A potential anti-Alzheimer's drug tested in mice unexpectedly reduced general symptoms of aging, according to a study led by Salk Institute researchers. The study examined the effects of the drug, J147, in a strain of mice bred to rapidly age and show signs of senescence. It is the second mouse model to show effectiveness. Besides improved cognition compared to controls, the treated mice exhibited better metabolism, reduced blood leakage from microvessels in the brain, and other improvements. Researchers ... published the study Wednesday in the journal Aging. Abrexa Pharmaceuticals, a San Diego company formed to commercialize J147, has licensed the compound from Salk. The drug is to be tested for Alzheimer's, not for anti-aging properties. Derived from a spice in curry, [J147] was developed ... based on the observation that people in India, where curry is widely consumed, rarely get Alzheimer's. The potential drug has been previously tested in Alzheimer's model mice. It was found to have memory-enhancing effects. The new study, showing effectiveness in another strain of mice, lends further credence to J147's usefulness.
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