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Antidepressants Might Accelerate Dementia Decline
Key Excerpts from Article on Website of US News & World Report
Posted: March 6th, 2025
https://www.usnews.com/news/health-news/articles/2025-02-25/...
Antidepressants are frequently prescribed to people with dementia for symptoms like anxiety, depression, aggressiveness and sleeplessness. But a specific class of antidepressant medications - selective serotonin reuptake inhibitors (SSRIs) - actually might speed up brain decline among some dementia patients, a new Swedish study suggests. Heavier doses of certain SSRIs are tied to a higher risk for severe dementia, researchers reported in a new study ... in the journal BMC Medicine. The SSRI drug escitalopram was associated with the fastest cognitive decline, followed by citalopram and sertraline. For the study, researchers tracked the brain health of more than 18,700 patients enlisted in the Swedish Registry for Cognitive/Dementia Disorders between May 2007 and Oct. 2018. The patients’ average age was 78. During an average follow-up of more than four years, about 23% of patients received a new prescription for an antidepressant, researchers said. SSRIs were the most commonly prescribed antidepressant, amounting to 65% of all those prescriptions, the study says. “Higher dispensed doses of SSRIs were associated with higher risk for severe dementia, fractures, and all-cause mortality,” the researchers concluded. “These findings highlight the significance of careful and regular monitoring to assess the risks and benefits of different antidepressants use in patients with dementia.”
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