In the mid-1950s, LSD and other psychedelic drugs took the medical world by storm. Studies at the time suggested that the hallucinogens were effective against a variety of difficult-to-treat mental health problems. The research stalled in the early 1970s ... but [it] is picking up again. If the drugs prove to be as safe and effective as recent research suggests, we may be on the brink of what some are calling a revolution in mental health care. People with mood disorders, including those who are unresponsive to conventional therapies, might be able to ditch their antidepressants and antianxiety medications. Those with terminal illness could enjoy their remaining days without the fear of death looming over them, while people with PTSD could return to a normal life unobstructed by paralyzing flashbacks. We're not at this point yet. But such is the promise of psychedelic medicine. What makes psychedelic therapy so powerful? Experts say it may be because the drugs work on a deep emotional as well as biological level, with patients experiencing a transformative sense of positivity, benevolence, and unity. "Unlike almost all other psychiatric medications ... these drugs seem to work through biology to open up a psychological opportunity," says Matthew Johnson, a Johns Hopkins University psychiatrist. And the drugs' benefits may go beyond simply treating specific disorders. In 2011, Johnson and his colleagues showed that a single psilocybin session can give people a more "open" personality, as well as a greater appreciation of new experiences.