROLUBICAI-I 6 BEHAVIORAL SIGNS OTHFHWI2SE NORMAL 005 HEART RATE 126 BLATS/MINUTE RESPIRATIONS @ER MINUTH 30 tiOVY TEMPLRAITJKE C 3895 NOSE WARM ANU MUIST PHYSICAL9 NLVROLUGI"@'-ALt 6 B@-HAVIORAL SIG143 OTHERW15E NORMAL PEN!510N METHYLCELLULOSE 095% bus PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS #1 (I-V) CAT NO* DOSIE WT* TIME OBSERVATIONS D SEX MG/KG KG* HOURS AN 55 F 3 4 1 0 HEARL RATE L38 BKA]SIMINL)TE 2 RI@@5P!RATIONS PEI@ filNUTE 30 i,400Y TEMPLKArtUR:,@-; C 39oO NOSE R-OOL AMU MU151 Ni@IUROI-OGICAL9 6E.4AVIOPAL SIGNS OtHERWT.5- NL'Ri%iAL 2,0 kiL-ARI RATE 1'30 54 HESPIRAFIONS"PEIZ VIINUTE tiolly '[EIAPLRA(URE C 39o4 2 .114USE WARM AND OkY PHYSICAL* NEUPOLOGICAL9 ULHAVIORAL SIGNS OTHERWISE NORMAL 3,5 HEAR'F RATE 136 BhAIS/MINUTF- HLBPIRA]IONSIVER MINUTE 42 2 BUUY TEMPERATURE C 3894 N05L COUL ANU MULST PHYSICALT N@UROLUGICALL BEHAVIORAL SIGNS OTHEROISE NORMAL rn 5 btJSPENSION -IMETHYLCELLULOSE 095% PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS #1 (I-V) CAT NO* DOSE WT* TIME OBSERVATIONS AND SEX MG/KG KG* HOURS 55 F 34 5,0 HEART RATE 138 BEATS/MINUTE RESPIRATIONS PER MINUTE 36 2 BODY TEMPERATURE C 38o3, NOSE WARM AND DI?Y PHYSICALI NLUROLUGICALI BEHAVIORAL SIGNS OTHERWISE NORMAL 24*2 HEART RATE 138 BLATS/MINUTE RE5PIRATIONS PER MINUTE 36 7tiou RAIURE C 38al Y TEMPE PHYSICAL9 NEUROLOGICALI BEHAVIORAL SIGNS NORMAL 5USPENSION METHYLCELLULOSF. 0-o5% Walt PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS -1139 #2 (I-V) CAT NOo D05E WTo TIML OBSERVATION$ AND SEX MG/KG KG* HOURS 55 F 2991 2oO6 0.0 HEART RATE 162 BEATS/MINUTE. 2 RESPIRAIJUNS PER T-IINUTE 42 BODY TEMPERATURE C 3893 NOSE COOL AMU MOIST CALM BEHAVlOH9 GENERAL APPEARANCE9 AMU CONDITION NORMAL NEUROLOGICAL TESTS 2 NORMAL PRE-DO5E (iiAME DAY) 0*2 HEART RATE t5O BEATS/MINUTE kE5PIRAlIONt PER MINUT4 36 BODY TEMPERATURE C 3894- N05F, WARM AND DRY 2 PHYSICALT NLUROLOGICAL9 BEHAVIORAL SIGNS OTHERW15E NORMAL 0*6 HEART RATE 108 BLATS/MINUTE RESPIRATIONS PER MINUTE 48 BODY TEMPERAFURE C 38o2 NOSE WARM AMU DRY 2 PHYSICAL9 NEUROLOGICALI 4 OKHAVIONAL SIGNS OTHERWISE NORMAL 141 HEART RATE 120 BEAIS/MI14UTE RESPIRATIONS PER MINUTE 42 BODY TEMPERAIURE C 38*4 NOSE WARM AMU DRY 7 PHYSICAL* HEUROLOGICALI 4 BEHAVIORAL SIGNS OTHERWISE NORMAL 4@i 101097PLIC T flhi L MCTWVI rt;i I III nCL -f e4 PHYSICAL AND NEUROLOGICAL EXAMINATION OF %@-ATS 4MI13,p #2 (I-V) DOSE 6T,, TIME OBSERVATIONS CAT NO* AND SEX MG/KG KG* HOURS 2 0 HEART RAT 55 F 2991 20 E 156 BEATS/MINUTE RESPIRATIONS PER MINUTE 42 BUOY E *4 TEMPERATUR' C 38 NOSE COOL AND MOIST 2 PHY51CAL9 ALUROLOGICALI 4 BEHAVIORAL SIGNS OTHERWISE NORMAL 308 HEART RATE 144 BEATS/MINUTE RESPIRATION2 PER MINUTE 30 -199 2 LIODY TEMPER.TURE C 3 NOSE COOL AND DRY PHYSICALs AEOROLOGICALI BEHAVIORAL SIGNS OTHERWISE NORMAL 5,3 HEART RAIL P56 BLATS/MINUTE RESPIRATION4 P2ER MINUTT 48 UODY TEMPERAFURE C 38ol NOSE COOL AND MOIST pHysicAL9 NILUROLOGICALI 13EHAVIORAL SIGNS NORMAL 22*7 HEART RATE lt"!)O BLAT2S/Mlt4UTE NE5PIRATION@ PER MINU'TT 42 BUOY TEMPERAIURE C 38o5 NOSE COOL AND MOIST PHYSICAL* N@hUROLO(-31CALI BEHAVIORAL SIGNS OTHERW2ISE NORMAL BUSPENSION -iMETHYLCELLW@Q$@ PHY51CAL AND NEUROLOGICAL EXAMINATION OF CATS 113* #2 (I-V) CAT NO* DOSE WTp TIME OBSERVATIONS AND SEX MG/KG KGo HCUR5 64 F 17 3. 44 0,0 HEART RAIE @l!)6 BEATS/MINUTE HESPIRAIJON5 PER MINUTE 48 BODY TEMPERATURE C 3Uo4 CALM' BEHAVIOR* GENERAL APPEARANCE9 AND C014DITION NORMAL NEUROLOGICAL lEbT5 NORMAL PRE-DOSE (SAME UAY) 2 0,2 HEART RA14,144 BEATS/MINUTE RESPIRATIO PER MINUTE 48 BODY TEMPERATURE C 38.9 P@iY§ICAL* NEUROLOGICALI & BEHAVIORAL SIGNS NORMAL 005 HEARI RAIL'132 BLATS/MINUTE 2 RE5PIRATIONS PER MINUTE 80 BODY TEMPERAIURE C 39oO PHYSICALT NLUROLOGICALT BEHAVIORAL SIGNS NORMAL 0,9 HEART RATE@144 BLA'15/MINUTE RESPIRATIONS PER MINU8TE 78 BODY TEMPERAIURE C 38o8 PHYSICALVINEUROLOGICALI BEHAVIORAL 5116GNS NORMAL bU5PENSIONi-@, METtlY@CEL@UL05E 0*5% T)HYSICAL AND NEU14OL061CAL tXAMItIATION OF CA75 51139 #2 (1-Y) 40 CAT NCO 005E i@T TIME 085ERVATIONS AND -QEX MG/KG KG* HOURS 64 F 17 2,tO MLART RATE 144 2 BEA'[S/MICiUTE @?LbPIRA'FIONS IIER MINUTE 72 UODY TEMPERAIURE C 39*0 PHYSICAL'I NEUKOLOGILAL9 BEHAVIORAL SIGNS NORMAL 3,5 @IEART.RA7t 2 126 BLAIS/MINUTE KEbPIRATION6 PER MINUTE 42 BUOY'TEMPERAIURE C 38.8 PHYSICALs NEUROLUGICAL* & BEHAVIORAL SIGNS NORMAL 5,0 HEART RAIL i32 BEAIS/MINUTE 2 RESPIRAIION,@ PER MINUTT 54 TJODY TEMPERA'IURE C 39*2 PHY51CALt NEUROLUCilCAI-9 & BEHAVIORAL SIGNS NORMAL 24*Z HEART RATE 20 BLATS/MINUTE H1E-SPIRAlION6 PER MINUTT 60 tiouy TEMPLRhfURE C 38-1 PP.YSICA4'..g NLURULOGI(-ALT 4 BEHAVIORAL SIGNS NORMAL bU5PENSION METtiYLCELLULOSE 09596 PHYSICAL AND NEUROLOGICAL EXAMINAI'ION OF CATS 41-V) CAT NO* 00!)E WT* TIME OBSERVATIONS AND 5EX MG/KG KGo HOTJRS 39 F La 3o25 000 HEART RAT@- 144 BLATS/MINUTE SPIRAIIUN§ PER MINUTE 36 HE MODY TEMPERAI'URE C3890 CALM tJLHAVI(Ro 4t-.NERAL APPEARANCE9 ATID CONDITION NORMAL NEUROLOGICAL TE52TS NORMAL PRE-DOSE (SAME OAY) 0,0 Al END CF bOb I N(,s EXCLSS SALIVATION FLEXOR REFCLX AUSENT9 ONE HIND FOOT EXTENSOR TIJRUST REFLEXES ABSEN2T9 HIND LIMBS KNEE JERK NO'l TESTED LEGS MOVE WITH DIFFICULTY HIND OTHER NEUROL061LAL. l@-515 NORMAL OTHER TESTS NOT DONE Al THIS TIME 0903 P3UPIL DIAMilER NORMAL EMESIS LXCE55 SALIVATION SUSPENSION METHY@CELLVLOS' 095% PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS IM5124 (I-V) CAT NCe D05E WTo TIME UB5ERVA]ION5 MG/KG KG* HOURS AND SEX 39 F 18 094 HEART RATE 144 BEATS/MINUTE RESPIRATIONS PER MINUTE 60 BOUY TEMPERATURE C,37*8 NOSE COOL AND MOIST EXCESS SALIVATION LOW GROWLING SLDATEU FLEXOR REFUEX AB5LNT9 ONE HIND FOOT 2 EXTENSOR TANUST REFLEX WEAK OTHER NEURULOGICAI- IESTS NOliMAL BEHAVIOR AND APPEARANCE OIHERWISE NORMAL 'RATE @50 BEATS/MINUTE 0 HEART NESPIRATTUN$ PER MINUTE 48 2 BODY TEMPERAIURE C 3798 NOSE WARM AND DRY BTHAVIOH AND APPEARANCE OTHERW15E PORMA4 NEUROLOGICAL TESIS NORMAL HEART RATE 162 BEATS/MINUTE 29 3 2 RESPIRATIONS PER MINUTE 30 BODY TEMPERATURE C 37o9 NOSE COOL AND M0151' PHYSICALs NEUROLOGICAL* 6 BEHAVIORAL SIGNS OTHERWISE NORMAL SUSPENSIO5N METHYLCLLLULO$G 095% PHYSICAL ANV NEUROLOGICAL EXAMINATION OF CATS IM5124 (I-V) CAT NOo 00!iE WT9 TIME U85ERVATIO@S AND 5EX MG/KG KGo HOURS 39 F 18 500 HEART RATE 126 BLATS/Mlf4UTE 2 RESPIRATIONS PLR MINUTE iO tiL)DY TEMPEAAIURE C 3893 PHYSICALT NLUROLOGICAL9 BL@IAVIORAL SIGNS NORMAL HEART RATE?162 BLAIS/MINUTE 2lo2 2 IRATlOt4S PER MINUTE 36 HE5P UOVY TEMPERALURE C 3198 PHYSICAL9 NEUKOLOGICAL9 BEHAVIORAL SIGNS NORMAL !)USPENSION@- METHYLCLLLULOSE O95Y6 PHYSICAL AND NEUROLOGICAL EXAMINATION OF CAIS qW5l29 (I-V) CAT MOO D05E WTo TIME OBSERVATIONS AND SEX MG/KG KG* HOURS HEARI RATE 138 BEATS/MINUTE 39 F 490 3945 ogo HESP2IRAIIONS PER MINUTE 32 800Y TEMPERAIORE C 37o9 N05E COOL AND MOIST CALM BEHAVIOR* @LNERAL APP@ARANCE9 AND CONDITION NORMAL NEUROLOGICAL lEbTS NORMAL 2 PRE-DO5E (SAME bAY) E144 BLATS/MINUTE 0*2 HEART RAT RE5PlRATIONS PER MINUTE 48 ODY TEMPERALURE C 38*2 NOSC WARM AND2 DRY VIORAL SIGNS OTHERW15E NORMAL PHY51CALt NEUROLUGICALT OLHA 097 HEAR)- RATE iO8 BLAIS/MINUTE RESPIRATIONS PER MINUTE 78 BODY TEMPERAT8URE C 3893 NOSE WARM AND DRY PHYSICAL9 NTUROLOGICALI BI:HAVIORAL SIGNS OTHERWISE NORMAL bULU71ON DlbTIL@LD WATER Nil @'p. XAMINA14ON OF CATS PHYSICAL AND NEUROLOGICAL E 5129 1 1 CAT 005ERVATION5 NO* Do5E WTo TIME AND SEX MG/KG KG* 2HOURS lo4 HEART RATE 13z BLAISIMINUTE 39 F 4*0 RESPIRATIONS PER MINUTT 60 BODY TEMPERATUKE C 3UQ4 t4obE COOL AND MOIST PHY51CAL* NEUROL-OGICALL & BEHAVIORAL SIGNS OTtiENW15E NORMAL 297 HEART RATE 132 BLATS/MIMUTE HE5PIRATIONb PER MINUTE 48 BODY TEMPLRI%IUKE C'31J*Z 'PHYSICAL9 NLUROLOGI2CALT & BEHAVIORAL SIGNS NORMAL 4o7 HEART RATE 138 BLATS/MINUTE RESPIRAIION$ PER MINUTE 54 BODY TEMPERAIURE C 38ol AL SIGNS NORMAL PHYSICALT NLUROLUGICALI & BEHAVIOR 22794 HEART RATE @32 BLAT5/MIMUTE KE5PIRAlION6 PER MINUTT 54 tiody TEMPERATURE C 37*9 PHYSICALT NtUROL061CALt BEHAVIORAL SIGNS NORMAL SOLUTION P157TILLLD WATER PHY51CAL AND NEUROLOG. ICAL EXAMINATION OF CATS 5211 (I-V) CAT NO* D05E WT* TIML OBSERVATIONS AND SEX 'MG/KG KGo HOURS 32 M 18 4900 090 HEART RATE 162 BEA15/MINUTE RESPIRATIONS PER MINLJI@- 90 BUUY TEMPERATURE C 3Uv9 ACTIVE CALM BEHAVIORT 6LNLRAL APPEAkANCE9 AND CONDITION NORMAL NEUROLOGICA2L TESTS NORMAL PRE-DO5E (5AME OAY) 002 HEART RATE 162 BEAT5/MINUTE RESPIRAtION6 PER MINUTE 42 BODY TEMPLRA'FURE C 38oS MOTOR ACTIVIIY UECREASED + 2 PHYSICAL's NEUROLO(ilCALI 6 BEHAVIORAL $IGN5 OTHERW15E NORMAL 0*7 HEART RATE 444 BEATS/MINUTE RESPIRATION'S PER MINUT@- 4@ t3ouy TEMPER@TURE C'38.5 ACTIVE + 5 CALM PHYSICAL* NtUROLOGICALt 6 BI:HAVIOIZAL SIGNS OTHERW15E NORMAL SUSPENSION METHYLCliL@ULOSE 005% GICAL EXAMINATION OF CA15 PHYSICAL ANU NEUHOLO 5211 (I-V) 5 CAT NO. DOSE WTo TIME UBSERVATION AND 5EX MG/KG KG. @IOURS- 32 M 18 1.2 HEART RATE 150 BEA'15/MINUTE L 84 NESPIRATION5 PER MINUT tiOI)Y TEMPLRAIURE C 38.8 PHY51CAL.9 NLUROLOGICALI BEHAVIORAL SIGNS NORMAL 2 2.4 HEART RATE 132 BtATS/MINUTE RESPIRATIONS PER MtNUTt 84 UOVY TEMPLRAIURE C 38v8 -PHYSICAL !CAL9 BEHAVIORAL 5IGN5 NORMAL NEUROLOG 4.3 HEART RATE 150 2 BLAIS/MINUTE REbPIRAlION5 PER MINUTE 72 tiOL)Y TEMPERA'IURE C 3[io5 PHYSICALT NLUROLOGICAL? BEHAVIORAL 5IGN5 NORMAL 25.3 HEART RATE 156 BLATS/MINUTE 1 RESPIRATION5 PER MINUTL 48 HODY TEMPLRAIURE C 38ob PHYSICALs NtUROI-OGICAL9 4 BEHAVIORAL SIGNS NORMAL SUSPENSION METflYI-CLLLUL05E 0#5% CATS PHY51CAL AND NEUROLOGICAL EXAMINAIJON OF 4&9346-3 (I-V) T I tAE -UBSERVAIIONS CAT NO* DOSE WT* AND 5EX MG/KG KGo HOURS 52 F 5*6 2 3 000 HLARI RATE 162 BEATS/MINUTE RE5PIRATION5 PER MINUTE 36 tiOL)Y TEMPERAIURE C 3790 NOSE COOL AND MOIST CAT-M NOKMAL BE2HAVIOR9 GF-NERAL APPLARANCE@I AND CUNDIIIOM NEUROLOGICAL TE515 NCHMAL PRE-DO5L (SAME OAY) 001 HEART RATE 156 BhATS/MINUTE RESPIRATIONS PER MINUTE 36 2BODY TEMPERATURE C 3894 PHY51CALI N@UROLOGICALI BEHAVIORAL 54GNS NORMAL 095 HEART RATE 120 BEA.TS/MINUTE RESPIRATIONS PER MINUTE 39 BODY TEMPERAtUgE c 3ti95 PHOTOPHOBIA 1 PHYSICAL9 N@-UROLOGICALI BEHAVIORAL'SIGNS OTHERWISE NORMAL SUSPENSION METHYLCEILU@OSE 09594 PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS 09346-3 (I-V) U85ERVATIONS CAT N09 D05E WTo TIME AND SEX MG/KG KG* HOURS 52 F 5*6 loz HEART RATE t44 BEAIS/MIIIUTE 2 RESPIRATIONS PER t..iINU7'f- 36 UODY TEMPERATUKE C 38o3 NOBE COOL AND DRY NU PH07OPHObIA OGICAt2-9 6 BEHAVIORAL SIGNS OTHERWISE NORMAL PHY51CAL9 NEUROL 2 2 HEART RAIE 150 BLAIS/MINUTE RE5PIRATIONS PER MINUTE 36 FUKE C'38#it 2 t3ODY TEMPERA NOSE COOL AND DRY VIORAL SIGNS OTHERWISE NORMAL PHYSICAL NEUROLOGICALL BF--HA 305 HEART RATE 156 BEA!5/MINUTE 2 RESPIRATIONS PER MINUTL 36 BODY TEMPERAIURE C 3893 NOSE COOL AND DRY PHYSICAL9 NLUKOLOGICAL* BEHAVIORAL SIGNS OTHERWISE NORMAL bU5PEN51ON METHYLCLLLW@OSE 095* "'AL LXAMINATION OF CATS PHYSICAL AND NEUKOLOGI, 409346@3 (I-V) UB5ERVATIONS CAT MO# D05E WTO TIML AND SEX MG/KG KG* HOURS 52 F 5*6 52ol HEART RAIE 156 SLAT'/MINUIE RESPIRATIONS PER MINUTE 36 UODY TEMPERATURE NOSE COOL AND MOIST PHOIOPHOBIA -0 PHYSICAL9 NEUROLOGICAL* 0 BEHAVIORAL SIGNS OTHERW15E N2ORMAL 24.9 HEART RATE 168 BEAIS/MINUTE kE5PIRATIONS PER MINUTE 36 IJOUY TEMPERAIURE C 37o7 PHOTOPHO81A + NOS@ COOL AND DRY PHYSICAL* N0EUROLOGICALI 6 BEHAVIORAL SIGNS OTtIERW15E NORMAL 5USPENSION-- METHYLCELLUL05E 095% PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS 09346-21 (I-V) CAT MCe D05E Ot35ERVATION5 WT* TIME AND SEX MG/KG KG* HOURS HEART RA7E 1!@i6 BLATS/MINUTE 2 000 55 F I 8 2,t'&4 NE5PlRATION5 PER MINUTE 27 U(JDY TEMPERA'FUIZE C 3890 CALM BEHAVIORT GENERAL APP@.ARANCE4 APID CONDITION NORMAL 2 NEUROLOGICAL !ESIS NORMAL PRE-DO5E (5AME DAY) 092 HEART RATE 150 BLAT5/MINUTE NE5PIRATIONS PER MINUTE 42 URE C 38*'l 2 BOUY TEMPERAI PHY51CAL9 NLUROLOGICALI 6 BEHAVIORAL SIGNS NORMAL HLA RATE 150 BEATS/MINUTE 0*6 RT HEBPIRA'IIONS PER MINUTL 42 8ODY2 TEMPERAIURE C 389!) PHYSICALT NEUROLOGICAL* BEHAVIORAL SIGNS NORMAL I 9 0 HEART RATE 150 BEATS/MINUTE RESPIRATIONS PER MINUTE 40 BODY TEMPERATURE C 38*4 PHY51CAL9 NEUROLUGICALI BEHAVIORAL SIGN$ NORMAL SUSPENSION METHYLCkLLUL05E 095% N OF CATS PHYSICAL AND NEUROLOGICAL EXAMIPIATIO 469346-21 (I-V) OBSERVAlION5 CAT No* DOBE T TIME AND !iEX MG/KG KG* HOURS 55 F 2 200 HEART RATE 126 BLA15@MINUTE I a i4E$PIRATIONS PER MINUTE 36 TJOUY TEMPERAJUIZE 3818 PliY51CALi NEUROLOGIC-AL-I & BEHAVIORAL SIGNS NORMAI2- 3,5 HEART RATE 168 BtAJS/MINUTE RESPIRATIONS PER MINUTE 36 BODY TEMPERATURE C 3799 PHYSICAL* NEUROLOGICALI BEHAVIORAL SIGNS NORMAL 4*9 HEART RAT@-ilbO BLA15/MINUTE KEBPIRATIONS PER MINVIL 30 t3ODY'TEMPLHAIURE C 38oZ PHY51CALO NEUROLOGICALI BEHAVIORAL SIGNS NORMAL 2109 HEART RATE,144 BLAIS/MINUTE NE5PIRAT0ION5 PER MINUTE 36 BODY TEMPERATURE C 3892 PliY51CAL, NEUROLOGICALI BEHAVIORAL SIGNS NORMAL .5U5PENSION METHY@CELLU@05E 095% 9;6, PHYSICAL AND NEUROLOGICAL LXAMINAIJON OF CA15 J*9346-31 (I-V) 085ERVAIJONS CAT NO* D05E WT* TIME HOURS AND 5EX MG/KG KG* 2 la 398 000 HEART RATE 16Z BEATS,'MINUTE 64 F KE5PIRATIONS PER MINUTE 27 BODY TEMPERATURE C B6o5 CALM BEHAvioRt GENERAL APPEARANCE9 AND CONDITIO2N NORMAL NEUROLOGICAL TEBTS NORMAL PRE-DOSE (SAME L)AY) Oo2 HEART RATE 144 BtiAT5/MINUTE RE5PIRATION5 PER MINUTE 42 BODY TEMPERATURE C 39oO AV2IORAL SIGNS NORMAL PHY51CALID NLUROLOGICALI 6 BL-H MINUTE 095 HEART RATE 150 BEATS/ RE5PIRAlION5 PER MINUTE 50 BODY TEMPERATURE C 38o7 2 PHYSICAL* NEUKOLOGICALT & BEHAVIORAL SIGNS NORMAL 1,0 HEART RATE 138 BEATS/MINUTE RE5PIRATION5 PER MINUTE 40 BODY TEMPERATURE C 3890 PHYSICALI NEUROLOGICAL9 4 OF-HAVIORAL SIGNS NORMAL 7 SUSPEN51ON METHYLCLLLU@Q5@ Oo5% ATION O@ CAIS PHYSICAL AND NEUROLOGICAL tiXAMIN 09346-31 11-V'j' ob5ERIVAIIONS CAT NCe 1;05E WTO TIME HO2UR3 AND sEx @IG/KG KG,# TE 144 BtATS/M I TIUTE 2 0 HEART RA 6't F NUTT 72 R@-bPIRA'fIONS PE2R MI body IEMP@RAIURE C 39q@ AVIONAL SIGNS OTHERWISE NORtiA$%. UROLOGICAL* f, OLH PHYSICAL9 NE 2 HEART RATE 150 BLA'f5/t4lt4U'I'- 3 94 NESPIRAIJONS PER MINUT@. 