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Pharmaceutical Corruption News Stories

Below are key excerpts of revealing news articles on pharmaceutical industry corruption from reliable news media sources. If any link fails to function, a paywall blocks full access, or the article is no longer available, try these digital tools.

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Vitamin C 'gives chemotherapy a boost'
2014-02-09, BBC
Posted: 2016-04-11 09:45:45
http://www.bbc.com/news/health-26038460

High-dose vitamin C can boost the cancer-killing effect of chemotherapy in the lab and mice, research suggests. Given by injection, it could potentially be a safe, effective and low-cost treatment for ovarian and other cancers. US scientists ... call for large-scale government clinical trials. Vitamin C has long been used as an alternative therapy for cancer. In the 1970s, chemist Linus Pauling reported that vitamin C given intravenously was effective in treating cancer. However, clinical trials of vitamin C given by mouth failed to replicate the effect, and research was abandoned. It is now known that the human body quickly excretes vitamin C when it is taken by mouth. However, scientists at the University of Kansas say that when given by injection vitamin C is absorbed into the body, and can kill cancer cells without harming normal ones. The researchers injected vitamin C into human ovarian cancer cells in the lab, into mice, and into patients with advanced ovarian cancer. They found ovarian cancer cells were sensitive to vitamin C treatment, but normal cells were unharmed. The treatment worked in tandem with standard chemotherapy drugs to slow tumour growth. "Because vitamin C has no patent potential, its development will not be supported by pharmaceutical companies," said lead researcher Qi Chen. "We believe that the time has arrived for research agencies to vigorously support thoughtful and meticulous clinical trials with intravenous vitamin C."

Note: Read more about this amazing cancer research. For more along these lines, see concise summaries of deeply revealing news articles on promising cancer research that has been suppressed by the medical industry.


Rattled by drug price increases, hospitals seek ways to stay on guard
2016-03-13, Washington Post
Posted: 2016-03-20 22:24:39
https://www.washingtonpost.com/national/health-science/rattled-by-drug-price-...

Doctors at the University Hospitals of Cleveland see an immediately recognizable symbol pop up alongside certain drugs when they sign in online these days to prescribe medications for patients: $$$$$. The dollar signs, affixed by hospital administrators, carry a not-so-subtle message: Think twice before using this drug. Pick an alternative if possible. The ... approach is just one of the strategies hospitals nationwide are using to try to counter drug costs. The increases often involved brand-name drugs with little or no competition as well as commonly used generics around for decades. Among those tagged were Nitropress and Isuprel, injectable heart medications that are a staple at many hospitals. Their 2015 list prices rose more than 200 percent and 500 percent, respectively. Hospital officials around the United States point to similar experiences, saying their predicament illustrates one dimension of a broken prescription-drug system. A recent Bloomberg Business survey of about 3,000 brand-name prescription drugs found that prices had more than doubled for 60 medications since December 2014 and at least quadrupled for 20. Prices for many other drugs continued to rise at 10 percent or more annually. The patient doesnt initially see the price increase, said Scott Knoer, chief pharmacy officer at the Cleveland Clinic. But it raises the cost for the hospital. Eventually, it catches up and it raises the cost for insurance companies, which is passed on to employers, employees and taxpayers.

Note: For more along these lines, see concise summaries of deeply revealing big Pharma profiteering news articles from reliable major media sources.


GlaxoSmithKline fined $3bn after bribing doctors to increase drugs sales
2012-07-03, The Guardian (One of the UK's leading newspapers)
Posted: 2016-03-14 19:14:18
http://www.theguardian.com/business/2012/jul/03/glaxosmithkline-fined-bribing...

