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Hunt for New Flu: Looking for Bugs in All the Wrong Places
Key Excerpts from Article on Website of New York Times
Posted: November 11th, 2006
http://www.nytimes.com/2005/11/08/science/08flu.html?ex=1289...
Researchers...scratch their heads over the weird genetic sequence of the 1918 flu virus. Dr. Jeffery Taubenberger, a molecular pathologist at the Armed Forces Institute of Technology [said that] the 1918 virus appears to be a bird flu virus. But if it is from a bird, it is not a bird anyone has studied before. It is not like the A(H5N1) strain of bird flus in Asia, which has sickened at least 116 people, and killed 60. It is not like the influenza viruses that infect fowl in North America. Yet many researchers believe that the 1918 virus, which caused the worst infectious disease epidemic in human history, is a bird flu virus. And if so, it is the only one that has ever been known to cause a human pandemic. That, Dr. Taubenberger said, gives rise to a question. Are scientists looking for the next pandemic flu virus in all the wrong places? Birds, Dr. Slemons said, do not have much of an immune response to influenza, and so there is no particular pressure for the virus to mutate. He said birds are chronically infected with lots of flu viruses at once, and all the viruses coexist peacefully. Some experts like Dr. Peter Palese of the Mount Sinai School of Medicine in New York say the A(H5N1) flu viruses are a false alarm. He notes that studies of serum collected in 1992 from people in rural China indicated that millions of people there had antibodies to the A(H5N1) strain. That means they had been infected with an H5N1 bird virus and recovered. Despite that, and the fact that those viruses have been circulating in China more than a dozen years, almost no human-to-human spread has occurred. "The virus has been around for more than a dozen years, but it hasn't jumped into the human population," Dr. Palese said. "I don't think it has the capability of doing it."
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