70 BODY TEMPERATURE C 3899 P AND LABORED BREATHING DEE 2 E NORMAL IGNS OTHERWIS EUROLOGICAL, 6 BEHAVIORAL 5 ptiys ICALs N 4*9 2HEART RATE 150 BLA'FS/MINUTE. RESPI PER MINUTE 66 RA'IIONS BODY TEMPLRAIUKE L 3900 BREATHING DELP ANU LABORED PHYSICAL* NEUROLOGICALT 6 BEHAVIORAL SIGNS OTHERWISE2 NORMAL EART RATE 150 BLAIS/MINUTE 2109 H RESPIRATIONS PER MINUTE 60 MODY TEMPERAJURE C 3896 AND CUNDITION NCHMAL BEHAVIOR* GEN0ERAL APPLARANCE9 NEUROLOGICAL IESTS NURMAL SUSPENSION METHYLC@-@@U@OSE 09594 Ali PHYSICAL AND NEUROLOGICAL LAAMINATION OF CAJS 09346-63 (I-V) CAT M09 DOSE wie TIME UUSERVATIONS AND 5EX MG/KG KGo 1-iGURS 39 F 5*6 3915 000 HEART RATE 150 BEAT5it4lfiUTIE HEBPIRAF]UNS I-'Ell MINLJ-O@ 40 UUVY TEMPERAFURE C 3893 N05E COOL AND MOIST (.ALM ULHAVIOR9'GLNERAL APPL2ARANCE9 AND CONDITION NORMAL NEUROLOGICAL TESTS NORMAL PRE-,DOSE 4SAME UAY) 0,3 flEART RATE 144 BLAIS/MINUTE RESPIRATIONS PER MINUTL 54 T2JODY TEMPERATURE C 30ob HEARTBEAT WEAK NOSE WARM AND DRY PHY-SICALI "NLUROLOGICAL9 BEHAVIORAL SIGNS OTHERWISE NORMAL 100 HEART RATE 156 B4AI'S/MINUTE RESPIRATIONS PER MINUTE 46 BODY TEMPERATURE C 3093 NOSE WARM AND DRY HEARTBEAT WLAK PHYSICALT NEUROLOGICAL* BEHAVIORAL SIGNS OT14ERWISE NORMAL. %USPEN51ON METI-IY8@CELLULOSE 005% PHYSICAL AND NEUROLOGICAL @XAMINATION OF CAIS &9346-63 (J-V) 0 t3SERVAlION5 CAT NOo DOSE V@T TIME AND SEX MG/KG KG* HOURS HEA2RT RA7E 120 BEATS@'MI14UTE 39 F 596 293 RESPIRATIONS PER MINUIL 72 LIODY TEMPERATLJRE C 38a5 NOSE WARM AND DKY HEARTBEAT WEAK 2 ERwl5E NORMAL PHYSICAL.1 Nt@URriLOGICALt 4 BEHAVIORAL sir4NS OTH 408 HESPIRAIIONS PER MINUTE 80 BODY TEMPERATURE-C 3894 HEARTBEAI WT2AK NOSE COOL AND DRY PHY51CALt NEUROLOGICALT 6 BEHAVIORAL SIGNS OTHERWISE NORMAL 27 HEART RATE 150 B@-ATS/MINUTE NESPIRATIONS PER MINUTE 30 BODY TEMPERA'FURE C 37*8 8 NOSE COOL AND MOIST PHYSIcAL9 NEUROLOGICALV 6 BEHAVIORAL SIGNS OTHERWISE NORMAL SUSPENSION METHYLCEL@ULOSE 005% PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS 4.9346-85 (I-V) I IA@h UBSERVAIIONS CAT NOo DOSE V., T o AND 5EX MG/KG KG* HOURS 52 F 18 2o3 000 flEART RATE 162 BLAI2S/MINUTE NLBPIRAIIONS PF-R MINUTE 3 CALM NOliMAL BEHAVIOR-) GENERAL APPLARANCkg AND CONDITION -TS NORMA2I. NLUROLO(3icAL 'FE5 -DOSE VAY) PRE (SAME 000 AT END OF 005IN(i OF15THOTONOS CLONIC CON2VUL5ION ENURE515 OTHER TESTS NOT PONE AT THIS TIME 0,03 PRO@TRATE COULD NOT STAND BREATHING DELP AND LABORED OTHER TESTS NOT DON@ AT TH15 TIME 3 5USPENSION METHYLCELLUL05E 095% PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS *9346-85 (I-V) VAIIONS CAT Noo D05E WTo TIME UBSER AND SEX MG/KG KG* HOUR5 la S PER MINIJTE 96 52 F 002 NEBPIRAT2ION PROSTRATE " COULD NOT STAND PUPILS DILAILD +%% PUPILLARY RLFLEX INCOMPLETE FLEXOR REFL@XES AUSEN'L GUMS PALE TWITCHIN GOF UPPER 4LIP OTHER TESTS NOT DONL AT THIS TIME 0,4 CAT DEAD BY (AT) TH15 TIME BUSPENSION MET@IYLCELLULOSE 095% 'let V.A. W, Alt jf AL L)(AMINATION OF CAT5 PHYSICAL AND NEUROLOGIC *93426-85 ME 085ERVATIONS CAT NOo D05E WTo Ti AND SEX MG/KG KG* HOURS IIEAttT RATE 150 f3@AISIMINUTE 1*83 000 66 F 3,0 HE5PIRATIONS PER MINUTE 66 2 BOUY 7EMPLRAIURE 39,al ACTIVE ULHAVIOIIT GTNERAL APPLARANCL9 AND CONDITION N014MAL NLUROLOGI-CAL IEI)-15 NORMAL FKE-DOSE (5AM@- UAY) 0 2 IIEAGT RATE 144 BLAI.S/MINUTE RE5PIRAlIONS PER MINUTE 60 tiouy TEMPTRAIURE C39v2 MOTQR ACTIVI'IY I)LCRLASLD + 2 R,IING REACII(N WEAK + SUPPO PHYSICAt.9'@@@NLUKO VIORAL SIGN$ OTHERWISE NORMAL LOGICAL9 & BEHA OLA45/MINUTE Op 7 HEART RATL 14 HL5plRATIONS PLR MINUT@- 66 ii(L)Y TEMPERATUHE C 39#4 (:ALM ACTIVE + APPEARANCE9 AND CONDITION N8ORMAL BEHAVIQR*IGLNERAL NEUROLOGICAL lEbT5 NORMAL bUbPEN5lot4 METHYt-CEL@k)LO5E ...... .. .. NEUROLOGICAL LXAMINATION O@ CAT5 PHY51CAL AND &9346-85 il-V) CAT NOo D05E VTo TIME oBbERVATIUNS 2 HOURS AND SEX MG/KG KGo 40 HEART RATE 150 B@-AT5/MI14UTE 66 F 3 RESPIRATIONS PER MINUTT@ t, 6 8uuy IEMPLRAIURE C 40*7 PHySICALi NL2UROLOGICALT BEHAVIORAL 5IGN5 OTHERWI-SA- NORMAL A15/MINUTE 3,1 HEART RATE@144 Bt RESPIRATIONS PER MINUTE 48 VODY TEMPERATURE C 39*5 2 PliY51CAL's NEUROLOGICAL, & BEHAVIORAL SIGNS OTHERWISE NORMAL 4,7 HEART RATE,138 BEATS/MINUTE RESPIRATIONS PER MINUTE 48 tiODY'TEMPERAIUKE C 30#9 ACTIVE.+ 2 PHYSICALI NEUROLOGICALI BEHAVIORAL SIGNS OTHERWISE NORMAL 2190 HEART RATE ilbo BLAIS/MINUTE RESPIRATIONS PER MINUT4 66 BODY'TEMPLRAIURF- C 38#8 7 ACTIVE PHYSICAL9 NEUROLUGICAL* BEHAVIORAL SIGNS OTHERWISE NORMAL SUSPENSION METHYLC@LLVI-05E 095% e3 SICAL AND NEUROLOGICAL EXAMINATION OU CATS PHY 09346-8'r I"V) utiSERVATIOM§ CAT NO# D05E WTO TIME HOURS AND SEX MG/KG KG* 55 F 5*6 201 000 HEAKI RATE 150 BtATSIMltiUTe RE5PIRATIONS PER MINUTE 36 BODY TEMPERATURE C 3895 CALM BEHAVIOR9 GENERAL APPLARANCE9 AND CONDITIOtl - NORMAL NEUROLOGICAL TE'.-,T$ NORMAL PRE-DO5E ($,AME PAY) 0.2 HEART RATE @50 B@ATS/MINUTE RESPIRAlION5 PER MINUTE 60 BODY TEMPERAFURE C'389i 2 PHYSICAL9 NEUROLOGICAL9 & BEHAVIORAL SIGNS NORMAL 0*7 HEART RATE t44 BEATS/MINUTE RE5PIRA.11ON PER MINUTE 36 BODY TEMPERATURE C 38*3 PHYSICALs NEUROLOGICAL2I & BEHAVIORAL SIGNS NORMAL 1*5 HEART RATE iSO BLATS/MINUTE HEbPIRATION,5 PER MINUTE 40 bot)Y TEMPERATURE C 39ol IGNS NORMAL 8 PHYSICALT NEUROLOGICAL*,6 BEHAVIORAL 5 SU5PENSION METHYLCTLLVLQSE Oq5% PHYSICAL AND NEUROLOGICAL EXAMINATION OP CATS &9346-87 I-V) CAT NO* DOSE WT* TIME OB5ERVA71ONS MG/KG KG* HOURS AND SEX 55 F 5*6 3ol tiEAP@T RATE .162 BEATS/MINUTE 2 RESPIRATIONS PER MINUI 33 UOUY TEMPERAIURE C 38ol PHYSICAL9 NEUROLOGICAL* 4 BEHAVIORAL SIGNS NORMAL 590 HEAR[ RATE@150 BLATS/MI14UTE RESPIRA2TIONS PER MINUTE 28 LIUDY TEMPLRA'I'URE C 37o8 PHYSICAL9 NEURO@OGICAI-I & BEHAVIORAL.51GNS NORMAL HEART RATE@150 BEATS/MINUTE 2 21*1 RESPIRATIONS PER MINUTE 3 2 'TEMPERATURE C 3892 800Y PHYSICAL9 NEUROLUGICAI-9 6 BEHAVIORAL SIGNS NORMAL 1 SUSPEN510N@r- MET@IYLCELLU@OSE 095% PHYSICAL AND NEUROLOGICAL EXAtilNATIOI,i OF CATS 09405-13 (I M 6 SUB-CUT) CAT 1400 DOSE WT* TiflE OBSERVATIONS AND SEX MG/KG KG* HOURS 44 F 4o8 2,o7O 000 HEART RATE 144 BEATS/MINUlE 2 RESPIRATIONS PER MINUTE BODY TEMPERATURE C 3898 k NOSE COOL AND MOIST CALM BEHAVIOR9 @GENERAL APPEARANCEs AND CONDITION NORMAL NEUROLOGICAL TESTS NORMAL2 PRE-DOSE (SAME DAY) 002 HEART RATE@150 BEATS/MINUTE RESPIRATIONS PER MINUTE 66 8ODY TEMPERATURE C 39#2 NOSE WARM AND MOIST PHY§ICALT NEUROLOGICALT & BEHAV2IORAL SIGNS OTHERWISE NORMAL 008 HEART RATE'138 BEATS/MINUTE RESPIRATIONS PER MINUTE 72 BODY TEMPERATURE C 38o8 NOSE COOL @AND MOIST PHYSICAL-p@NEUROLOGICAL* F, BEHAVIORAL'SIGNS OTHERWISE NORMA2L 2ol 14EART RATE 144 BEATS/MI14UTE RESPIRATIONS PER MINUTE, 60 BODY TEMPERATURE C 38#0 PHYSICAL.9'NEUROLOr.IICA@t OEHAVIORAL S16NS NORMAL SUSPENSION@ METIJYLCELLULOSE0 095% ilySICAL AND NEUROLOGICAL EXAt4l@IATIOtl OF CATS p 09405-13 (I-M 6'SUB-CUT'i CAT @10* DOSE WT* TIME OBSERVATIONS AND SEX MG/KG KG* IIOURS 44 F 4*8 4o7 HEART RATE2 156 BFATS/MTNUTE RESPIRATIONS PER MINUTE 75 BODY TEMPERATURE C 3845 PHYSICALs NEUROLOGICAL* & BEliAVIORAL SIGNS NOR14AL KNEE JERK NOT TE5TED 2698 HEART RATE i756 BEAT$/MINUTE RESPIRATIONS PER MINUTE 78 BODY TEMPERATURE C 38o5 PHYSICAL9 NEUROLOGICALT BEHAVIORAL SIGNS NORMAL SUSPENSION METHYLCELLULOSE 0*5% WI PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS 109405-35 II-V) CAT NO, DOSE WT. TIME OBSERVATIONS AND SEX MG/KG KGo HOURS 55 F 10*0 2002 0*0 HEART RATE 132 BEATS/MINUTE 2 RESPIRATIONS PER MINUTE 48 BODY TEMPERATURE C 38o6 CALM BEHAVIORI GENERAL APPEARANCEs AND CONDITION NORMAL NEUROLOGICAL TESTS NORMAL PRE-DOSE (SAME DAY) 50 BEATS2/MINUTE 092 HEART RATE 1 RESPIRATIONS PER MINUTE 36 BODY TEMPERATURE C 3892 'PHYSICALT NEUROLOGICALT & BEHAVIORAL SIGNS NORMAL I 0 HEART RATE i44 BEATS/MINUTE 30 2 RESPIRATIONS PER MINUTE BODY TEMPERATURE C 3893 PHYSICAL* NEUROLOGICAL9 BEHAVIORAL SIGNS NORMAL 2,0 HEART RATE 144 BEATS/MINUTE RESPIRATIONS PER MINUTE 27 BODY TEMPERATURE C 38898 PHYSICAL9 NEUROLOGICALI 6 BEHAVIORAL SIGNS NORMAL SUSPENSION ME,THYLCELLULOS@ 0 596 All LOGICAL EXAMINATION OF CATS PHYSICAL AND NEURO 4.9405-39 (I V@ CAT NO* D05E WT* TIME UBSERVAIIONS AND 5EX MG/KG KG* HOURS 552 F 18 2912 0,0 HEART RATE 138 BLA'15/MINUTE PER MINUTE 32 RESPIRA]IONS OODY TEMPERATURE C 3894 CALM BEHAVIORT GENERAL APPtiARANCEs AND CONDITION NORM2AL NEUROLOGICAL TE5T5 NOKMAL PRE-DOSE (BAME DAY) E @108 BLATS/MINUTE 001 HEART RAT KE5PIRA'[ION5 PER MINUTE 36 TJODY TEMPERATURE C 3895 2 PHYSICALT NEUROL(GICALT & BEHAVIORAL SIGNS NORMAL 005 HEART RATE 114 BLAIS/MINUTE RESPIRA]ION5 PER MINUTE 60 LIUDY TEMPEHAFURE C 3892 PHYSICAL* NLUROLOGICALT &2 BEHAVIO14AL SIGNS NORMAL 101 HEART HATEsil44 BLA15/MINUTE NE5PIRATIONS PER MINUTE 34 UOVY TEMPERATURE C 3994 PHYSICALT NhUROLOGICAI-i 4 BEHAVIORAL 54GNS NORMAL 1 @5USPENS1014 -P-.MEIHYLC@L@ULOSE 0*5% @i4 PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS 09405-39 (I-V) CAT N09 QOSE WTO TIME OBSERVATIONS AND-SEX MG/KG KG* HOURS 55 F 18 2,,3 HEART RATE 132 2 BLA15/MINUTE RE5PIRATION5 PER MINUTE 36 'TEMP4RATURE 389'f BODY PHY51CAL* NEUROLUGICALs 4 BEHAVIORAL SIGNS NORMAL 4*4 HEART RATE @!120 BLATS/MINUTE RESPIRATIONS PER MINUTE 24 UOUY TEMPERATURE C 38ol PHYSICALV NEUROLOGICAI-9 & BEHAVIORAL SIGNS NORMAL 26*8 HEART RATE BEATS/MINUTE RESPIRATIONS PER MINUTE 32 8ODY'TEMPLRATURE C 37*8 6 PHYSICAL* NEUROLOGICA4* 6 BEHAVIORAL 5.IGNS NORMAL ,!IUSPENSION METHYLCLL@,UL05E 0*5% 414 OH 4g v*," PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS 109405-4 t (I-V) CAT N09 DOSE WT* TIME UB5LRVAIIUNS AND SEX MG/KG KG* HOURS 66 F IS 1977 000 HEAR2T RATE 156 BLAT5/MINUTE RESPIRATIONS PER MINUTE 54 BODY TEMPERATURE C 5896 ACTIVE + BEHAVIORI GENERAL APP@ARANCEI AND CONDITION NORMAL NEUROLOGICAL T2ESTS NORMAL PRE-DO5E (SAME DAY) opi HEART RATE 144 BLA151MINUTE RESPIRATIONS PER MINUTE 84 BODY TEMPERATURE C 39*2 PHYSICAL* NEUROLOGICALT & BEHAVIORAL S2IGNS NORMAL 0*6 HEART RATE 108 BEAT5/MINUTE RESPIRATIONS PER MINUTE 66 PHYSICALT NEUROLOGICAL*;& 13EHAVIORAL SIGNS NORMAL 102 HEART RATE 144 BLATS/MINUTE HESPI0RATION5 PER MINUTE 60 PHYSICAL* NLUROI-OOICALI & BEHAVIORAL SIGNS NORMAL SUSPENSION METHYLCLLLULOSE 005% PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS 409405-4 7 (I-V) CAT N09 D05E WTo TIME UBSERVAlION5 AND SEX MG/KG KG* HOURS 66 F 18 205 HEART RATE 150 BLATS/MINUTE 2 RESPIRATIONS PER MINUTE 48 PHY51CAL$,NLUROL061CAL* 4 BEHAVIORAL SIGNS NORMAL 496 HEART RATE 144 BEAT$/MINUTE H85PIRATIONS PER MINUTE 80 PHYSICALs NLUROL064CALt 4 BEHAVIORAL SIGNS NORMAL 5 27oO HEART RATE 144 BEAIS/MINUTE RESPIRATION$ PER MINUTE 48 BODY TEMPERATURE C 3990 PHYSICALT NTUROLOGICAL* BEHAVIORAL SIGNS NORMAL SU5PENSION@@ METHYLCELLULOSE 005% PHYSICAL AND NEUROLOGICAL EXAMINATION OF CATS 20% CAT NOo DOSE WT* TIME OBSERVATIONS AND SEX ML/KG KG* HOURS 44 F too '2080 000 HEART RATE 132 BEATS/MINUTE RE5PIRATION5 PER MINUTE 54 2 BODY TEMPERATURE C 3892 NEUROLOGICAL TESTS NORMAL CALM BEHAVIORI GENERAL APPEARANCE* AND CONDITION - NORMAL PRE-DO5E (SAME DAY) 0*03 MEWING Os 05 MOTOR ACTIVITY (300D 0 1 HEART RATE 138 BEATS/MINUTE RESPIRATIONS PER MINUTE 102 BODY TEMPERATURE C 38*7 SEDATED NEUROLOGICAL TE5T5 NORMAL Oq,3 HEART RA2TE J56 BEAT5/MINUTE RESPIRATIONS PER MINUTE 108 BODY TEMPERATURE C 3Bo6 PANTING LYING ON 510EI BUT CAN STAND NO( ATTENTIVE TO SURROUNDINGS 3 NEUROLOGICAL TESTS NORMAL KNEE JERK NOI TESIEP SOLUTION DISTILLED WATER LOGICAL EXAMINATION OF CATS PHYSICAL AND NTURO 2096 4@@ I I-V) OBSERVATIONS CAT NO DOSE W!4 TIME AND SEX ML/KG KGo HOURS 44 F iso 1*0 HEART RATE 144 BL2ATS/MINUTE RESPIRATIONS PER MINUTE 102 BODY TEMP@RAfURf C-37*3 NICTITATING MEMBRANE RELAXED SCLERA - VA5ODilLATION EAKS RED NOSE COOL AND MOIST 2 LYIN'G ON SIOET;WITH HEAD UP NEUROLOGICAL ITSIS NORMAL .14,8 HEAkt RATE 120 BLAIS/MINUIE 9 RE5PIRATIONS PER NU 2BODY TEMPLkAlUkE C 37o4 '.'@NE RELAXED NICTITATING MEMbt-, NOSE'COUL ANO DRY BEHAVIOR ANU APPEARANR@E - OTHERWISE NORMAL NEUROLOGICAL IESI'5 NORMAL 4 KNEE JERK NO'l TESTED 3*0 NiCtITAIING MEMBRANE kELAXE[i + OTHER IESTS NOT DONE AT THI!I TIME 25 NICTITATING MEMBRANE NORMAL SOLUTION D15TIILLD WATER PHYSICAL AND NEUROLOGICAL LXAMI MATION OF CATS (I.V) CAT NO# DOSE WTs TIME OBSERVATIONS AN D SEX MG/KG KG# HOURS 53 F 54.6 2*76 0,00 HEART RATE 168 BEATS/MINUTE 2 RESPIRATIONS PER MINUTE 72 BODY TEMPERATURE C-38*5 CALM BEHAVIOR* GENERAL APPEARANCEs AND CONDITION NORMAL NEUROLOGICAL TESTS NORMAL PRE-DOSE (SAME UAY) 062 HEA2R! RATE 132 BEAT5/MINUTE RESPIRATIONS PER MINUTE 90 BODY TEMPERATURE C 38o4 PHYSICAL* NLUROLOGICALO BEHAVIORAL SIGNS NORMAL 0*6 HLART RATE 162,BEATS/MINUTE RESPIRATIONS 2 PER MINUTE '18 t3ovy TEMPERATURE C 38*5 GROWLING WHEN HANDLED PHYSICALT NEUROLOGICAL9 BEHAVIORA4 SIGNS OTHERWISE NORMAL 102 HEAR! RA L 150 BEATS/MINUTE 2 RESPIRATIONS PER MINUTE 60 BODY TEMPERATURE C 38*A PHYSICALs NEUROLOGICAL9 BEHAVIORAL SIGNS NORMAL SOLUTION DISTILLED wAiER f ;7 HYSICAL AND NEUROLOGICAL EXAMINATION OF CATS p it V) CAT NO# DOSE WTo TIME USSEkVA'tIONS AND SEX MG/KG KGi 14OURS 53 F 5*6 2 3 HEART RATE 162 BLATS/MINUTE RESPIRATIONS PERIMINUTE 60 800Y TEMPERATURE C 38,6 PHYSICALs NEUROLOGICALT BEHAVIORAL SIGNS NORMAL 3.6 HEART RATE 132 B@ATS/MINUTE RESPIRATIONS PER@ MINUTE 78 BODY TEMPERATUREI2C 39*5 GROWLING WHEN HANDLED PHYSICAL* NEUROLOGICAL* 6 BEHAVIORAL SIGNS OTHERW15E NORMAL B @62 HEART RATE 1.118 EATS/MINUTE RESPIRATION.. PERIMINUTE 60 2 HODY TEMPERi4iURE C 3966 PHYSICAL$ NLUNOt@.)GICALt BEi4AVIORAL SIGNS OTHERWISE NORMAL 25 HEART RATE 162 BEATS/MINUTE RESPIRATIONS PER MINUTE 66 13ODY TEMPERATUREI C 40,0 2 GROWLING WHEN HANDLED PHY51CALt.NEUROLOGICAL9 BEHAVIORAL SIGNS OTHERWI!IE 140,rZMAL- DISTILL@D WATER SOLUTION ill,@1i@@ tit @.50 PHY ICAL AND NEUROLOGICAL EXAMINATION OF CATS (I -v) CAT No* DOSE WT& TIME OBSERVATIONS AND SEX MG/KG KG# HOURS 53 F 546 29,60 HEAR! RATE 168 PLAYS/MINUTE RESPIRATIONS PER MINUTE 72. 