The pharmaceutical group GlaxoSmithKline has been fined $3bn (1.9bn) after admitting bribing doctors and encouraging the prescription of unsuitable antidepressants to children. The company encouraged sales reps in the US to mis-sell three drugs to doctors and lavished hospitality and kickbacks on those who agreed to write extra prescriptions. The company admitted corporate misconduct over the antidepressants Paxil and Wellbutrin and asthma drug Advair. GSK also paid for articles on its drugs to appear in medical journals and "independent" doctors were hired by the company to promote the treatments. Paxil which was only approved for adults was promoted as suitable for children and teenagers by the company despite trials that showed it was ineffective. Children and teenagers are only treated with antidepressants in exceptional circumstances due to an increased risk of suicide. The second drug to be mis-sold was Wellbutrin another antidepressant aimed only at adults. The prosecution said the company paid $275,000 to Dr Drew Pinsky, who hosted a popular radio show, to promote the drug on his programme, in particular for unapproved uses. US attorney Carmin Ortiz said: "The sales force bribed physicians to prescribe GSK products using every imaginable form of high-priced entertainment, from Hawaiian vacations [and] paying doctors millions of dollars to go on speaking tours, to tickets to Madonna concerts." Despite the large fine, $3bn is far less than the profits made from the drugs.

Note: In February 2016, GlaxoSmithKline was fined another $53 million by the UK for preventing generic competition. The list of huge fines to top drug companies includes five fines of over $1 billion and dozens over $100 million. How can we trust these companies on the safety and reliability of their products?


GlaxoSmithKline fined $490m by China for bribery
2014-02-19, BBC
Posted: 2016-03-14 19:12:34
http://www.bbc.com/news/business-29274822

China has fined UK pharmaceuticals firm GlaxoSmithKline $490m (297m) after a court found it guilty of bribery. The record penalty follows allegations the drug giant paid out bribes to doctors and hospitals in order to have their products promoted. The court gave GSK's former head of Chinese operations, Mark Reilly, a suspended three-year prison sentence and he is set to be deported. Other GSK executives have also been given suspended jail sentences. The guilty verdict was delivered after a one-day trial at a court in Changsha, according to the Xinhua news agency. Chinese authorities first announced they were investigating GSK in July last year, in what has become the biggest corruption scandal to hit a foreign firm in years. The company was accused of having made an estimated $150m in illegal profits. GSK said it had "published a statement of apology to the Chinese government and its people". This is a humiliating outcome for one of Britain's biggest companies: pleading guilty to systematic bribery, facing the biggest fine in Chinese history and making an abject apology to the Chinese government and people.

Note: In February 2016, GlaxoSmithKline was fined another $53 million by the UK for preventing generic competition. The list of huge fines to top drug companies includes five fines of over $1 billion and dozens over $100 million. How can we trust these companies on the safety and reliability of their products?


Drug Distribution Becomes Weapon to Block Competition
2016-03-03, ABC/Associated Press
Posted: 2016-03-07 13:34:17
http://abcnews.go.com/Business/wireStory/drug-distribution-weapon-block-compe...

The same strategy that Martin Shkreli used to get away with a 5,000-percent price increase on an old drug is used by many other drugmakers. Before the price hike that made him infamous, the former CEO of Turing Pharmaceuticals had to ensure that no competitor would be able to launch a cheaper version of Daraprim, the 60-year-old anti-infection pill that is no longer under patent. Shkreli had the perfect weapon: a tightly-controlled distribution system which would make it virtually impossible for a competitor to obtain enough Daraprim to develop their own version. Many larger drugmakers have also turned drug distribution into a powerful tool against competition. The strategy takes advantage of a simple fact: If generic drugmakers can't get their hands on the original product, they cannot perform the tests needed to develop a generic version. When the original drugmaker controls the drug's distribution, they can simply refuse to sell. The effect on patients is higher prices for drugs. At least 40 drugs worth an estimated $5.4 billion are sheltered from competition by distribution hurdles, according to a study commissioned by the Generic Pharmaceutical Association, an industry trade group. The Food and Drug Administration is aware of the misuse of distribution programs. The agency does not penalize companies for the practice.

Note: For more excellent information on drug prices hikes, read this penetrating article in the Daily Beast. For more along these lines, see concise summaries of deeply revealing big Pharma profiteering news articles from reliable major media sources.


