The United States apologized Friday for a 1946-1948 research study in which people in Guatemala were intentionally infected with sexually transmitted diseases. A statement by Secretary of State Hillary Clinton and Secretary of Health and Human Services Secretary Kathleen Sebelius called the action reprehensible." President Barack Obama called his Guatemalan counterpart Friday "offering profound apologies and asking pardon for the deeds of the 1940s," President Alvaro Colom told CNN. "Though it happened 64 years ago, it really is a profound violation of human rights," said Colom. The U.S. Public Health Service Sexually Transmitted Disease Inoculation Study of 1946-1948 aimed at determining the effectiveness of penicillin in treating or preventing syphilis after subjects were exposed to the disease. Gonorrhea and chancres were also studied. The tests were carried out on female commercial sex workers, prisoners in the national penitentiary, patients in the national mental hospital and soldiers. According to the study, more than 1,600 people were infected: 696 with syphilis, 772 with gonorrhea and 142 with chancres. The published literature contains more than 40 other U.S.-based studies "where intentional infection was carried out with what we could now consider to be completely inadequate consent in the United States." Many of those studies were funded by the Public Health Service.