2 HODY TEMPtkA[URE C 39,,9 GROWLING WHEN MANDLED BEHAVIOR AND APPEARANCE - OTHERWISE NORMAL NEUROLOGICAL EXAMINATION NOT DONE 46 HEART RATE 156 BEATS/MINUTE 14ESPIRATIONS PER MINUTE 78 80UY TEM2PERA'IURE C 39#2 CALM HEH VIOR AN AP V RAN O'f ERW 0 NT-UROLOGICAL.EXAMINATION NOT DONE SOLUTION DISTILLED WATER ICAL AND NEUROLOGICAL PHYS EXAMINATION OF CATS CAT NO* DOSE Wt* tiME OBSERVATIONS AND SEX MG/KG KG* HOURS 32 M Ool 3*8 000 HEART RAVE 156 BEAT5/MINUTE RESPIRATIONS PER MINUTE 84 BODY TEMPERATURE C-37*8 ACTIVE BEHAVIOR4 GENERAL APPEARANCEO AND CONDITION NORMAL NEUROLOGICAL TOSTS NORMAL PRE-DOSE (SAME DAY) Oo2 HEART RATE 168 OEAT-S/MINUTE RESPIRATIONS PER MINUTE 96 BODY TEMPERATURE C 38*6 PHYSICALT NEUROLOGICALs 6 BEHAVIORAL SIGNS NORMAL 066 HEAR! RATE 2 i68 BLATs/MINUTE RESPIRATIONS PER MINUTE 102 BODY tEMPEPATURt C 38*2 NASAL CONGESIION + PHYSICALO NLUROLO(31CALt 01:1.IAVIORAL-SIGNS OTHERWISE NORMAL 2 HEART RATE 144 BLAIS/MINU'fE 1#9 RESPIRAIIONS PER MTNUTE 78 BODY TEMPERAIU14E C 38*4 BEHAVIORs GENERAL APPLARANCLO AND CONDITI'TON t4ORMAL TEBTS tiORMAI- NEUROLOGICAL SOLUT!ON Dlu@l'It-LED WATER PHYSICAL AND NEUROLOGICAL LXAMINATION OF CATS (I-V) CAT NO* DOSE WT* TIME OBStkvATIONS AND SEX MG/KG KG6 HOURS 32 M 001 2,i7 HEART-RATE 150 (3LAT5/MINUTE RESPI2RATIONS PEC-MINUTE 84 8ODY TEMPERA'FUR C 38*3 PHYSICAL* NEURPLOGICALo.6 BEHAVIORAL SIGNS NORMAL 60 HEART RATE 162 OLAIS/MINL)TE 4 kESPIRAlIONS PER MINUTE 102 BODY TEMPERA7URO C 38*6 NASAL CONGESIIQN PHYSICALO NLOKOLOGICALO 6 8EHAVIUkAL SIGNS OTHERWISE NORMAL 24*2 HEART RATE 162 BEAIS/MI2NUTE RESPIRATtbNS PER MINUTE 80 BODY TEMPERATUKE.C 3890 NASAL CONGE5TION4 PHYSICALI NEUROLOGICAL9 6 BEHAVIORAL SIGNS OTHERWISE t4ORMAL 6 D SOLUTION ISIILLED WATER MOTIVATION TEST$ IN HOODED RATS START AND RUN SPEEDS IN RECIPROCAL SECOND$ 2 TRIAL 3 TRIAL 4 TRIAL 5 2 TRIAL 6 CPND DOSE MOTTV RAT TIME TRIAL I TRIAL NO RUN START RUN START RUN N START MG/KG Noe START START RU RUN START RUN 2 950 1900 2o86 ifol 1975 1910 2*94 jpl6 2 438 3o2o APRCH 496 2OoOO 2*70 o93 3903 q,93 1200 2*94 o,81 2o94@ 1.,22 ?922 lo23 3913 1920 3o45 1015 2.78 loll 430 3t2O APRCH 496 2 1 01 1992 loll. !409 3*45 1915 2,r 56 *96 2o94 lols 2 a 86 lolo 3903 438 3o2O APRCH 496 2 438 3.20 APRCH 496 14404 2050 2 988 2133 1*03 2#00 lool 3st3 1910 2q63 loO2 3457 1#11 2438 3o2O APRCH 498 2OoOO 4*35 *81 4o76 1901 4917 087 3,70 o84 5oOO 994 4o55 1909, 2438 3685 *83 5900 q,83 3920 APRCH 498 120o 4917 181 03* 2438 3o2O APRCH 498 240,0 1,82 903 o33 oO3 0 3 2 3,20 APRCii 498 144o, 2,,94 48 003* IF65 924 003* 903* 438 903it 438 3*20 AVOID 4721 20*00 3oO3 o73 4*55 1,56 3985 t@49 1908 lolg 2922 lo85 2vl3 lo7'-' 438 3o2O AVOID 471 120o 2-56 *77 1*64 2933 3q85 lr,45 4,00 1*54 3945 lo75 3o33 299i, 438 3*20 AVVID 471 240, lo64 1.12 2963 lo25 4o76 1,59 3.70 lo47 1979 1982 2,44 2oO/i 438 3o2O AVOID 471 1440t 2.33 952 3945 #97 Zo86 loto 2o22 lo27 2o$6 1933 2908 le3i 438 3.20 AVOID 503 20,00 2,22 38 .20 13 3 8 1,@45 022 17 2970 lo23 1,20 2 o 5 Ci( 438 3*20 AVOID 503 1209 .92 32 2,13 *69 2 1947 93 lo25 lo2a 1-079 102? 2956 1,14i 438 3o2O AVOID 503 240, 1 015 loOO 1954 lolg 2,44 lol8 1*69 Igloo Zo38 1923 lofg 1064. 438 3,20 AVOID 503 14400 118 2o56 1961 1*67 lp6@ *85 1*61 984 2#17 994 2oO8 I,Oii 438 @,20 E sC[,E 6 2o.oo 5@56 lo28 6,2t 1.30 h.56 2 4*35 IV I'@ 5 4 5,@ -3. -,9 1.22 438 0 ESCPE 466 120. 4.55 1,23 5o56 loll 2 5, Ufi 1,,22 '3 5 1 4, 4,p !) 5 I.,@ -2 2,17 1 , 3.2( ESCPE 466 240, 5,56 1,52 is v'l 6 lt33 !i, all 1115 5188 1 i) 5'. 2") 1 ?o 6 1 , 7, 'SCPE 466 1 4 3 ti 3*20 E .33 o i)4 6ip25 tv23 f4.oOo lt.-I 3 4!;5 1 0, ',('f COt4PI f-TV R(JI,L O@l THIS TP.IAI MOTIVATION TE5T5 IN HOODED RATS START AND RUN 5PEE05 IN OECIPROCA4 SECOND5 CPND DOSE MOTIV RAT TIME TRIAL I TRIAL 2 TRIAL 3 2 TRIAL 4 TRIAL 5 TRIAL 6 MG/KG NOO START RUN START RUN START RUN START RUN START RUN START RUN NO* 5926 1016 6967 1 2438 3.20 E5CPE 508 ZO.00 5*88 1.33 5,86 1043 L*23 5,,@54 1920 5*88 1*20 120. 5,26 1930 5.88 1*52 64o25 lp4l 7*14 2 l@19 5*56 lo22 5.88 1,11 2438 3920 ESCPE 508 2438 3o2O 4o35 1.22 5.00 lo39 5 2 18 3 70 I*Olj' ESCP2E 50a 240* 456 lol5 *94 1.27 6925 11 & 43a 3*20 ESCPE 508 1440. 11 40-55 995 4,o@7 1.12 5o26 t9O3 4.76 1919 2 2.08 .4 I 1904 5t56 l,p7t 977 ol7 970 60 085 t68 051 .72 INE OOOO 2 APRCH 492 20#00 2.86 o79 -o73 4@ 120. 1045 .71 .71 t48 2.o44 089 .26 *18 v87 965 o7O ,63 INE 0*00 APRCH 492 2 240 2.00 o53 01,2 922 1937 978 053 o8O 2!i o34 90 87 SALINE OOOO APRCH,492 0900 APRCH 499 2OoOO 2o56 58 2.6h *34 o54 2 049 2*13 963 3923 963 lo72 .6g-@ SALINE SALINE OOOO APRCH 499 120o 2o27 050 1082 068 2*04 .65 2*17 071 2*50 983 2o5O .76 SALINE OOOO APRCH 499 2 2401, 2,70 .67 1959 971 2.38 075 lo79 o72 1954 .70 lo27 o35 SALINE 0,600 AVOID 504 20.00 1*30 1#45 2o3@ 1982 2q$6 1972 2.27 1992 3145 1992 3970 1.13 IE o 2994 lo64 2*33 1087 SALIN 0.00 AVOID 504 120# 2.50 jo43 2oO4 1.64 lo4l 2*08 2o5 1 49 2 40, o53 2o33 3*1@ li85 1982 2o22 2'a 86 1 2o7O 1 o 9 6 SALINE oooo AVOID 504 2 t32* 2 1*14 ALINE 00 9 52 2o94 951 lu67 ,52 954 o83 290 2o56 *51 2o86 5 00 AVOID 508 20*00 9 5 3 o46 o66 2oOO 937 2ol3 9 38 1*37 90 lo54 #62 0:00 AVOID 508 120 SALINE 2 f) .2# 1 *8 SALINE 'O AVOID 508 1,39 084 2oOb 985 lq54 St 2o86 905 2o44 098 2*17 2 0 0 240, 952 1#45 951 1 o 9'$'. 0 5 -Z. INE' 0*00 'RSCPE 509 20ooo I'll 951 3*54 953 4900 2 1 $AL 911 4o7b 0ESCPE 509 1209 lo33 1925 1196 tv#'9 2#43 953 2i22 153 2,p86 to32' 3,ali7 ille 52:;LINE 0.0 oESCPE 509 240* 2*56 952 3;,I)@ 1052 3OZ3 *50 3,tl3 953 2 44 950 3o85 1 6 q TCOMPLETE RUN O@l Tli I 5TRIAL DED RATS MOTIVATION T94TS IN HOO START AND RUN SPEgP5 IN RECIPROCAL SECONDS 2 RIAL 5 TRIAL 6 CPND DOSE MOTIV RAT TIME TRIAL I TRIAL 2 TRIAL 3 TRIAL 4 T START N START RUN START RUN START RUN NO* MG/Kr3 NO,, START RUN -START RUN RU 5,56 *93 INE 0*00 2 ESCPE 487 2OoOO 3913 *51 4955 @80 o92 3,oSS o94 4076 o89 4q,55 120* 3*23 #52 4*00 *51 4oOO 2 985 3*33 #50 4p55 999 3970 *52 NE Osoo ESCPE 487 2409 3*45 o5O 2*63 1920 3 9 as o53 4900 1932 3123 1943 4ol7 052 NE 0*00 E2SCPE 487 598 loOO APRCH 492 20,0 0 1059 66 1932 948 993 #92 1#00 *43 9,49 o38 2908 83 0 2 86 lol6 q,77 992 *77 1949 *87 598 140a APRCH 492 1209 2*38 972 o52 *7fl 089 It 598 1*00 APRCii 492 2400 2,22 979 v75 968 080 ,79 1,64 091 lo243 *80 1,72 49 598 440* 2*17 77 *92 9 38 979 *78 o57 957 1#00 APRCH 492 1 978 091 o48 938 2598 1,00 APRCH 499 20,00 3.33 936 3045 078 3.33 968 82 060 913 005 3.03 36 2598 120a 3*23 o74 2944 q,63 1089 966 leS@ 963 3o33 2 76 2oO4 o72 loOO APRCH 499 2598 1.00 API@CH 499 2400 2944 37 2059 *65 lo59 o36 2.13 972 2o86 968 2.56 9 66 2598 1*00 APRCH 499 14409 2@94 2 *36 3923 970 2Q86 988 2o7Q q7O 2o94 974 2a33 677 2598 1.00 AVOID 504 20,00 3,23 lo64 3,03 1,39 3145 1969 3.57 -1,64 3,03 1079 2,94 75 2598 1.00 AVOID 2 504 1209 1#69 1*59 2963 1114 1.79 1#41 1952 1989 2978 IQ37 2o7O 1:69( 2&50 1#69 3o33 lo59 4.00 196 2598 1*00 AVOID 504 240, 3.23 2 1447 1 3t33 1*09 4ol7 1*79 ?598 loOO AVOID 504 14409 1'.79 954 2qll 1147 2978 t954 2,86- 1*49 3923 1956 3oO3 -1,72 )598 1.00 AVOID 480 20#oo 2*56 o66 292i 93 3*13 o96 2,86 7@, 1 -7 5 5,;, 2 6 3,03 89 ?59B 1.00 A%jo i r, 4aO 12 a I fig 90 2 7d *'I i 2,)27 6 9 1082 P.2 3 21598 1.00 AVOID 480 240, e83 q,87 2:5,0, 50 2o2-2 I.-A43 I.,)2 a52 ?.450 11:0 -@,63 &I '591i 1,00 AVOID 480 1440* @.56 i,37 2 *86 2.00 *54 1433 q'IS 1 @'12 2070 .9@, ESCPE 487 20*00 2,o 9A .96 4ooo v9t @000 1 5 611%, ot) t@ 5000 1 I 1: #,lox MOTIVATION TESTS IN HOODED RAT3 START AND RUN SPEED5 IN RECIPROCAL SECONDS TIME TRIAL I TRI#L 2 CPND DOSE'MCTIV RAT 2 TRIAL 3 TRIA@ 4 TRIAL 5 TRIAL 6 NO* MG/KG NO. START RUN START RUN START RUN START RUN START RUN START RUN loll 4oOO 1.41 1#00 ESCPE 487 120* 51 4,o74@ I,Z7 dt9l7 1 18 4*00 1*28 4900 598 3,85 9 & 1.-,00 ESCPE 487 240* 6.25 2 1941 5 1941 3o3@ @,47 5056 o56 1932 5*00 lo47 2*63 1*56 598 3,03 o63 4#17 *78 3 too 993 5*00 o$O 3*70 sa3 598 1*00 ESCPE 487 1440a 913 977 5 lo56 3933 1*22 3433 1943 3945 1#67 3,13 1,33 2598 1,00 ESCPE 509 20900 2,86 1,49 4,200 120. 4o55 1,75 3got 1.75 2070 1,59 ?-978 1923 3 9 4 5 1982 3ol3 1,32 598 1,00 ESCPE 509 598 1#00 ESCPE 509 '4140. 1056 1 9 33 2*9f 953 3o223 I 9 56 4055 1,@47 3 45 1,43 3.70 1 .*52 a33 2 -to 1#79 o96 1*20 -053 1972 ogi 3ot3 050 2406 052 *30 598 1#00 ESCP"@ j-;Og 14' -;36 alp -p48 3 9 03 2 i64 3o45 #68 2o94 o56 4ol7 &28 2615 #32 APRCH 4a8 20,)00 I 8 615 o32 APRCH 488 1209 2*44 o44 *II t5O 2970 *48 3o33 *58 3970 955 30,.3 2o6O 2615 *32 APRCli 48a 240q .05 046 'lo47 1,52 3.45 0 59 119 0 50 1967 957 014 942 gkO 390$ a 65 2o63 o56 .938 *31 o92 o56 2 3o23 9 (,7 2615 #32 APR%RH 488 1440o 906 2615 32 APRCH 498 20,00 4.35 84 4976 *97 4o76 984 4,76 994 5926 088 5000 1002 2 3 5 86 4955 87 4 35 9 7 2615 .120, 3#13 969 4.5@ o86 4#17 9,96 .32 APRCH 498 5 1009 4*55 1909 4 0 76 1904 4o76 1,,O 2 2615 *32 APRCH 498 240, 4035 1.06 4955 lool 4 9 5 4 17 o75 4o7',6 98 5,00 1 06 5,00 1908 4955 1,04 .04 961 Z 6 1':* *32 APR2CH 498 1440* 20 00 3.70 49 4035 t85 4,00 1 0 05 3.57 994 3945 1906 4o55 1.3-i 615 *32 AVOID 475 9 . 2 120* 3,13 0 5 1 3*13 o76 3 4 '10 8 4#76 1*15 4tt7 19-12 4c4,5 .37 615 o32 AVOID 475 tg 615 o32 AVOID 475 240, 3o33 68 2o862, 168 3,003 loO4 3#13 990 3#45 lol4 00 1.0 o 3't' AVOID 475 14409 2o78 Q41 lq35 968 3433 9'16 3*@3 3065 1010 4 5 I*LU 2615 #32 AVOID 503 Z09030 .22 1,33 1982 o7l 2904 1111 2933 996, 2970 lo28 2oO4 1*31 MOTIVATION TE5T5 IN HOODED RAT4 START AND RUN SPEEDS IN RECIPROCAL SECONDS CPND DOSE MCTIV RAT TIME TRIAL I TRIAL 2 TRIAL 3 TRIAL2 4 TRIAL 5 TRIAL 6 START RUN START RUN $TART RUN START RUN START RUN START RIJN NO* MG/KG NO* 2 lo6l 9 93 *8 *97 1#69 061 o79 1947 2o5O lol9 6215 .32 AVOID 503 1200 o72 o29 2*50 1447 lo79 lo6l 2 615 *32 AVOID 503 2409 919 2*04 o56 1*47 2050 1905 2*86 1928 954 968 Zo-04 950 1096 1969 2*44 32 AVOID 503 1440o 2 22 1,52 1982 944 1947 615 615 .32 E5CPE 506 @0,00 3.e5 1.15 4,,5 1,08 4*35 1923 5o56 184 4976 1006 5.56 lo33 615 132 ESCPE 506 120, 1#61 o39 32'90 o68 3985 083 4917 975 2oC4 F,60 4o35 'ge, 615 32 E5CPE 506 240, 3970 o7i 5*8 lots 5026 10 2 lol5 5056 997 3#70 o9O 5*88 00 *74 4455 996 4ol7 *79 5126 loO8 4o55 615 012 ESCPE @c,06 14409 2 ol2 5o5 086 615 .32 ESCPE 50a 20,00 5*26, lo45 6*6@ 1.47 5v56 1018 4955 1906 4435 1.16 4935 1916 2615 2 32 ESCPE 508 120, !i.00 I a 37 493 1*43 5o2b 1*05 4,-5 1923 4* 1 1,, 5,26 -1.39 '-'6 1 5 *3? ESCPE 5C8 240q, 4.35 lo67 3,p 76 2 4,00 5,p56 1.9 56 4935 lv64 2 4o7'0 lo33 3a85 16-73 615 .32 ESCPE 508 14400 3*13 o83 580 ltio 3.-,70- 1 03 4.55 999 3i85 loO6 4o!7 15 2 lo 2776 1.00 APRCH 488 20,00 1.32 36 2*10 .71 3,85 86 2027 o4O 4 35 985 2,33 2 36 2776 1*00 APRCH 48a 120, 2o86 C.57 969 *76 3o23 .78 4.17 a96 3o85 069 071 1165 2776 LOOO APPCH 48P 240, 2ol3 o56 2922 .61 4*127 #85 4,17 oSS 4935 o92 3oi5 .75 776 ISOO APRCH 488 1440, 2,00 59 4011 o84 3o45 075 3*85 gal .2#ol3 997 3.45 094 27-16 1*00 APRCH 4922 20*00 3o57 c,86 2,84 096 2q38 vSl 2*44 .85 2963 92 lo5g ,,-)3 ?776 1*00 APRCH 492 120. Z*94 81 3o2l 090 2*70 086 2o5O 981 2i.94,2 @39 .644@ 7 @'776. 1 6 Cf) APPCH 49? 240), 3.33 o78 1 04 03 2, I&I @,77 to4l vOO 2 2.86 615 ?2 w Z7#'6 1,00 APRCH 492 14404 3.23 ,75 2o7Q 9 89 ?9?1 49? 2.-06 95' 1 -',.63 7'.., 1*00 AVOID 475 20,00 3 9 45 5 o43 2o3 *71 3q57 097 tv3@ o93 2 o 0;3 1406 3.57 1 o WV-L., N HOODED RAT$ MOTIVATION TESTS I START AND RUN SPEEDS IN RECIPROCAL SECONDS CPND DOSE MOTIV RAT 2TIME TRIAL I TRIAL 2 TRIAL 3 TRIAL 4 TRIAL 5 TRIAL 6 START RUN START RUN START RUN START RUN START RUN START RUN NOo MG/KG NO., 776 1*00 AVOID 475 120a 2*78 49 2*56 *70 5957 981 1954 *78 2917 993 3o7O o94 776 1.00 AVOID 475 240. 2o86 o57 3o45 o88 3ol3 991 3ol3 p84 2!9,78 1,08 2.94 1 222 o47 2o56 3 5 lo96 1 03 3,23 1:16 776 loOO AVOID 475 1440o 2,38 *61 3 0 2 972 3.13 Oa 2776 1,00 AVOID 504 20,00 3.85 78 4935 3 33 1,59 3,,@45 1956 1*43 4017 1945 4,17 1947 11 2 776 1.00 AVOID 504 120, 3,85 1,39 4955 1,41 3 1045 3433 1,37 2ol3 1,54 45 lo35 4,55 776 1,00 AVOID 504 2409 3#572 1*39 3o45 lo56 4935 1443 4#35 lo67 3o7O IQ69 2o56 1*64 776 loOO AVOID 504 1440, 4,55 1'016 3,85 1*04 3o7O 1932 2-,03 198r,, 4,00 1945 3,70 1*79 2 loOO ESCPE 505 20900 5988 1,56 4*16 lo23 5oK6 lol6 1*89 1927 2o38 lo56 3o23 1,16 776 1900 E6CPE 505 1 20 9 2.33 1912 3*57 1,11 4o 1-7 1 9 33 4,55 1 32 5 56 1, 3" 2o-ie .1 49 .776 2400 4*76 1*00 ESCPE 505 lo2O 4o76 lo27 2970 lo39 4o55 I 9 22 2#17 19ZB 2,13 I:o, 2 776 1#00 ESCPE 505 1440o 5956 o93 3985 a79 3970 1425 3933 loZO 2950 096 3o23 o96 776 loOO FSCPE 509 20;00 3,45 1,33 4*00 lo25 3,70 lo3G 2 2,86 1469 4,17 1,32 4oOO 1,33 776 1*00 ESCPE 509 120, 2 9 70 lo43 2o63 1*23 4.76 1,56 4,00 1033 2494 1049 3o33 2776 1,00 ESCPE 509 240o 2.56 1064 5,06 2 1*64 4,17 1035 3o33 1045 5*00 1945 2070 1&985 2'176 1.00 ESLPE 509 1440, 2,50 1,01 1*63 1,37 3,23 1049 @950 lo59 2o94 1949 4oOO 1052 803 2 3,20 APRCH 497 20,00 2o22 o66 2917 .89 1472 993 2o86 085 1067 990 2c33 95 BCJL4 3,20 APRCli 497 120, 2,i3 o96 2o7O 095 2o56 1901 2470 1905 2o263 1405 Z,17 -)oCC t) AIRCH 2404 2 t@ 78 Q50 2906 #99 2v,-6 497 i3 C, 8 B*20 4PRCII 497 14iOe 2o'-Aa 1 945 2 9 442 -1406 @,44 V90 2*9i 9 99 2t94 o9@l 2o3a 495 t 3920 APRCVI 499 20*00 4 5 54 3970 Q68 1496 -o 78 4i.55 #79 4,t 3 75 418 4o35 97@@ :, Al MOTIVATION TESTS IN HOODED RATS START AND RUN SPEEDS lt4 RECIPROCAL SECONDS CPND DOSE MOTIV RAT TIME TRIAL I TRIAL 2 2 TRIAL 3 TRIAL 4 TRIAL 5 TRIAL 6 START RUN START RUN START RUN START RUN START RUN START RUN MOO. MG/KG NOo 280fl 3.20 APRCH 499 1200 3.57 56 4,005@ 2 978 5.00 9-(g 3,57 *el 4.35 o85 2.27 *79 76 83 4,55 o79 76 2 4,55 81 41 808 20 APRCH 499 2400 4,35 .57 3985 79 4tl7 ip 82 3 0 85 975 4,17 a I 2 2 9 13 0 4 2 4900 .79 4ot7 o76 4,35 2808 3.20 APRCti 499 1440, t.43 4,17 1,15 2808 3,20 AVOID 2502 20000 *--22 o68 1975@ 1,15 3oO3 1033 3,33 1,32 1.79 '>808 3,20 t.-Volf.) 502 120,., .31 ,76 2,50 lol6 3eO3 lol2 4,55 1920 31403 1&011 1,14 2 1,15 2808 .J*20 AVOID 502 240* 22 2,44 3*03@ 1,.33 o23 1,22 3*23 le0a 2963 1905 2.38 *85 2150 1128 2*623 1,05 2808 3,20 AVOID 502 It.40c@ 't. 81 2*63 96 3957 1922 2v27 1932 2806 2 0 AVVI I 1; .4SO 20*00 1 a i, I o66 Zo7O *78 Z494 p78 2994 979 3913 o285 2o94 *91 3ol3 6a 2o44 976 2#63 o89 3z33 280fl '30,20 AVCID 480 1209 la96 947 2*27 *63 2 82 3ol3 1,00 3o57 81 2aO8 44 3903 972 2.08 978 2o56 -AVOID 48( 240. 1.64 2808 480 1440 1*45 44 1*67 o73 3103 o67 1985 966 985 1,30 lo89 86 3v2O AVOID 0 808 3.20 ESCPE 507 20,00 4.00 1912 5#00 998 3057 2 lo52 4,76 1009 5 4118 lo39 4.55 097 3o2O C$CPE 507 1209 3.23 .85 3945 *76 4976 0 65 5000 1*03 4*76 1,10 4935 IOc- 808 2 3o45 'L" ( *28 5o26 oc)8 3.03 lolo 4q76 loO3 1004 008 3*20 E5CPE 507 2409 4.17 1910 5956 1 992 4o55 1916 4917 99 4917 1 . 808 3o2O ESCPE 507 14400 4935 85 4900 83 3 70 d,20 2 FSCPF 487 20-00 5.26 lo2O 3#33 lo43 4935 1919 4o55 lo?2 9988 IQ!9 5.67 lol 8013 99 4o55 lgl( 3905 1927 5,,2',6 It'Lf'. 79 3,33 1020 3970 fiop 3,20 FSCPE 487 120, 41 7 6 .11 7 lv22 5o26 lo22 SQ26 tg?3 5a 56 ' la I -0. o93 4o35 1#28 4 9 I fjoe -1.20 ESCPE 487 2 5#26 .52 4976 tea 5OU0 oBS 83oA5 1001 5626 cg'f 5,26-. 