Pharmaceutical companies cause doctors to receive biased information about drugs costing hundreds of thousands of lives
2016-02-24, The Independent (One of the UK's leading newspapers)
Posted: 2016-02-28 20:35:55
http://www.independent.co.uk/news/uk/home-news/pharmaceutical-companies-cause...

Dr Aseem Malhotra, an NHS cardiologist and a trustee of the Kings Fund health think tank, claims there is a systemic lack of transparency in the information being given to doctors to prescribe medication, in terms of the benefits of drugs being grossly exaggerated and their side effects under reported in studies. Dr Malhotra said the prevalence of pharmaceutical companies, which are profit making businesses being able to fund studies and drug trials causes biased information to be recorded and reported on in medical journals. This is in turn creating an epidemic of misinformed doctors, he said. This lack of transparency ... harms patients through the adverse side effects of drugs, Dr Malhotra said, citing an FDA report that found adverse events from prescribed medications caused 123,000 deaths in the USA in 2014 and 800,000 serious patient outcomes, which include hospitalisation or potentially causing disability. The FDA report also states that the number of adverse events from prescribed medications have tripled in the past 10 years in America. While the UK does not have the same kind of data, Peter Gotze, professor of research design at the University of Copenhagen, has evidence to suggest that prescribed drugs are the third biggest killer behind heart disease and cancer. Last year the Academy of Medical Royal Colleges launched a campaign to stop doctors from over-treating patients.

Note: The editor of The Lancet, one of the most prestigious medical journals in the world, recently wrote that half of all claims made in medical science journals may be untrue. For more along these lines, see concise summaries of deeply revealing big Pharma profiteering news articles from reliable major media sources.


Shkreli Was Right: Everyone's Hiking Drug Prices
2016-02-02, BloombergBusinessweek
Posted: 2016-02-14 09:56:50
http://www.bloomberg.com/news/articles/2016-02-02/shkreli-not-alone-in-drug-p...

After Martin Shkreli raised the price of anti-parasitic drug Daraprim more than 50-fold to $750 a pill last year, he said he wasnt alone in taking big price hikes. The former drug executive was right. A survey of about 3,000 brand-name prescription drugs found that prices more than doubled for 60 and at least quadrupled for 20 since December 2014. Skyrocketing prices are getting increased scrutiny ahead of a U.S. congressional hearing this week: Democratic Representative Elijah Cummings, ranking member on a committee that is probing drug pricing, said Tuesday that pricing tactics are not limited to a few bad apples, but are prominent throughout the industry. The cost of many drugs [rises] at annual rates of more than 10 percent. Drugmakers raised the prices of products as wide-ranging as erectile dysfunction drug Viagra, heart treatments, dermatology medicine and even brands that long have lost their patents. While specialty companies have had the steepest hikes, giants such as Pfizer Inc. and GlaxoSmithKline Plc kept pushing through smaller rises. About 400 formulations of brand-name drugs went up at least 9.9 percent since early December. Valeant Pharmaceuticals International Inc., which in recent months has been under fire for its pricing was among the most aggressive, with 13 drugs that doubled or more since December 2014.

Note: For more excellent information on drug prices hikes, read this penetrating article in the Daily Beast. For more along these lines, see concise summaries of deeply revealing big pharma profiteering news articles from reliable major media sources.


Gates Foundation accused of 'dangerously skewing' aid priorities by promoting 'corporate globalisation'
2016-02-19, The Independent (One of the UK's leading newspapers)
Posted: 2016-02-07 10:57:24
http://www.independent.co.uk/news/world/politics/gates-foundation-accused-of-...

