Some users of LSD say one of the most profound parts of the experience is a deep oneness with the universe. The sensation ... correlates to changes in brain connectivity while on LSD, according to a study published Wednesday in Current Biology. An MRI scanner [showed that] the brains of people on acid looked markedly different than those on the placebo. Their sensory cortices, which process sensations like sight and touch, became far more connected than usual to the frontal parietal network, which is involved with our sense of self. "The stronger that communication, the stronger the experience of the dissolution (of self)," says Enzo Tagliazucchi, the [study's] lead author. Researchers also measured the volunteers' brain electrical activity with another device. Our brains normally generate a regular rhythm of electrical activity called the alpha rhythm, which links to our brain's ability to suppress irrelevant activity. But in a different paper published on Monday in the Proceedings of the National Academy of Sciences, he and several co-authors show that LSD weakens the alpha rhythm. He thinks this weakening could make the hallucinations seem more real. The idea is intriguing ... says Dr. Charles Grob, a psychiatrist at the Harbor-UCLA Medical Center. "They may genuinely be on to something. This should really further our understanding of the brain and consciousness." And, he says, the work highlights hallucinogens' powerful therapeutic potential.