011 a C. 3*20 ESCPE 487 1440, 4*55 3!. "It-0 loo APPCH 496 ?0900 2.70 88 3*57 1#06 3970 IvOl 2, Ci-4 !v 1%@ 2o7Q t 'I, MOTIVATION TEST$ IN HOODED RATS START AND RUN SPEED$ IN RECIPROCAL SECONDS p DOSE MOTTV RAT TRIAL 1 TRIA@ 2 TRIAL 3 TRIAL 4- TRIAL 5 TRIAL 6 C D 2 TIME t4o, MG/KG' START RUN START RUN START RUN START RUN START Rt)N NO, START RUN 120 3945 997 3957 loO6 t69 2 91 3,23 1,27 844 lOoOO APRCH 496 2,63 81 3o45 1.01 240, 3,45 .90 21.94 *88 3923 188 3.03 1010 3933 toOO 32o57 1012 2844 13,00 APRCH 496 loll 2 63 tolg 3.85 1 28 2844 10*00 APRCH 496 1440* 3*45 488 4-p35 1925 4900 1*22 4#17 2844 10,00 A2PRCVI 498 20000 3,45 59 4.35 9'16 3,13 *78 2*54 975 4o@7 88 3,,03 .50 98 120* oO3# 844 10*00 APRCH 4 2o56 6@4 10.00 APRCH 498 240 907 76 2 *23 oO3 q,03-* oO3* 03it 03* 844 lOoOD APRCH 498 1440t 105 1030 008 qU3 0 3 -4 0 3 03it 903* 844 lOtOO AVOID 471 20*00 2#63 o38 3o23 2 989 4917 lal4 3*85 loll 2ol3 lo32 2*00 1975 844 10,00 AVOLD 471 120o 3*57 o7l 2*38 1916 3e45 IP03 2*38 1928 Zo7O lo32 3*03 lo52 844 10,00 AVOID 471 2400 2,70 47 2 2978 1,27 3t45 1127 3957 1*33 2027 lo32 3a57 lo56 844 10,00 AVOID 471 1440, 1932 41 2,70 .93 2,63 1000 3,o23 1,33 3985 1.25 3,45 1.35 844 10900 AVOID 503 20.00 22 lo69 to67 957 2c,13 *90 1*33 1910 2.33 1,00 1*72 1,25 844 10900 AVOID 503 120o *60 1,22 la96 092 099 1,23 o97 1039 2978 lol5 980 1,64( 844 10900 AVOID 503 240* *21 oO6 1*67 2 *94 2o63 1932 2*33 lo-'17 2144 1*30 2*38 1019 844 10,00 AVOID 503 1440. 1.64 o39 1947 1961 *97 1.49 IoO? 2413 1,32 I.r. 167 2 6 1,67 10*00 E5CPE 466 Z04QO 5*26 lo22 5*26 lo32 5I)OO lo39 6*25 lol2 4*17 14,15 3o33 *99 844 844 10900 ESCPE 466 12(lo 1),035 o9R 2 4*17 1#43 Zt5O lolo 5t26 1*25 3933 1916 5900 1*23 844 10900 ESCPE 466 ?400 5,56 lc,02 2*33 1.15 6967 IvOl 2o94 o94 6925 1019 6o25 985 844 2 10-00 E5CPE 466 1440a 5,56 *68 5*88 1933 5,,88 ltl4 4o76 1910 5o56 1 03 2,50 -1.09 00 ESCPE 508 20900 4*00 19,05 8 9 3 -18 2 1,,05 5*00 .1*10 59@6 3 to 22 5926 IQOB 34-@,3 ioog 10ooo ESCPE 5oo 120, 3*45 lo'5 5 qo 2 00 1*33 7.14 lol9 6*25 1*23 6967 1411 5o26 1*19 1.0 00 ESCPE 508 240c 3.85 lol2 5tOO lo52 5926 1910 5900 1911 5*06 tul9 5o26 6 1630 n I AI MOTIVATION TESTS IN HOODED RATS 5 IN RECIPROCAL SECONDS START AND RUN SPEED 2 TRIAL TRIAL 3 TRIAL 4 TRIAL 5 TRIAL 6 CPND DOSE MOTTV RAT TIME TRI#L 2 RUN START RUN START RUN 2 UN START NO* START RUN STAR! RUN START R NO* MG/KG 50 4oO@, 1,23 4,.17 1,,18 a 26 ipog 3,@ 7 1,14 4c.35 1905 2 2*00 402844 10900 ESCPE 508 1440* 2a5G 3o2O APRCil 496 20000 1*22 *85 2o22' *95 ?a33 *51 2950 o5O 2o5O 051 1169 *5@ 2850 2 3,20 APKCH 496 120, li62 53 1952 1,15 3ol3 *53 2,50 o53 2oO8 051 1*61 III(, 2850 3*20 APRCH 496 2409 1985 *99 1982 052 10'79 *54 2o5O 1922 14285 9 94 2o86 016 1 2850 3*20 APRCH 496 1440o 2994 o52 2i63 *51 ?v33 953 2,22 @016 2*04 2 lo23 2,78 *51:, 8!50 3620 APPCH 498 20*00 4.00- 1.23 3,45 19,33 3933 1*18 3970 1*23 3#65 o54 3o7O ,5'-@ 050 3#20 APPCH 498 1209 2*70 lo23O 391@ lolb 2922 1*32 3985 lo35 3oO3 C,51 11.82 052t@, 850 3,20 APRCH 498 2409 3*57 52 4900 o53 3*57 *53 i,ag 053 2o7O @,52 3c.03 1925 2 t 850 3.20 APRCH 496 1440. 3,65 :5'3 3.57 1,19 4,17 *51 31023 1920 2a33 lo27 3.33 2 850 3,20 AVOID 501 20*00 2.17 1947 2*78 1189 3GO3 1*79 lo89 1969 lo79 lob9 3,57 850 3,20 AVOID 501 120, 2,22 1943 2.38 1.49 2922 1043 2v5O 2 lo54 2963 1065 l@,82 1,5 2850 3-20 AVOID 501 240* 2*2f- 1952 3*13 1*59 1964 1954 2994 1*35 2913 lo6g 2oOo loa 10 21150 32e2O AVOID 501 'L44 -*94 1*54 3o33 1*39 3913 1.33 2.22 4lo69 2v63 1,92 3,85 1*61, ii5o 3920 AVOID 503 20.00 L -4@ 8 1080 o93 @979 *82 loZO *53 2f7O lol5 lo22 2850 3*20 AVOID 503 120* f661 *71 2.00 *73 2oo8 989 2,44 V65 I,,-ti 051 32c,03 1;11 2850 3,20 AVOI %D 503 2400 35 1,30 1*82 *97 ?963 55 2o27 9 91 2@70 1,20 1159 112@ 'BrIo @420 AVOID sO3 I 0 41 2(154 a36 *53 10 9 3 1*45 *50 2.56 1016 li96 ig&'5 1#82 *5i ii C #20 E5CPF 466 2040C 4o76 lo27 2o33 1#30 2 o 9it V83 300@) 2 3 it, iOO3 i# 3*20.E$Ct)E 466 ',20P 2o6B 1*39 4 5 4,,27 3o33 5 4 2o76 052 29d6 5 i 3 3 *9i &.20 ESCP 466 @40. 3.4!; 1,41 4o76 ),?O 3@85 V!5 B 'i 6 t92'5 4900 -1,28 2,56 1 , E MOTIVATION TESTS IN HOODED RATS START AND RUN SPEEDS IN RFCIPROCAL SECONDS CPND DOSE MOTIV RAT TIME TRIAL I TRIAL TRIAL 3 TRIAL 4 TRIAL'S2 TRIAL 6 t4of MG/KG Noe START RUN START RUN START RLJN START RUN START RUN START Rt)ti 3*20 ESCPE 466 1440 4.m55 51 3.8$ 91 3;,33 ge 5900 991 3945 lo23 3,33 2 1,00 9 W850 4*41.7 *80 850 3#20 E5CPE 508 20*00 2944 o5l 4900 2 *90 3,70 985 4*17 .89 2150 o74 @S3 1.20 Escpr-- Von 12(ii 4600 051 1985 loOO 2o86 o86 2*78 990 17 095 4*55 50 3 20 FSCPE 508 240, 3,233 086 3*80 *52 4o55 0 93 2o63 999 3.85 .82 2-,78 850 3920 ESCPE 500 14400 3*70 o8l 4917 0 91 5*00 8 7 1,61 0 85 495-n 983 5*00 of 2 80 3#70 1*20 851 o32 APRCH 496 20,00 3e23 a 3*03 1909 2*70 p97 3 -to 9 3985 2 rj 851 .2 120, 3a57 1.2? 4900 23 l'o - 9'2 APKCH 496 a 93 3.57 1015 3.70 1,03 32.13 I.Oe 3 851 *32 APRCH 496 240 4,00 lol2 3185 lt25 3*33 1,39 3.45 1925 3*03 1932 4ol7 102-0 851 CH 496 4il7 21,16 3o33 le3co *32 APR 1440* 3*70 1*01 4935 lo22 5oOO I 9 33 3970 lo2B 851 32 APRCH 499 2OoOO 3*65 .55 88 2 1,59 7E ,65 4900 p79 4955 077 4,17 88 4 0 ,951 *32 APRCtl 499 120, 4.35 974 3-85 o9O 2o63 o97 3957 #94 3a57 2 o9l 4o76 "9q 851 *32 APRCH 499 240* 4,55 069 3t7o *93 3,45 997 4*17 996 4017 93 2o38 2 18 851 932 APRC@L 499 14409 3*85 56 4006 .87 3.03 1190 4*17 0 993 4*00 o89 2963 .52 AVOID 471 2OoOO 4*00 7851 *32 1.03 4*34 1.30 2o27 1,25 i6lol7 1956 3645 1,3'r 3,70 1 4-@ 851 *32 AVOIO 471 '?Uo 3,70 941 3.01 o78 4at7 1%03 2.91-'* 1016 2 3o23 lcl9 20i@4 1047 851 o32 AVOID 4 -I* 1 240 9 3o33 0 42 3,p 51 1 -P I 1 3*45 1952 1,85 1 61 3170 o;S 1 4a:@ -851 .32 AVOID 471 1440. 2 -I.85 o37 3 @3 033 44A5 obi 3oO3 o89 5t .26 3 1 02-2 AVOID 430 2COOO 1.23 2 o A,, 8 2*70 o9i 3,rJ3 C)3 I * 4 lolb 3lati ltl,l C)SI *32 AVOID 480 120o 1.82 (@76 297d 96 2o44. 01-)3 11,92 o83 3 13 4 02 &',75 Ibb 5 *32 AVOID 4oo 240c 2,44 *73 3980 lsil -)-R70 It'3? 3 23 1 O' 4t76 lo"5 4slY 1,-,16 I'k4 MOTIVATION TESTS IN HOODED RATS START AND RUN SPEEDS IN RECIPROCAL SECONDS CPND DOSE MOTIV RAT TIME TRIAL I TRIAL 2 TRIAL 3 2 TRIAL 4 TRIAL 5 TRIAL 6 fjo MG/KG @!00 START RUN STAR. RUN START RUN START RUN STt.,9T RUN CTART RI)N 2 9 33 *83 402851 *32 AVOID 480 14409 2908 o48 2oO6 o82 2994 t92 2o5O o69 2*44 495 285) 32 ESCPF 466 20*00 4v35 1910 2.17 1,33 3923 1641 3oO3 19'27 1464 1;,32 32.85 1,1!, 851 .32 ESCPE 466 120 9 5 9 00 1.45 4ol7 1.52 1.69 lo85 2*27 1,35 1,79 1189 '610 8 6 1 I I 1; 851 3 2 ESCPE 466 240,, 5p26 lo49 4#06 1 9 267 2 9 33 1#49 4955 If,02 I'@ o 4 5 1 r, g@ 4c76 1.25 8 5.1 9 32 FSCPE 466 1440c 3o45 o9O 5*00 lolo 3*13 lo2O 4*35 lal4 2r,00 IC-23 5w26 1*49 2 851 .32 ESCPE 487 20,RCO 5,Eg 1.02 4,76 lo25 3957 1915 4,17 1,27 4c,00 1420 3,33 2.44 o 2 ',2 2 'lal4 fisi 932 ESCPE 487 120o Z,33 2963 1*39 2o86 IP39 3oO3 lp4@l 3o23 1927 851 *32 ESCPE 407 240 5.56 1.37 3.70 lq,47 4,55 1.85 4.17 lp56 3.8= 1 -1.69 6-@ 4,76 8151 932 ESCPF 487 1440. 2 9 94 63 5o26 .93 3,,13 lti6 3,2t 57 1009 2 9 78 1.04, 2,38 'I 0 4- 5 867 .25' APRCH 488 20,00 .09 16 007 o46 oj o67 *43 105 34 23 021 2 17 0 867 25 APPCH 488 120 a 1,69 924 2,50 9 7 1 2,22 2.17 55 .36 990 37 o33 o39 @867 925 APPCH 4Ha 240o 910 005 *94 *36 2156 8 5 2o7O 9 63 916 o72 2*00 *77 867 25 APRCH 488 1440. 1.19 12 2o44 *71 2,13 o67 1022 932 IV56 57 1082 o C, 3 867 *25 APRCH 497 2OoOO 1*19 914 1954 0 2 2a 909 *35 56 4 934 1., 39 43 1 4 867 .25 APRCH 497 120* 40 ,64 1.96 o88 1*75 o76 1972 9 75 2lo43 ol7 1943 10 867 *25 APRCti 497 240; 2oOO o 99 1 0 6'? OJ95 lt82 #91' 2,p 17 093 leo3a a93 lo85 *83 2867 925 APPCII 497 1446,. 1.83 a96 2 1*56 .50 Zo5o c5l 1 -n, 97 2o?2 9 72 a9l 26c7 'iVC'.D 475 2OoOO 2o63 *14 lo82 *72 493 P88 1*47 vOO 3f'.? 50 -25 2 *?5 AVO!D 4'1 5 120o 3*03 .8 1 3# 13' ,89 IP82 !r83 2#86 96 2*08 .3 51 4),.55 1 3 2*33 93 2 o ol T G189 i@i3 1 1 0 1 I:j ii 6'1 .?S Av(-.-D 4-15 2401? .95 411.96 14!9 4 v ohm MOTIVATION TESTS IN HOODED RATS START AND RUN SPEEDS IN RECIPROCAL SLCONDS CPND DOSE MOTIV RAT TIME TRIAL I TRIAL 2 2 TRIAL 3 TRIAL 4 TRIAL 5 TRIAL 6 NO* START RUN STA Fi. '1,00 AVOID 500 240& ?*57 2 lol6 4*35 lo33 4955 lv89 4955 1*61 4#76 lo8? @'e55 loci !,.00 AVOID 500 1 C-,. 2 , E.- e, o69 3o85 1 4 2!5 4 1.5!> 1,67 3o85 lt72 4, 1,69 5,,24's O@t. 1.00 ESCPE 5G5 -&'OtOC 5900 to4l 3o33 loigo 2o7o t*54 @-91;05 ITZO 2#38 2oO4- 4oi7 1*30 03tt 1,.00 2 E5CPE 505 120. 3.45 *79 2*94 1#30 4tt7 *99 2#70 lo22 3,p45 I.tOo 3.70 I.I@- 8 I 3 5*@tj i 5 3; 23 L 6 MOTIVATION TESTS I-N HOODFD RAT5 START AND RUN SPEEDS IN RECIPROCAL SECONDS -PND DOSE MOTIV RAT TIME TRIAL I 7RIAL 2 TRIAL 3 2 TRIAL 4 TRIAL 5 TRIAL 6 START START RUN START RUN START RUN START RI,JN NOO MG/KG NOo RUN START RUN 036 1*00 ESCPE 505 1440* 22*63 89 4o!6; *88 4955 1*25 2*44 1935 4976 lpl4 5o.R,6 1#10 2400 1 2 3 3,33 1 , 4 1 4t55 1 1. 45 1.96 1*69 4t76 1.54 2 'I 8 1 33 036 12,00 ESCPE 509 2OaOO 03-i 1,00 C'SCPE 509 1200 3,70 1,20 3o57 1,56 4917 1,45 3,45 1*32 21050 1,22 3z33 1:23 - 240, 3.85 lo56 3.70 3036 2 1.00 ESCPE 50q loll 5926 1927 5.26 1025 3185 1,43 .2,,@4 1959 5036 ISOO ESCPE 509 1440* 2-70 lcO4 1*79 1967 3913 lq-45 3o45 1019 4917 1*52 4oOO 2 lb52 049 3.20 APRCii 497 ?OOOO -11 oO7 2o2Z 1*02 3.03 993 2o33 loO6 2oO4 997 3.13 098 049 3*20 APRCH 497 1209 l*cw4 965 2*94 1909 2*94 loO5 22#10 1#06 2927 lqO5 3Q33 1,08 049 3.20 APilC@l 497 240, 4,00 oO4 2.63 1.01 3e?3 1*23 3945 10'30 2.78 1*22 3o'3 taC9 049 3,20 TPRCH 497 1440. 2*94 o7O 2*38 loO4 1.25 990 2,22 laO6 3oO3 1,14 3*33 979 049 3,,20 APPCH 492 20*00 3923 979 2.63 987 1916 i88 2,78 *90 3ol3 o92 2o@,4 o92 2 '495 049 3o2O APRCH 492 i2o, 2*27 *93 2,,22 *99 2o27 @94 2.33 igoo 3ol3 o-)3 2.63 049 3,20 APRCH 492 240, 2 2.38 027 2.44. 921 2,94 099 3.33 o86 2913 990 2,,Oe .90 049 3*20 APRCH 492 1440a 3o5T o92 2*78 995 3oO3 loO2 lo47 P984 2oO4 997 2o33 *92 2 049 3.20 AVOID 502 ?0,00 1.08 4,6 2o56' 1925 3*57 lol6 4*17 1.1;@z4 3vO3 1#43 3957 1,045 049 3o2O AVOI[) 502 120, I:* 65 o59 2.63 1906 2o44 1*06 2 3.33 Itig 2#44 1*12 2.2-7 .1)4 049 3o2O AVOII) 502 0 3S 1,96 o58 3 33 lq59 2933 .622 3.70 1052 392S 1,67 1,-PO 2400 049 3e2O AVOID 502 14409 o4l !ol2 3945 1919 :3o33 la37 2.86 tor@5 3oZ3 142( ?;,91, U49 3,20 2 AVOID 504 20*00 3.03 t95 3* 85 1*43 4435 1,43 4 * 0(i I o ii 3 3913 5 3. 1 41 240- P-7 lo35 4917 L t 'i2 o 115 1 C, a,@ 4#!Y 2qO( 4 I'l 3.20 AVO!D 504 12C, 4-00 1,05 3o7C) lot32 :io23 1,9f, 3.65 1.92 3913 ?,C, -.920 AVOID 504 2 lv&9 3457 DED RATS MOTIVATION TESTS IN HOO START AND RUN SPEEDS IN RECIPROCAT. SECONDS 2 IAL 6 I TRIAL 2 TRIAL 3 TRIAL 4 TRIAL 5 TR DOSE MOTTV RAT TIME TRIAL CPND 2 START RUN START RUN START RUN START RUN START RUN START RUN NO* MG/KG NO& 3945 lo56 4,00 1947 3c57 lo49 490 049 -7.20 AVOID 504 1440,0 3*70 1*15 5*00 1959 0 1*69 oo I.2?E o@s 3o2O ESCPE 507 20#00 4,55 lo23 3e45 1-54 3,,13 1*19 5900 1*12 4q55 I-O'K 5a 501%S 3.2C ESCPE 507 120. 2.70 25 5 00 193 4100 998 32o57 lol8 5900 97 3a57 I*Ox, 2400 3*45 o52 5:26 1#03 5o26 1*10 5,56 1909 5*56 1,01 5000 1*30 5049 3*20 ESCPE 507 2 - .66 5156 *99 5908 1,19 5,26 88 3,23. 1915 4,55 09-1 5Oio9 3,20 FSCPE 507 1#4409 0 20,00 342.33 1906 4935 1*32 3#33 1925 3.57 1 35 4*00 1947 r-Q26 ltic, 5049 B620 ESCPE 509 0 O IF 1; 3,20 ESCPE 1204 4,676 1932 4o76 2 .1937 3,23 1,019 4.55 1,37 3o85 1,28 4.17 1.14 505 5049 3.20 ESCPE 509 240, 2.86 70 lo39 4.35 lo3O 5@,00 3923 la49 5,56 -c 2 1945 3 9 1,54 3,,70 loll 2904 1*61 3cO3 1937 lo45 1*56 3.03 lo28 4935 loi@ @@o 0 4 ri -o2O ESCPE 509 2 1440a 104 0*00 3o57 o92 2o38 *97 2o94 985 2o38 986 3o7O loOO 3a57 og-. 3*20 APP@R-H 488 104 3920 APRCH 488 1202a 3*33 086 3913 999 3,t3 o93 3o7O 095 3,03 89 2944 ilo; 10-@, 3*20 APRCH 486 240a 2*17 .970 4*35 loll 4955 loll 3-45 1903 3,85 1,14 3a5-@ 1011, 3*20 APRCH 2 48C '-1440, 2,u6 66 3oliS *91t 3,o4r) o9O 2978 084 31,33 976 -o45 1,901 10,@ 3*20 APRCH 499 20900 4000 74 4917 o86 3o45 182 3403 *82 2422 aB2O 2470 7f. 3a2O APRCH 499 9 3985 090 2033 v65 2994 983 3923 o94 2o3i 98@ 5101, 120(, 3 #. li 7 7 510 31020 API@CH 2 49q 240t '4o45 o63 2938 o83 4tol7 994 4917 993 2#17 c,98 4c.00 93@ I rj 2;-94 a 1.00 292? 2 99 'K,82 9C 2, t-@ 1194, 20916 1420 AI)RC@I 4 9,@, 1440, 0 101. 2 1410 3 5 la 3,,20 AVOID 471 2OoOC- 2*70 2o7o 85 ot3 1900 3*33 o 98 29,6:). io 0,4 3v4ll, o I 6 2o5O 1 o I2 11 78 li-20 2063 1*3@ f.,@ 3a2O AVOID 471 120c 3o33 081 Z%50 lot ..20 AVC'F) 471 240, 1,85 3f, Z.33 1.06 2938 lo2? 2,17 @9?64 2 1 ei@ I q. 3 3 3.45 1.4' MOTIVATION TESTS IN MOOOFD RATS START AND RUN SPEEDS IN RECIPROCAL SECONDS CPND DOSE MOTIV RAT TIME TRIAL I TRIAL 2 TRIAL 3 2 TRIAL 4 TRIAL 5 TRIAL 6 NOD MG/KG NO* START RUN START RUN START RUN START RUN START RUN START RUN 2,13 939 2 03 081 3123 1906 3,33 1,22 2 4WI04 3,20 AVOID 471 1440* o5O 39 l,tO 4,,00 o76 104 3,20 AVOID 4aO 20,00 2*22 963 3,57 97.8 2,44 2*79 2970 019 2,44 o86 2*70 75 5 104 3,20 AVOID 480 120, 2*13 62 1923 970 iv59 72 a97 69 1,)03 o98 3.03 89 104 3#20 AVOID 480 240* lo75 o53 22*08 992 1967 1919 1092 1912 2933 1,23 1,9t@ 14-03 104 3&20 AVOID 480 1440, .92 .37 2*00 63 @996 963 1*85 059 o79 o75 2o44 *'16 104 3*20 ESC2PE 46& 20900 2*56 loll 1959 lv6g 3oO3 1*16 10#23 lo23 2o63 lol2 IQ69 1*37, 514.04 3*20 ESCPE 466 120,, 5*00 lol5 3*03 1919 ?*50 1.00 2-44 loO2 2 2,17 o95 ZQ63 1923 104 3*20 ESCPF 466 240, 2*22 1037 2022 1937 4*17 lo(5 2917 o88 1,85 1,64 2c56 lo!7 5104 3,20 ESCPE 466 1440, 3*45 1002 3*70 1915 2978 2 1015 2o86 lol5 3 0 32- o94 3,P,5 'I . ',3 104 3,20 ESCPE 487 20,00 3*70 o99 3*03 1OZ8 3933 1,33 3,03 1030 lo82 1.69 2.86 1 49 104 3o2O ESCPE 487 120. 3,13 2 o9l 2*17 1915 to45 lo43 2.08 1008 1*69 l,r@-6 2o27 1:19 240. 2,44 .88 3.23 1145 3oO3 1,45 2,33 lo82 2,06 1972 3,12 1 47( 2 104 3.20 ESCPE 487 104 3*20 ESCPE 487 1440o 2#70 o64, 3#85 990 3903 #95 Lo85 1903 2#08 lo35 lo92 1947 124 3#20 APKCH 488 2OeOO 2.o 33 *05 3*45 q8g 2 3923 0 86 3#57 9 88 3*33 o85 2*63 091 124 3,20 APRCif 488 120o 4*17 o95 3933 9 8 5 3o45 9 89 3970 1.00 4 00 95 3 Q' 2 7 7,4, 1&24 3,20,APRCH 4lia 24014 4.00 065 *63 80 2,04 076 3,23 e4 207a U94 6"10 - 0 APRCII 488 1440. 