Bill and Melinda Gates are facing calls for their philanthropic Foundation, through which they have donated billions worldwide, to be subject to an international investigation. The Gates Foundation is about benefiting big business, especially in agriculture and health, through its ideological commitment to promote neoliberal economic policies and corporate globalisation, according to [a] report published by the campaign group Global Justice Now. The report accuses the Gates Foundation of [turning] basic needs into commodities controlled by the market. The report is critical of the close working relations between the Foundation and major international pharmaceutical corporations. It accuses the Gates Foundation of promoting specific priorities through agriculture grants, some of which undermine the interests of small farmers. These include promoting industrial agriculture, use of chemical fertilisers and expensive, patented seeds, and a focus on genetically modified seeds. The criticism echoes the accusations made by the Indian scientist Vandana Shiva who called the Gates Foundation the greatest threat to farmers in the developing world. The Foundations emphasis on technological solutions often ignores real solutions involving social and economic justice. This cannot be given by donors in the form of a climate-resilient crop or cheaper smartphone, but must be about systemic social, economic and political change issues not represented in the foundations funding priorities.

Note: The Gates Foundation is heavily invested in GMO giants like Monsanto. It also provided $5 million to Oxitec, a company criticized for secretly releasing GM mosquitoes into the wild in 2009. Oxitec was purchased last August by biotech giant Intrexon for $160 million. By December, the Zika virus was all over the news and Intrexon was ramping up production of these GM insects to "fight Zika" in Brazil. For more along these lines, see concise summaries of deeply revealing corporate corruption news articles from reliable major media sources.


Taking antidepressants during pregnancy linked to increased risk of autism
2015-12-14, USA Today
Posted: 2016-01-31 19:26:25
http://www.usatoday.com/story/news/2015/12/14/taking-antidepressants-during-p...

Women who took antidepressants in the last six months of pregnancy were 87% more likely to have a child later diagnosed with autism. Doctors saw no increase in autism rates in women who took medication for depression in the first three months of pregnancy, according to [a new] study, published online Monday in JAMA Pediatrics. In the U.S., about 2.2% of children ages 3 to 17 - about one in 45 - have autism, according to the Center for Disease Control and Prevention's National Health Interview Survey, conducted in 2014. Women who took a specific type of antidepressants, called selective serotonin re-uptake inhibitors, or SSRIs, had more than double the risk of having a child with autism. Women who took more than one medication for depression ... were four times as likely to have a child with autism. The new study is ... part of a growing body of research that suggests that the events that cause autism largely occur before birth. Studies have found that children are at higher risk for autism, for example, if they are born early or very small. Children are also at higher risk if they are in medical distress during delivery; if they have older mothers or fathers; or if they are born less than a year after an older sibling.

Note: For more along these lines, see concise summaries of deeply revealing health news articles from reliable major media sources. Then explore the excellent, reliable resources provided in our Health Information Center.


Pricey hepatitis C drugs threaten health care system
2016-01-11, San Francisco Chronicle (San Francisco's leading newspaper)
Posted: 2016-01-31 19:24:22
http://www.sfchronicle.com/opinion/openforum/article/Pricey-hepatitis-C-drugs...

When does Big Pharma profiting become profiteering? This issue was the subject last month of a Senate Finance Committee investigation of pricing practices of Gilead Sciences Inc., a leading provider of hepatitis C medications. After examining 20,000 pages of internal company documents, looking at Medicaid data and interviewing health care experts, the authors concluded that the Foster City drugmaker pursued a calculated scheme for pricing and marketing its hepatitis C drug based on one goal: maximizing revenue regardless of the human consequences. With the hepatitis C virus affecting about 3 million people in the United States, the impact of Gileads pricing strategy is real, measurable - and devastating. With a 12-week course of Gileads Harvoni priced at nearly $100,000, taxpayer-funded Medicare Part D spent $4.6 billion on hepatitis C alone in the first half of 2015. When insurers refuse to pay for treatment, all but the wealthy are left at risk for cirrhosis, liver cancer and death. While anticipating record profits of $30 billion in 2015, Gilead virtually eliminated its medication assistance program. More than 90 percent of hepatitis C patients can achieve a cure with as little as one pill a day. But to realistically address this epidemic at current pricing levels would bankrupt our health care system. Pharmaceutical innovation holds great promise for the future of our health care system. But not if none of us can afford it.

