To microdose is to take small amounts of LSD, which generate subperceptual" effects that can improve mood, productivity and creativity. Michael Pollan's new book, "How to Change Your Mind," is not about that. It's about taking enough LSD or psilocybin (mushrooms) to feel the colors and smell the sounds. If Pollan's wide-ranging account has a central thesis, it's that we're still doing the hard work of rescuing the science of psychedelics from the "countercultural baggage" of the 1960s. In the mid-60s "the exuberance surrounding these new drugs gave way to moral panic," and ... "the whole project of psychedelic science had collapsed." Before collapsing, though, that project discovered in psychedelics the same potential that scientists are exploring as they reclaim it today: possible help in treating addiction, anxiety and depression, and "existential distress" - common in people "confronting a terminal diagnosis," which of course, broadly speaking, is all of us. Pollan doesn't give a lot of prime real estate to psychedelics' naysayers. But given that those on LSD can appear to be losing their minds, and that the drug leaves one feeling emotionally undefended (a potential benefit as well as a profound risk), he does strongly recommend having an experienced guide in a proper setting when you trip. With those safeguards in place, he believes usage could be on the verge of more widespread acceptance.