4.17 1.00 3*03 991 fioOO 1909 1,25 a;) *30 -;'5 1,03 -24 3 2 512it B.7-0 APPCti 497 20,00 2.50 e94 2#44 qp96 4970 1404 2,56 o97 I. o 41 1 C, 2ob 3 0':') *99 I 21@ 3.20 APR'--H 497 120, 2,86 0 9 6 29@63 loO6 3oO3 lwll 3,t3 IOa ',.03 !.,Ca 2@,50 1 Ci 2-;O. ?.38 8 0( 3.:Io APf@(:H 497 ,92 2 t3 .1 2 MOTIVATION TESTS IN HOODED RATS START AND RUN SPEED$ IN RECIPROCAL SECONDS CPND DOSE MOTTV RAT TIME TRIAL 1 TRIAL 2 TRIAL 3 TRIAL 4 TRIAL 5 TRIAL 6 START RUN 2 START RUN START RUN START RUN START RUN START RI-IN tiog MG/KG NO* 1WI24 3.20 APRCH 497 1440, 2 44 1996 1916 1 6 3 1 1 6 2 7 B o82 2994 1 9 0 5 28 1 1 6 2 3*20 AVOID 475 20*00 2044 ,79 2t78 076 ZoB3 988 2,56 ,91 2994 loll 3,85 1.15 124 3.20 AVOID 4 1209 1,54 o56 2970 4p79 2917 87 1*56 o78 l@*03 19122 2o63 100c) 124 75 124 3*20 AVOID 475 240o 2#56 o47 1*60 *67 2o7O #83 2978 091 2*94 1,01 @,-00 1*25 A 14409 2,00 *60 1,92 954 2927 968 2,00 983 2,33 1,03 3045 1,05 124 *20 AVOID 475 124 3.2o AvolD 502 20*00 3o45 1941 2o63 1933 2o94 1933 3*-10 1939 3oOS lo27 2o44 1,04 4 3*20 AVOID 502 120* *76 093 3004 lo2O 1-82 lolg 2956 2 lo25 1*47 lo28 4ol7 1#15 1 2 5,88 1,69 2.86 1041 3.23 1,47 2o94 1033 2*08 lo54 2,50 1128 3,20 AVOID 502 124 240, 14402* o27 *79 1969 ItU5 1*61 1910 2*78 1923 2963 lo22 j97 I 9 12 124 3o2O AVOID 502 124 3.20 ESCPE 506 20,00 5.00 o96 2,36 1*18 3.70 1,06 3o85 1,45 4055 1,08 6,25 1,09 124 3*20 2ESCPE 506 120o 3*33 1,08 4,76 1.30 3970 1,22 3.70 974 4,55 1.16 5,00 94 240Q 4917 124 3*20 ESCPE 506 ol4 3o7O 1*02 3*33 o75 5o88 loOB 5o26 loOO 5oOO 1.216 124 3920 ESCPE 506 2,78 1440 906 3945 i@70 4ol7 1004 3.57 o97 4*17 loll 5,00 lo28( .954 3945 4,8 5 124 3o2O ESCPE 507 2OoOO 3*70 2 3o57 1*12 4900 1925 5*26 1.27 2o86 1-5-@' 3o33 1*04 3o33 1920 39 124 3&20 ESCPE 507 120* 57 loz';9 4*76 lo39 2994 lol6 3o23 1#'C 2 124 .0,20 ESCPE 507 240, 2.63 lo27 4,17 Iga2 3v7O 1*20 4,35 lv27 2063 1,5c'_ 4,00 %G& 124 3*20 ESCPE 507 1440o 3*03 *45 4*00 *70 3945 1#19 3*85 090 4&35 1933 5456 li43 2 1*72 *75 1#45 o87 -,47 s-82 2t2Y o@;-3 1*23 45, -,00 APHIH 492 20,00 5120 ,Lroo TPRCII 492 120,, 1*69 o92 1992 o86 lo45 #79 o36 7@69 o-#2 1461 f; 51'.1'@@9 1.00 APRCH 492 240* 1.33 09 8 1*79 .87 ar-2 P91 1.69 f,50 @97 t,4 f 2 MOTIVATION TESTS IN HOODED RATS AND RUN SPEED5 IN R !@TARY fCIPRO-'AL SECONDS CPt4D DOSE MOTTV RAT TIME TRIAL I TRIAL 2 TRIAL 3 TRIAL 4 5 'TRIAL 6 NCO MC-/KG 11401, LI'Ai4'@ RUN START RLIN SIART RUN '.START RUN STAki 9, i)i4 TAIZT R(.Jfi 2 2938 76 &wl2g 1*00 APPC!L 497' 144Cj-@ 2*08 o97 76 oi36 9 98 q,92 o52 *91 *97 lo96 129 i,00 APPCIJ 49S 20.(jO 1 . "ib .68 3,4!@ a76 3,t,23 0 76 2, @f 2 978 11264 '14 2a7O i, 1.4 5129 1-00 APRCH 499 120. 2#38 982 3*23 t9O 2994 *63 2986 085 3CO85 088 2 o52 060 5129 1900 APR'%--H 499 240a 2*94 o68 2 2@ 79 lo'41 . *69 2*00 9-19 2*00 o74 2986 oijo 5129 1*00 APRCH 499 1440, 3,13 70 2:86 2 t83 1682 *77 1996 078 1992 979 2.44 80 129 1900 AVOID 504 20*00 2*38 lo45 2o84 lo52 4900 1941 3#57 1#47 3#33 IQ82 2o94 1*54 2129 1-00 AVOID 504 120* 3,03 1,56 390i 1939 3o33 1952 2*06 lo69 ?o7O 1967 2986 1*69 129 1,00 AVOSO 504 240* 2,22 1935 3.33 1975 @q45 3933 2la5( 1982* 2 2o38 2897 129 1.00 AVOID 504 1440o 2,56 951 1982 2.33 1,92 1*75 3*,33 1.79 2986 1,54 2994 1,96 *52 2 9 70 0523 2o33 5129 1*00 AVOlf)-480 2OoOO 2*22 979 2*lf 1945 2o78 ltl4 4*00 94 5129 1*00 AVOID 480 120o 2*50 978 1*79 *95 954 988 22050 o76 2950 o85 2o38 :65 'i!29 1,00 AVOID 480 240, 1*32 095 2.76 *95 2*22 o52 3,33 1*22 3.57 1914 3.13 091) 2 9c; 129 1.00 AVOID 480 1440, 1,37 75 .70 2,17 o72 2.08 53 2o44 98 2.56 0 5129 1.00 ESCPE 509 20.00 2*27 lo72* 2 1-27 1,33 4955 lo4l 4oOO 1 3#05 lo43 43 5129 1900 ES(-PE 509 1200 2*86 lo33 3e7d 1-54 2038 2 951 3913 o55 2927 1*61 3933 1:44 2*78 1941 4,76 1*35 3v33 1,37 2*00 j.29 1*00 ESCPE 509 240* 1#47 4*3@ 1*37 3*33 2 1,54 129 1*00 ESCPE 509 1440. 2.22 .53 2.84 .51 @,@7 52 3,70 'I , 15 lo85 ).28 2.1-0 1 , 23 5129 1,00 ESCPE 487 20.00 5,00 2 52 2*3i lt28 ?*@2 1,1@9 5900 1923 4*35 1,45 5.7--6 1.33 5129 1900 ESCPE 487 120a DOOO 1016 4:5'1 lo3? 5*88 If,32 5*56 1925 59,56 1.25 1,47 5129 12,00 ESCPE 487 2400 5,56 1920 4 76 1*Z2 29@3 194.r 4,76 lito 4,35 52 5o56 r ).45 099 5129 !*00 ESCPF 487 l@40o Z*94 #3 398 IPOO 4.76 .93 4417 o99 3,11 ;@51 3,20 APIlCii 48A 20,,(')Cj 1*41 9 2 5 o 5'e 8'$ 49!)5 999 4#17 *143 Ol V.9 4*35 2 *9, A r, :,IOT COVPLT:TE Rtiti of@l l'i-i I '@' 'I l@ I AL .. .. ....... MOTIVAI'ION TESTS IN IIOODED RAIS 2 START AND RUN SPEEDS IN R'-CIPROCAL SECOND- CPND DOSE MOTIV RAT 'TIME TRIAL I TRIAL 2 TRIAL. 3 TRIAL 4 TRI,@@. 5 (RIAL 6 2 '4 START RUN ST START RUN START RUi4 START RL]i ART RU[4 START L@IJN No, MG/KG NO, 321L 2 3.20 APR@RH 488 120, 4*UJ o6O 4#35 1*06 4 o 1 7 1 04 3*a3 98 3 47 4-@ 17 8 3 5211 3,20 APPCH 488 240. 2.78 43 1943 061 1010 2 75 !,,,17 .88 1962 z45 3,45 192 7 4 o 1 7 1 0 4 1 5211 3,20 APPCH 488 1440, 2oO8 o34 3o85 *92 4o35 o96 4,17 p8 85 211@ 3,20 APRCH 499 20,00 5,00 65 5026 080 4976 083 3057 69 5too 978 2 4o35 211 3P'O APPCH 499 1209 4*76 o68 3*57 *79 39@5 e95 4o76 o8l 4o76 685 4455 *80 211 3*20 APRCH 499 240, 4*17 0263 2.94 81 4t55 IR72 4955 p86 3957 481 1,47 a64 211 3,20 APRCH 499 1440, 4.00 o45 4*00 *79 4955 .75 @935 081 4c,17 0-@6 4ol7 2 81 2"&! 3*20 AVOID 475 23,00 1.89 946 2.31 o5O 2,17 60 3ol3 985 395-Y 098 3,70 -i,io 211 3920 AVOID 475 120, 3.23 .75 297A 2 o78 2.63 978 1,69 o93 3o57 loll 3003 1.06 211 3920 AVOID 475 ?409 3.57 954 3ol3 *69 3@,33 *81 3*45 q9S 3o85 1912 3oO3 1912 2 5211 3*20 AVOID 475 1440, 2-33 o5P 390 072 2o7O o64 2*70 979 3s85 loO6 4cOO isi.,L 5211 3t2O AVOID 480 20*00 2o7D *67 3-31 2088 3ae5 989 3eO3 *96 2o63 loO6 '-,@,63 ;;B".@ 5211 3*20 AVOID 480 120 9 1*69 956 2911 1005 2027 9 90 2oOO 976 2o27 2lcO5 2*'L3 qp 8 3 52i'L 3*20 AVOID 480 240, 2*63 o85 3*45 ISIO 2,94 1 000 3 9 57 78 2,13 2 1,06 3o45 094 0 2944 055 lo@4 5211 3#20 AVOID 480 14409 1*69 -8 I&B #67 ZQOB v73 087 2o27 *641-)@@.I. lv28 2,,86 3.;23 5;0r) 1006 3.70 1,16 3,70 2!1 3920 ES2CPE 505 20,00 5,56 1411 6*24 @i2it 3o2O ESCPE 505 120, 4.00 1,23 2,3i 058 2066 1914 5,@03 1,,ii 4,a'lb 1919 le 4-; 5211 2 3.20 ESCPE 505 2409 5,00. lolo 500@ lo23 596a 1 27 5,26 1930 5.88 1922 5,26 1 06 5211 3,2o ESCPE 505 1440o 5o26 1918 4*11 12*18 5Q56 1932 4900 1927 3o23 1022 IC89 1*@ ESCP '3,20 .,00 4.17 Ic@00 5.54 1 .3,7 3 . ti -,j s,239 41 3,, 3 E 437 iD o 4:5 3 20 ESEPE 487 1209 &,00 oe7 lia 121 I a 2'@? 1 9 39 2*86 1 9 3'e@ 3 o ';p'3 141-1 4CI7 0 E.SCPE 487 240o 4*35 1,19 4,30 1 * 5.1! 5956 1 a 6-@ 4,55 1 52 6 25 1 37 2 o 8 f I L4 MOT TESTS IN HOODED RAT2S START AND RUN SPEEDS IN RECIPROCAL SECONDS TRIAL 5 TRIAL 6 CPND DOSE MOTIV RAT TIME TRIAL I TRIAL 2 TRIAL 3 T2RIAL 4 riot MG/KG N09 START RUN $TART RUN SLART RIJN START RUt) START RUN START RUN lq22 5o26 loig 2o9q 1037 )211 3.20 ESCPE 487 1440o 5o56 1904 5 88 lo?O 5q26 lo4l 5o26 ol5 3,,13 1,06 4,.I- 1.2- 2 52 !'@1,00 APPCH 496 20,00 2,56 96 2,76 1,16 2970 *99 3,45 1 @*00 APRR@H 496 120a 4,17 loOR 3*85 lol6 3o85 1,25 4917 1 23 3,03 1,19 4,00 lo22 2 52 ')-vl.-OO APRCH 496 2400 4,35 1*04 4*00 lo22 3923 1919 3*03 :97 3#03 lol9 3.@@70 1*19 2 I 9 00 144-rO-p 3 1928 4*00 21#32 4#00 loZ3 1*2- APRCil 496 o7O lo!6 3o4l 1622 4076 1.00 APPCH 499 20,00 3.85 66 4.00 983 4955 V82 5oCO .86 2922 78 3o27o 185 1,00 APRCH 499 1209 4.17 69 4917 q88 3,03- 74 4,35 980 3933 79 2o86 *86 loOO APRCH 499@ 240* 4*17 068 2*38 082 2o5O o83 2 3o4m, o84 2938 o79 4ol7 '060 1.00 AP@-'CH 499 1440* 4.55 73 2o7 *87 3o7O '088 4976 88 4917 o96 to64 b34,:.- 1*00 AVCID 2 471 20'00' 3,45 24 3 5i 1,06 la4l lo,25 3.45 1941 2,78 1,32 2.06 1.4't !*00 AVGXD 2 1*00 2#94 1*10 471 12024 2994 *44 3: 4 o OLI 'I Q 12 3913 1*35 ',-03 1#39 1,00 AVR,.ID 411 7 4.li 1,47 3.'z3 1 1,=-> 2 240. 2.27 1.2 .37 3.70 1,,39 297a I ,; 45 1 3 1*00 AVOID 471 14409 3 301 103 4.00 1*04 3.4"-, 996 3o5T 1908 3oO3 1113@ ,33 36 1.00 Avr,'.D 480 20,00 423 1,59 2:3 1*06 3v)3 1900 2.50 995 2#38 1,.@(-'9 i-,..78 C7 1,.QO /-V O 1 1) 480 120 2,22 64 1 4 -(o 2,13 .82 1,67 9.c ;,00 A V' D 480 2100 Z.GB .94 2,3t t.41 0 4'f-' '.i I .1 ii 5,,CO 0 2 'iD 480 14@,Oo 1*82 o39 195 043 2022 9 7e, 2 o l'O 977 291@ 1 . 1 1.0() AVO 11) i 10 Lr: 5(.PE 466 :,O,,00 4.5r,- 19,16 3,8@@ )f,?O 1,20 1,0( 3. 3 .38 5 "'-IIVATION TESTS IN HOODED RATS Mi START AND RUN SPEEDS IN RECIPROCAL SECONDS 4 TRIAL 5 TRIAL 6 CPND DOSE MOTIV RAT TIME2 TRIAL I TRIAL 2 1'RIAL 3 TRIAL START RUN START RL)N START RUN START RUN START RUN START RIJN MG/KG NOe, NO* loll 4,76 1.05 2 17 1919 1975 1,,64 1,6 1 2 4.55 .89 4.001 7 1 3 7 00 ESCPE 466 1209 1*00 ESCPE 466 4900 1*32 2#70 1956 2ol3 Iola 2 33 1*19 3-85 1.12 2o63 1:33 2400 0 2 1,00 ESCPF 466 1440* 3,57 1,,06 3970@ 1.10 3o45 igll 3.95 1912 4.15 lo23 3o57 laii 1.0( ESCPE 487 20900 3,57 94 -D95@ 967 004 1916 2,38 lo2$- 3,,70 lo2O 3o33 110, 1,,00 El'-OCPE 487 120, 4*35 1.03 3310 lo52 3933 1*35 2,94 1947 3,33 lo56 3o7O 1952 1.00 ESCPE 487 240. 4.17 1954 3,03 1.72 3.70 1,69 2oO8 2,00 3,85 1,61 --7ol7 la56 1*00 ESCPE 487 14409 2*70 1-@27 7-978 060 1989 1005 2vO4 1*16 195,5 lo43 lo67 2a22 SRBA SEQUENTIAL RESPONSE BE@IAVIORAL TEST fM24386 '@AT No* D 0 E V.- T TIME 065ERVATIONS @ND SEX MG/KG GMu H c L;. P 489 M 3lb2 463 000 NOR@;AAL 2 0 DET:F,EASED LOCO['CTOR ACT'Vl'r't COi@'i'!NL'ALLY R't-iA'I.@) s SLIGHTLY DISRUPTED PATLERN tiORNIA&- 2 NORMAL 24 NORMAT@ sill iA 5*2 358 0,0 NORMAL o*25 DECREA5ED 40COMOTOR ACTIVITY CONTINUALLY i4uDGE5 REV4AIRD DOOR 'RN 7 5'-IGHTLY DISRUPTED PATTL RESPON5F TO LIGHT F@ASti NORMAL 4 NORMAL 2-# NORMAL tk SRBA SEQUENTIAL RESPONSE BEHAVIORAL TEST t"26 1 5 k' RAT Noe DOSE wT. TIME OBSERVATIONS AND SEX MG/KG GM, HOURS 2510 M 0*32 342 000 NORMAI- NORMAL NORMAL 2 4 NORMAL 24 NORMAL 51'f m 0*32 347 000 CIRCLT&NG od,25 NORMAL 2 MODERATEL2Y DISRUPTED PATTERN AIMLESS WAt4DERlf4G INTERMITTENT RESPON5E 10 LIGHT FLASH INCREASED REARING UP SIDES OF CAGE 4 AIMLESS WANDERING rn HEAD C-EARCHING SHOVELNOSR-_ REACHES FOR HOUSE LIGHT A@l TOP OF CAGE VI@IDERATELY DISROPIE6 PATTOERN t4CRMAL SIEQIJ@---,,4TIAL RESPOt4SE 6@-H.4VIO1141. I-F-ST' 'I 7 6 RAT NO* DOSE WTo Ti@iE OBSERVATIONS @ND c@EX t@. GK G CHo liouRS 491 m 2 3.0 309 000 NOR.N4,AL 0.)z NORMAL 2 SLIGHTLY DISRUPTED PATTERN 4 c@NEEZItJG DUE TO WATER IN NOSE 24 NORMAL 010 NORMAL 2 51, @i 1.0 355 o*25 HESITARIONS 2 NORMAL 4 NORMAL 24 NORMAL 4 ni SRBA SEQIIENTIAI. RESPONSE BEHAVIORAL TESI 2308 OBSERVATIONS RAT 140o DOSE V. T T AND SEX MG,IKC GMO HOloiRr) -iAL2 NOR! 461 M 3*2 452 0110 ti 0 i-'@ 1-i A L@ICREASED SENSITIVITY TO SOUI;. NORMAL NORMAL 24 362 3 090 NOP%MA'. 3*2 o*25 NORMAL INCREASED SENSITIVITY TO S,"IUND 2 NORMAL 24 NORMAL SRBA CEQUENTIAL RESPONST BEHAVIORAL TEST @@2844 RAT No* DOSE WT* TIML OBSERVATIONS AND S@:X MG/KG GM* Hcucll 48. 100 455 oto NORMAL op25 NORMAL 0 2 NORMAL 4 NORMAL 24 NORMAL 514 M 1000 352 ogo NORMAL o,*25 NORMAL 2 NORMAL 4 NORMAL 2it NORMAL SRBA SEQUENTIAL RESPONSE BEHAVIORAL TEST IMZ850 ME OBSERVATIONS RAT tIO& DOSE T AND SEX MG /KG GM* I I 0 I., 0 NORr4AL 2 2o2 o.25 NORMAL 2 NORMAL NORMAL 4 24 NORMAL 405 0*0 NORMAL 528 14 3*2 oo25 NORMAL. 9 NORMAL 2 4 NORMAL 24 NORMAL SRBA SEQUENTIAL RESPONSE BEHAVIORAL TEST RAT NO, DOSE WT.) TIMF OBSERVATIPNS A -10 'I GG tioup,@l t SIX t G, 4 8 c; 0,32 447 oto NORMAL oio25 DISPLAYED2 SIGNS OF FEAR GLASSY-EYED STARE SNIFFS WHERE CAGE FLOOR AND SIDES MEET SLIGHTLY DISRUPTED PATTERN HEAD SEARCHING 2 SAT ON REWARD PEDAL WITH HEAD OUT OF DOOR 4 NORMAL 24 8 NORMAL 5 357 oeu GLASSY-EYED STARE 14 i4 Oo32 oo25 NORMAL NOsli4AL NORMAL 2 MOR14AL SRBA SPONSE 5EHAVIORAL SEOLIENT'KAL RE @@2881 NOt DOSE Wye TIME OBSERVATIONS RAT c C.,. Hb-,iR-z. AND tiG/KG ri2ki 000 NORMAL 52F 1.1 3o2 336 DECREASED LOC(MOTOR ACTIVITY 0025 DECREASED t.0comOTOR ACTIVITY 2 4 14ORMAL 7 24 NORMAL 0,0 0 NORMAL 526 li 392 409 oq25 NORMAL NORMAL NORMAL NORMAL SRBA cr:r@UEt4TIAL RESPO@ISF- BF-HAVIOP@AL TF 897 1 2NP $AMI-i-U. WTo T I RAT NO* DO ME OBSERVATIONS SE i G 2 .4D NORMAL 000 *2 361 NORMAL o*25 2 NORMAL 4 NORMAL 24 DECREASED LOCOMOTOR ACTIVITY EXERT2ION TREMORS 2 340 NORMAL oto M 3* NORMAL o*23 INCREASED SCR,NTCHING JUMPING EXERTION TREMOR$ 0tiORMAL 2 NORMAL SRBA Si:QLIE',IifIAL RESPONSE EE:HAVIORAL I'EST IM5034 RAT No# DOSE WT# TIME 005ERVATIONS AND !EY MC,/KG 4-P. H C Ur@, 1. 51@ !/I 100 337 .000 2 NORMAL' 0025 EXTERNAL AUDITORY INTERFEREN,C 2 SLIGHTLY DISRUPTED PATTERN RESPONSE TO LIGHT FLASH AIMLESS WANDERING REACHES FOR HOUSE LIGHT AT TOP OF CAGE 4 NORMAL .24 NORMAL 9 514 to. 100 354 oto NORMAL 092'. DECREASED LOCOMOTOR ACTIVITY SAT ON REWARD PEDA@ WIT,@L fiEAD OUT Of-,DOOR 4 NORMAL 24 NORMAL 4,',I)Ktkt9 SRBA Stc-QUENTIAL RESPONSE BEHAVIORAL TEST 1"5036 OBSERVATIONS NO* DOSE WTO TIME RAT AND GMe HOUR;S SEX MG2/KG 491 M 1*0 314 0 0 NORMAL NORMAL 0925 2 NORMAL 4 NORMAL 't.. 24 NORMAL 040 NORMAL 525 M 1 0 342 0925 NORMAL5 2 NORMAL 4 NORMAL 24 NORMAL SRBA SEQUENTIAL RESPONSE BEHAVIORAL TEST IM5049 OBSERVATIONS RA N09 DOSE WT, TIME AND SEX MG/KG GM* HOURS NORMAL 481 M 3*2 450 0200 i HEAD OUT OF DOO 0025 HESITATED ON REWARD PEDAL WITI R 2 5AT ON REWARD PEDAL WITH HEAD OUT OF DOOR EXERTION TREMORS 4 NORMAL .24 NORMAL 2 517 m 348 000 NORMAL 0-o 2 SLIGHTLY D15RUPTED PATTERN 5NIFFS WHERE CAGE FLOOR AND el-IDES MR@-ET CIRRLING AIMLE55 WANDERING JUMPING jumpiNG INCREASED 5CRAT%-HING INTF-RMITTENT!-Y DI-SRUPTfi) PATI@'.RN SRBA ',.EOUEN,riAL RESPONSE OEHAVIORA@ TEST W5104 ME OBSERVATIONS RAT No* DOSE WT* TI HOURS @ND SEX MG/KG GIA 2 416 010 NORM2AL 489 M 30 (q.25 NORMAL 2 INCREASED SCRATCHING SLIGHYLY DISRUPTED PATTERN 'NORMAL 4 24 NORttiAL 491 M 302 299 010 NORMAL 8 os25 NORMAL INCREASED SCRATCHING 4 NORMAL NORMAL k.' lit, t SRBA f-,EQLIE@ITIAL RESPONSE BEHAVIORAL TEST @5124 RAT NOo DOSE V.,T,. TIME OBSERVATIONS ANO SEk' MG/KG GM, HOURS 48-) 21.1 3*2 430 00(i NORVAL o$25 NORMAL 2 NORMAL 4 NORMAL 24 NORMAL 49) M 3 2 301 0.0 NORi4AL op253 NORt/AL 2 NORMAL NORMAL 2 NORMAL SRBA SEQUEN'flAL RESPONSE SEM,4,VIORAL TEST 1'29 RAT NO* DOSE WTo TIME OBSERVATIONS AND SEX MG/KG GM, HOURS 517 1.1 100 363 000 NORMAL 0*25 NORMAL 7 2 NORMAL 4 NORMAL 24 NORMAL 525 M L*O 342 O$c t4ORMAL oo25 NORMAL 2 NORMAL NORMAL 24 NORIO-AL SRBA SEQOENTIAL RESPONSE OtEliAVIORAL Ti@Si IM5 2 1 1 RAT NO* DOSE t-@T* Til@,E OBSERVATIONS AND SEX MG/KG GM* liOURS 491 M 362 302 0,0 NORMAL 2 (,25 NORMAL 2 NORMAL 4 NORMAL 24 NOR@IAL 510 m 3*2 341 010 NORMAL oo25 NORMAL 2 NORMAL 4 NORMAL 24 N2ORMAL SRBA SE@,;,FNTIAI. RESPONSE BEHAVIORAL TEST KAT NCe D(il-.E l T! AND 5'@X f-C- K C. i -1 2 0 $k L C, 1.0 3-,,) 2 5 N,)I@PIAL 2 t.