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Study Probes Link Between Pesticides and ALS
Key Excerpts from Article on Website of Wesleyan University
Posted: December 16th, 2025
https://www.wesleyan.edu/about/news/2025/12/study-probes-pes...
Research on ALS, a debilitating condition also known as Lou Gehrig’s disease that leads to muscle weakness and death, has found a link between exposure to pesticides and disease development. A new study led by ... Alison O’Neil provides insight into how a specific pesticide damages the nerve cells affected in ALS patients. The paper, published in the prestigious multidisciplinary journal PLOS One, is a follow up to another study O’Neil conducted on the pesticide known as cis-chlordane, which is banned but persists in the environment. “The goal of the study was to try to figure out why cis-chlordane is able to kill motor neurons,” which are the nerve cells that die in ALS (amyotrophic lateral sclerosis), she said. “It turns out that [the pesticides] are affecting the mitochondria, which are the powerhouse of the cell,” said O’Neil. Without mitochondria, the motor neurons weaken and die. This insight points to potential for more effective treatments for a disease when current therapies extend life by only a few months. “The implications of that finding helps us determine what kind of drugs people need,” said O’Neil. Since there is clearly an environmental component in most cases of ALS, said Clackson, the research can help pinpoint what is contributing to the disease and potentially change disease trajectory. “If we see these early biomarkers, say pesticides in the blood, then we can perhaps treat them earlier and have a completely different outcome,” he said.
Note: It's recently come out that the popular pesticide paraquat probably causes Parkinson's disease. For more along these lines, read our concise summaries of news articles on health and toxic chemicals.
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