Note: For more along these lines, see concise summaries of deeply revealing news articles about big pharma profiteering. Then read an in-depth essay titled "The Truth About Drug Companies" by acclaimed author Dr. Marcia Angell.


Doctor-pharma industry ties examined in 'embarrassing' report
2016-01-08, CBC (Canada's public broadcasting system)
Posted: 2016-01-10 19:00:54
http://www.cbc.ca/news/canada/british-columbia/doctor-pharma-industry-ties-re...

A report commissioned by the College of Family Physicians of Canada to examine the relationship between doctors and the pharmaceutical industry is being criticized. The document ... was completed in 2013 and only released this month after a number of doctors challenged the college board to make it public. In one of its key findings, the report notes, "There have been instances in which marketing messages have been portrayed as education and health care and pharmaceutical industries have attempted in this way to influence physicians' behaviour or practices," it says. "Evidence suggests that there could also be significant influence on the behaviour of individuals who may be offered gifts or other forms of support, even when the recipients perceive neither obligation nor influence." The report makes 20 recommendations dealing with issues such as conflict of interest, financial relationships, marketing and other relationships with the pharmaceutical and health care industries. But they don't prevent a doctor with ties to the pharmaceutical industry from serving in leadership positions, sponsoring certain events, or even from contributing to an "unrestricted" education fund. Alan Cassels, a drug policy researcher at the University of Victoria, is critical of the college for sitting on the report as long as it did. He suspects the college held it back because it's "pretty embarrassing."

Note: For more along these lines, see concise summaries of deeply revealing news articles about the corruption of science and big pharma profiteering. Then read an in-depth essay titled "The Truth About Drug Companies" by acclaimed author Dr. Marcia Angell.


Researcher issues 'call to action' to force release of hidden drug safety data
2015-12-22, CBC (Canada's public broadcasting system)
Posted: 2016-01-03 13:52:08
http://www.cbc.ca/news/health/drug-safety-data-herder-1.3375325

Dr. Nav Persaud, a family doctor in Toronto, asked and received thousands of pages of documents from Health Canada, and what he saw made him question the effectiveness of a popular morning sickness drug. But he can't talk about it, because Health Canada forced him to sign a confidentiality agreement, and threatened him with legal action if he makes the data public. Matthew Herder, [a] health law associate professor ... is calling on other doctors, researchers and journalists to bombard Ottawa with their own demands for drug industry data, using [a] new legislative lever written into ... the Protecting Canadians from Unsafe Drugs Act, which was passed late last year. Today, in the Canadian Medical Association Journal, Herder is urging Canadians to use the clause [to request] data that has long been protected by a wall of bureaucratic and corporate secrecy. The European Medicines Agency has started publishing all of the clinical reports submitted as part of drug marketing authorization applications - the same material Health Canada refuses to disclose. Almost half of the drug trials remain secret. [In the US], one group looked at 12 antidepressants, comparing the published studies with the internal FDA assessments. 94 per cent of the published studies were positive, compared to 51 per cent when they included all of the studies assessed by the FDA. The authors concluded that without seeing all the data, drug effectiveness can be exaggerated, leading doctors and patients to assume the medications work better than they do.

Note: For more along these lines, see concise summaries of deeply revealing news articles about government corruption and big pharma profiteering. Then read an in-depth essay titled "The Truth About Drug Companies" by acclaimed author Dr. Marcia Angell.


Disgraced CEO Shkreli embodies problem with U.S. pharma industry
2015-12-18, San Francisco Chronicle (San Francisco's leading newspaper)
Posted: 2015-12-27 21:13:30
http://www.sfchronicle.com/business/article/Disgraced-CEO-Shkreli-embodies-pr...