@'-VEI@ELY Di'@IRI;P"'E2D PATif-R,4 laon -% F F 5 @j@itc-RE CA(@E FLO()@! 0,1@iD Sir)E5 O',EEY iriCrkc.A@-Fi'j Lt--rv"k@,T@l2 OF S'ri-@II)E I tjkLI AT TO@' OF CAGE 1: '-;;S FCk H(,USE L 2 A R fc- 5 P %noNSE TO L7Gri'l FLA5ri 24 ti("RtAL 514, m 1.0 359 Ole N04MAL 2 5t, T 2 'AFFS ;4liFkE CA(JE FLOOli ATJD @IDLS @IFET SLIGHTL)' D15HL;PIE.D PATTL-H(-$: 2 $HOVE'LNOSE RESPOI-..5E TO L16kiT FL."k5ti -VIE5 I-'OR ;.OiJEL' I (@ti f AT 6C-F t! 14 A L ... .. ...... SEGUENTIAL RESPONSE TEST IN HOODED RATS NKJMBER OF RFWARDS RESPONSES AND PER CENT ERRORS FOR FIVE MINUTF INTEKVALS CPND 2 RAT PRE DOSE 15 MIN 2 HOUR 4 H3UR 24 iiOUR NO RWO TOT PC7 RWD TOT PCT RWD TCT PCT RWD TOT PCT RWC TOT PCT 438B 4U9 33o 1059 37, 8* 30* 509 18, 639 43q ?5, a 5 9 35t 320 ;6# 340 3,20MG/KG 28. 90* 37o 4* 180 56* 2'@le 759 374 23c 76 38* 27, 6at 38o 31* 107* 37o 4# 169 50* 230 74* '35# Z7* 2 849 6# 270' 85* 36o ME;;,4 31) 101* 3',Ii, 5* 21# @29 71* 38* 25e e2l 36o 299 36,, 4.--80 517 26, 98* 45# 12* 49i 519 Ili 57* 589 234 92# 50* 23# 49, Z,114G/K,,G 354 i26, 449 18* 729 50o 25* 1061 54, 2r,-,. 999 509 32,a le@ 49;. 3!. 115o 46# 15o 580 48* 242i 97 519,27it Ot 5it 309 122t 51., MEAti 31v 113* 45a 15* 609 50* 209 879 54o 25o 100o 509 28* 1*44* 50,: ft2@@15 517 140, 57* 60* 17o 2 81* 58* Igo 839 549 99 47* 57o 29 105* 45@, .93:?MG/KiS 26, 1059 44a 31. 127* 46#@10* 48,p 520 6* 36* 67* 31v 112# 410a 214 72* 40* 21* 94* 549 3 o 241 47@ 17* 75# 559 29. li@9 46,0 '78 9 48a 23* 10lq MEAN 19, 539 119 52* 589 119 539 60o 30o 1099 45* 102615 51r, 16@. 51o 3729 14* sot 449 14* 500 409 14o 51* 45t 119 509 469 32MG/KG 19 65,p 42o 17* 609 43o 18* 619 41 9 12f, 53 479 16 60# 424 18, 7!o 49* 22o 78* 41o 10# 709 479 18* 67' 429 18 65* 42* MEAt4 18, 62* 439 18* 63* 43* 179 60q 439 15* 579 #45t 150 58# 430 9rn .9i SFn!JENTI/11- RFSPONSE TEST Ill HOODED RATS NUt-1'3FP OF R!FWARDS RESPONSES AND PER CENT ERRORS FO[4 Flvr 2 Mlt4tJTE iti7rf?@IALS CPND RAT PRE DOSE 15 MIN 2 HO(JR 4 HOUR 24 IJOI)P N C' I'D T Pr,T RWL) TOT PC1 2 IZWI) TOT PCT RWI) TOT PCT RWr,- 'InT PCT GW776 659 ?3* 77* 409 ?5* 82# i7,t 17,i 6?qo 45t 20v 749 43o I*OOMG/KG 2 lq4 76* 45o 19* 71v 42* il@t 75* ?9* 2n- 664 39, 17o 729 30, 20.-, 69,, 42 9 2 3 9 83i 419 20t 499 4 2 9 2 -0 it 70* 409 12* 4-@'t 4'2 M IF /'I I 7'1 22* 77* 1 'i 4o 75o .19r, 19, 66* 4? 1 6 4 217C-) 491 27, 904 39@, 369 121* 409 27,p 92, 419 25, 83 9 409 33a Illo 4 2 I Cjt)IiG/K(-) 3?. 101* 36o 27 9 94, 409 33r 98 34a lee 6 7,r 45,) 36 , I I 3 -1 4 5 9 1 2 43o 371 37 @ZOQ 36o 2 2 72 3 8. 3 1 , 102* 39* 1 1 4 4 MEAN 2i 889 379 319 1069 40, 24v 784 409 18, 649 419 35o 1159 39, 1. 1,3;i 4812 2ell 97. 46* 24o 88o 45# 169 779 56* 209 81f SI* 179 759 559 23, 112# 5as 20# 83# 529 19. 823 54* 234 geo 53a 209 CJO' 511,0 2 17, 82o 57. 199 75, 529 199 799 52q 24o 1069 55t 16o 45* 40q MEAN 22. 97qo 54* 21f 829 50o 18t 79i 549 22* 95# 53* 18* 77i 52o 2 rj . 26* 1 50o 27* 99t 45* 259 109o 53* 51-t 3 1009 44* 03* 45* 260 1089 2@ 2 0 f-i G /'K G 25. 93 9 44. 22o 91* 51# 14* 52q@ 4-4* 25* 92 46V 26 @03, 50V 20, 78# 45, 20o 80* 49o IOV 44# 5 5 9 12, 469 48o t5o 73* 560 MEAN 25, 933o 44* 23* 91* 48* 170 68o 50# 21* 7941 046* 22* 95* 53# rn TEST IN HOODED RATS SEQUENTIAL RESPONSE .S AND PER CE14T ERRORS FOR FivE MINUTE INTEI'i'4A, :5 NUMBCR Of- f-FW-4r,"5 2 kE'PONS%c . b. OUR 1 5 MIN 2 HOLIR -RE DOSE CPND R,%T PCT IWD TOT PCT RWO TOT f,' C I' NO P1.14D TOT PCT RWD TOT RVID TOT PCT 154o 63, 43, i. - do 9- it 1. 51-1 'i 7 15'32@ 31, 24a 989, 48' 2'1,p 136a 60o 28a 0 944 739 49, 3 7 163* 554 26, 359 3 9 23, 1139 5 0 02') t1176 2 -IC-/KG 10 00f 469 259 123* @49 95 9 459 369 1289 44, 3--t", i349 499 219 78* 12?, 53, 414 I. 2 8,, 51; 4 87 4 15.. 470, 40,o 14,l 36@ 149 44, 30# 57 9 37o. 4 8 11, 38. 242. 913o 4.i 42., 35 9 :17# 56* 50# 4ii is., 54* 41t 14* 409 Ila4 12 2 17* 47* 309 121 It 4 t 5,p 12 -Z. 43* 40* 13o 47# 36c, 12@, 43* 42o 52o 40* 13a, 479 43# 130 46# 39t) MEA2N II,. 45- 42* '5* 44* 31* 1 6,p 9 o 38t 50,0 156. 609 42* 19* 5,) 36. 18, 74 39* 18* 64* 389 0 528 2 149 47 9 409 19i 669 419 14o 519 419 t9q 72; 44,, 20, 80* 43 42t 19; 639 41t 189- 70t 46a 23, 76, 39a 18# 2 64o 390 1 6,1 594 20,@ 77* 40* 179 501 390 159 549 44i MEAN 16 9 58* 419 199 67* 42c 491 28, 90q 3 2 Be 28o 479 376 29. 99* 399 30* 100o 4u 2 38 289 67* 36, 3 3@.G/ K 5 29, 9!5 t 38. 339 Ills 41 q, 374 1 15.0 36o 340 107t 36, 309 291o 34,o 28,. 940 39o 239 789 40t 249 78* 37* 324 1029 369 269 77# 324 MEAN 28.,, 93o 38, 289' 95o 399 30@ 97,t 37, 32i 103o 37,@ 280 059 34* 0 -u %A S[nUV-NT'JAI. RESPONSE TEST IN @IOODED RATS T!UMBER OF REWARDS RES@)ONSES AND PER CENT ERROR$ FOR FIVE MINUTE INTEFZVALS 2 HOUJI 4 CPND 2 RA-f PRE DOSE 15 MIN NC 'C('Ir PCT RWD TOT PCT FI'ID -(O-l PCT RIJD -(CT PCT RWI) i) C Mll--)l 469 1 4320 ll@, 409 454 130 43* 4 41 47, 40o 5# 24 9 58* 6* 21* .32MG/KG 13,., 49. 45* 10 9 32q 38* 12; @it 37* 11, 43 40* 159 49t2 413 15* 53 30 149 419 43* 1&; 5 42 1 2 9 43* 40* 36* 45 9 2 k 41 14. 4.- ME',v l@ 49.o 9,, 33o 4@,a 39, i 514 38, 153# 51* 289 133* 57 9 28* 105t 47, 33, 126* 4892 42,p 1 4 416 42,. 1509 43* ?Bo 1269 569 25t 99t 43 v 1 9,o 83* 549 42* 1 2;! 9 48,, 29: 2 116, 49v 89, 4ao 26,, 105,0 509 21, 78o 45 97, 55o 12* MEAN .36, 140. 489 26. 119- 56o 25* 98a 48f 26@l 105o 519 35o 1159 4 2@l-ii 525 45, 143. 35v 42, 129, 35* 29v 89, 354 194 126o 379 510 16oo 36, 3 -ICFiC/K,@i 47, i47* 35r, 2 309 95, 34. 199 @58, 34, 84, 370 .429 1299 36, 47., 146o S4* 28, 37, 33* 23o 75a 32, 184 54* '-Jlg 3 14 'o 98v 5 @6iE 145t, v 3 4 1343 34i '"141 7t) 1 34,@ 28, 38. 1-5v 1 12@, 36-s SEQUENTIAL RESPONSE TEST IN HOODED RATS NUMBE TCRVALS R OF RFAARDS RESPONSES AND PER CENT ERRORS FOR FIVE MINUTE IN 2 RAT PRE DOSE 15 MIN 2 HOUR 4 HOtiR 24 liOUR CPND PCr RWD TOT PCT :,@WD TOT PCT RWD TOT PCT RWO TOT PC'f R t.. Li TOT 2 5; 1 Qt 38,l 45* 12* 36,@ 16o 529 374 dw7sal 52.3 8. 399 5,it Ile 42* 4 o 44# 2 Z. 17o 42v @Oa 3,20MG/KG 160 579 394 19o 579 32* 124 43t 40q 13# 52* 4 13, 5?q 38i 14o 44* 34* It* 38o 239, 14 58 9 409 604 38 9 t7o 37* lit 40 1?, 49,p 2 ME:& @l -4 -+ 5,p 48* -ilo 13, I v 39* 17, W-391- 525 42 i26, 33o 45o 1359 33# 31,@ 939 330 38a 118o 35,p 46,p 133o 334 2 30p 94# 37V 30* 35, 24o 849 33 3,20@IG/KG 909 349 20* 63q,? 70,t 3le-26 37, 115* 35* 22a 1009 225* 17* 649 44 9 18o 6 1 9 34t 149 4 1 9 32, MEAN 36, 112. 35a 32* 108* 31* 23i 739 37* 279 83* 34o 29@ 08o 33* P.97 517 20. 920 519 21, 2909 53o 209 76* 47o 194 79* 49t 14o 7?t 47, 3 $IOPG/KG 19, 84g 54* 229 940 52o 20* glo 55 24o 1009 52, Ile 8 4 t 49, 19, 83* 52* 2 Zio 1C)5* 56o 20o 93# 529 22* lllt 599 13a 85* 550 MEAN 19. 86* 52, 219 96o 54q 209 079 r@19 22, 97o 53t 13a 80t 50. IW5)34 2 514 37. 149& 50* 29* 119o 51* 20o BOQ 49,t 19* 799 52* 459 162* 444 1,3otAG/KG 419 32i I'@ia 4-@. 28, 100it 44* 46o 159t 41@ 2 30# 119* 50a 29* 1109 35, 1260 449 26o 949 45a 30* 1109 :43* 28* 949 38o 33, 129t 494 2 150# 45o 1-4,EAN 34. 131* 48c 280 108* 48* 179 1001 45# 25# 919 .45t 410 1 n SFOUENTIAL RESPONSE TE'@-T lti kiOODED RATS NLIMBER OF RFWARDS RESPONSES AND PER CENT ERROR5 FOR FIVE MINUTE 2 INTERVAL.S CPND RA'r PRE DOSE' 15 MIN 2 POUR 4 @IOUR 4 VIOUF( 1.4 L) Rt.@iD TOT P,@T RWD TOT PCT RWO TOT PCT R@-)D TOT PCT 2 TO-,. P T IM034 510 1 5 4 41. 30, 1010 419 13w A44 41* 13. 52, 46 2, 75o 3,;.@ I,OOMG/KG @1(i. lora @9* 2 290 98o 409 131 43 400 23. 85- 39 3 Y o 99* 39o 2 1 a 80# 489 10t 39 49o 26# 84* 3?o 34 9 lt7o 3Jo 2 I., F. A N 1 03 5 27o, 93@ 42@ I 7-i 42 3 o 2) 74 43.9 10i 3 0 6 .525 o 61 3@-o 16a z@So 33* 17# 57# 37* 2 -23 6,0 o 3 1 6,7 5( I,OOMG/KG 12, 4 4@* 19* 57* 33* 21@ 64P 34? 22o 69u 36* 159 2 4!3 55a 351. 13* 45 9 36o 15* 494 '399 20o 68.) t , 3 7ti., 3 E, o 18o 2 MEAN !II, 58 37# 18o 539 54o 17 5 5;, 36 9 19 9 5@l 4 369 !7o 5 $i's JW036 4-)! 26, 96, 460 30o 102, 42* 23, 79, 42, 252, 78o 360 27'0 31)4 "1.1 I.OOMG/KG 2E, 9@., 3eo ?So 90o 38,* 281 06o 35, 2-@ ;.30 2 83 .3 394 31 0 loi4 - 274 864 38, 21. 69* 38o 19. 589 34@ 209 69v 38 33, 103, Ble 2 MEAN 27 92, 4Co 26* 87 9 399 ?3v 74o 37 24,, 770 38 0 31 a 984 i M5049 5i7 5 , 93 43, 27. 93* 42t 2B* 105 0 47, 29. 96 9 2 40o 31 9 109 a @.1 3,20MG/KG 31 , I 1 r', 440 299 103v 4 3 9 1 6 9 74 9 509 2 310 800 43 q, 30 0 110o 44o 10. iorio 3840 9* 42t 52q 120 52* 52* 10* 3$o 45o 239 83* f,34 MEA14 29., 1 0 42* 22 79. 40* 191 77* 50* 21* 71. 9 42. 209 tolo 439 Ilk' SEOUENTIAL RESPONSE TFST 114 HOODED RATS NU@IPER (F RFt-.,ARDS RESPONSES AND PER CENT ERRORS FVR FIVE MINUTE INTERVA!-S CPND R@0,7 PR 2 E DCCF: 15 MIN 2 liOUR 4 @IO(JR 7-,4 HOUR fil) Rvir) TIT P T RIND TOT PCT RWD TOT PCT RV.ID TOT PCT R2-t!f) TOT P@'T imo."( Asi 2!. 91o 4!o 22a 969 54n 15* 60 a 47* IBP 059 45, 21, 71 41 3920MG/KG 2-@, 8@- 449 2 20* 649 389 239 1029 449 $Ov 430 309 971. 349 3 114, 459 20* 689 40,p 28# - 87 9 36* 1 1 i, 37 38 2 0 41t 32a 101-o 4 'i 2 1 769 44-a 2@t 03. i? 61c, 4 2,p 2 i,. 9@)@- 39.: -tN 1&5104 491 3 Ot 9-@ i 't-o 38o 115* 349 31* 98Q 36t 27, alig 35. 290 87, 3.20MG/KG 30* 9 -:' :o 31-t 38* 122& 38o 344 1104 1 a 9 329 101# 38* 30* 1110 a 36, 10?o 33t 38c, 113o 33. 24,, 78,o 56, .'.72o 85* 35* 32, 98, 3't,, '7o 2le 9tll 369 32i, 99t) ilio MEAN 42* 9F@ 35& 3286 117* 35* 30* 95t 40!104 439 11. 4 C. 45. 12a 409 40. 149 @4o 36* 1 2 42, 43, 149 434 1,2oMc,/Y 1 3 52, 2 38. 10 9 -43 4 -,'o !3o 4 38,p 15 53a 4 @G 120 4k, 43. 12. 44, 43. 130 47* 38. 139 45o 400 17. 53;, 2 369 18 64. 44, MEAN i2, 42, 449 13. 469 39o 12* 4Ao 41* 14# 469 39, 169 53o 40o ft5l24 439 t3. 45, 42t 14* 482* 42. 11, 42t 489 13o 45t 429 lag 574 35a 3,20MG/KG i5,4 5?, 389 15, 554 449 15. 46o 35o 179 5'-;g 379 170 60* 379 2 j4. 4(,.,) 36d, 14* 50* 404 15t 54-P 419 140 439 40. lo@o 58* 38o riEAN 14, 4'?j 394 14. 51. 42# 149 2 47, 41t 15, 480 399 184 589 379 'U 2 rn SEQUENRIAL RESPONSE TE5T 11-i HOODED RA-45 NL'IV'BER OF RlFv.ARDS RESPONSES AND pFR CENT ERROR5 FOR FIVE MINUTE INTERVALei CPND R@.- P,--,E DOSE 215 MIN 2 HOUR 4 iiOUR 24 tiOUR 14,%,J% Rt,@D TOT PLf RWD TOT PCI' RWD TOT PCT RWD TOT PCT R ',.'D T 0 T PCT 124 4v-- 2 36@ 113# B6* 2e* 904 369 26* a 2 9 3'1 o 2 6.. 86. 34c 3*20MG/KG Gla 36o 41a 131* 37-- BS* '108* al@& '--3a 10'-24 359 35o 110# 35r. 2 16, 112* 36* 354 113* 374-. 319 IUO,, 59* 29* 869 34o 32, 97o 349 if,EAN 102 3u' o. 37# 1 19 c, 37& 32o 99it BS i. 2 9 -i -91,, 2, 'I@. o3 9t- 3 4w3l29 .51-7 14, 5(:, 42* 'L 4 o 45. 36. Iclo 479 3 %'O o169 60* 459 !6o 66i I OOMG/KG 16, :-3 C, 916. 57 9 40,. 13 9 6 6 552,0 1 jL),; 921, 5 9 oI 62 o 5'3 0 9 824o 4 9 14o 5 3 9 3 o 2 6 54., 39o 14, 54 9 43* 20* 73o 49o 1 9 0 MEAN 15. 52,, 40. 15, 52a 40* 17* 42, 47t 189 76* 52o 'L59 60i fl@io 2 2 34, 28. 859 34, 399 126, 3 -0 9369 1139 35* 41, 1264 Z. 5 a IM129 525 ft2 I,OOMG/Kri 24, 33a 25- 7ti 36* 27* 869 36o 2 31* 104' 40a 29o 89* 35o a, 304 43# 24* 73* 34, 249 73# 34, 20* 74* 43o 33* 10(o 36a MEAN 7'ii 37& 26o 799 35a 33-o 2 95* 35,, '-)99 97-,; 40# 34 107v 3'ji, I I LO 12 . 5A 52, 1. 5 o 5'5 s 43a 13#, 57* 5 1 v 19v 6'1 o 42* 12q 53 45. 920MG/KG 17, 62* 40, 20o 65a 34# 21* 679 37t 20* 67* 39 o 19* 66* 3 9 22, 764 39,. 21* 64* 309 18* 669 44o 20o 8 67s 370 19,@ 76* 41. MEAN 17* 62, 44* 19. 610 36* 179 639 440 20* 67o 394 17, 65* 429 ifOUENTIAL RESPONE-E TE6] Tti IIOODED RATI NUf-!a,-R LF RFV.ARD5 RESPONSES AND P'C--R CENT ERRORS r'CR FIVE MINOTE It,'2iERV-Ai.! CPIID RPT PRC- DOSE 15 MI(4 HOUR 4 HOUR. 2 ii IIOIJR (11 Rlo,D TOT P@'@'T R@%.D TOT PCY RWD TOT 2 PCT RV;D TOT P-@.-T R@ir, TO-1 -rcT 102, 41o 25t 97, 42 310 102, 39 9 411@.20MG/KG 29% 9=t 2115t 42# 27* 99& 116o 37 9 4., IO;- 36 36# 104o 414, 259 849 3 S 41t 25. 27i* 3 7 127* 43t 30f 284 97t 1,.C-AN 89o 3.@ 115c 42o i7o 10(4 3ow 101,, .0 2 i 4 I 14(i 4@# 0 3 1249 48* 27* 112* 54a 2 t3 o 9'$ 9 4 3dq - 0 IOOMG/KG 39, 13es 4 --- o 3t44 122. 49v 20, 83, 52 9 20, 1049 4:,:, 3 4 1.414 24. 8'c'q 3@4 22* 919 499 10o 45o 56* 22# 84-o .5 36o 140% 48o ME"ii 2 35 i2-, 420 280 li2* 49. 19, 83, 5-44 2,@. 964 440 36, t4!-@--, io @9. 1.0- 3-ib 28a 1029 42* 2 'Lf Zlo 399 2 -t 9 2 87v B9o 2-6a 934 -7o 88,) @9o 24, 85, 4le 334 lllo It t4C/KC 211 9'j, 374 30* 293* ?@5 @4, q 4 2 , 2 6;) 93 9 41v t 250 52* 32o 1119 42,6 31c 102a 3')a WE AN 27. 96.. 39@, 2ho 969 5 40, 18,a 61 4 o 21o i I 30, 102.) J PAGE A- PHYSIC.7kL, NEUROLOGICAL, AND_BEHAVIORAJ. E.-"aMNATIO-IS ON SQTJIRREL MONKR"YS ComDound Number-!M2438B: (soln. H 20 I'V.) If2ionkey Dose Weight Time Ise:x_ il, Flu.. mg/kg g. hrs, Effects P3 18.50 650 0.00 In sh,@,t,tle box: crouch; quietr alE Female Normal reactions to all stimal't clic 2 0.20 No=al- reactions. to all stimuli cuc- 0.30 On atte-mpted handling by expe--4--rra,-i+-- plast4-z immobility- incoordina---.-;&cr.,- 2 balance poor; grasp good; eyes unat to to visual cue,- piinils normal,-, reac-o'--s to light by atteT.,,n E orienta+-joxi responses, 0.35 2 No impzovement. 0.40 Iiinrotreiient; be't".-ter loco=tor cooi nation; proper visual fixation to c 0.45 Ofter lr--tris head to one side(abnor,- 2 PUSL@@-W'.; a'Lert resronse to sot,--id ci. balanc--n -still p,-,or; 3.n unu.-uai down flat@positiovi with ',.ieFad belly- 2 orien7.2d at 45'L upwards; -tjlaesy x stare f- ated on ceiling. 0.50 Same aa ,bove; palpebral- c'Losa-e; still in sprea2d-out, head-up Po s I t..4 Oil, 0.60 Vc::i- ha!.--ing locc),notion,- anorexic; palpabral closure; opan.,.t,.y to sound c4ue. PAGE A-0 PHYSICAL, NEUROLOGICAL, AND BEHAVIORA,-. EXAMII'.ATIOtif7' ON SQUIRREL MONKEYS CornDound Number-@@2438B.- (soln. H 0 cot-.tinuad 22 MonJcey Dose Weight Time- No- mg/kg T- hrs. Effects P3 18.50 0.70 Still postu--es wit:a head angled Female upward; palpebral closure- palpebr.-,! open,..-ig on 2sount@ is still only reaction; balance poor. 0.80 Head (sleep-sedation?) no response to sound. 0.90 2 Head u-, fixates on glassy stare. 1.05 AnoreX4C; fear responses to exper4n -..enter; locomotion much idproved; balance better. 2 2.20 Eats a!),Z,.Ie: fear response to exper@latc-.itez; locomotion good (ccczdi.-.ated) 2.50 Normal reactionz to all stimuli cues7. 4.00 Normal reactions to all Stimu.L.16 Cuez. 24.00 Home cage: normal reacls--ions to al.", -.ues. PAGE A-400 PHYSICAL, NEUROLOGIU.L, AND BEHAVIORAI-. EYAMII,'.IATTONS ON SQUIRREL MCNKEYS Comnound Number-IM2438B: (soln. H 0 I.'