U.S. intelligence reports ... suggest the Chinese People's Liberation Army was conducting secret animal research with highly contagious viruses at the Wuhan Institute of Virology, without notifying the World Health Organization even after the pandemic began. [This raises] new questions about the possible laboratory origins of COVID-19 that must be addressed. If sloppy biolab security or reckless military experimentation followed by a coverup were the proximate cause, we need to prioritize developing rules and safeguards to make a global pandemic less likely to happen again. If the origins are revealed to be more innocent - a virus jumping naturally from mammals to humans - we will need to prioritize monitoring and containing future zoonotic outbreaks. But while evidence of a zoonotic jump in the wild, or at a market, or farm has been starkly absent, the case that COVID-19 might have reached humans through an accidental leak from the Wuhan Institute of Virology seems like an ever-greater possibility. We know that many viruses at the Institute were manipulated using "gain of function" research to develop hybrid viruses to test their ability to infect human lung cells and humanized mice. Is it just coincidental that SARS-CoV-2 appears to have emerged in late 2019 already adapted for transmission to humans and that the COVID-19 outbreak occurred ... in the only Chinese city with a high-level virology institute that was experimenting with novel and diverse bat coronaviruses?