Martin Shkreli ... gained notoriety in August when, as CEO of Turing Pharmaceuticals, he acquired a drug to treat parasitic infections, especially in pregnant women and AIDS patients, and proceeded to hike the price to from $13.50 to $750 per pill. He resigned from Turing Friday after being arrested on unrelated charges of securities fraud at a hedge fund. Shkreli was no doubt a first-class tool. But to focus exclusively on shaming Shkreli risks missing the larger problem, that the American health care system allows opportunists like him to [exploit] the lack of transparency on how drugs are priced in the United States. His price gouging was perfectly legal and even justified under the market-based system that underpins the health care industry. Theres no law that he has to be ethical, said [Dr. Jeffrey] Lobosky, author of It's Enough To Make You Sick. His job is not to make drugs available and save patients. His responsibility is to make a profit for his shareholders. On paper, Turing is a drug company, but it more closely resembles a private-equity firm: it buys undervalued assets - older drugs already approved by federal regulators - and makes money by charging more than what it paid. Many firms make drugs that are mere copies of others and offer no real therapeutic value, Lobosky said.

Note: The unrepentant profiteering of big pharma and financial industry corruption go hand-in-hand.


Pharma Bro Martin Shkreli arrested for securities fraud
2015-12-17, Washington Post
Posted: 2015-12-20 18:06:57
https://www.washingtonpost.com/news/business/wp/2015/12/17/pharma-bro-martin-...

Martin Shkreli, the 32-year-old former hedge fund manager notorious for jacking up the price of an obscure but critical drug, was arrested Thursday on securities fraud charges. The charges are unrelated to Shkrelis leadership of Turing Pharmaceuticals. Instead, the charges brought by the U.S. attorney for the Eastern District of New York are related to Shkrelis time at Retrophin, another bio-pharmaceutical company he founded, and his time at MSMB Capital Management, a hedge fund. Federal prosecutors alleged that for five years, Shkreli lied to investors in two hedge funds and bio-pharmaceutical company Retrophin, all of which he founded. After losing money on stock bets he made through one hedge fund, Shkreli allegedly started another and used his new investors money to pay off those who had lost money on the first fund. Then, as pressure was building, Shkreli started Retrophin, which was publicly traded, and used cash and stock from that company to settle with other disgruntled investors. Shkreli engaged in multiple schemes to ensnare investors through a web of lies and deceit, U.S. Attorney Robert L. Capers told reporters. His plots were matched only by efforts to conceal the fraud, which led him to operate his companies ... as a Ponzi scheme. At his arraignment Thursday afternoon, Shkreli pleaded not guilty. He was released on $5 million bond.

Note: The unrepentant profiteering of big pharma and financial industry corruption seem to go hand-in-hand for Martin Shkreli.


Doctors' group calls for ban on prescription drug ads
2015-11-17, CBS News/Associated Press
Posted: 2015-11-23 13:45:45
http://www.cbsnews.com/news/doctors-group-calls-for-ban-on-drug-ads/

The American Medical Association on Tuesday called for a ban on direct-to-consumer ads for prescription drugs and implantable medical devices, saying they contribute to rising costs and patients' demands for inappropriate treatment. Delegates at the influential group's policy-making meeting in Atlanta voted to adopt that as official policy as part of an AMA effort to make prescription drugs more affordable. It means AMA will lobby for a ban. "Today's vote in support of an advertising ban reflects concerns among physicians about the negative impact of commercially driven promotions and the role that marketing costs play in fueling escalating drug prices," said Dr. Patrice Harris, an AMA board member. According to data cited in an AMA news release, ad dollars spent by drugmakers have risen to $4.5 billion in the last two years, a 30 percent increase. Other data show prices on prescription drugs have climbed nearly 5 percent this year, Harris said in the news release. She also raised concern that advertising spurs use of newer brand-name drugs when other possibly lower-cost options might be just as good. "Direct-to-consumer advertising also inflates demand for new and more expensive drugs, even when these drugs may not be appropriate." The pharmaceutical industry opposes the AMA's stance.

Note: For more along these lines, see concise summaries of deeply revealing big pharma profiteering news articles from reliable major media sources. Then read an in-depth essay titled "The Truth About Drug Companies" by acclaimed author Dr. Marcia Angell.


The life-saving pill pharma bro increased to $750 now has a $1 competitor
2015-10-23, Washington Post
Posted: 2015-11-08 20:36:04
https://www.washingtonpost.com/news/to-your-health/wp/2015/10/23/the-life-sav...

