The US Food and Drug Administration announced the resignations of two top vaccine officials on Tuesday, and reports said the two were leaving in anger over the Biden administration's plan to roll out COVID-19 booster shots before officials had a chance to approve it. Dr. Marion Gruber, the director of the FDA's Office of Vaccines Research and Review, and her deputy, Dr. Philip Krause, plan to leave the FDA. Dr. Peter Marks, the director of the FDA's Center for Biologics Evaluation and Research, praised the pair for their work during the COVID-19 pandemic. He didn't give a reason for their departures. But sources told ... Politico that Gruber and Krause were upset with Biden administration's booster-shot plan. One former senior FDA leader [said] that Gruber and Krause were leaving because they felt that the Centers for Disease Control and Prevention was making vaccine decisions that should have been left to the FDA and were upset with Marks, the leader of their division, for not insisting on the agency's oversight. The source said the final straw was the Biden administration's announcing the booster-shot plan before the FDA had officially signed off on it. A former FDA official told Politico that the resignations were tied to anger over the FDA's lack of autonomy in booster planning.