Gov. Kate Brown of Oregon announced the members of the state's newly formed Psilocybin Advisory Board this week. Oregon is about to become the first state in the country to try to build a support infrastructure through which psychedelic mushrooms can be woven into everyday life. This framework is different from what we've seen before: not legalization, not medicalization, but therapeutic use, in licensed facilities, under the guidance of professionals trained to guide psychedelic experiences. The ... pressing case for psilocybin comes from research out of Johns Hopkins, U.C.L.A., N.Y.U. and elsewhere that has shown it to be a potentially effective treatment for major depression, end-of-life anxiety and drug addiction. "One of the things I've come to is that addiction medicine in 2021 is in desperate need of transformative technologies," Todd Korthuis, a ... member of Oregon's Psilocybin Advisory Board, told me. Studies ... are "showing dramatic change in people's lives that's what we need for cocaine use disorder, methamphetamine use disorder, even alcohol and tobacco." A recent study on major depressive disorder, published in JAMA Psychiatry, found more than half of the subjects in remission four weeks later, after just two treatments alongside psychotherapy. A study on tobacco addiction, out of Johns Hopkins, found two-thirds of the subjects who received psilocybin in combination with cognitive behavioral therapy abstinent a year later.