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Zyprexa risks and dangers hidden
Key Excerpts from Article on Website of New York Times
Posted: October 17th, 2009
http://www.nytimes.com/2006/12/17/business/17drug.html
The drug maker Eli Lilly has engaged in a decade-long effort to play down the health risks of Zyprexa, its best-selling medication for schizophrenia, according to hundreds of internal Lilly documents and e-mail messages among top company managers. The documents ... show that Lilly executives kept important information from doctors about Zyprexas links to obesity and its tendency to raise blood sugar both known risk factors for diabetes. Lillys own published data, which it told its sales representatives to play down in conversations with doctors, has shown that 30 percent of patients taking Zyprexa gain 22 pounds or more after a year on the drug, and some patients have reported gaining 100 pounds or more. But Lilly was concerned that Zyprexas sales would be hurt if the company was more forthright about the fact that the drug might cause unmanageable weight gain or diabetes, according to the documents, which cover the period 1995 to 2004. Zyprexa has become by far Lillys best-selling product, with sales of $4.2 billion last year, when about two million people worldwide took the drug. Critics, including the American Diabetes Association, have argued that Zyprexa, introduced in 1996, is more likely to cause diabetes than other widely used schizophrenia drugs. As early as 1999, the documents show that Lilly worried that side effects from Zyprexa, whose chemical name is olanzapine, would hurt sales. Olanzapine-associated weight gain and possible hyperglycemia is a major threat to the long-term success of this critically important molecule, Dr. Alan Breier wrote in a November 1999 e-mail message to two-dozen Lilly employees.
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