!.) c--It-,zinued 2 Monlcey Dose 2 Weight Time Sax-4". L,40- mg/kg CY- hxs. Effects F3 18.50 0.70 Still poztu--es with head angled Female upward- palpebral closure; palpeb;---i open4ng on soun@i is 2 only zeaction; balance still poor. 0.80 Head dc-@-ri (s leep.-sedation?) -no response to sound. 0.90 Head'u-,, fixate::- on ce4-l-i-ng,- 2 glassy stare.. 1.05 Anorexic; fear,responses,to expezirqenter; locomotion much iatproved; balance better. 2.20 Eats ap-le; fear response to 2 exper nte--; locomotion good (ccczdi.-,.ated) 2.50 Normal reactions to all stimu-1-6 cues. 4.00 Normal reactions to all Stimu-L-A. C:,.Ies. 6 24.00 Home -@aqe: normal reac-ions to a.L --:ues. .. .... ..... P.; G C-" REHAVIORA PHYSICAL, NEUROWGICAL, A-Lill L EXMINATIONS ON SQUIRREL MONKEYS cor@pound Numbe -IM2438B2.- (soln. H o i.v,) 2 Monkev Dose Weight Time Sex & No.. ma/'k hrs. 9 F5 10 710 0.00 in sh@-,'@.tle box: alert; Female tail (,7roo2m. 0.10 Alert; sneeze; groom; coord@nt,--ed,locomotion-@ pupillary resdonse normal. 0,15 Constant sneezing; nose to grill, 0.20 Sn6eze;- nor-2.&,nal coordinaticr.: ot locomotion; groom; alert; crouch, head down. 0.25 Quiet; 'crouch; alert; locorre@,tion good. 0.30 Locomc+--.-,@.on ;cod,-2 coordina-tsd. 0. @!&O @iorna'4. response to.all stimu cues. o.r-o Normal response to.all stimu'.i cues. 5 0.70 Normal @3,eaponse to all (15)cunulative stimuli cues. C@75 Vev: vrcr,.entary ba'ilancs! Loss auxing locomotion; crouch. PAGE A Pil L) BFIIAVTOPA-L- EXAMINATLONS ySICAL, NEUROLOGICAL-R ANI ON SOU3:RRE@L MONKEYS@ 438B: (soln. HIO I.V-) 'Co2=ound. E4urrber-A@@ Monkey Dose Weight Time hrs. fr-cts Sex & -No SL!' 0.9G Norjral response to all F5 stimuli cues. remalp- (IS)cl=ulative 1.00 NorTial response to all stim-,21-i cues. i3 Pons& to- all 1.30 Norra' -res stiT.Ul2i cues. -esponse. cr-mal -r Home ct@ge: -n 24.00 I sti.T.Uli cues. to4 al PAGE A-! PHYSICAL, NEUMLOGICALR AND BEAAVIORAL EXAMINATIONS ON SQUIRREL MONKEYS 'Co=ound Number-@@2438B..- (soln.. H20 IIV.) Morikey Dose Weight Time tex & No. mE2/kg 9'. hrs. Ef-@ects G 14.C(o 772 0.00 Neg:t+-;,?e reinforcement shuttle; Male no spontaneous locomotion; fas-t respop-.S-- to Cl"as; f'zst 2 shuttle-, order. O.la Sits apart; quiet; alert- L.L responsa norma-'L. , , @a7 first in huttles. 2 s 0.20 St-ill L.,-its. apa=t; alert.; -ocomo crouch,-. 1 tidn good; shuttles 2properly.@ 0.30 Normal response to all stlimuli cues. 0.40 Norm&l re--ponse to all sti-Tvi-,I.j- cizes. 0.60 2 Noxval- responsa to all stimuli cues. 0080 Positive reinforcement shiittle- some arooming; mostly croucb.; alert, 0.85 A3lertt sits ai)art,- crouch. 0.90 conr-act crouch; huddling. PAGE A.-" AND BEHAVIOP.AL EXAMINATIONS PHYSICA3@, NEUROLOGICAL -------- ON SQUIRREL MONKEYS Comoound Number- 43BBz (soln. H2.0 1.,V.) %,.Qntinued 2 Dose Weight Time ma..k3y hrs. E:f f ects' & mg/kg normal 1.00 14ore rovement; G 14.00 response to all stimuli cues*- Male@ 2 1.20 Normal response to all stimu'3. cues. to all 1.30 Norm&l response stimuli cues. 1.40 No=a'L all 2 Stimuli cues. 4,00 Home cage: normal response to all stlmuli cues. al rcsponse 24@00 norm 33+-@MU!i cues. a PAGE A-L PHYSICAL, NEUROLOGICAL, AND BEHAVIOlzAl; EXAM I t7 ATT ON SOUIRREL MONKEYS (soln. 0.5% '2tlTRi:lund Number- Dose Weight Ti-.Me 2 1-iciikev mg/kg g7-. hrs. "cfectz 7 37.-13 645 O..05 In shuttle box--on removing frr,.-,t, Female injection tube.- mmrle-.-L tion,! dsep !&.a'--ored 2breati,.-@-nLj :,-,o U opens rhythmically with breatl'l small "peep" noise on expi;:ation. 0.10 BrearAi.'Lng. ceased; artificially-; revit,-ed. 7 0.15 Died. PAG A- PHYSI,Z-kL* NEUROLCGICALF AND BEHAVIORAL EXAMINATIONS @1ONKEYS 7, 2F PEG 300 I.V.) - -76: 2 (soin. 100% comid 1) N 7 e Dose weiuht, Time hxs. Ef-1,2ects ................ ..................... Sax & shuttle box: normal P8 2 6 0 543 0.00 In. reactions to all stimul:L cues. to all 0,10 Normal reactions es; (contact) stj.MU13@. cu (huddle) behavior. 0.30 Crouch: palpebral cloSUre'r O:rm-,i rep.-,+,,,Lons. to all n stimuli. cues. 2 0.50 s al. ame as above; norm 0.90 Same as -above; normal. 1.00 Normal reactions to all stimuli cues. Noxi0tia 1reactions to all stimul@- cues. In hnmp- cage: normal reactions to all stimuli cues. PAGE A-4C AL EX.AMTNA!RIONS PHYSICAL, NEUMLOGICAL, AND BEHAVTOB ON SQUIRREL MONKEYS JIION HCL !.V-) 2808: (soln 2 Compound Nimbe Weight Time monkey Dose ±e c ts mg/kg hrs. s--x-a No 9- monkey 645 Pre- In siur-tle box: P6 2 es, not flees when Dose apprOaLcn Female 0.00 Normal. reSpOnses:tO all 4.04 stimul iL cues oordinated locomotion-#- 2 0.20 Alect" C pupiil..zy Idspt:;ase norra-L all norx,&.L ce_4t-,-r-ir.;ris 'to- stimuii cuese above; normal. 0.40 S ame c-Ls 0.60 s ama aLs tLbc..ve;, riarma.Le 'ir ons to all 8.08 1.20 Nor'LLL2CLI imu St (,L2. 12) ciu-nul ative 1.40 S ame &buve; norxqal S &Lme as above; normal. 2 1.60 16.16 2.60 Normal reactions to all "2 S IM "ati St ul@ (,)8.28) -qe Same normal. 1 2.70 a@i above; 3.00 to dil Cues. PAGE A PHYSICAL, NEUROLCIGICAL, D BEHAVIOPAL EXMINATIONS ON SQUIRPXL MONKEYS r-oittoc,und NLanbei- 2808. (soln. 11"-ON "CL :L.,;.)ccntin@. Monkey Dose We3.ghr- Time Sax N6.- mg/kg g, hrs. Effects F6 40 Normal reactiona to all 16.16 Female (28.28) cu,-ail-ativa st2.muli cues. 3.60 Same as cloove; normal. 9 4,00 Home cage:. normal reactions to all stig:uli cues.@ -le -C-"e: nornal reacticr-s: t4 a s PAGE A-4 PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS, ON SQUIRREL MONKEYS -Comt)cund Numb r-,MMW850: (soln. li 0 I.V e 2 Monkey Dose Weight Time 2 Sex &.no. mg/kg g,, hrs. Effects A2 31,.25 764 0.00 In shuttle box: immediate Male vertical nystagmus; tonic convulsions; prostration. 0.20 Ataxia; faulty equilibri=; poor visual orip2ntation- fi.Xa*@l-on; pupillary kesponse normall. 0.30 C=ouci---@ eniesis,--_-_he-ad dowr,., 0.40 E-nesis; eyea shut; crouch 2 posture., 0.45 Escape -ceactiorl to exper4mf-,nter; no lignt cue response; improvttd general activity. 0.60 Shuttlas to light cue; alert; good dtientatlo,A(proper fixation). 0.70 Alext; normal reactions to all stimuli cues. 0.75 Hind ieg stand; exploration; pxoper shuttle and escape reatK,4-i.-es; apple. 0.80 Noznal reactions to all stir,.uli cues. .01" cage: normal behavior. 24,00 Hoirte cage: normal behavior. hem PAGE A-; PHYSICAL, NEUROLOGICAL, AND BEHAVIOP-4i. LXAMINATIOLIS ON SQUIRREL MONKEYS Compound Number:@@,2850; (soln. H 0 l@V.@) 2 !,Iwllxe-2y Dose Weight Tizie. Sax & No.- mg/kg hrs. C@'ffects G 10.0 728 G.UO Negative reintorcement shuttle: Male all monkeys shuttle after shock. 0.30 Pupillary response normal; 2 crouch; alert; normal huddle;,-, shutties an c re C.'O Quiet; all hudc3le(normal); crouch; Q Ati- i first iri e. -'l 2 shut (.,ioanal) 0.70 Same as above: norm",l.. 0.80 Positivi ze:'.nforcement sht-,tt let G tirs,:. all the time; crolcl. aletr. and quiet in between. i.00 No c@qange in behavior or shuts-.le order. 1.20 G sti.Ll first; alert; ct;,-s PxQpez:.@.y2; crouch. 1.50 (End) !-,!o cnange. 4.00 Negative reinforcement shuttle- G croi)--h; quiet., alezt. 4.20 G f..Lrz L all the time; quiet; crouz:h. PAGE A-L PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS ON SC)UIRREL MONKEYS -Co=ound Number-;AW2850: (sdln. H 0 I.Vo) --ontinued 2 Monkey Dose Weight Tizne 2 mg/kg Cit hrs. 'Effects G 10.0 4.40 G first all the time; quiet; Male crouch. No=al. 4.60 (End) No change. 4.75 Positive reinforcement,shuttle- G reasts well to cue,- fast; 2 eats reiard. 4.80 G shuttles readily-#- -C-@,fixst all tne time; crouch; alert in between. 5.20 (End) G, always first; crouch, huddi.e; alert. PAAE A-4 PHYSICKL, NEUROLOGICAL,'AND BEHAVIORAL EXAMINATIONS ON SQUIRREL MONKEYS 'Comt)ound NurrLber- 850. (soln. H 0 I.V.) imp 2 Weight Tim2e Monkey Dose Sex -No., mg/ka hrs. Effects G 15.0 715 0.00 Negative reinforcement shuttle; Male alert; head orientations; active; seeks contact. 0.05 G fast; pupillary respon2se normal; cues properly; alert; now sits apart from group. G.. 10 G fast and alert. Normal. shuttles. 0.15 Same as above; normal. 0.20 Crouch; alert. 2 0.25 G cues properly alert; overall activit@ as.above: norrnal. 0.30 Same as above; normal. 0.60 P6sil@-.ive reinforcement shuttle- 2 self -.-Lit6vection (groom) 0.65 G f.-7LXst to shuttle; normal. i;. 70 Norw.". 0,80 Norr,,al. 9'1'1 G f alert. 1.20 3Nox-ira'. reac@--ioas to all stiinuli cues. PAGE A-L PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS ON SQUIRREL MONKEYS -Co,miDound Numbe @@2851: (soln. 111ON H CL Z,V.) Monkey Dose Weight Time Sex No.- mg/kg hrs.@ 2 Effects P2 8.96 685 0.00 In shuttle box: alert; Female coordinated locomotion; normal reactions to all. stilituli, cues. 0,20 Normal reactions to all 2 stimuli cues.. 0.40 Same &6 abrve; normal. 0.60 Same as above,- normal. 17.92 1.20 Normal reactions to all (26.88)cumulative stimuli. cues. 1.50 Increased loc2omotory activity; slow spontaneous shuttles; walk, 2.00 Increised locorqotion; slow coordinated ma-,@ements; prope-.- reacti.ons to iiivestigator,, 2 lignt, sound, shock. 2.20 Same as above; normal, 26.88 2.40 Pupillary response normal; @53.'f6)cumulative normalu reactions to all sti.-lul i cues. 4 2.60, Norm.-il; stif-@roominq. ---bow PAG E A- 1+ INATIONS PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAM KEYS ON SQUIRREL MON 4Comoound Number-Alow as I 2 (soln. 1/101%1 HCL I.V.)conti-nusd Monkey Dose Weight Time Effects -kg hrs.. Sex & No. mcr/ F2 26.88@ 2,.7C Croucn; quiet; Alert. Female (523.76)cumulative- Nozma."L. zeact-6ons to all szliauli cues. 3.00 Same as above,- normal. 3.50@ Same as above; normal. 9Z4.00 Home calge: raziral reacticzs to all stimuli cues. PAGE A-i@ PHYSICP-LO NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS ON SQUIRP@RL MONKEYS Mumber-11IMS67: (soln. II 0. SQ)- 2 horr-ty Dose Weiant. Time 2 /k:t B- 910 Pre- Pulse: 300-400/minute Zla'a Dose Respiration3: 1001/minute Pupil size-and.reflex no=al. 2.00 0.00 In shuttle box: normal reacti-ons to all stimuli cues. 0.20 Stiuttled to licht cue. 0.30 Shuttling spontaneousl five y times/minute; appearance. and behavior normal. 0.40 SI-.i).ttled to light cue. Ap2pearance and behavior normal; reduced 2oc.-:.:.qotory activity. 4.00 1.90 Normal reactions to all t'6 0 0) camul at.-&ve stimuli cues. 2.20- Generally sitting very still"- 'I.30 shuttled spontaneously three 7 t4-mes in four minutes. 2.40 Behavior as at previous inte--val; awake and rlert; @,zli@ttled ti:t Jght cua; pupil size and reflex normal. PAGE A-L PHYSICAL,. NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS ON SQUIML MONKEYS' ("'rii"rvund Number3@@2867: (soin. HIO SQ) y Dose Weight Time 2 T-q/], T Cf, hrs. 'F.:E E. cg B 8.00 1.10 Normal reactions to all oo) ctuntilativp@. stimuli cues. 3.')g PLpils@s2eem constricted. Shuttled to light cue (response to light cue delayed); movement ghtly slow and atik@vard. 3-70 Piilse: 300/minute 2 Respirations: 72/minute, Pupils: constricted Di-d not shuttle to light cue or tc high electric shock; sat bent- -ar as 2 in distress. oN:, 4.30 Read hunq low, face on floor. 4.50 Mcvements sluggish; shutt-@.ed to 14Laht cue and to e.lectric s'Liock, 2 b--.,t only if doors closed, then At6r cue or shock; opened a@. shuttled snontan6ously a little. 4.70 2 Salivation. 2 1. -lO r.,-.Pc-aran,-:f@ ---lnd L-,,I@pvj.or rortaal; c s',.;-l+--tled s-t)ntaneo,-isly at nor.-ral 3 rare; pupil size and reflex normal. PAGE A-4 )GICAL, AJNR, BEHAVIORRL EXAMIINAT'ONS PHYSICAL., NEUROLC ON SQTIIRPEL tiONKEYS d (so'ln. 0.5% Mer-hYlcellu!uSe V. -*-n P, N ex-@@288 Dose Weigi-it Tine h@-s. 0..00 In shuttle box, reactions p6rfect; 720 eat--s wel'i T@V. 2 0.20 Lccomor-ion coordinated alert; 11 punillary response normal. 40 Sane as above; normal. 0. Sa,.-..a as aoove; Aorma.;L. 2 ormal. i.00 Sa-,ae as al-ove; n Excellent locomotion; normal 7.40 1.50 all tizvali cues rczzzions to 2s 1.70 sime as acoove; noi-mal. i:.90 Same as &-Ijcive; (grooming) rcr-,nal. 2. @ll 0S as above; normal. 2.20 Eats apple. 4.IU Normal reactions to all 6 stimuli cues. 2 4c H-.@rte cage: nor.-Lna@ reaczioiis to .1 a.6.6 atiriu'Li cues. PAGE A PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS ON SQUIRREL MONKEYS Compound Number--@@5034-.@ (soln. H20-1-V-) Dose Weight Time @ionkey mg/kg hrs. 2 Effects F2 0.71, 670 0600 In shuttle box: normal reactions Female all stimuli cues. 0.20 In shuttle,box: normal reactions,'' all stimuli cues. Pupillary, 2 responses normal- 0.40 Normal reactions to alL stimuli. cu( 0.60 Normal reactions to all stimuli du( 1.42 0.70 Alert; self-grooming; good (2.13)cumulative locomotor- coordination. 0.80 Nor2mal;-active. 1.00 Good.reactions to light, sound, shock, experimenter; palpebral closure. 1.20 Normal responses to all stimuli cuE 1.30 Normal responses to all stimull cuc 2 2.13 .1.70 Face rub; crouch. (4.26)cumulative 1.90 Slow orientation reaction to light good locomotion; normal reaction t sound, shock; normal fear response experimen5ter. PAGE A-@ PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS ON SQUIRREL MONKEYS Compound Number-1=5034-. (soln. H o-i.,v,) continued 2 Monkey Dose Weight Time gex & Now2 MgZh q __a. hrs. Effects F2 2.00 Normal reactions to all stimuli a 2.13 Female (4.26)cum ulat've 2.10 Eats apple; normal. 2.30 Normal reactions to all stiMU13-,- 4a 2.70 Normal reactions to all stimul@L c 3.10 Normal reactions to all stimuli- c 7"7 p AGE A-- gHySICAL, NEUROLOGZCAL, AND BEHAVIORAL EXAMINATIONS ON SQUIRREL MONKEYS Comoaund Number--AIWS034: (soln. 0.5% Met.qylcellulose I.V.W) 2 Monkey Dose Weight Time $ex & No. mg/kg g. hrs. Effeczs F3 9.30 645: O.,00 In shuttle box: normal reactions Female- all stimuli cues. 0.10 Pupillary responses no=al; norma rea2ctions to all stimull cues. 0.20 Normal reactions to all stimuli c 0.60 Normal reactions to all stimuli-.Cu 18.60 1. OOF Normal reactions-to all. stimuli c-i (27.90)cumulative 1.20 Eats well; normal.reactions2 to all stimuli cues. 1.40 Normal reactions to all stimuli cu 1.80 Normal reactions to-all stimuli c,-, 3.00 Normal reactions to all stimuli cu 5.00 Normal reactions to all s-timu3li a-@. 