c e -M-ei;ioraii..,iiiii- U@,TITED STATE@--GOVER@IMENT TO DATE: 7 Jailu@ll-v ic?53 .qn t FP,OM Pranch, "DR,3, I&.SO SUBJECT: Request for tledical Office Investigation Into New Compound 1. Ditriilg the writerts recent trip t wri.ter met and eni7aqed in a leng7ttiv--rLi--,@mi@s of the 2 r'n the a rankirr, staff member Department of Anesthesiolog,@, regar-ded as exce tionally able by hi.s associ-a;,es, n e t e writer thqt in the recent as handled, experimentally, a new compound for the /3 22. -.stated that tt was workinf7 on ex,ocriplprt,a7'compounds to either displace or improve on the al.read,@@ well- known barbitiirates. He stated th@t they had sent hi.ni a conit)ound and r@i- qiies2f,eo i,@iat he try this during operative l@rocedi-ir:r--- stated he gave it to a very conservative memt)er of t a uity during a minor throat oderation an the. t e dri3v 0 ccessfuily for operative purposes. He stated, fto-..iever, thtt during the recovery_p2eriod, thi.s compound produced ve...ry uninhibited re- ictions on the part of the subject. He suated th,3t for forty-eight hours af'tp-r the iise of the druf,. this conservative member of the facillt,y u -atory manner about the had talked a' f@2r@,.at lenftli and in a @@-Fhly deror-, faculty, a@-,out the administration of Lhe school, about certiin profes- sional" secrets at had cur@-ed, had wandered about the corridors and had strong tendencies to attack the nurses at the 2 3. The writer aske- if he had tried the compound on C, other patients and he stated that he had done this, thinking Perhaps an eccentricity existed in the above-case, but the comnound reacted. t.lic- S-ime on the other two cases and,.-there@iftei.-. 2 ad abandoned(:- all use of this chemical. Ttie-reaftp-r, the ,jrit..er, without ittemptinp,, to ci,e,),t,e any iin- iisiial interest reqiiested the name of @he chemical 'f.rc,, and stated that it w,,3,s known ap Si@lliO-OXY-I'Al@DI'I'URA (iii[S If@c) thp writr--r hact an irtForm@31. ccrif. r:,reti(,e iqith 01- ine ;taff cone,@@i-ri.Lnp,, and, it 2 writ,cr ilol.d ihovr,, slor@- hiiii tiie niitie of the comoound ill (IU.CFLion Iti(J m;iclc .7ii -irif'oi-mii at that tinle@ that ave this compound checked to deteritline wh0ether or not it had kF.TlCffOKF. value. 6 It is -:7u7,c@e,-tef] th,).t, yoii i,ri over q cop..-; o with your approv;al to ttie Chief of t@,e i,ic'(ticil taf.f inereiy f or ti piirnose of confirmin@ in writing the informal request made of o-mentioned above. 8 -2- -@,'TRANSMITTAL,S j, 1,4. 1112153 2 4@. T J Mr 6ulLDING ROO@A 2 R E MARKS: Herewith is self-explanatory memo in the "case of the'new compound.-It-at I hive 4 lw 2 informally requested to re e t @;search out. .@I think, how you could send a copy ovel, 2 OTS3 for his, i th )ROJO" I will take the matter up w orally.when t a cha ce@to seq him 2 99 ",fit 3 FROM:' BUILDING 2 ROOM NO kx-rENSION 13 2 3362 FORM 3 6-8 66268-1 opo 2 SEP i946 @At 'A@ ir 4,* It 2 'A Li t,il t 7 POO t f