One of the more unsettling discoveries in the past half a century is that the universe is not locally real. In this context, "real" means that objects have definite properties independent of observationan apple can be red even when no one is looking. "Local" means that objects can be influenced only by their surroundings and that any influence cannot travel faster than light. Investigations at the frontiers of quantum physics have found that these things cannot both be true. Instead the evidence shows that objects are not influenced solely by their surroundings, and they may also lack definite properties prior to measurement. Blame for this achievement has now been laid squarely on the shoulders of three physicists: John Clauser, Alain Aspect and Anton Zeilinger. They equally split the 2022 Nobel Prize in Physics "for experiments with entangled photons, establishing the violation of Bell inequalities and pioneering quantum information science." From about 1940 until as late as 1990, studies of so-called quantum foundations were often treated as philosophy at best and crackpottery at worst. Today quantum information science is among the most vibrant subfields in all of physics. It links Einstein's general theory of relativity with quantum mechanics. It dictates the design and function of quantum sensors. And it clarifies the often confusing nature of quantum entanglement, a phenomenon that is pivotal to modern materials science and that lies at the heart of quantum computing.