For most of his adult life, Aaron Presley, age 34, felt like a husk of a person, a piece of garbage." Then, all at once, the soul-crushing, depressive fog started to lift, and the most meaningful experience of his life began. The turning point for Presley came as he lay on a psychiatrist's couch at Johns Hopkins University. He had consumed a large dose of psilocybin, the active ingredient in what's more commonly known as magic mushrooms, and entered a state that could best be described as lucid dreaming. Visions of family and childhood triggered overwhelming and long-lost feelings of love, he says. Presley was one of 24 volunteers taking part in a small study aimed at evaluating the effectiveness of a combination of psychotherapy and this powerful mind-altering drug to treat depression"an approach that, should it win approval, could be the biggest advance in mental health since Prozac in the 1990s. Depression ... affects 320 million people around the world. Roughly one-third of those who seek treatment won't respond to verbal or conventional drug therapies. Magic-mushroom therapy is offering some hope for these hopeless cases. In the Hopkins study, published last year in JAMA Psychiatry, the therapy was four times more effective than traditional antidepressants. Two-thirds of participants showed a more-than 50-percent reduction in depression symptoms after one week; a month later, more than half were considered in remission, meaning they no longer qualified as being depressed.