Turing Pharmaceuticals chief executive Martin Shkreli found himself in the middle of a media firestorm last month as he adamantly defended his company's 4,000 percent drug price hike. Daraprim, which treats a life-threatening infection in patients with HIV/AIDS and other immune problems, was increased to $750 a pill, a move resoundingly decried. Now, another company will offer a Daraprim alternative, at just $1 a pill. It's not an exact replica of Daraprim. San Diego-based Imprimis Pharmaceuticals announced Thursday that it is selling pills containing a "customizable compounded formulation" of pyrimethamine and leucovorin, both ingredients in Daraprim. The Food and Drug Administration doesn't approve compounded drugs, such as this one offered by Imprimis. Typically, compounded drugs are prescribed to patients who can't take FDA-approved drugs, such as for those who are allergic to an inactive ingredient. Compounded drugs are no stranger to controversy; a compounding pharmacy was at the heart of a deadly meningitis outbreak in 2012 that killed 64 people and sickened more than 600. Federal legislators subsequently tightened regulations over such companies. And compounded drugs can be very pricey, too. But it appears the Daraprim alternative compound was not born out of a physical inability to use Daraprim, but a financial one.

Note: Read more about Turing Pharmaceuticals' outrageous Daraprim price-hike. Those in charge of the compounding pharmacy mentioned above were charged with homicide, but when a meningitis outbreak killed 11 children in an illegal Nigerian drug trial conducted by Pfizer, no one at Pfizer was charged with a crime. For more along these lines, see concise summaries of deeply revealing news articles about big pharma corruption.


When Crime Pays: J&Js Drug Risperdal
2015-09-17, New York Times
Posted: 2015-10-11 16:18:07
http://www.nytimes.com/2015/09/17/opinion/nicholas-kristof-when-crime-pays-jj...

Risperdal is a billion-dollar antipsychotic medicine with real benefits and a few unfortunate side effects. It can cause strokes among the elderly. And it can cause boys to grow large, pendulous breasts; one boy developed a 46DD bust. Yet Johnson & Johnson marketed Risperdal aggressively to the elderly and to boys while allegedly manipulating and hiding the data about breast development. J&J got caught, pleaded guilty to a crime and has paid more than $2 billion in penalties and settlements. But that pales next to some $30 billion in sales of Risperdal around the world. In 1994, J&J released Risperdal. The Food and Drug Administration said it ... was effective primarily for schizophrenia in adults. Thats a small market. So J&J reinvented Risperdal as a drug for a broad range of problems, targeting everyone from seniors with dementia to children with autism. The company also turned to corporate welfare: It paid doctors and others consulting fees and successfully lobbied for Texas to adopt Risperdal in place of generics. Even though Risperdal wasnt approved for the elderly, J&J formed a sales force called ElderCare. The F.D.A. protested and noted that there were an excess number of deaths among the elderly who took the drug. At the same time, J&J ... began peddling the drug to pediatricians, so that by 2000, more than one-fifth of Risperdal was going to children and adolescents. In 2003, the company had a back to school marketing campaign for Risperdal. By 2004 Risperdal was a $3-billion-a-year drug.

Note: For more, see this NY Times article and this one. For more along these lines, see concise summaries of deeply revealing big pharma corruption news articles from reliable major media sources.


Study 329: Antidepressant trial's upended results show need for sharing all data
2015-09-17, International Business Times
Posted: 2015-10-04 18:18:19
http://www.ibtimes.co.uk/study-329-antidepressant-trials-upended-results-show...