24.00 Home cage: normal reactions to a-! stimuli cues. -iA" PAGE A-L PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS ON SQUIP.REL MONKEYS Comnound NumbiBr--ift5O36: (soln.- H 0 I.V.) 2 2 Monkey Dose Weight Time Sex & No. ma/kq hrs. Effects F3 2.71 635 0..00 In shuttle box: normal Female reactions to all stimuli cues, 0.10 Pupillary response normal; 2 alert; crouch; groom;@ perfect locomotion. 0.30 Very good reactions to light, sound, shock, investigator; eats app_,Ie. 0.50 Same as above; normal. 2 5.43 0.70 Normal reactions to all (8.14) cumulative stimuli'cues. 0.80 Good reactions to all stimuli cues; locomotion coordinated; alert. 0.90 Same as above; normal; 2 self-groom. 1.10 Normal reactions to all stimuli cues. 1.40 Same as above; normal. 1.60 Same as above; normal. 3.30 Same as above; normal. 3 5.30 Same as above,- normal. 24.00 Home cage: normal reactions to all stimuli cues. All PAGE A- PHYSIC.@l, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS ON SQUIRREL MONKEYS Compound Numbera@@5049: (soln@ 0.5% Methylcellulose I,V.) Monkey D.,)Se Weight Time 2 Effects Sex & No. mg/kg 9- hrs. F4 2.40 670 0.00 In shuttle box: normal reactions Female I.V. to all stimuli Cues. 0.05 pupillary response normal.- 0.35 No=al reactions to all-stimuli, 2 Cues; eats food. 0.50 same as above; alert; locomotion coordinated. 1.50 Same as above; quick; locomotion excellent. . 1.70 same as above; normal reactions 2 to all stimuli cues. 9.50 1.80 Normal reactions to all (11.90)cumulative stimuli cues, 2.00 Normal reactions; eats; exploratory behavior. 2.20 Quiet (normal); eats food. 2.40 Normal reac7tions to all stimuli cues. 19.00 2.60 Normal reactions to all (30.90)cumulative stimuli cues. PAGE PHYSICAL, NEUROLOGICALE AND BEHAVIORAL EXAMINATIONS ON SQUIRREL MONKEYS Compound Number--dNbO49: (soln. 0.5% Methylcellulose I.V.) continued Monkey Dose Weight Time Sex & Xm. mg/kg g.2 hrs. Effects F4 19.00 2.80 Pupillary response normal,- Female (30.90)cumulative, general behavior unchanged. 3.0 Eats apple- normal reactions to all stimuli cues* 3.40 Normal reactions to all 7s timuli cues-. 4.00 Same as above; normal. 24.00 Home cage:, normal reactions to all stimuli cues. PAGE A-'- AND BEHAVIORAL EXAMINATIONS PHYSICAL; NEUROLOGICAL ON SQUIRREL MONKEYS ComDound Number-4§WO58: (soln. H 0 SQ 2 @7 Monkey Dose Weight 2 Time Sex & No. mg/kcj g._ hrs. Effects B 870 Pre- Pulse.- 222/minute 90/minute Male dose Respirations: Pupil size and reflex normal Appearance a 2 nd behavior no=al. 0.00 'In shiittle b6x,- normal reactions 1.00 to all'stimuli cues. 0.20- 0.30 rate of nine times/minute; appearan2ce and behavior normal. 0.50 General exploratory behavior; shuttling; standing; looking around; hand manipulation of floor.' 1.10 Pulse: 252/minute Respirations2: 96/minute Pupil size and reflex normal. 2.20 1.10 Normal reactions to all (3.20)cumulative stimuli cues. 1.10- Decreased activity. 1.30 1.30 Previous shuttling activity 0 resumed. PAG E pHySICAL, NEUROLOGICAL, AND BEHAVIORAL EXMUNATIONS NKEYS ON SQUIRREL MO Co=ound Number-i@5058: (soln. H 0 SQ continued Monkey Dose Weight Time Sex &2 NO. mg/kg hrs. Effdcts B 4.50 1.80 Normal reacti6ns to all Male. (7-70)cumulative stimuli cues. 1.90 Pulse: 264/minutL- Respirations: 78/minute@ Pupil size2 and reflex normal. 1.80- Continual contact huddling; 2.30 minimal lodorn@ot@ory ac@tivity,-' awake; alert; appearance and behavior normal generally. 2.30- Increasing locomotory activity, 3 2.80 2.80 Shuttling spontaneously eight times/minute. .4 PAGE PHYSICAL, NEUROLOGICALT AND BEHAVIORAL EXAMINATIONS ON SQVIRREL MONKEYS Compound'Number--MM5113'.; (soln. 0.5% Methylcellulose I.V.) Monkey Dose Weight Time Sex & No..mg/kg 9-2 hrs. Effects -,F3 16.0 625 0.00 In shuttle box:. normal reactions Female to all stimuli cues. 0.05 Very-active; spontaneous locomotion,- self-grooming; definite,increase@in, number of shuttles2. 0.20 Eats; active; normal reactions to all stimuli cues. 0.40 Same a.,--atavL-; 0.60 Same as above; normal. 0.80 Natural shiittles; normal. 32.00 12.00 Immediate increase in overall (48-OO)cumulative activity; eats., 1.10 Alert; eats; good coordination of motor activity. 1.30 Palpebral closures; arouses and reacts normally to all stimuli cues. 5 1.50 Normal;. locomotion good. 1.70 Same as above; normal. 1.90 Same as above; normal. PAGE PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS- ON SQUIRREL MONKEYS Compound Nui@her-Aft5ll3: (soin. 0.5W Methyldellulose I.V.) continued monkey Dose Weight Time 2 Sex & No. mg/kg 9- hrs. Effects F3 32.00 2.10 Normal reactions to all stimuli Female (48.00)cumulative cues. 2.30 Same as above; normal. 4.00 Normal reactions to all stimuli cues_ 7 24.00 Home cage: normal reactions to all stimuli cues. PAGE PFLYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS ON SQUIRREL MONKEYS ComDound 'Number-A@5113: (soln. 0.5% Methylcellulose I.V.) Monkey Dose Weight Time Sex & No, mg/kg 92 - hrs. -------- Effects G 2.00 805 0.00 In shuttle box: negative Male reinforcement; G quick; alert; Self-groom; first in shuttle., 0.20 Normal behavior during intervals., 0.40 Alert; normal r2eactions to all stimuli cues. N- 0.60 response excellent. 0.80 Quick reaction to stimuli. 1.00 (Positive reinforcement shuttle),. 2 normal. 1.20 Crouch; alert. 1.40 Movements quick; responsesnormal. 1.60 Locomotion quick; some palpebral closure. 2.00 Normal reactions to all st imuli 5 cues.. 4.00 Home cage: normal. 24.00 Home cage: normal reactions to all stimuli cues.- PAGE PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS ON SQUIRREL MONKEYS Compound Number-.fAllltl29: (soln. H 2P "V') Monkey Dose Weight Time Sex & No. mg/kg 9. hrs. 2Effects Fs 4.40 680 0.00 In shuttle box:. good locomoti-on@ Female response to shock; crouch7 contacr- huddle; alert; good visual orientation - fixation.. 0.20 Pupillary response normal; normal 2 reactions to all stimuli cues. 0.30 Eats apple7 sluggish movement.%. 0.40 Quick reaction to sound; very frightened (possibly sedated?) (slow?). 0.45 Crouch; palpe2bral closure; alert; eats apple. 5.80 0.90 Quiet; crouch; alert. (10 . 2 0) cumulative' 1.00 Normal reactions to all stimuli cues. 1.10 Slight anterior-posteri2or rocking movement during crouch; however,,- alert; anorexic. 1.15 Crouch; head down; palpebral closure; alert to sound, shock, cues; normal escape reaction to 2 inves tigator. PAGE PHYSICAL','NEUROLOGI-CAL, 'AND.BEHAVIORAL EXAMINATIONS ON SQUIRREL MONKEYS Comnound Number-2iW5129. (soln. E 0 i.v,) continued monkey Dose Weight Time Sex & No. mg/kg 9. hrs. Effects F5 1.40 Alert to sqund; crouch; Female 5.80 palpebral closure. (10.20)cumulative 7.40 1.60 Increased locomotory activities. (17.60)cumulative 1.70 Good gr2asp reflex;, normal reactions to sound, light. 1.75 Normal escape reaction to i n v e s t i S-a-t o z,-- st: Lt I- a no - r a crouch; head down; palpebral closure. 2 2.00 PalpebraI closure; quick to react to stimuli, however,6 2.10 Very quick,- nervous;'escape reaction to investigator. 2.20 Palpebral closures; alert-to sound 2.30 Normal reacti5ons to all stimuli cues. 2.60 Same as above; normal. 3.00 Same as above; normal. 6.00 Home cage: normal. 24.00 Home cage:. normal reactions to all stimuli cues. --- ---- -... PAGE PHYSICAL, NEUROLOGICALT AND BEHAVIORAL EXAMINATIONS ON SQUIRREL MONKEYS Com-pound Number--gliMS211: (soln. O.,S% Methylcellulose I.V.) Monkey D2ose Weight Time Sex & No. mg/kg 91 hrs. Effects F2 2.34 676 0.00 in shuttle box: normal reactions Female to all stimuli-cues. 0.20 Pupillary response normal; alert; active; normal reactions to all 2 stimuli cues.. 0.30 Same as above; normal. 0.90 Same as above; normal. 4.68 1.05 Eats; ntmmal -ix@t.,l (7.02)cumulative- stimuli cues. 1.25 Crouch (normal); normal 2reactions to all stimuli cues. 1.45 Same as above; normal; eats, 1.55 Same as 'above; normal. 2.00 Normal reactions to all stimuli cues. 5.59 2.20 Normal; eats2. (12.61)cumulative 2.40 Good locomotion; self-groom; eats, 2.60 Same as above; normal. 2.70 Same as above; normal. 3.00 Normal reactions to all stimuli cues. 8 24.00 Home cage: normal reactions to all stimuli cues. PAGE PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS ON SQUIRREL MONKEYS Com-pound Number--09346-29: (soln@ H 0 I.V.) 2 Monkey Dose Weight Time 2 mg/kg hrs. Effects F6 645 Pre- Temperature--101.8 P Female dose Pulse--188/minute: Respirati6ns--68/i@inute, Pupil size--l.5mm 5.255 0.00 In shuttle box: normal reactions to all stimuli cues. 0.20 Alert; normal reaction to sound -;-l::L@t@ reaction to shock. 2 Temperature--101.4 P Pulse--228/minute Respirations--80/minute Pupil size--l.5mm 0.30 Normal reactions to light, 2sound; no reaction to shock; good 'Locomotion-escape to experimenter. 0.40 Same as above; no change, 0.50 Slight bob to shock; all else normal. 0.55 Better shock reaction; lif ts hands. 0.60 Normal reactions to light, sound; alert; twitch to shock, PAGE PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS ON SQUIRREL MONKEYS ComDound Number-409346-29: (soln. H 20 I.V.) continued Monkey Dose Weight Time Sex &,No. mg/kg T-1 hrs, 2 Effects F6 5.55 0.61 Jerk--escape reaction to shoc@ Female 0.80 Escape reaction to shock. l@50 Escape--jump reaction to sh ock 1.80 Alert; activer ighores apple. 2 2.00 Temperature--100.80 F Pulse@--212/minute Pupil size--l.5mm 3.00 Normal reactions to all stimali cues. 24.00 Normal reactions to al6l stimuli cues. PAGE PHYSICAL, NEUROLOGICAL, AND BEHAVIORAL EXAMINATIONS ON SQUIRREL MONKEYS Comnound Number-ft-9346-37: (soln. H T-.V.) 2 Monkey Dose 2 Weight Time.. Sex & No., mg/kg 9. hr.§. Effects F5 708 Predose Temperature: 101.61*"F., Female Pulse: 228/minute Respirations% 88/minute Pupil size: 2 I.Omm 10.45 0.00 In shuttle box: normal reactions@ to all stimuli cues. 0.20 Normal;@ exploratory behavior; alert; self-grooming. Temperature: 1:021.4*F., Pulse: -- 228/mixiiite Respirations: 80/minute Pupil size: l.Omm 0.30 Crouch; -palpebral closure; self-groom. 2 0.35 Eats apple; normal. 0.40 Same as above; normal. 0.60 Normal reactions to all stimuli cues. 2.610 Normal. Temperature: 101.4'F.2 Pulse: 220/minute Respirations: 72/minute Pupil size: l.Omm 4.00 Home cage: normal. .24.00 Home cage: normal reactions to 6 all stimu i cues, EFFECT OF TEST COMPOUNDS ON DOMINANCE BEHAVIOR OF SQUIRREL MONKEYS Compound Monkey Dose Rein- Hour from Number of Shuttles Number 'Sex &, No.' mg/kg,fo,rcement Injection First Second Third G R T .-G R .,.T G R T Male 2 - - - - - - - - 850 G 10.0 N.R, Pre' 10 0 0 0 4 6 0 6 4 7 So injection 0,00-0,70 9 0 1 0 2 8 12 8 1 4.00-4,60 10 0 0 0 0 10 0 10 0 P.R. Pre- 10 0 0 0 4 6 0 4 injection 0.80-1.50 10 0 0 0 2 0 10 0 10 0 4.65-6.20 10 0 0 0 0 10 0 10 0 15.0 SQ N*Ro Pre 10 0 0 0 5 5 0 5 5 injection 2 0.00-0.30 9 0 1 0 8 2 1 2 7 P. R. Pre- 9 0 1 0 4 6 1 6 -3 injection m 04 0 0 0 6 4 n 4 r. .EFFECT OF TEST COMPOUNDS ON DOMINANCE BEHAVIOR OF SQUIRREL MONKEYS Compound Monkey Dose Rein- Hour from Number of Shuttles Number Sex & No. mg/kg forcement Injection First Second-. Third G R T G R T G R T ?4ale AIM867 G 120.0 N@R. Pte- 11 0.5 0 0.5 11 0 0 0 11.5 injection' (Median of 2 control runs) 0.3-0.7 1 11 0 6 1 6 52 0 6 4.9-5.3 11 1 0 1 11 0 0 0 12 24.5 12 0 0 0 12 0 0 0 12 P'.R.. Pre- 12 0 0 0 11 1 0 1 11 injection 2 (Median of 2 control runs 1.2-1.7! 3 0 2 9 1 1 0 11 5.3-5,8 @2 0 0 0 10 2 lo. 6 m > EFFECT OF TEST COMPOUNDS ON DOMINANCE BEHAVIOR OF SQUIRREL MONKEYS Compound Monkey Dose Rein- Hour from Number of Shuttles Number Sex & No. mg/kg forcement ection First Second Third G R T G R T G R T Male 405058 G 2 7.7 N.R. Pre- 12 0 0 0 10 2 0 2 10 so injection 0.20-0.60 12 0 0 0 11 1 0 1 11 4,50"4.90 12 0 0 0 12 0 0 0 12 P.2R. Pre@- 12 -0 0 0 8 4 0 4 8 injec@tioil 0.60-1.00 12 0 0 0 12 0 0 0 12 4.00"4.40 -,12 0 0 0 12 0 0 0 12 Male IM2438B G- 14.0 N.R, Pre- 10 0 0 0 8 2 0 2 9 S( injection 0100-0.70 10 0 0 0 9 1 0 1 9 P6Ro Pre- 10 0 0 0 4 6 0 6 4 1 injection > 0.80-1.40 10 0 0 0 i 9 > ,-EFFECT OF TEST COMPOUNDS ON DOMINANCE BEHAVIOR OF SQUIRREL MONKEYS Number of Shuttles Compound Monkey Dose Rein- Hour from Number , Sex '& N'O.' mg/kg 'forcement 'In on ird -iecti 2 irst Second G R T G R T G R T' Male 41,@5113 G 2.0 N.R. Pre" 10 0 0 0 8 2 0 2 8 SQ injection 0.10-1.00 lo o o 0 8 2 0 2 8 P.R. Pre- 9 1 0 0 1 9 1 8 1 injection 1.00-1.60 10 0 0 0 2 8 0 8 2 EFFTCT OF COMPOUNDS ON ALOOD PRESSURET BEART RATE AND RESPIRATION AFTE4 ADMINISTRATION TO CHLORALOSED CATS Cliange In Change in Compound Dose Mean Blood Pressukd H6art 'Rate Respiration Remarks mg/kg mm@ -1 2 jg beats/min.. ',58-53 1.0 -23- 0 0 3.3 -11 k.+24 0 0 )58-91 0.5 0 0 1.7 -5 0 0 3.1 2 -21 +12 0 0.3 -33 0 0 EKG voltage increased 1.0 -54 0 0 EKG voltage increased 3.3 -76 0 0 EKG voltage increased Von 0.3 -10 0 2 0 1.0 -14 0 0 1.0 -23 0 0 low* 3.3 -24 0 0 10..O -24 0 0 9346-29 .0.3 0 0 0 1.0 2 0 0 0 3.3 0 0 9346-31 0.3 0* 0* 0* i.0 -33* 0* 0* 3.3 -37 -48 0 > 7 rTi 0.3 0 0 0 EFFECT OF COMPOUNDS ON@@BLOOD PRESSURE, HEART RATE AND RESPIRATION AFTER AD MINISTRATION TO CHLORALOSED CATS (Contd) Dose Change in Compound Mean Blood P Change in mg/kg res4ure Heart Rate Respiration Remarks 2 nun Hg beats,/min 9405-35 0.3 o@ 0 I.o 0 0 0 3.3 0 0 0 9405-39 0.3 0 1.0 -12 2 0 0 0 0 3.3 -48 0 0 )405-47 -0.3 0 0 1.0 -lo 3.3 0 0 -22 1 0 003 0 0 1.0 +72 +66 0 EKG 2.4 +59 +12 0 changes EKG changes EFFECT OF COMPOUNDS ON BLOOD PRESSURE, HEART RATE AND RESPIRATION AFTER ADMINISTRATION TO CHLORALOSED CATS (Contd) Dose Change in Ch4nge xn Compound mg/kg Mean Blood Pressure Heart Rate Respiration Remarks mm Hg beats/min .9346-63 1.0 !O 0 3.3 -30 +42 0 9346-85 0.3 0 0 0 1.0 0 0 0 3.3 0 0 0 9346-87 o.3 0* 2 0* 0* 1.0 0* 0* 0* 3.3 -35* 0* 0* becrease in blood pressure not blocked by atropine. 3.3 -40 0 0 2 Response to norepinephrine and 'tyramip6 may hhve been enhanceds 9405-13 0".3 0 0 Increased depth 3.3 -67 0 Increased depth 9405-21 1.0 2 0 0 0 EKG voltage increased 3.3 0 0 0 EKG voltage increased 10.0 -10 +18 0 EKG voltage increased 9405-33 0.3 0 0 0 1.0 6 0 0 0 3.3 0 t3o 0 > 0