Ojqi@@ Memora,il..,-@um 'D U.N ]'-CED STATE.- GOVERNMENT TO File DATE: 9 llarcii 1953 FROM SUBJECT: Spiro-(r,-y-Darbiturate 1. After the iTrite.-Is visit to and 2 i-n mid- Decei-iber 11052, the wr'iter turned over h4! -n@forri@a@ion on -DDiro-,)x-,r- Barbiturate to the lledical Division both informall,r i-n a conversation with and for,-,ially in:a memorandun addressed to dated 2 1953- 2* C-- nt ly, in a conversation I)ctTee.. e full details of tlie..@4@a-I arbiturate to n'Uiqliti_es o p i r 2 e expressed imediate interest and stated hp- 1-1 di onle in s or-anizati-on to deter,-Tiin@ what proiierties cauoed the un-Li.,3uai activities associated with this drug -and further stated these peoole i@iould inmedi- ately get in touch with the here 2 he stated he has verj- close connections. Ap 1 in a conference between y two -,,Tee m@ , stated that the: inf ornation on Sp iro -0:@,-7,r--Bar ad T)roven ver7i interesting andres-,-ilts2 had come to the f r oni different parts of the United @Dtates whicii further results e Tted b3olpfW .A4"@!cter his conversations i,ri tli a At this point,ag l@rsee-ned iq 0 to think that the Spi -Oxy-Darbiturate was interesting and deserved serious research and he informed the @ariter such research was being carried out and would be carried out in obnnection with this drug. t4 D PSYCliOCHaiICAL IGIEiTj Derivatives of er-ot si:-cli as lyseriic acid amide, derivatives of marijuana (cannabine), mescaline- and its deriv,-LI-Ii-,Tes, ai,e bein7 studied as a basi:7, L'or.' the s@rnt2,ill(,.,3j-3 of cL,-nclidc?.tc psilchccheTtliev-1 a.-ents. Thel-c subst.e.nces haic in co,.-@,Tron the E-bility to produce la--.1.3.ucin--tions -patest difficultir in this -rcup of arrciits nd riontal ab@@,rrationa.2 The gi I c@ has be-n the establic;llric-nt of s@iitable screerirg tochiiiclies. An a-Cti;e c t to this enO is b(!iiag rro-secuted @.,ith th 110'and wi-' ,,h the IIATUPTAILY OCCURING TOXII,13: This group includes s@el--I- fi-sli poison, fi-iffcr fish roison e-lid the -njsl)roori poisons from 1-manit,-- muscarip-. ILitel-ial is coll.ected frotr, the natural sources, concentrated. -.rrJ. purified, At,te2,i t,s -,rc,. t2lacr,-, r,,aclc to det-@r!.-!ine structure. If these cor.-.potinds turn out to be s-ufficicnt3,v sinple s,,,nthesis w e attempted. 1,,Iorl-, on this Crot,,p of toxins is teing done under contr@,ct with the i nc.] @@2 -,,Aiw -. INWP.-9" F040MMMEWI-W - - -- - - - -T@r "or shell fish poison, and witn for the muqliroom idoisons. arc for toxic com this as well as other fields is being c 2@ !-,ouzicls in'@- i.,iplif'ied uiider contract with- ir- subcontracts i.riclucie studies Of pUffEir fish, 0 IV and ,i-Lclli I I (frori; @ICAL la@lliliTi@@s of t '11' 8 April 1953, RON"