In 2001, a "landmark" study published in the prestigious Journal of the American Academy of Child and Adolescent Psychiatry purported to show the safety and effectiveness of using a common antidepressant to treat adolescents. The original published findings were biased and misleading. Known as Study 329, the randomised controlled trial ... was funded by SmithKline Beecham now GlaxoSmithKline (GSK) the manufacturer of paroxetine. The research has been repeatedly criticised, and there have been numerous calls for it to be retracted. To re-analyse the evidence of effectiveness and safety of paroxetine, we used documents posted online by GSK. We also had access to other publicly available documents and individual participant data. We found that paroxetine [Paxil] was no more effective than a placebo, which is the opposite of the claim in the original paper. We also found significant increases in harms with both paroxetine and imipramine, [another antidepressant]. Compared with the placebo group, the paroxetine group had more than twice as many severe adverse events, and four times as many psychiatric adverse events, including suicidal behaviours and self-harm. And the imipramine group had significantly more heart problems. Our re-analysis ... identified ten strategies used by researchers in this clinical trial to minimise apparent harms. More importantly, our findings show influential peer-reviewed research published in leading medical journals can be seriously misleading.

Note: We all know that clinical trial are skewed when they are sponsored by drug companies, but here is undeniable proof of this published in the UK's most respected medical journal. See this key study on the website of the British Medical Journal. Then don't miss that amazing documentary "Bought" available for free viewing.


Valeant Pharmaceuticals' drug price hikes in crosshairs of U.S. Congress
2015-09-29, CBC News (Canada's public broadcasting system)
Posted: 2015-10-04 18:16:09
http://www.cbc.ca/news/health/valeant-pharmaceuticals-price-hikes-1.3248265

Quebec-based Valeant Pharmaceutical's price hikes of drugs long off patent has raised the ire of U.S. legislators and frustrated Canadian physicians. Democrats on the House of Representatives committee on oversight and government reform sent a letter Monday to the committee's Republican chairman seeking a subpoena that would force Valeant to turn over documents tied to the U.S. price hikes of two heart drugs. In the U.S., the price of Isuprel or Isoprenaline increased 2,500 per cent and Nitropress went up 1,700 per cent in three years, as the drug changed hands. Valeant purchased the rights to both heart drugs from Marathon Pharmaceuticals in February. As huge overnight drug price hikes becomes an election issue in the U.S., some doctors in Canada struggle to get other prices rolled back. In late 2013, Valeant Canada announced that as of January 2014, the price of a one-month supply of Syprine would match the U.S. price of roughly $13,244, or about 13 times higher than the previous price. The medication makes the difference between a full and productive life or a downward course of increasing liver and neurological disease. For physicians, the price increase put them in the position of having to tell patients their disease can be managed or cured but at an out-of-pocket price of $200,000 a year for the rest of their lives.

Note: For more along these lines, see concise summaries of deeply revealing news articles about big pharma profiteering from reliable major media sources.


Daraprim 'profiteering' controversy lifts lid on soaring cost of prescription drugs
2015-09-27, The Guardian (One of the UK's leading newspapers)
Posted: 2015-10-04 18:13:27
http://www.theguardian.com/us-news/us-money-blog/2015/sep/27/daraprim-profite...

Until this week most of us had never heard of Daraprim, a drug that fights toxoplasmosis. But after the decision of the drugs new owner, Turing Pharmaceuticals, to boost its cost per pill from $13.50 to a whopping $750, were all unlikely to forget its name or the name of Turings owner, 32-year-old Martin Shkreli. The outrage over the astronomical hike in a life-saving drug has opened the doors to a ... debate about the soaring costs of prescription medications in the United States. Daraprim ... has been around since the 1940s. Logic suggests that drugs that have been around for a while should decline in price. It turns out that isnt the case. The profit-minded individual or company snaps up the patents, suddenly hikes the drugs price and puts consumers from insurance companies to individuals in a position of either paying what is demanded or going without. Late this summer, Rodelis Therapeutics boosted the cost of 30 tablets of cycloserine, a tuberculosis drug, from $500 to $10,800. Early in the year, Valeant Pharmaceuticals International Inc boosted the prices of two heart drugs, Nitropress and Isuprel, by 525% and 212% on the same day that they acquired them. Our duty is to shareholders and to maximize the value of Valeants products, a company spokeswoman told the Wall Street Journal at the time.

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